Clinical trials: Buprenorphine
HIV Infections, Opioid Use Disorder
NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings
The investigators plan to conduct an R61/33 hybrid type 2 implementation-effectiveness trial that includes 1) a one-year exploratory R61 phase that will enable the development of the intervention protocol needed for the R33 trial…
- Conditions
- HIV Infections, Opioid Use Disorder, Incarceration; Lens
- Trial name
- NOTRE (NCT06854029)
- Testing
- Cabotegravir Injection, Cabotegravir Pill, Buprenorphine injection
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Duke University
Knee Arthroplasty, Total
Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty
The purpose of this research study is to compare two different combinations of anesthetic medications to see which works the best in providing the longest lasting pain relief for total knee arthroplasty surgery.
- Trial name
- NCT07097493
- Testing
- Liposomal Bupivacaine, Bupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Wake Forest University Health Sciences
Opioid Use Disorder, Chronic Pain
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
This study seeks to improve the treatment of chronic pain in people who are taking buprenorphine (also known as Suboxone, Subutex, Zubsolv).
- Trial name
- TREETOP (NCT06367387)
- Testing
- Patient-Oriented Dosing (POD), Pain Self-Management (PSM), Usual Care
- Where
- 13 sites in United States
- Volunteers
- 273 people
- Sponsor
- Erin Winstanley
Opioid Use Disorder
Social Functioning in Opioid Use Disorder
Problems with social functioning are core to opioid use disorder (OUD), though specific, modifiable social functioning targets and how they relate to OUD treatment outcomes are poorly understood.
- Trial name
- OUD (NCT07044466)
- Testing
- CBT4CBT-Buprenorphine
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Opioid Use Disorder
Assessing Optimal XRB Initiation Points in Jail
This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescriptions who enter Middlesex County House of Corrections (MCHOC) as pre-trial…
- Trial name
- NCT06051890
- Testing
- Extended-Release Buprenorphine (XRB), Sublingual Buprenorphine (SLB)
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Opioid Use Disorder, Pregnancy Related
Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy
This study will be a 12-month prospective, genotype-blinded longitudinal observational study with current standard of clinical care. This study will enroll 100 pregnant women with OUD at UPMC Hospitals with its high volumes.
- Trial name
- NCT05942313
- Testing
- Buprenorphine/ Methadone exposure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ilana Hull
Major Depressive Disorder, Depression
Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
The central goal of this application is to demonstrate the causal contribution of reward learning signals (expected values and reward prediction errors [RPE]) to antidepressant responses (Aim1) by experimentally manipulating…
- Trial name
- RAISE (NCT04276259)
- Testing
- Buprenorphine, Naltrexone, Theta burst stimulation (TBS) of the ventromedial prefrontal cortex.
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Marta Peciña, MD PhD
Opioid Use Disorder
High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED)
This project, involving two distinct clinical trials, tests whether induction to a higher than currently recommended buprenorphine (BUP) induction dose is safe and can improve the proportion of patients who engage in…
- Trial name
- NCT05589181
- Testing
- High Dose Buprenorphine, Standard Buprenorphine Dose
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Rutgers, The State University of New Jersey
Opioid Use Disorder
Pilot of Mailing Buprenorphine
This pilot study evaluates the feasibility, acceptability, and preliminary effectiveness of mailing buprenorphine to individuals with opioid use disorder (OUD) following medical hospitalization.
- Trial name
- NCT07421102
- Testing
- strategy of mailing buprenorphine
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
Over half of women in the US who are breastfeeding their infants take prescription drugs. You are being asked to participate in this study because you are breastfeeding your infant and are currently taking, as part of your…
- Trial name
- NCT03511118
- Testing
- Tranexamic acid (TXA), labetalol, metformin
- Where
- 22 sites in United States, Canada
- Volunteers
- 1,600 people
- Sponsor
- Duke University
Postoperative Pain, Thoracic Surgery
Analgesia With Transdermal Buprenorphine Patch in Adults Undergoing Video-Assisted Thoracoscopic Surgery
Postoperative pain remains a major challenge after video-assisted thoracoscopic surgery (VATS), despite the use of multimodal analgesia.
- Conditions
- Postoperative Pain, Thoracic Surgery, Video-Assisted Thoracoscopic Surgery
- Trial name
- NCT07733128
- Testing
- Buprenorphine (BUP)
- Where
- Chile
- Volunteers
- 90 people
- Sponsor
- Clínica Dávila
Suicide Crisis Syndrome, Psychological Distress
Psychopharmacological Treatment of Emotional Distress
This is an inpatient four-arm randomized control trial comparing single drug clonazepam (S arm), a two-drug combination clonazepam/olanzapine (D arm), and a three-drug combination clonazepam/olanzapine/buprenorphine (T arm) with…
- Trial name
- NCT06133114
- Testing
- Clonazepam, Olanzapine, Buprenorphine
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Opioid Use Disorder
Low-dose Buprenorphine Initiation for Opioid Use Disorder
The purpose of this study is to test whether low-dose buprenorphine initiation for treatment of opioid use disorder is safe and effective.
- Trial name
- NCT05450718
- Testing
- buprenorphine-naloxone
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Montefiore Medical Center
Opioid Use Disorder
Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder
This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care outpatient buprenorphine treatment for…
- Trial name
- BIPOD-Out (NCT06067737)
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Opioid Use Disorder, Substance-Related Disorders
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
The goal of this observational study is to learn about the long term effects of prenatal opioid exposure. The main objectives are: Long term goal: to improve the safety and efficacy of maternal Opioid Use Disorder (OUD) and…
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Pregnancy Related, Narcotic-Related Disorders
- Trial name
- NCT06415994
- Testing
- Buprenorphine or Methadone Treatment, Fetal and Placental MRI, Child Developmental Assessment
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Opioid Use Disorder
Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use
The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal.
- Trial name
- ROLDI (NCT06379984)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Opioid Use Disorder
Extended-release Buprenorphine as a Novel Low-dose Induction Strategy
This is a clinical trial to characterize the safety and pharmacokinetics of using extended-release buprenorphine (XR-BUP) as a novel low-dose buprenorphine induction strategy.
- Trial name
- NCT06441604
- Testing
- Extended-release Buprenorphine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Brigham and Women's Hospital
Fracture
Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department
The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are: Is buprenorphine as effective as opioids to treat pain? Are there less…
- Trial name
- NCT07430345
- Testing
- Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- The Cooper Health System
Opioid Overdose
Measures to Improve Outcomes After an Opioid Overdose
This is a pilot study that aims to develop good clinical practices to improve outcomes after an opioid overdose and transition of care from the Emergency Department (ED) into an Office Based Opioid Treatment (OBOT) clinic for…
- Trial name
- NCT03968237
- Testing
- Buprenorphine/Naloxone
- Where
- United States
- Sponsor
- Nassima Ait-Daoud Tiouririne
Dependence, Opioid
A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment
The US Veteran community continues to feel the impact of the overdose crisis, and opioid use disorder (OUD) diagnoses among Veterans continue to rise.
- Trial name
- NCT05189223
- Testing
- Brief, values based intervention for early buprenorphine treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development