Clinical trials: Buprenorphine
Hepatitis C, Chronic
Treatment of Chronic Hepatitis C With Pegylated Interferon and Ribavirin in Participants With/Without Substitution Therapy (P05255)
Although injection drug users represent the majority of new and existing cases of infection with hepatitis C virus (HCV), many lack access to treatment because of concerns about adherence, effectiveness, and reinfection.
- Trial name
- NCT00725751
- Testing
- Pegylated interferon alfa-2b (PegIFN-2b), Ribavirin
- Volunteers
- 353 people
- Sponsor
- Merck Sharp & Dohme LLC
Opioid-Related Disorders
Assessing Abuse Potential of Parenteral Buprenorphine/Naloxone in Non-Dependent Opioid Abusers
Buprenorphine, a treatment for opioid dependence, can be mixed with another drug, naloxone, to limit abuse potential. Parenteral administration (intravenous or intramuscular injection) of buprenorphine/naloxone causes withdrawal…
- Trial name
- NCT00134875
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Osteoarthritis
Buprenorphine Transdermal Patch in Subjects With Osteoarthritis Pain Requiring Opioids. Includes a 52-Week Safety Extension.
The original objective of this study was to assess the safety and efficacy of the buprenorphine transdermal system (BTDS) (5, 10, and 20) in comparison to placebo transdermal system in subjects with moderate to severe…
- Trial name
- NCT00315458
- Testing
- Buprenorphine transdermal patch
- Where
- 48 sites in United States
- Volunteers
- 107 people
- Sponsor
- Purdue Pharma LP
Caesarean Delivery
Comparison of Different Methods of Pain Control After Cesarean Section for Patients on Buprenorphine or Methadone
More and more women are on buprenorphine or methadone during pregnancy for a history of opioid addiction. Currently, pain control after cesarean section for women already on these medications, if they need operative delivery, is…
- Trial name
- NCT02091297
- Testing
- TAP Block, Ropivacaine, Acetaminophen
- Where
- 3 sites in United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cocaine-Related Disorders, Opioid-Related Disorders
Combined Buprenorphine and Behavioral Treatment With and Without Contingent Reinforcement on Opioid and Cocaine Abstinence. - 22
The purpose of this study is to test combined buprenorphine and behavioral treatment with and without contingent reinforcement on opioid and cocaine abstinence.
- Trial name
- NCT00000240
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- University of Vermont
Opioid-Related Disorders, Heroin Dependence
Ability of Aprepitant to Block Opioid Reward in Non-Dependent Opiate Abusers
The objective of this study is to determine whether aprepitant blocks the opiate reward system in non-dependent opiate abusers, indicating its potential as a safe, non-addictive first line therapy for early heroin abuse.
- Conditions
- Opioid-Related Disorders, Heroin Dependence, Substance-Related Disorders
- Trial name
- NCT00726960
- Testing
- aprepitant
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Opiate Dependence, Drug Dependence
A Randomized Acceptability and Safety Study of Suboxone Induction in Heroin Users (P05042)(COMPLETED)
The purpose of this study is to assess the acceptability and safety of Suboxone in heroin users as a replacement therapy for opioid dependency by comparing the clinical response of participants who are inducted directly onto…
- Conditions
- Opiate Dependence, Drug Dependence, Substance Dependence
- Trial name
- NCT00604188
- Testing
- Suboxone (SCH 000484), Subutex (SCH 028444)
- Volunteers
- 188 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain
Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain
To compare the analgesic and anti-hyperalgesic effect of Buprenorphine and Fentanyl against experimental pain in skin, muscle and bone. The study will be performed with healthy volunteers.
- Trial name
- NCT00647127
- Testing
- Buprenorphine, Fentanyl
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Osteoarthritis
Safety of Buprenorphine Transdermal Patch (BTDS) in Osteoarthritis Pain: a 52-Week Extension Phase
The purpose of this phase is to evaluate the long-term safety and tolerability of BTDS. Qualified subjects are started on BTDS 5 and the dose may be titrated, if necessary, to a maximum of BTDS 20 to achieve stable pain control.
- Trial name
- NCT01135524
- Testing
- Buprenorphine transdermal patch
- Where
- 89 sites in United States
- Volunteers
- 196 people
- Sponsor
- Purdue Pharma LP
Complex Regional Pain Syndromes
Neuroimaging Study on the Effect of Transdermal Buprenorphine in Complex Regional Pain Syndrome Patients
In the present study, we aim to investigate the effect of buprenorphine on neuroinflammation in patients with complex regional pain syndrome, using [11C]-(R)-PK11195 PET.
- Trial name
- NCT03977012
- Testing
- Buprenorphine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Procedural Pain, Buprenorphine
Addition of Buprenorphine to Paracervical Block for Pain Control During Osmotic Dilator Insertion
Cervical preparation with osmotic dilators is commonly used prior to dilation and evacuation (D\&E) procedures to decrease the risk of complications.
- Conditions
- Procedural Pain, Buprenorphine, Adjuvants, Anesthesia, Dilation and Evacuation
- Trial name
- ABCD&E (NCT04254081)
- Testing
- Buprenorphine 0.15 MG, Lidocaine 1% Injectable Solution
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of California, San Diego
Opioid-Related Disorders
Buprenorphine Maintenance for Opioid Addicts - 1
The purpose of this study is to evaluate the efficacy of buprenorphine and desipramine in treatment of opiate and cocaine dependence.
- Trial name
- NCT00000202
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- Yale University
Post Operative Pain, Acute
Serratus Anterior Plane Block With and Without Adjuvants in Video-assisted Thoracoscopy
The purpose of this study is to determine whether the addition of the serratus anterior plane block (SAPB) alone (30 mL of 0.25% bupivacaine) or plus Magnesium (150 mg of magnesium sulfate) or plus Magnesium + Buprenorphine (300…
- Trial name
- NCT05090761
- Testing
- Bupivacaine 0.25% Injectable Solution, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 150 mg, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 150 mg, Buprenorphine 300 mcg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Opioid Use Disorder
Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder
This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care buprenorphine treatment for Opioid use…
- Trial name
- BIPOD-In (NCT06005662)
- Testing
- Psilocybin
- Where
- United States
- Sponsor
- Johns Hopkins University
Laparoscopic Cholecystectomy
Transdermal Buprenorphine Patch for Laparoscopic Cholecystectomy
Preliminary studies of the transdermal buprenorphine patch target chronic pain patients, and the pain relief effect and safety have been proven.
- Trial name
- NCT05871424
- Testing
- buprenorphine patch group
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Gangnam Severance Hospital
Major Depressive Disorder, Depression
Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
The central goal of this application is to demonstrate the causal contribution of reward learning signals (expected values and reward prediction errors [RPE]) to antidepressant responses (Aim1) by experimentally manipulating…
- Trial name
- RAISE (NCT04276259)
- Testing
- Buprenorphine, Naltrexone, Theta burst stimulation (TBS) of the ventromedial prefrontal cortex.
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Marta Peciña, MD PhD
Cesarean Delivery
BUprenorphine Versus Morphine for Postcesarean Analgesia (BUMP)
In this study the researchers are randomizing pregnant patients coming for elective cesarean delivery to receive either intrathecal buprenorphine or morphine for their analgesia.
- Trial name
- NCT07786012
- Testing
- buprenorphine, morphine
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cocaine-Related Disorders
IV Cocaine Abuse: A Laboratory Model - 3
The purpose of this study is to evaluate the effects of buprenorpine on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving in non-opiate dependent cocaine users.
- Trial name
- NCT00000214
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Opioid Dependence
Improving Buprenorphine Detoxification Outcomes With Isradipine
This application seeks to address the problem of opioid withdrawal by examining the utility of the L-type calcium channel blocker (CCB) isradipine as an adjunct to BUP detoxification.
- Trial name
- NCT01895270
- Testing
- Isradipine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Arkansas
Opioid Use Disorder, Cigarette Smoking
E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
The purpose of this an open-label, randomized controlled trial study is to compare the effectiveness of electronic cigarettes (e-cigarettes/e-cigs) versus telehealth motivational counseling with combination nicotine replacement…
- Trial name
- NCT05722561
- Testing
- Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC).
- Where
- 2 sites in United States
- Volunteers
- 302 people
- Sponsor
- NYU Langone Health