Clinical trials: Bupivacaine
Thoracic Surgery, Video-Assisted
Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection
Intercostal cryoanalgesia is a technique that allows extensive and prolonged analgesia of the hemithorax. The aim of this study is to demonstrate the efficacy of intercostal cryoanalgesia as an adjunct to a single-injection…
- Conditions
- Thoracic Surgery, Video-Assisted, Cryotherapy Effect, Paravertebral Block
- Trial name
- CRYO-VATS (NCT05896150)
- Testing
- Cryoanalgesia AND single-injection paravertebral block, Single-injection paravertebral block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Analgesics, Opioid, Anesthesia, Spinal
Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery
Pain management after total hip replacement is one of the most important aspects of postoperative care for patients and clinicians alike.
- Conditions
- Analgesics, Opioid, Anesthesia, Spinal, Total Hip Replacement, Adverse Anesthesia Outcome
- Trial name
- NCT06878014
- Testing
- Spinal Anesthesia (bupivacaine), Postoperative pain management with acetaminophen, PCA IV Oxycodone
- Where
- 3 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Silesia
Postdural Puncture Headache
Study Evaluating Sphenopalatine Ganglion Block (SPGB) for Treatment of Postdural Puncture Headache (PDPH)
Postdural puncture headaches (PDPH) are a consequence of spinal and epidural anesthesia in approximately 1% of cases when performed in obstetric patients.
- Trial name
- PDPH (NCT02365909)
- Testing
- 0.5% bupivacaine, normal saline
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Pediatric Postoperative Pain
Ultrasound Guided Pericapsular Nerve Group Block Versus Quadratus Lumborum Block
Hip surgeries in pediatrics consider as one of the common nowadays surgeries with sever postoperative pain so pain management is essential to decrease postoperative complications, early mobilization and hospital discharge.
- Trial name
- NCT05444309
- Testing
- Quadratus lumborum (QL) block group, Pericapsular Nerve Group (PENG) block group
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Zagazig University
Pain, Postoperative, Developmental Dysplasia of the Hip
Postoperative Analgesic Effect of Two Peripheral Nerve Blocks for Hip Surgery in Pediatrics
Hip joint surgery for developmental dysplasia of the hip (DDH) in children is extremely painful and associated with considerable postoperative pain despite the use of systemic opioids.
- Conditions
- Pain, Postoperative, Developmental Dysplasia of the Hip, Regional Anesthesia Morbidity
- Trial name
- NCT05348421
- Testing
- FTPB, PENG Block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Pain
Pain Perception After Tubal Ligation
The purpose of this study is to attempt to determine retrospectively whether there was a statistically significant difference in patient need for postoperative narcotics between two different groups of women who received a…
- Trial name
- NCT01062087
- Testing
- Bupivacaine, Lidocaine
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Breast Cancer
Selective Intraoperative Administration of Local Anesthesia in Breast Reconstruction
Subjects are being asked to participate in this study because they will be undergoing unilateral (one) or bilateral (two) mastectomy surgery with immediate reconstruction involving insertion of a tissue expander.
- Trial name
- NCT02525718
- Testing
- Saline, 0.25 % bupivacaine (2.5 mg/ml) w/ 1:100,000 epinephrine & 4 mg dexamethasone
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Northwestern University
Intraoperativ Pain
Intrathecal Fentanyle Versus Dexamethasone in Gynacological Laparoscopic Surgeries
Laparoscopy was first introduced to the medical field of in the middle of the last century. It revolutionized the surgical interventions; it reduced the total medical expenditures and hastened postoperative recovery .
- Trial name
- NCT04779060
- Testing
- intrathecal fentanyle, dexamethasone, saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Thoracic Epidural Analgesia, Fracture Ribs
Thoracic Epidural Analgesia in Multiple Traumatic Fracture Ribs
This work aims at comparing the analgesic effect of Thoracic Epidural Magnesium sulfate versus Fentanyl when added as adjuvants to Bupivacaine in patients with multiple traumatic fracture ribs.
- Trial name
- NCT03595397
- Testing
- Bupivacaine, Magnesium Sulfate, Fentanyl
- Volunteers
- 60 people
- Sponsor
- Assiut University
Caudal Block for Postoperative Analgesia
Effect of Adding Different Concentrations of Dexmedetomidine to Bupivacaine in Caudal Block for Pediatrics
Pain is one of the medical problems frequently misdiagnosed, undertreated, and poorly under-stood, particularly in children.Poor pain management during childhood may have long-term deleterious impacts, including damaging…
- Trial name
- NCT06668220
- Testing
- Dexmedetomidine, Bupivacain
- Volunteers
- 50 people
- Sponsor
- Assiut University
Liver Resection, Upper Abdominal Surgeries
Comparative Effects of ESP Block and EOIP Block on Postoperative Respiratory Recovery Following Liver Resection
This study evaluates respiratory recovery as a multidimensional construct using clinically relevant and measurable parameters, including LUS, diaphragmatic excursion, oxygen requirement, and PPCs.
- Trial name
- NCT07740382
- Testing
- Ultrasound-guided bilateral external oblique intercostal plane (EOIP) block, Ultrasound-guided bilateral erector spinae plane (ESP) block
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Menoufia University
Postamputation Pain, Lower Limb Amputation
Acute Post-Amputation Pain Management After Combat-Related Lower Limb Injury
Acute post-amputation pain remains a significant clinical challenge in patients with combat-related lower limb injuries and may negatively affect early rehabilitation, mobility, and opioid consumption.
- Conditions
- Postamputation Pain, Lower Limb Amputation, Combat Trauma
- Trial name
- APAPMACRLLI (NCT07863921)
- Testing
- Continuous Peripheral Nerve Blocks, Peripheral Nerve Cryoablation, Standard multimodal analgesia
- Where
- Ukraine
- Volunteers
- 36 people
- Sponsor
- Kharkiv National Medical University
Nerve Block/Methods
Comparing Suprascapular Nerve Block and Interscalene Block for Post-thoracotomy Pain in Pediatric Patients.
The goal of this clinical trial is to determine which regional block provides superior analgesia in pediatric patients undergoing thoracic surgery.
- Trial name
- NCT07796399
- Testing
- Interscalene brachial plexus block, anterior Supraclavicular nerve block, Thoracic Epidural Analgesia (TEA) only
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Prostate Cancer
Stellate Ganglion Block for Hot Flushes in Men Treated With ADT
Androgen deprivation therapy (ADT) is widely used as standard therapy in the treatment of locally advanced and metastatic prostate cancer. Hot flushes and night sweats are one of the main side-effects of ADT.
- Trial name
- NCT02295163
- Testing
- Stellate ganglion block
- Where
- Netherlands
- Sponsor
- Rijnstate Hospital
Cardiovascular Diseases
ESPB vs TPVB for Cardiac Surgery
Pain is a common and serious problem after cardiovascular surgery. It is associated with increased morbidity and mortality, and additional risk factors of cardiac surgery such as sternotomy and cardiopulmonary bypass contribute…
- Trial name
- NCT05476393
- Testing
- Postoperative management
- Where
- Turkey (Türkiye)
- Sponsor
- Medipol University
Pediatric Hip Surgery
Ultrasound Guided Erector Spinae Muscle Block in Pediatric Surgeries
Surgical repair of the hip can be extremely painful and is associated with considerable postoperative pain in children despite the use of systemic opioids.
- Trial name
- NCT05832671
- Testing
- Erector Spinae muscle block, caudal block
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
PENG Block, Hip Arthroplasty, Total
PENG vs PHPB for Hip Arthroplasty Analgesia
Total hip arthroplasty (THA) is a commonly performed surgical procedure, and its incidence continues to rise with the aging population. Effective postoperative analgesia facilitates early mobilization and accelerates recovery.
- Conditions
- PENG Block, Hip Arthroplasty, Total, QoR-15, Numeric Rating Scale
- Trial name
- NCT07263932
- Testing
- PENG Block and Posterior Hip Pericapsular Block, PENG Block
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Ankara City Hospital Bilkent
Intraoperative Pain
Analgesic Efficacy of Intrathecal Fentanyl-Morphine Combination Versus Morphine Alone for Intraoperative Pain During Elective Cesarean Delivery
Pregnant women scheduled for elective cesarean sections under spinal anesthesia are randomly assigned to two groups: 1) the Fentanyl-Morphine (FM) group, and 2) the Morphine (M) group.
- Trial name
- NCT06570343
- Testing
- Fentanyl-Morphine, Morphine
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pain, Postoperative
Caudal Bupivacaine vs Bupivacaine Plus Two Doses of Dexmedetomidine for Postoperative Analgesia in Children
The aim of this prospective randomized double-blind study was to compare the analgesic efficacy and the side effects of two doses of dexmedetomidine (1 and 2 µg.kg-1) co-administered with bupivacaine with bupivacaine alone for…
- Trial name
- NCT02385435
- Testing
- Bupivacaine, dexmedetomidine 1μg.kg-1, dexmedetomidine 2μg.kg-1
- Volunteers
- 91 people
- Sponsor
- University of Jordan
Maternal Hypotension After Spinal Anesthesia
Height Versus Height and Weight Based Spinal Bupivacaine on Maternal Haemodynamics for Elective Cesarean in Short Stature Patients
Doses of intrathecal bupivacaine based on patients either height or height and weight has shown to lower the risk of maternal hypotension with similar quality of anesthesia compared to conventional doses.
- Trial name
- NCT04082676
- Testing
- Hyperbaric bupivacaine spinal
- Where
- Nepal
- Volunteers
- 112 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
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