Clinical trials: Bupivacaine
Spinal Anesthesia, Cesarean Section
Predicting Spinal Hypotension in Cesarean Section
This prospective observational study investigates the predictive value of anthropometric and hemodynamic indices for spinal anesthesia-induced hypotension (SAIH) during cesarean section.
- Conditions
- Spinal Anesthesia, Cesarean Section, Hypotension
- Trial name
- prediction (NCT07499947)
- Where
- Turkey (Türkiye)
- Volunteers
- 321 people
- Sponsor
- TC Erciyes University
Epidural Analgesia, Postoperative Pain
Comparison of the Incidence of Inadequate Epidural Analgesia Between Protocol Based and Current Practice
Epidural analgesia is the recommended analgesic technique in patients having surgery with severe postoperative pain such as thoracic and upper abdominal surgery.
- Trial name
- NCT04111406
- Testing
- Current practice, Protocol based
- Where
- Thailand
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Spine Fusion, Spine Metastases
Erector Spinae Plane Block in Spine Surgeries for Postoperative Pain
This prospective single-blind randomized controlled study on 50 patients between 18 and 65 years, both sexes, with ASA I-II and undergoing elective lumbar spine surgical procedures.
- Conditions
- Spine Fusion, Spine Metastases, Postoperative Pain
- Trial name
- NCT06970704
- Testing
- Erector Spinae Plane Block using 0.25 % bupivacaine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Thoracic Surgery, Glycemic Variability
Comparison of Liposomal Bupivacaine Paravertebral Nerve Block Versus Intercostal Nerve Block on Postoperative Glycemic Variability in Patients Undergoing Minimally Invasive Pulmonary Resection: A Randomized Controlled Non-Inferiority Trial
In this randomized controlled non-inferiority trial, we will test whether liposomal bupivacaine intercostal nerve block is non-inferior to paravertebral nerve block for the coefficient of variation (CV) of glucose during the 0…
- Trial name
- NCT07754916
- Testing
- Paravertebral nerve block, Intercostal nerve block
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Xiangya Hospital of Central South University
Hip Disease
Evaluation of LB in THA
This study aims to compare the effectiveness of liposomal bupivacaine (LB) versus standard of practice local injection containing plain bupivacaine.
- Trial name
- NCT03341104
- Testing
- Bupivacaine liposome
- Volunteers
- 173 people
- Sponsor
- OSF Healthcare System
Musculoskeletal Diseases or Conditions
Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block
Sciatic nerve block at the popliteal fossa is indicated for foot or ankle surgery, and the introduction of ultrasound guidance (USG) has improved the ease and accuracy of the performance of this block.
- Trial name
- NCT04397484
- Testing
- 0.5% Levobupivacaine, 2% Xylocaine with adrenaline 1:200,000
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Neurophysiological Monitoring Under TIVA
The Impact of ESP on Neurophysiological Monitoring in Scoliotic Patients
Scoliosis surgery requires intraoperative neuromonitoring. Electrophysiological monitors used include somatosensory evoked potentials (SEPS) and motor-evoked potentials (MEPS).
- Trial name
- NCT05632016
- Testing
- erector spinae block (ESP)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Total Hip Arthroplasty, Analgesia
Spinal Nalbuphine for Analgesia in Total Hip Arthroplasty
60 patients ASA I-III, undergoing total hip arthroplasty were randomly assigned, into one of two groups, namely group E (n=30), where levobupivacaine will be administeral intrathecally ; and group N (n=30), where levobupivacaine…
- Trial name
- NCT06577155
- Testing
- Levobupivacaine, Levobupivacaine plus nalbuphine
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Asklepieion Voulas General Hospital
Pelvic Organ Prolapse
Preoperative Analgesia by Infiltration of the Pudendal Nerve Prior to Sacrospinous Ligament Suspension
Pelvic organ prolapse is a common problem. It affects about half of women and causes uncomfortable bulge sensations (similar to sitting on a ball), urine and stool problems, difficulty with sexual activity and embarrassment.
- Trial name
- PAINS (NCT04733560)
- Testing
- Pudendal nerve block, Bupivacaine Injectable Product
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fraser Health
Pain, Postoperative
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
Laparoscopic colorectal surgery (LCS) has gained wide acceptance in the treatment of various pathology from diverticular disease to colon cancer.
- Trial name
- NCT02086123
- Testing
- Epidural Analgesia, Parenteral Analgesia (Intravenous)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Irvine
Erector Spinae Block, Lumbar Fusion Surgeries
Adding Dexmedetomidine to Bupivacaine for Bilateral Erector Spinae Block
The aim of this study is to compare the analgesic effect of bilateral US-guided ESPB using bupivacaine alone versus bupivacaine and DEX in lumbar fusion surgeries.
- Conditions
- Erector Spinae Block, Lumbar Fusion Surgeries, Dexmedetomidine
- Trial name
- NCT06231979
- Testing
- Dexmedetomidine, Bupivacain, Normal saline
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Assiut University
Analgesia
Efficacy of Dexmedetomidine VS Magnesium Sulphate With Bupivacaine in Erector Spinae Block for Thoracotomy Pain
Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy…
- Trial name
- NCT05851768
- Testing
- Bupivacaine, Bupivacaine + Magnesium, Bupivacaine + Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Anesthesia, Local
Ice as an Adjunct for Local Anesthesia During Anorectal Surgeries
The purpose of this study is to determine, among patients receiving elective anorectal surgery, does application of ice to the perianal area prior to the procedure, lead to use of decreased amounts of intravenous (IV) anesthesia?…
- Trial name
- NCT04000191
- Testing
- MAC, Perianal ice application
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Medical Center
Colon Cancer, Inflammatory Bowel Diseases
Spinal Analgesia for Colonic Resection Using an Enhanced Recovery After Surgery (ERAS) Program
This is a blinded randomized controlled trial in patients undergoing laparoscopic colon surgery. The aim of this study is to assess whether spinal analgesia with a mixture of bupivacaine and morphine provides better pain relief…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01477190
- Testing
- Spinal analgesia, Patient Control Analgesia (PCA) Morphine
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Analgesia
Comparison Between Perineural and Systemic Effect of Dexamethasone for Interscalene Brachial Plexus Block.
The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block. The aim of this study is to determine whether this a systemic or local effect.
- Trial name
- NCT02190760
- Testing
- Dexamethasone, Bupivacaine
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Hillel Yaffe Medical Center
Gall Stone Disease
Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy
Comparison of intraoperative infusion of lidocaine and esmolol in the postoperative requirement of opioid for postoperative pain management after laparoscopic cholecystectomy to decrease opioid related side effects and enhance…
- Trial name
- NCT02327923
- Testing
- Lidocaine, Esmolol, Paracetamol
- Where
- Nepal
- Volunteers
- 90 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Atrial Fibrillation
A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation
The purpose of this study is to test if a nerve block procedure called a stellate ganglion block can help decrease the chance of atrial fibrillation after surgery.
- Trial name
- NCT05357690
- Testing
- Stellate ganglion block, Bupivacaine
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Pain
The Use of Liposomal Bupivacaine in TAP Blocks for Women Undergoing Cesarean Section
This present investigation aims to determine whether a transversus abdominous plane(TAP) block, utilizing liposomal bupivacaine (Exparel), at the conclusion of a cesarean section decreases post-operative pain.
- Trial name
- NCT02847013
- Testing
- TAP block w Liposomal bupivacaine, TAP block w normal saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pain, Hip Fracture
PENG vs. FIC Block for Hip Fracture ED Patients
Ultrasound-guided nerve blocks are an important tool for treating pain due to orthopedic injury in the ED. They provide long lasting, opioid-sparing pain relief that is generally safe and well-tolerated by patients1.
- Trial name
- NCT05102760
- Testing
- Nerve Block using FIC Proceedure, Nerve Block using PENG Proceedure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Antonios Likourezos
Rotator Cuff Tear, Pain, Postoperative
Single Shot Liposomal Bupivicaine in Rotator Cuff Surgery
This document is a protocol for a human research study. This study is to be conducted according to United States standards of Good Clinical Practice in accordance with applicable Federal regulations and institutional research…
- Trial name
- NCT03822182
- Testing
- liposomal bupivicaine, Dexamethasone
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Indiana University
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