Clinical trials: Buprenorphine
Opioid Use Disorder, Sleep Disturbance
Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment
Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep disturbance, even when treated with medications for opioid use…
- Trial name
- MOUD (NCT06104280)
- Testing
- Post-Illumination Pupillary Response (PIPR), Polysomnography, Multiple Sleep Latency Test
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Opioid-related Disorders
Abuse Liability of Suboxone Versus Subutex
The study is designed to compare the abuse liabilities of intravenous buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT00710385
- Testing
- Heroin, Naloxone, Low Bup Dose
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid-use Disorder, Recidivism
Fostering MAT Use in Justice Populations
The grant will test two timely and successful evidence-based implementation practices, NIATx Coaching and ECHO, with jail/community-based healthcare providers to increase medication assisted treatment (MAT) use with justice…
- Trial name
- NCT04363320
- Testing
- NIATx Coaching, ECHO
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of Wisconsin, Madison
Opioid-Related Disorders, Behavior, Addictive
Adolescent Community Reinforcement Approach in Combination With Buprenorphine/Naloxone for Severe Opioid Use
The study assesses whether adding a behavioral intervention, known as the Adolescent Community Reinforcement Approach (A-CRA), to the treatment of individuals already receiving buprenorphine/naloxone can improve treatment success…
- Trial name
- A-CRA/MAT (NCT03287180)
- Testing
- Adolescent Community Reinforcement Approach (A-CRA), Combination of buprenorphine/naloxone 4/1
- Sponsor
- Emory University
Opioid Use Disorder
Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder
This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care buprenorphine treatment for Opioid use…
- Trial name
- BIPOD-In (NCT06005662)
- Testing
- Psilocybin
- Where
- United States
- Sponsor
- Johns Hopkins University
Healthy Volunteers
Pharmacokinetics and Pharmacodynamics of Buprenorphine in Healthy Volunteers
The purpose of this study is to determine the amount of buprenorphine and its metabolites in blood and urine after administration of 0.6 mg buprenorphine in healthy volunteers.
- Trial name
- NCT00347815
- Testing
- Buprenorphine
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Danish University of Pharmaceutical Sciences
Major Depressive Disorder
A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD)
This study will evaluate the efficacy, safety, and tolerability of adjunctive ALKS 5461 in adults who have treatment refractory MDD.
- Trial name
- NCT03188185
- Testing
- ALKS 5461
- Where
- 35 sites in United States, Australia and 1 more
- Volunteers
- 278 people
- Sponsor
- Alkermes, Inc.
Healthy Volunteer Study
Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Buprenorphine/Naloxone or Methadone
Drug-drug interaction study between Bemnifosbuvir/Ruzasvir (BEM/RZR) and Buprenorphine/Naloxone or Methadone
- Trial name
- NCT07314346
- Testing
- Buprenorphine/Naloxone + BEM/RZR, Methadone +BEM/RZR
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Opioid-use Disorder
Medication Maintenance Therapy in Community Pharmacy Settings
The goal of this study is to compare pharmacy-based medication assisted treatment (MAT) with usual care MAT for people with opioid use disorder.
- Trial name
- MATPharm (NCT04139213)
- Testing
- buprenorphine/naloxone oral product, injectable naltrexone, Pharmacy maintenance addiction care
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Lifespan
Opioid-use Disorder, Anxiety
MINDFUL-OBOT: Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment
The goal of this pilot study is to test the Mindful Recovery OBOT Care Continuum (M-ROCC) model in primary care office-based opioid treatment (OBOT).
- Conditions
- Opioid-use Disorder, Anxiety, Depression, Stress Related Disorder
- Trial name
- NCT03798431
- Testing
- M-ROCC
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Cambridge Health Alliance
Opiate Addiction
Onsite Buprenorphine Treatment at Syringe Exchange Programs
This trial will recruit syringe exchange participants with opioid use disorder in New York City and test whether starting buprenorphine treatment at the syringe exchange program is more effective than referral to a community…
- Trial name
- O-BMT (NCT03150173)
- Testing
- Onsite treatment, Enhanced referral, Buprenorphine
- Where
- 3 sites in United States
- Volunteers
- 97 people
- Sponsor
- Montefiore Medical Center
Opioid Use Disorder
Sublingual Buprenorphine Through Telemedicine vs In-Person Care as Usual
This study will compare in-person induction and maintenance dosing of sublingual buprenorphine to induction and maintenance dosing of sublingual buprenorphine through comprehensive telehealth sessions and telehealth medication…
- Trial name
- NCT05339256
- Testing
- Buprenorphine SL, Telehealth, In-person treatment as usual
- Sponsor
- New York State Psychiatric Institute
Telehealth at the Library, Control Group
"Bupe by the Book": Testing Library Telehealth With Unstably Housed Persons With Opioid Use Disorder
Public libraries nationwide are facing an on-premise opioid overdose crisis. Many persons with opioid use disorder (OUD) remained unhoused and profoundly hard to reach.
- Trial name
- BBB (NCT05872386)
- Testing
- Library Telehealth with Buprenorphine Provider, Treatment-as-Usual Control group
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Opioid-Related Disorders
Youth Opioid Recovery Support: Improving Care Systems
Opioid addiction, also referred to as opioid use disorder, among young people is a growing health concern for patients and their families.
- Trial name
- YORS (NCT04015115)
- Testing
- Youth Opioid Recovery Support service model
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Opioid-use Disorder, Stress Related Disorder
Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment (R33 Phase)
This will be a randomized controlled trial (RCT) designed to compare live-online Mindful Recovery Opioid Care Continuum (M-ROCC) groups with a live-online control group on the primary outcome of number of biochemically confirmed…
- Conditions
- Opioid-use Disorder, Stress Related Disorder, Anxiety, Pain Interference
- Trial name
- Mindful-OBOT (NCT04278586)
- Testing
- Live-Online M-ROCC, Live-Online Control
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Cambridge Health Alliance
Cocaine-Related Disorders, HIV
Diversion to Treatment for Injection Drug Users Arrested for Possession of Heroin
More Americans are arrested for drug offenses than for any other crime. In 2009, over 294,000 arrests were made for possession of cocaine or heroin.
- Conditions
- Cocaine-Related Disorders, HIV, Heroin Dependence
- Trial name
- NCT01723527
- Testing
- Methadone, Buprenorphine, Employment-based drug abstinence reinforcement
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Opioid Use Disorder, Pregnancy Related
Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE)
The goal of this clinical trial is to compare buprenorphine patch for induction (starting) of buprenorphine in pregnant patients with opioid use disorder. The main questions it aims to answer are: 1.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- Patch BRIDGE (NCT05790252)
- Testing
- Buprenorphine Transdermal Matrix Patch
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Washington University School of Medicine
Opioid-Related Disorders, Substance-Related Disorders
Effects of Buprenorphine and Naloxone in Opiate Addicts - 4
The purpose of this study is to evaluate the behavioral and physiological effects of buprenorphine and naloxone, both alone and in combination.
- Trial name
- NCT00000355
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)