Clinical trials: Buprenorphine
Opioid-use Disorder, Opioid Dependence
Neuromodulation and Cognitive Training in Opioid Use Disorder
The relapsing nature of opioid use disorder is a major obstacle to successful treatment. About 90% of those entering treatment will relapse within one year.
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opioid Abuse
- Trial name
- NCT03773523
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Rotator Cuff Tears
Clinical Study on the Effect of Tizanidine on the Function and Pain of Patients After Shoulder Arthroscopy
The perspective, randomized controlled trial is to investigate and evaluate the effect of Tizanidine on the function and pain of patients with rotator cuff tear after shoulder arthroscopy;
- Trial name
- NCT05852093
- Testing
- Celecoxib+Buprenorphine Transdermal Patch, Celecoxib+Buprenorphine Transdermal Patch+Tizanidine
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Non-cancer Pain
Pilot Trial of Opioid Taper Support
The proposed research will develop, demonstrate the feasibility of, and pilot test in a randomized controlled trial a prescription opioid taper support intervention.
- Trial name
- POTS (NCT01883882)
- Testing
- opioid taper support
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Washington
Opiate Addiction
Efficacy of Computer Delivered Community Reinforcement Approach (CRA) (Bup II)
This study is designed to examine the effects of combined buprenorphine and voucher incentives to promote abstinence from illicit opiate use, along with or without computer-delivered therapy, during treatment of opioid dependence.
- Trial name
- CAT (NCT00929253)
- Testing
- Suboxone, CRA, Therapy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Virginia Polytechnic Institute and State University
Opioid-use Disorder, Cocaine Use Disorder
Cariprazine for Comorbid Cocaine and Opioid Use Disorder
This is a phase IIa, randomized, placebo-controlled pilot study designed to examine whether low-dose cariprazine (1.5mg/d) impacts cocaine use in medically-stable OUD patients with co-occurring CocUD who have already been taking…
- Trial name
- NCT05063201
- Testing
- Cariprazine 1.5 MG
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Kyle Kampman
Postoperative Pain, Thoracic Surgery
Analgesia With Transdermal Buprenorphine Patch in Adults Undergoing Video-Assisted Thoracoscopic Surgery
Postoperative pain remains a major challenge after video-assisted thoracoscopic surgery (VATS), despite the use of multimodal analgesia.
- Conditions
- Postoperative Pain, Thoracic Surgery, Video-Assisted Thoracoscopic Surgery
- Trial name
- NCT07733128
- Testing
- Buprenorphine (BUP)
- Where
- Chile
- Volunteers
- 90 people
- Sponsor
- Clínica Dávila
Pain
Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine
Tissue injury is associated with pain from the injured site (primary hyperalgesia) and pain from non-injured tissue in the vicinity of the trauma (secondary hyperalgesia).
- Trial name
- PASORII (NCT01296334)
- Testing
- morphine LO, Morphine Hi, Buprenorphine LO
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- mads u werner
Depression, Depressive Disorder
Buprenorphine for Treatment Resistant Depression
The purpose of this study is to compare the safety and efficacy of buprenorphine with placebo for adults with treatment resistant depression (TRD).
- Conditions
- Depression, Depressive Disorder, Depressive Disorder, Major
- Trial name
- BUP-TRD (NCT01407575)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pittsburgh
Opioid-Related Disorders
Buprenorphine Pharmacology Related to Addiction Treatment - 18
The purpose of this study is to examine the interactions between buprenorphine and naltrexone, and to assess how they may directly impact the clinical issues involving: transferring patients from buprenorphine to naltrexone…
- Trial name
- NCT00000236
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders
Alternate-Day Buprenorphine Administration. Phase II - 4
The purpose of this study is to determine if two times a subject's daily maintenance dose will hold for 48 hours without changes in agonist and antagonist effects.
- Trial name
- NCT00000222
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Abuse
Hair Testing to Assess Consumption of Illicit Psychotropic Agents and Alcohol by Patients Treated With High-dose Buprenorphine and Methadone. Search for a Pharmacogenetic Contribution to Low Efficacy of Substitution Medications
Justification and aims of the study: The principal aim of use of opiate substitutes such as methadone or high-dose buprenorphine (HDB) is to reduce the need or the desire to consume the opiate to which the patient is addicted.
- Trial name
- NCT01285856
- Testing
- hair and saliva samples
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Opioid-use Disorder
Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use
The focus of this study is to examine the effectiveness of imFREE relative to mHealth ED in facilitating treatment retention and adherence and reducing opioid use among adults with OUD initiating BUP treatment.
- Trial name
- UCimFREE (NCT04808479)
- Testing
- imFREE mCBT, mHealth ED
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of California, Los Angeles
Opiate Dependence
Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence
The aim of the study is to determine whether buprenorphine/naloxone maintenance versus detoxification using buprenorphine/naloxone, in prescription opioid dependent patients receiving primary care management and drug counseling…
- Trial name
- NCT00555425
- Testing
- Behavioral: Buprenorphine/naloxone maintenance (Mtn), Behavioral: Buprenorphine/naloxone detoxification (Dtx)
- Where
- 2 sites in United States
- Volunteers
- 113 people
- Sponsor
- Yale University
Opioid Use Disorder
Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices
This study will provide longitudinal data for 6-months on a target sample of patients with Opioid Use Disorder (OUD) recruited from Prisma Health Mobile Health Clinics in South Carolina.
- Trial name
- BRIDGE-SC (NCT07541417)
- Testing
- Certified Peer Support Specialist Intervention
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Prisma Health-Upstate
Opioid Use Disorder
PRoducing Outcome Measures for OTP Quality Improvement
This study tests ways to help opioid treatment programs (OTPs) keep patients in care. Staying on methadone or buprenorphine is linked to better outcomes, yet many people leave treatment early.
- Trial name
- PROMOTE-QI (NCT07214389)
- Testing
- Quality Measures (Audit and Feedback), Quality Improvement (QI) Toolkit, External QI Facilitation
- Where
- United States
- Volunteers
- 4,500 people
- Sponsor
- RTI International
Opioid Use Disorder
STAMPS: South Carolina Buprenorphine Treatment Initiation, Adherence, and Retention Utilizing Mobile Health Units and Peer Support Specialists
The study is a 1-arm prospective interventional cohort quasi-experimental with retrospective control group. Enrolled participants will be compared to previously established mobile health patients, who did not work with a peer…
- Trial name
- NCT06384781
- Testing
- Peer Support Checklist
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Prisma Health-Upstate
Opioid-use Disorder, Pain, Acute
Acute Pain Management in Patients on Opioid Replacement Therapy
This is an outpatient randomized within subject placebo-controlled human laboratory investigation of analgesia (as assessed with quantitative sensory testing; QST) from ketamine alone and in combination with hydromorphone in…
- Trial name
- NCT03933865
- Testing
- HYDROmorphone Injectable Solution, Ketamine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, San Francisco
Opioid-Related Disorders
Alternate-Day Buprenorphine Administration. Phase I - 3
The purpose of this study is to determine if two times a subject's daily maintenance dose will hold for 48 hours without changes in agonist and antagonist effects.
- Trial name
- NCT00000221
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders
Clinical Rescue Protocol - 2
The purpose of this study is to detect increasing medication dose results in heroin cessation for patients still using, to determine if decreasing medication dose in patients unable to tolerate medication dose increases…
- Trial name
- NCT00000206
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- University of California, Los Angeles
Pain
Evaluation of the Tolerability of Switching Subjects on Chronic ATC Opioid Therapy to Buprenorphine HCl Buccal Film
The primary aim of this study is to determine if chronic pain subjects on around-the-clock opioids who are receiving 100 to 220 mg oral morphine sulfate equivalent (MSE) can be safely transitioned on to buprenorphine…
- Trial name
- NCT01871285
- Testing
- Buprenorphine, Oxycodone, Morphine sulfate
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- BioDelivery Sciences International