Clinical trials: Buprenorphine
Opioid-use Disorder, Opioid-related Disorders
An Observational Study of Environmental and SocioEconomic Factors in Opioid Recovery
The RECOVER Study will examine clinical, environmental and socioeconomic factors in recovery from opioid use disorder (OUD) over a 24-month period following exit from a Phase III clinical program for a buprenorphine…
- Trial name
- RECOVER® (NCT03604861)
- Testing
- Not applicable - no defined intervention
- Where
- 35 sites in United States
- Volunteers
- 534 people
- Sponsor
- Indivior Inc.
Opioid-Related Disorders
Alternate-Day Buprenorphine. Phase V - 6
The purpose of this study is to evaluate buprenorphine blockade challenge.
- Trial name
- NCT00000224
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-use Disorder
Interim Buprenorphine Treatment to Bridge Waitlist Delays: Stage II Evaluation
Despite the demonstrated effectiveness of agonist treatment for opioid dependence and alarming recent increases in overdose deaths, waiting lists for treatment persist.
- Trial name
- NCT03420313
- Testing
- Buprenorphine/naloxone sublingual tablets
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Telehealth at the Library, Control Group
"Bupe by the Book": Testing Library Telehealth With Unstably Housed Persons With Opioid Use Disorder
Public libraries nationwide are facing an on-premise opioid overdose crisis. Many persons with opioid use disorder (OUD) remained unhoused and profoundly hard to reach.
- Trial name
- BBB (NCT05872386)
- Testing
- Library Telehealth with Buprenorphine Provider, Treatment-as-Usual Control group
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Opioid Use Disorder
A Multi-site Intervention to Expand Hospital Based OUD Treatment Provision
The investigators implemented a multi-site hospital-based opioid use disorder (OUD) treatment intervention across 12 hospitals in Colorado to address an OUD treatment gap among hospitalized adults with OUD.
- Trial name
- NCT06291090
- Testing
- OUD treatment intervention
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pain
Study of Buprenorphine Sublingual Spray for the Treatment of Moderate to Severe Pain
The primary objective of this trial is to evaluate analgesic efficacy of Buprenorphine Sublingual (under the tongue) Spray compared with placebo in participants with postoperative pain after bunionectomy.
- Trial name
- NCT02634788
- Testing
- Buprenorphine
- Where
- 4 sites in United States
- Volunteers
- 322 people
- Sponsor
- INSYS Therapeutics Inc
Opioid Dependence
Memantine-enhanced Buprenorphine Treatment for Opioid-dependent Young Adults
The purpose of this study is to examine the effect of memantine and buprenorphine on opioid abusing behavior, to determine the effect of memantine and buprenorphine on early relapse and to evaluate the tolerability of memantine…
- Trial name
- NCT01052662
- Testing
- Memantine
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Massachusetts, Worcester
Standard of Care, Standard of Care + CBT4CBT
An Integrated Intervention Involving Recovery Coaching and Cognitive Behavioral Therapy for Opioid Use Disorder
The Overcome II study is a randomized controlled trial among adults receiving sublingual buprenorphine to help prevent or reduce illicit drug use.
- Conditions
- Standard of Care, Standard of Care + CBT4CBT, Standard of Care + CBT4CBT + RC
- Trial name
- OVERCOME 2 (NCT06102200)
- Testing
- CBT4CBT, RC, Sandard of care
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Prisma Health-Upstate
Opioid-Related Disorders
Fetal Neurobehavioral Development in Methadone Maintained Pregnancies
The purpose of this study is to examine differences in fetal neurobehavior at peak (2 hours after oral dose) vs. trough (2 hours before oral dose) maternal plasma methadone levels.
- Trial name
- NCT00067184
- Testing
- Toitu 320/325
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Johns Hopkins University
Chronic Pain
Sublingual Buprenorphine for Chronic Pain
The purpose of this study is to develop and pilot test clinical guidelines for the use of buprenorphine for the treatment chronic pain among patients with substance abuse histories.
- Trial name
- NCT00612287
- Testing
- buprenorphine
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder
Pharmacokinetics, Safety, and Tolerability of Depot Buprenorphine at Three Different Molecular Weights in Treatment-Seeking Subjects With Opioid Use Disorder
This is a single-center, randomized, open-label, single-dose, parallel-group study which will enroll and randomize approximately 48 subjects (to achieve 36 completers) with opioid use disorder (OUD) who are seeking treatment for…
- Trial name
- NCT02559973
- Testing
- RBP-6000, SUBOXONE Sublingual Film
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Indivior Inc.
Healthy
Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations
The purpose of this study is to determine whether Transtec(R) PRO 70 µg/h and a new buprenorphine patch formulation lead to same plasma levels of buprenorphine after multiple dose application.
- Trial name
- NCT00387777
- Testing
- Patch with centrally acting analgesic, Transtec(R) PRO (buprenorphine)
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Depression, Pain
Efficacy of Pain Treatment on Depression in Patients With Dementia
The purpose of this study is to determine whether pain treatment can reduce symptoms of depression in patients suffering from dementia and depression. Depression is commonly diagnosed in patients with dementia.
- Conditions
- Depression, Pain, Dementia
- Trial name
- DEP-PAIN-DEM (NCT02267057)
- Testing
- Paracetamol, Buprenorphine
- Where
- Norway
- Volunteers
- 163 people
- Sponsor
- University of Bergen
Buprenorphine, HIV
Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)
The purpose of this study is to assess the feasibility, cost and effectiveness of interventions designed to integrate buprenorphine treatment for opioid dependence into HIV primary care in ten HIV care centers in the U.S.
- Conditions
- Buprenorphine, HIV, Drug Abuse, Drug Addiction
- Trial name
- BELIEVE (NCT00798538)
- Testing
- Services will be provided at one site, Services remain dispersed; i.e., not centralized to one-location or provider.
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Opioid Use Disorder, Opioid Use Disorder, Moderate
Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder
The primary objective of this research study is to evaluate the effect of tirzepatide, relative to placebo, as an adjunct to BUP on retention, substance use, and sleep outcomes in individuals with OUD.
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
- Trial name
- TAB (NCT06651177)
- Testing
- Tirzepatide
- Where
- 9 sites in United States
- Volunteers
- 310 people
- Sponsor
- T. John Winhusen, PhD
Opioid-Related Disorders
Buprenorphine Maintenance Protocol - 1
The purpose of this study is to compare the efficacy of buprenorphine versus methadone.
- Trial name
- NCT00000205
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- University of California, Los Angeles
Opiate Addiction, Pregnancy
Impact of Pregnancy on Buprenorphine Pharmacokinetics and Pharmacodynamics
The primary purpose of this study is to determine whether buprenorphine and metabolite exposure (reflected as the dose-adjusted plasma concentration x time curve [AUC]) differs during pregnancy and between pregnancy and the…
- Trial name
- NCT02863601
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Neonatal Opioid Withdrawal Syndrome
Target Trial Emulation for Pharmacologic Treatment of Neonatal Opioid Withdrawal Syndrome
The goal of this observational study is to learn how two medicines used in routine care-buprenorphine and morphine-affect recovery in newborns (≥36 weeks' gestation) with Neonatal Opioid Withdrawal Syndrome (NOWS).
- Trial name
- TreaT NOW (NCT07278375)
- Where
- 22 sites in United States
- Volunteers
- 796 people
- Sponsor
- HELP for NOWS Consortium
Dental Pain
Safety and Efficacy Study of NTC-510 to Treat Pain Following Dental Surgery of Third Molars
To evaluate the efficacy of a single dose NTC-510 or NTC-510A for dental pain following third molar extraction.
- Trial name
- NCT02161354
- Testing
- NTC-510 capsules, NTC-510A Capsules
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NanoSHIFT LLC
Depression
Buprenorphine for Late-Life Treatment Resistant Depression
The goals of this pilot study are to gather data about the safety and clinical effect of low-dose buprenorphine in older adults with treatment resistant depression.
- Trial name
- BUILD (NCT01071538)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh