Clinical trials: Caffeine, completed
Enuresis, Nocturnal
The Behavioral Therapy for Primary Monosymptomatic Nocturnal Enuresis
A prospective randomized clinical study was conducted at Urology departments, faculties of medicine, Fayoum and Cairo Universities.
- Trial name
- NCT07015320
- Testing
- urotherapy, no intervention
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Chemotherapy-induced Nausea and Vomiting
An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects
The objective of this Open Label Study is to evaluate effects of Rolapitant IV solution, and its metabolite, on the pharmacokinetics (PK) of the P-gp substrate (digoxin), the BCRP substrate (sulfasalazine), and multiple…
- Trial name
- NCT02434861
- Testing
- Rolapitant, Digoxin, Sulfasalazine
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Tesaro, Inc.
Healthy
Coffee Polyphenols Antioxidants
Coffee is one of the most widely consumed beverages. It contains polyphenols (chlorogenic acids) and bioavailability of these bioactive compounds is now somewhat well understood.
- Trial name
- NCT01832662
- Testing
- coffee, maltodextrin enriched with caffeine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Pain Score (VAS)
Nebulized Dexmedetomidine or Lidocaine for Treatment of Post Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia
Post-dural puncture headache (PDPH) is a well-recognized and potentially serious complication of subarachnoid block. While advancements in spinal needle design have reduced its incidence in recent years, PDPH still affects a…
- Trial name
- NCT06607861
- Testing
- saline group, dexmedetomidine group, lidocaine group
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Minia University
Cognition, Mental Fatigue
Investigation of Dietary Supplement Liquid Shot Products on Mental Energy, Cognition (Acuity),and Mood
This is a single center, randomized, double blind, placebo-controlled, crossover study to determine the acute effect of a developmental dietary supplement liquid shot product on cognitive task performance and perceived effect…
- Conditions
- Cognition, Mental Fatigue, Mood
- Trial name
- NCT06384586
- Testing
- Functional energy shot
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- The Water Street Collective
Climbing, Caffeine
Caffeine and Sport Climbing Performance
To determine the effects of ingesting caffeine at a dose of 3 mg/kg body mass on pull-up performance and handgrip-related measures in trained climbers.
- Trial name
- Climbing&CAF (NCT07333443)
- Testing
- Acute and moderate dose of caffeine (3 mg/kg body mass)
- Where
- Spain
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Cognitive Function and Memory
Cognitive Effects of a Dietary Supplement With PQQ, GABA, Caffeine, and B-Vitamins in Healthy Postmenopausal Women: A Randomized Controlled Trial
Various food supplements have been shown to improve cognitive function. However, there is limited data on the impact of these supplements on postmenopausal women.
- Trial name
- NCT06748989
- Testing
- Cortexium food supplement
- Where
- Hungary
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- FEMPHARMA Kft.
Drug Interaction
Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates for Drug Metabolism and Transport
This is a single center, open-label, fixed sequence Phase 1, drug-drug interaction (DDI) study in healthy subjects.
- Trial name
- NCT05334108
- Testing
- Ecopipam, Cohort 1 Probe Substrate Cocktail, Cohort 2 Probe Substrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Emalex Biosciences Inc.
Diet Modification, Cardiovascular Risk Factor
Bioavailability and Beneficial Properties of Coffee and Cocoa Bioactive Compounds
The aim of this study will be to define the bioavailability and the beneficial properties of coffee bioactive compounds. Moreover, the contribution of cocoa-based products containing coffee to the pool of circulating metabolites…
- Conditions
- Diet Modification, Cardiovascular Risk Factor, Nutritional and Metabolic Diseases
- Trial name
- P4L (NCT03166540)
- Testing
- cup of espresso coffee, cocoa-based products containing coffee
- Where
- Italy
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Parma
Healthy
Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers
The objective of this trial was to quantify the effect of oral single-dose (480 mg) and steady-state BI 201335 NA (240 mg BID) on intestinal and hepatic cytochrome P450 (CYP) and P-glycoprotein (P-gp) probe drugs as a means of…
- Trial name
- NCT02182336
- Testing
- BI 201335 NA, Caffeine, Warfarin sodium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Cuff Pressure, Mechanical Ventilation
Comparison of Automatic and Manual Endotracheal Tube Cuff Pressure Monitoring in Pediatric Intensive Care Patients
This prospective, randomized controlled cross-over study compares automatic (IntelliCuff®) and manual methods of endotracheal tube cuff pressure (CP) monitoring in pediatric intensive care patients.
- Conditions
- Cuff Pressure, Mechanical Ventilation, Pediatric Intensive Care
- Trial name
- NCT06965400
- Testing
- Automatic Cuff Pressure Control
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Dr. Behcet Uz Children's Hospital
Supplementation, Sports
The Influence of Caffeine Supplementation on Specific Performance and Training Activities
The purpose of this study is to verify the effect of acute caffeine (CAF) and placebo (PLA) supplementation on physical capacity and discipline-specific exercise performance in athletes, in a randomised, double-blind…
- Trial name
- NCT03822663
- Testing
- Caffeine supplementation
- Where
- Poland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Scalp Health, Hair Condition
Scalp Care Efficacy Evaluation for Premium Scalp Revitalizing Essence
The study aims to evaluate the efficacy of the Premium Scalp Revitalizing Essence on human scalp skin. A total of 60 healthy adults, aged 18 to 60, will be recruited and randomly assigned into five groups receiving different…
- Conditions
- Scalp Health, Hair Condition, Hair Loss, Sebum Production
- Trial name
- NCT06985121
- Testing
- Base formula only, Base formula plus IGF-1 and FGF-7, Base formula plus Centella asiatica extracellular vesicles
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
ADHD
Improving ADHD Behavioral Care
Though the most effective treatment for children with Attention Deficit Hyperactivity Disorder (ADHD) consists of combined medication and behavioral strategies, the vast majority of children with ADHD are treated with medication…
- Trial name
- NCT03628781
- Testing
- Behavioral tools integrated within mehealth for ADHD software, mehealth for ADHD
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Healthy
A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants
The main purpose of this study is to evaluate the effect of LOXO-305 on single oral dose of caffeine cytochrome P450 1A2 (CYP1A2) substrate, S-warfarin (CYP2C9 substrate), and omeprazole (CYP2C19 substrate) when administered as…
- Trial name
- NCT06215430
- Testing
- Caffeine Tablet, Omeprazole capsule, Warfarin tablet
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Heart Failure, Congestive
Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure.
The purpose of this study is to evaluate the efficacy of a 24-hour infusion of levosimendan compared with placebo in the treatment of decompensated chronic heart failure.
- Trial name
- NCT00048425
- Testing
- Levosimendan
- Where
- 166 sites in United States, Australia and 2 more
- Volunteers
- 600 people
- Sponsor
- Abbott
Healthy
Effects of Combined Interventions to Optimize Recovery During High-intensity Exercises in Healthy Adults
The objective of the study is to evaluate the effects a complex recovery intervention during the breaks of a repeated sprint test on exercise performance compared to placebo and control conditions.
- Trial name
- NCT04508738
- Testing
- ERP
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Rheumatoid Arthritis
Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4
Olokizumab (OKZ) has been shown to reverse the inhibitory effect of IL-6 on the activity of Cytochrome P450 (CYP450) isozymes CYP1A2, CYP2B6, CYP2C9, CYP2C19, and CYP3A4/5 in vitro.
- Trial name
- NCT04246762
- Testing
- Olokizumab, Omeprazole, Caffeine
- Where
- 2 sites in Bulgaria, Moldova
- Volunteers
- 17 people
- Sponsor
- R-Pharm International, LLC
Self-identified Problematic Caffeine Use, DSM-IV Substance Dependence as Applied to Caffeine
Assessment and Treatment of Caffeine Dependence
Recent research has established that some individuals report that they are unable to cease caffeine use, despite feeling that caffeine is posing a health risk or causing significant impairment in their daily activities.
- Trial name
- NCT00338195
- Testing
- Individualized caffeine cessation instructions
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Apnea of Prematurity
Caffeine for Apnea of Prematurity (CAP)
At least 5 of every 1000 live-born babies are very premature and weigh only 500 to 1250 grams at birth. Approximately 30-40% of these high-risk infants either die or survive with lasting disabilities.
- Trial name
- NCT00182312
- Testing
- Caffeine citrate injection
- Where
- 34 sites in United States, Australia and 7 more
- Volunteers
- 2,000 people
- Sponsor
- McMaster University