Clinical trials: Buprenorphine
Heroin Dependence, Opioid-Related Disorders
Study of Buprenorphine Maintenance Treatment for Opioid Dependence in Primary Care
The purpose of this treatment research study is to assess the effectiveness of buprenorphine maintenance treatment for opioid dependence delivered in a primary care clinic setting.
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00471042
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Addiction, Opioid Use
Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion
The overall goal of this project is to collect initial human data on the effects of novel compounds on safety (interactions with an opioid drug, e.g., buprenorphine) and early efficacy signals (subjective effects on negative…
- Conditions
- Addiction, Opioid Use, Substance Use Disorders, Opioid Use Disorder
- Trial name
- NCT05976646
- Testing
- Auvelity
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Total Knee Arthroplasty, Pain, Postoperative
Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty
Patients undergoing Primary Total Knee Arthroplasty will be randomized to receive either multimodal single injection adductor canal block with sham infusion catheter or continuous infusion of local anesthetic (control) for…
- Conditions
- Total Knee Arthroplasty, Pain, Postoperative, Adductor Canal Block
- Trial name
- NCT02991404
- Testing
- Multimodal Peripheral Nerve Block Injection, Single Shot Adductor Canal Block, Initial Bolus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Basic Science
The Effects of Buprenorphine on Responses to Verbal Tasks
In this study, the investigators will examine the effects of buprenorphine, as compared to placebo, upon physiological, subjective, and hormonal responses to a stressful speech task and a non-stressful control task in healthy…
- Trial name
- NCT01860287
- Testing
- Buprenorphine 0.2 MG Sublingual Tablet, Buprenorphine 0.4 MG Sublingual Tablet
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Drug Addiction, Employment
Long-Term Treatment of Opioid Use Disorder
Poverty and opioid addiction are interrelated and chronic problems which have not been addressed adequately. The Therapeutic Workplace could treat the many adults with opioid use disorder who are unemployed and live in poverty.
- Trial name
- NCT05534815
- Testing
- Employment-based abstinence reinforcement
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Northern Michigan University
Opioid-use Disorder
CBT4CBT-Buprenorphine + Recovery Coach for Office-based Buprenorphine
To conduct an 8-week pilot, randomized trial evaluating the feasibility, acceptability, and efficacy of an integrated intervention involving CBT4CBT-Buprenorphine + Recovery Coach in a population of 60 individuals who meet…
- Trial name
- NCT04824404
- Testing
- CBT4CBT-Buprenorphine + Recovery Coach
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Healthy Volunteer, Opioid-use Disorder
Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Opioid Use Disorder
The primary objectives for the study are: Part I and Part II: Assess safety and tolerability of repeated doses of INDV-2000 in healthy volunteers.
- Trial name
- NCT04976855
- Testing
- INDV-2000, SUBOXONE® sublingual film
- Where
- 3 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Cocaine-Related Disorders, Opioid-Related Disorders
Buprenorphine Maintenance for Cocaine Abusing Opioid Addicts - 1
The purpose of this study is to compare the clinical efficacy of maintenance on low and high doses of buprenorphine with methadone for cocaine abusing opiate addicts.
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00000216
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- Yale University
Opioid-use Disorder
Emergency Department-Initiated Buprenorphine Validation Network Trial
This study will (1) recruit, train and provide resources to approximately 30 Emergency Department (ED) sites throughout the U.S.
- Trial name
- NCT04225598
- Testing
- CAM2038, Buprenorphine Sublingual Product
- Where
- 35 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Yale University
Opioid Use Disorder
Feasibility Study of Novel Prescription Digital Therapeutic Supporting Unobserved Buprenorphine Initiation & Adherence
The purpose of this study is to assess feasibility of an at-home digital therapy designed to support buprenorphine initiation and adherence.
- Trial name
- NCT05412966
- Testing
- PEAR-002B, reSET-O
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Pear Therapeutics, Inc.
Tobacco Dependence
Tobacco Intervention in Buprenorphine Treatment
Drug addiction treatment patients, including those in treatment for opioid dependence, have a high rate of tobacco dependence, especially cigarette smoking.
- Trial name
- IBIS (NCT01350011)
- Testing
- Innovative System, Standard Treatment Control (STC)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opioid Use Disorder
EMS-Initiated Buprenorphine
This is a multisite EMS study that will first conduct a sequence of pragmatic, prehospital field studies to provide preliminary feasibility, acceptability, and safety data for refinement and enhancement of a subsequent single-arm…
- Trial name
- EMS BUP (NCT07475728)
- Where
- 3 sites in United States
- Volunteers
- 495 people
- Sponsor
- Yale University
Neonatal Abstinence Syndrome
Interest of Concentrations in Meconium of Buprenorphine and Methadone as a Prognostic Factor of NAS Outcome
The aim of this study is to characterize the interest of concentrations in meconium of drugs used for treatment of pregnant opioid-dependent woman as a prognostic factor of time, severity and duration of neonatal abstinence…
- Trial name
- SUBOPGEST (NCT03334981)
- Testing
- Concentrations in Meconium of Buprenorphine and Methadone
- Where
- France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Caen
Patients Undergoing Ankle Surgery
Duration of Analgesia After Popliteal Fossa Nerve Blockade: Effects of Dexamethasone and Buprenorphine
Patients scheduled to go home after ankle surgery at HSS typically receive a sciatic nerve block in the popliteal fossa and oral analgesic tablets (such as Percocet).
- Trial name
- NCT01277159
- Testing
- A. Control Nerve Block. IV Dexamethasone (4 mg)., B. Nerve Block with Dexamethasone (4 mg). IV saline., C. Control Nerve Block. IV Dexamethasone (4 mg). IV Buprenorphine (0.3 mg)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis Disorders
Norspan Transdermal Patches Study in Osteoarthritis Patients
This is a single center, open label, randomized, parallel group single dose pharmacokinetic (PK) study.
- Trial name
- NCT01643759
- Testing
- buprenorphine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Opioid Use Disorder
Counseling for Harm Reduction and Retention in Medication-assisted Treatment - Cherokee Nation
The goal of this randomized clinical trial is to test the efficacy of a program meant to enhance Counseling for Harm Reduction and Retention in MAT in Cherokee Nation (CHaRRM-CN).
- Trial name
- CHaRRM-CN (NCT05733442)
- Testing
- Treatment as usual (TAU), CHaRRM-CN
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Washington State University
Opioid Use Disorder, Opioid Dependence With Current Use (Disorder)
Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement
There is growing recognition of the need for approaches to initiate treatment wherever patients touch the health care system, including the Emergency Department (ED).
- Trial name
- NCT05897788
- Testing
- Text Message Check-ins, Contingency Management
- Where
- United States
- Volunteers
- 1,808 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid Use Disorder
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
This study will evaluate the safety, effectiveness and tolerance of low doses of oral naltrexone along with buprenorphine to treat opioid use disorder prior to the first injection of VIVITROL.
- Trial name
- NCT02537574
- Testing
- NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
- Where
- 20 sites in United States
- Volunteers
- 380 people
- Sponsor
- Alkermes, Inc.
Cancer-Related Pain
Buprenorphine for Cancer Pain
This study will evaluate patients on both buprenorphine and full agonist opioids (FAO) to assess for withdrawal symptoms. Patients will be evaluated by clinicians and using validated tools to assess for pain and withdrawal.
- Trial name
- NCT05910190
- Testing
- Use of buprenorphine with FAO > 30 OME, CPM Rx application use
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fox Chase Cancer Center
Opioid Use Disorder, Stimulant Use Disorder
Contingency Management for Opioid and Stimulant Use Disorders in Primary Care
Contingency management (CM) is a behavioral intervention that involves incentivizing participants for target behaviors in a clinical setting.
- Trial name
- NCT05288751
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Minnesota