Clinical trials: Bupivacaine
Analgesia
Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine in Bilevel Erector Spinae Plane Block in Breast Surgeries
High percent of patients experience chronic pain following breast cancer surgeries thus proper perioperative pain control is crucial to lessen the incidence of such pain.
- Trial name
- NCT05591417
- Testing
- Bilevel Erector spinae plane block, Bilateral Erector spinae plane block with dexamethasone, Bilateral Erector spinae plane block with dexmedetomidine
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- National Cancer Institute, Egypt
Intraoperativ Pain
Intrathecal Fentanyle Versus Dexamethasone in Gynacological Laparoscopic Surgeries
Laparoscopy was first introduced to the medical field of in the middle of the last century. It revolutionized the surgical interventions; it reduced the total medical expenditures and hastened postoperative recovery .
- Trial name
- NCT04779060
- Testing
- intrathecal fentanyle, dexamethasone, saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Postoperative Pain
Efficacy of Preventive Ketamine on Postoperative Pain
Although bariatric surgery is mainly performed laparoscopically, analgesic optimization is still essential to reduce complications and to improve the patients' comfort.
- Trial name
- NCT04908579
- Testing
- bupivacaine(intraperitoneally) and ketamine (intraperitoneally), bupivacaine(intraperitoneally) and ketamine (intravenously), bupivacaine(intraperitoneally)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Pain, Postoperative
The Effect of Femoral Nerve Block on Postoperative Opioid Use After Anterior Cruciate Ligament (ACL) Reconstruction
This study evaluates the effect of a femoral nerve block on opioid requirements following anterior cruciate ligament (ACL) reconstruction. This is a double blind, prospective randomized controlled trial.
- Trial name
- NCT00175630
- Testing
- Administration of a femoral nerve block (bupivacaine HCL)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Hemodynamic Instability
Scalp Block -Craniotomi
Postoperative pain after craniotomy is an important clinical problem as it can lead to hypertension and increased intracranial pressure.
- Trial name
- scalp block (NCT06264765)
- Testing
- scalp block, Incisional infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Aydin Adnan Menderes University
Postoperative Pain
ssTAP vs TAP Catheters in TAH
Prospective, randomized study comparing local wound infiltration with local anesthetic (LA) versus single injection TAP blocks (ssTAP) with LA versus continuous TAP block (TAP caths) catheters with LA for treatment of…
- Trial name
- NCT02525900
- Testing
- Wound Infiltration, TAP Blocks, TAP Catheters
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Arkansas
PENG Block, Hip Arthroplasty, Total
PENG vs PHPB for Hip Arthroplasty Analgesia
Total hip arthroplasty (THA) is a commonly performed surgical procedure, and its incidence continues to rise with the aging population. Effective postoperative analgesia facilitates early mobilization and accelerates recovery.
- Conditions
- PENG Block, Hip Arthroplasty, Total, QoR-15, Numeric Rating Scale
- Trial name
- NCT07263932
- Testing
- PENG Block and Posterior Hip Pericapsular Block, PENG Block
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Ankara City Hospital Bilkent
Labor Pain, Epidural Analgesia
Different Spinal Needles Sizes and Dural Puncture Epidural For Labor Analgesia
The rationale behind the dural puncture epidural (DPE) technique lies in the fact that a dural perforation with a spinal needle purportedly creates a conduit for accelerated translocation of local anesthetics from the epidural to…
- Trial name
- NCT03389945
- Testing
- 25G Dural Puncture Epidural Block, 27G Dural Puncture Epidural Block
- Where
- 2 sites in Chile
- Volunteers
- 140 people
- Sponsor
- University of Chile
Pain, Postoperative, Cancer of Larynx
Efficacy of Adding Dexmedetomidine in Ultrasound-guided Intermediate Cervical Plexus Block for Thyroidectomy Surgery
The cervical plexus block (CPB) is one such block used to provide effective anesthesia and analgesia for surgery in the head and neck region.
- Trial name
- NCT05814744
- Testing
- dexmedetomidine, bupivacaine 0.25%, Thyroidectomy Surgery
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Analgesia
Extended Delivery of Bupivacaine Study in Herniorrhaphy
This is a phase 4, randomized, open-label study of the efficacy, safety, and pharmacokinetics of bupivacaine administered as liposomal bupivacaine or continuous infusion via elastomeric pump following unilateral open inguinal…
- Trial name
- NCT04102267
- Testing
- Bupivacaine liposome injectable suspension, Bupivacaine HCl without epinephrine via continuous infusion
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Heron Therapeutics
Hip Arthropathy
Comparıson Of PENG Block wıth Intra-articular And Quadratus Lumborum Block İn Primary Total Hip Arthroplasty
90 patients ASA I-III, undergoing Total hip arthroplasty (THA) under spinal anesthesia, will be randomly assigned into one of three groups, namely group A (n=30), where an PENG block, group B (N:30) where an inra-articuler, and…
- Trial name
- NCT05003544
- Testing
- Group A, Group B, Group C
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Surgery of Right Upper Extremity
Dose-Response Relationships for Hemidiaphragmatic Paresis Following Ultrasound-Guided Supraclavicular Block
This clinical trial is for subjects undergoing right upper extremity surgery. The aim of the study is to investigate the dose-response relationship between local anesthetic volume and ipsilateral hemidiaphragmatic paresis (HDP)…
- Trial name
- NCT03138577
- Testing
- Ultrasound Imaging, Supraclavicular Block, Bedside Negative Inspiratory Force Meter
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Weill Medical College of Cornell University
Pain Management, Anesthesia , Analgesia
Comparison Between External Oblique Intercostal Plane Block and Rectus Sheath Block Combined With Transversus Abdominis Plane Block
Effective perioperative pain management remains a cornerstone in enhancing recovery and improving patient outcomes in laparoscopic cholecystectomy.
- Conditions
- Pain Management, Anesthesia , Analgesia, Nerve Block
- Trial name
- NCT07384000
- Testing
- External intercostal plane puncture, control group (nalbuphine), the single-puncture technique of (rectus sheath block) combined with (Transversus abdominis plane block)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Pain, Postoperative
A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain
the purpose of this study is to compare opioid consumption in morphine equivalents between the groups that received postoperative analgesia with intrathecal morphine versus US guided QL blocks versus US guided QL catheters
- Trial name
- NCT04368364
- Testing
- Intrathecal morphine sulfate (ITM), Bupivacaine hydrochloride, ropivacaine hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Pain, Postoperative
Surgical Approach Affect on Post-operative Analgesic Requirement Following Laparoscopic Nephrectomy
Background: We performed this prospective clinical study to compare the post-operative recovery profile of our patients after transperitoneal and retroperitoneal laparoscopic nephrectomy techniques.
- Trial name
- NCT02622893
- Testing
- Transperitoneal laparoscopic nephrectomy, Retroperitoneal laparoscopic nephrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Post Operative Pain
Comparison of Exparel to Marcaine in Post-Surgical Analgesia in Bariatrics
This study is designed to evaluate the use of bupivacaine liposome 1.3% compared bupivacaine 0.5% in pain control in post-operative laparoscopic bariatric surgery patient The purpose of this study is to evaluate two local…
- Trial name
- NCT02752230
- Testing
- Laparoscopic Roux en Y gastric bypass, Laparoscopic Sleeve Gastrectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kettering Health Network
Total Hip Surgery, Pericapsular Nerve
Comparison of Pericapsular Nerve Group Block and Quadratus Lumborum Block
Adequate pain management following total hip arthroplasty (THA) is a key component for patient satisfaction and early ambulation.
- Conditions
- Total Hip Surgery, Pericapsular Nerve, Quadratus Lumborum
- Trial name
- NCT05654519
- Testing
- PENG/LFCN and QL Blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Anesthesia, Conduction, Arthroplasty, Replacement, Knee
Concentration Effect of Local Anesthetics on Femoral Nerve Block Efficiency
US-guided femoral nerve block is used effectively in post-operative pain management in the surgical treatment of the lower extremity.
- Conditions
- Anesthesia, Conduction, Arthroplasty, Replacement, Knee, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- NCT03623230
- Testing
- Ultrasound Guided Femoral Nerve Block, Dressing, Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Bozyaka Training and Research Hospital
Knee Osteoarthritis (OA), Postoperative Pain
Effect of Adding a Biceps Femoris Short Head Block to Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is frequently associated with moderate to severe postoperative pain, which may delay mobilization, increase opioid consumption, and impair functional recovery.
- Trial name
- BiFeS-TKA (NCT07803887)
- Testing
- Ultrasound-Guided Adductor Canal Block, Ultrasound-Guided Biceps Femoris Short Head Block
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Antalya Training and Research Hospital
Colorectal Surgery
Comparing Liposomal Bupivacaine Versus Standard Bupivacaine in Colorectal Surgery
The purpose of this study is to compare the difference between two different pain control methods in patients who will be having a colorectal surgery
- Trial name
- NCT03702621
- Testing
- liposomal Bupivacaine, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
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