Clinical trials: Bupivacaine
Arthroscopic Shoulder Surgery
Interscalene Versus Infraspinatus-Teres Minor Blocks for Arthroscopic Shoulder Surgery
This randomized controlled trial aims to compare the effectiveness of interscalene (ISB) and infraspinatus-teres minor (ITM) blocks for postoperative analgesia in patients undergoing elective arthroscopic shoulder surgery.
- Trial name
- ITM-ISB (NCT07253740)
- Testing
- Interscalene Brachial Plexus Block (ISB), Infraspinatus-Teres Minor Block (ITM)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Postoperative Pain Management
Magnesium Sulphate in Oblique Subcostal TAP Block
The aim of this study is to evaluate the effect of adding different doses of MgSO4 to bupivacaine via OSCTAB block on postoperative pain control for 24 hours in patients scheduled for LC.
- Trial name
- NCT06148168
- Testing
- Bupivacaine plus normal saline, Bupivacaine plus normal saline containing MgSO4
- Volunteers
- 72 people
- Sponsor
- Assiut University
Postoperative Nausea and Vomiting, Postoperative Pain After Laparoscopic Sleeve Gastrectomy
Paragastric Block for Pain and PONV in Sleeve Gastrectomy
This single-center, prospective, randomized, double-blind controlled trial aims to evaluate the effects of intraoperative paragastric block (PGBLOCK) on early postoperative visceral pain, postoperative nausea and vomiting (PONV)…
- Trial name
- BLOCK-SG (NCT07274215)
- Testing
- Bupivacaine 0.5%, Isotonic Saline (0.9% NaCl)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Umraniye Education and Research Hospital
Anesthesia
Dexmedetomidine Versus Fentanyl Plus Bupivacaine for Epidural Analgesia With General Anesthesia for Lumbar Disc Operations
The purpose of this study is to compare addition of dexmedetomidine or fentanyl to bupivacaine for epidural analgesia in combination with general anesthesia in elective lumbar spine operations as regard hemodynamic stability…
- Trial name
- NCT03438240
- Testing
- Bupivacaine, Fentanyl, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
CREST Syndrome, Peripheral Vascular Disease
Exparel as a Nerve Block for Severe Hand Pain
The purpose of this study is to investigate whether the use of the study drug (Exparel) is safe and effective for treating circulation problems and pain in the hand or fingers.
- Conditions
- CREST Syndrome, Peripheral Vascular Disease, Raynaud Disease, Scleroderma, Diffuse
- Trial name
- NCT02374320
- Testing
- liposomal bupivacaine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Jose Soberon, MD
Colorectal Disorders, Surgery
Transverse Abdominus Plane Block Study
Study the effect of laparoscopic guided TAP block on opioid consumption and associated costs using a mixture of dexmedetomidine, dexamethasone, and ropivacaine versus Liposomal bupivacaine (Exparel®) in patients who undergo…
- Trial name
- TAP (NCT05216055)
- Testing
- Ropivacaine, Dexmedetomidine, Dexamethasone sodium phosphate, Normal saline, Liposomal bupivacaine
- Sponsor
- University of Colorado, Denver
Pain, Analgesia
Fascia Iliaca Block Versus Intravenous Dexmedetomidine and Ketamine for Positioning Fracture Femur
Proximal femur fractures are one of the commonest fractures especially in the elderly population. Early surgical fixation is the best analgesic for associated pain.
- Trial name
- NCT05705726
- Testing
- ultrasound guided facia iliaca block, Intravenous drug
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Anesthesia
Application of Combined Lumbar Plexus and Sciatic Nerve Block
The research is to study the effectiveness and safety of combined lumbar plexus and sciatic nerve block by the guide of peripheral nerve stimulator (PNS) in unilateral knee replacement.There have be some papers which supported…
- Trial name
- NCT02084368
- Testing
- Nerve block, Combined spinal and epidural anesthesia, Ropivacaine
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Cesarean Section Pain
Intra Incisional Infiltration of Bupivacaine Versus Meloxicam on Post Cesarean Section Pain Relief
Investigation: compare the effect of local infiltration of incision site with bupivacaine and local infiltration with meloxicam in women undergoing cesarean sections on postoperative pain relief and analgesic requirement.
- Trial name
- NCT04538391
- Where
- Egypt
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Post-Traumatic Headache
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 2
Anesthetic greater occipital nerve (GON) blockade is a simple, inexpensive, and safe procedure that has demonstrable headache pain suppressing effects.
- Trial name
- NCT07796074
- Testing
- Bupivacaine bilateral greater occipital nerve block
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Yale University
Sevoflurane Agitiion in Pediatric
Comparing the Synergistic Effect of Caudal Dexmedetomidine and Propofol Versus Caudal Dexmedetomidine Only or Propofol Only in Prevention of Sevoflurane Related Emergence Agitation in Pediatric Patients Undergoing Congenital Inguinal Hernia Repair
evaluate the synergistic efficacy of propofol and caudal dexmedetomidine for postoperative EA in pediatrics aged from to 2 to 5 years maintained on sevoflurane inhalational anesthesia and scheduled for conginital inguinal hernia…
- Trial name
- NCT06734195
- Testing
- dexmedetomidine + propofol, Propofol alone, Dexmedetomidine
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Inguinal Hernia, Postoperative Pain
Ultrasound-Guided Ilioinguinal-Iliohypogastric Nerve Block Following Spinal Anesthesia Comparing Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Unilateral Inguinal Hernia Repair
This study evaluates and compares the pain-relieving efficacy and safety of adding either dexmedetomidine or nalbuphine to bupivacaine in an ultrasound-guided ilioinguinal-iliohypogastric nerve block for patients undergoing…
- Trial name
- NCT07837492
- Testing
- Bupivacaine, Nalbuphine, Dexmedetomidine
- Volunteers
- 102 people
- Sponsor
- Assiut University
Undergoing Open-Heart Surgery
Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery.
Due to their superior efficacy in analgesia, opioids continue to play a primary role in the control of intraoperative and postoperative pain.
- Trial name
- Opioid-Free (NCT06683911)
- Testing
- non Opioids, Opioid
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Ankara City Hospital Bilkent
Laparoscopic Cholecystectomy, Pain Management
Recto-Intercostal Fascial Plane (RIFP) Block in Laparoscopic Cholecystectomy Patients
Ultrasound-guided Recto-Intercostal Fascial Plane (RIFP) Block is performed by injecting local anesthetic deep between the 7th rib and the costochondral aspect of the rectus muscle.
- Conditions
- Laparoscopic Cholecystectomy, Pain Management, Plane Block, Acute Pain
- Trial name
- RIFPB (NCT06768593)
- Testing
- RIFP Block, Postoperative pain management
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Istanbul Medipol University Hospital
Post Tonsillectomy Pain
Glossopharyngeal Nerve Block on Post Tonsillectomy Pain Among Egyptian Children
Tonsillectomy is one of most common performed surgical procedure in children . tonsillectomy or adenotonsillectomy have high incidence of Post operative pain , it is very important and significant problem because it can lead to…
- Trial name
- NCT05109416
- Testing
- Bupivacaine Hydrochloride 0.5% Injection Solution, Saline 0.9%
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Minia University
Osteo Arthritis Knee, Analgesia
Comparing Local Anesthesia With and Without iPACK Block
Total knee arthroplasty is an effective surgical intervention for patients with chronic osteoarthritis commonly performed worldwide. Postoperative pain management has been a key focus in patient care for this procedure.
- Conditions
- Osteo Arthritis Knee, Analgesia, Pain, Postoperative
- Trial name
- NCT04635176
- Testing
- Real iPACK block (20 mL of 0.25% bupivacaine, 2.5mcg/mL epinephrine, and 50mcg/mL preservative-free dexamethasone)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Cardiac Output
The Effect of Left Uterine Displacement on Parturient Cardiovascular System
The aim of the study is to investigate the effect of different angles of lateral tilt on the maternal hemodynamics before and after spinal anesthesia
- Trial name
- NCT02828176
- Testing
- electric cardiometry, IV line insertion, spinal anesthesia ( subarachnoid block )
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hemorrhoids, Fissure in Ano
Multi-Drug Analgesia vs. Standard Solution for Anal Surgery
The primary aim is to test the magnitude and duration of analgesia provided by single dose multi-drug analgesia administered for perianal block, and compare with standard solution (Marcaine \& Lidocaine in 1:1 mixture - Total 60…
- Conditions
- Hemorrhoids, Fissure in Ano, Fistula;Rectal
- Trial name
- NCT03105674
- Testing
- Multi-drug local anesthetics (Combination), Standard local anesthetics (Combination)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Stress Urinary Incontinence
The Effect of Pudendal Blocks on Voiding Dysfunction Following Slings
To determine the effect of a bilateral pudendal block on voiding dysfunction following midurethral slings.
- Trial name
- PUBS (NCT03353714)
- Testing
- Pudendal block
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Michael Flynn
Comparing the Analgesic Outcome by ( 4 in 1 Block ) & ( Adductor Canal Block )
The Analgesic Efficacy of Ultrasound Guided Adductor Canal Block Versus 4 in 1 Block in Patients Undergoing Knee Surgeries: A Comparative Randomized Double Blinded Study .
Knee surgeries are associated with severe postoperative pain. Improper pain management affects patients' psychological status with prolongation of hospital stay time and rehabilitation period, with the possibility of progression…
- Trial name
- No acronym (NCT05794685)
- Testing
- adductor canal block, 4 in one block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahmoud Hussein Bahr
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