Clinical trials: Caffeine, completed
Placebo Effect, Drug Half Life
The Placebo Effect May Involve Modulating Drug Bioavailability
The total effect of a medication is the sum of its drug effect, placebo effect (meaning response of placebo), and their interaction.
- Conditions
- Placebo Effect, Drug Half Life, Pharmacokinetics
- Trial name
- NCT01501747
- Testing
- Caffeine, paracetamol, cephalexin, or ibuprofen
- Where
- Saudi Arabia
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center
Tinnitus
Effects of Caffeine in Tinnitus
Caffeine intake is reported by many authors to enhance the perception of tinnitus. The aim of this study is to determine the effects of 1 month caffeine intake reduction in the scores of validated questionnaire Tinnitus Handicap…
- Trial name
- NCT00628316
- Testing
- caffeine
- Where
- 2 sites in Brazil
- Volunteers
- 50 people
- Sponsor
- Faculdade de Medicina de Valenca
Healthy
Caffeine Disposition After Inhalation
The purpose of this study is to determine how fast caffeine gets into your body with a product called Aeroshot™. Aeroshot™ is a lipstick sized device that you slide open and then put your mouth over the opening and inhale.
- Trial name
- NCT02184104
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Advanced Solid Tumors, Excluding Breast Cancer
Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors
This is a multi-center, open-label, phase I study to assess the effects of dovitinib (TKI258) on the pharmacokinetics of a cocktail of caffeine, diclofenac, omeprazole and midazolam in patients with advanced solid tumors…
- Trial name
- NCT01596647
- Testing
- caffeine, diclofenac, omeprazole
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- Novartis Pharmaceuticals
Food-drug Interaction
Licorice Botanical Dietary Supplements - Metabolism and Safety in Women
Human safety studies will be carried out to test whether red clover botanical dietary supplements used by peri- and post-menopausal women are safe to use with Food and Drug Administration (FDA)-approved drugs.
- Trial name
- NCT03948243
- Testing
- Licorice, Alprazolam 2 MG, Caffeine 100 MG
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Caffeine and Resistance Exercise
Reproducibility of Acute Caffeine Effect
Introduction: Various studies have evaluated and verified the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance.
- Trial name
- NCT06606639
- Testing
- Caffeine
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Breastfeeding
Milk Production and Body Weight Response to Suggested Protocol in Obese Lactating Women
This study will investigate the milk production and body weight response of both mother and the newborn to aerobic exercise in obese lactating women.
- Trial name
- NCT06975527
- Testing
- Breastfeeding guidelines, Aerobic exercise
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caffeine, Burning Mouth Syndrome
Caffeine vs. ALA in BMS Treatment. (BMS: Burning Mouth Syndrome. ALA: Alpha-Lipoic Acid.)
The aim of this study was to evaluate the efficacy of caffeine and alpha-lipoic acid in the treatment of burning mouth syndrome by symptom assessment with visual analogue scale.
- Trial name
- NCT06195137
- Testing
- Caffeine, Alpha Lipoic Acid
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Lu Jiang
Morbid Obesity
Treatment of Low Metabolic Rate Following Bariatric Surgery
Purpose is to determine the effect of ephedrine and caffeine, on metabolic rate and weight loss after bariatric surgery. Approximately 40% of patients struggle with their weight loss rate, or metabolic rate, after bariatric…
- Trial name
- NCT01596907
- Testing
- Ephedrine sulfate with caffeine, cellulose
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Oregon Weight Loss Surgery, LLC
Hepatitis C
Advanced Electronic Population Health and Personal Health Record Tools to Improve Once Lifetime Hepatitis C Screening
This study involves randomizing patients due for once in a lifetime Hepatitis C screening based on Center for Disease Control and Prevention and United States Preventative Services Task Force guidelines in one of three primary…
- Trial name
- NCT03654365
- Testing
- Bulk ordering and bulk messaging, Routine alerting
- Volunteers
- 1,024 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Dietary Supplementation
Consumption of 4D Dietary Supplement on Perceptual-Cognitive and Visual-Motor Performance
The purpose of this investigation is to determine if supplementation with the 4D dietary supplement impacts perceptual-cognitive and visual-motor skills in healthy individuals.
- Trial name
- NCT04988919
- Testing
- 4D
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Musculoskeletal Pain
Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment
The purpose of this study is to evaluate the safety and efficacy of an association with one anti-inflammatory and one muscle relaxant plus caffeine compared to one anti-inflammatory plus caffeine in the treatment of osteomuscular…
- Trial name
- NCT02862977
- Testing
- ketoprofen and cyclobenzaprine association with caffeine, Cyclobenzaprine with caffeine
- Where
- 6 sites in Brazil
- Volunteers
- 414 people
- Sponsor
- EMS
Pharmacokinetics of Repaglinide, Pharmacokinetics of Caffeine
A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Repaglinide and Caffeine
The purpose of this study is to assess the effect of multiple doses of isavuconazole on the pharmacokinetics of Repaglinide and possible metabolites after single dose administration.
- Conditions
- Pharmacokinetics of Repaglinide, Pharmacokinetics of Caffeine, Healthy Subjects
- Trial name
- NCT02128321
- Testing
- Isavuconazole, Repaglinide, Caffeine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Healthy
Evaluation of the Potential CYP1A2-mediated Drug Drug Interaction Safety, and Tolerability of ABX464
A two part, fixed-sequence, open-label crossover study to evaluate potential CYP1A2-mediated drug-drug interactions of ABX464 in healthy subjects using caffeine and fluvoxamine as probe drugs
- Trial name
- NCT05121714
- Testing
- Caffeine, ABX464, Fluvoxamine
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Abivax S.A.
Health
Acute Effects of Coffee on Appetite and Inflammation Markers, Glucose Metabolism and Energy Intake
The purpose of the study is to investigate whether caffeinated and decaffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and…
- Trial name
- NCT01174576
- Testing
- caffeinated and decaffeinated coffee
- Where
- Greece
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Cardiovascular Diseases, Hypertension
The Acute Effect of and Energy Drink vs. Water Consumption on MAP, HR, and Energy Metabolism
The objective of this protocol is to investigate the effect of consumption of a commercially available energy drink beverage on blood pressure, heart rate, and energy metabolism
- Conditions
- Cardiovascular Diseases, Hypertension, Diet
- Trial name
- NCT06330649
- Testing
- Energy Drink, Water Control
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cognitive Function, Mood
The Effects of Caffeine and L-theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood
Although the beneficial effects of caffeine on cognition and mood have been reported in a number of studies, relatively few studies have looked at the effects of caffeine in combination with other phytonutrients despite the fact…
- Trial name
- NCT00981955
- Testing
- Caffeine and L-theanine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Migraine Disorders
Acetylsalicylic Acid (ASA) + Paracetamol + Caffeine Combination Compared With ASA + Paracetamol as Well as ASA, Paracetamol, and Caffeine in Headache Patients
To confirm the combination rationale for the combination of ASA + paracetamol + caffeine compared with the combination of ASA + paracetamol and the individual substances ASA, paracetamol, caffeine, and placebo administered orally…
- Trial name
- NCT02183688
- Testing
- Low dose ASA, High dose ASA, Low dose paracetamol
- Volunteers
- 1,889 people
- Sponsor
- Boehringer Ingelheim
Gestational Diabetes Mellitus, Hypertension in Pregnancy
Supporting Transitions to Primary Care Among Under-resourced, Postpartum Women (STEP-UP)
STEP-UP will promote linkage to primary care and ongoing chronic disease evaluation for postpartum women with prior gestational diabetes mellitus (GDM) and/or hypertensive disorders of pregnancy (HDP).
- Conditions
- Gestational Diabetes Mellitus, Hypertension in Pregnancy, Dysglycemia
- Trial name
- NCT05852054
- Testing
- OB Provider Clinical Decision Support (CDS), Patient Education (OB Visit), Text messaging
- Where
- 2 sites in United States
- Volunteers
- 2,306 people
- Sponsor
- Northwestern University
Palliative Care
A Pragmatic Trial of an Active Choice Nudge for Generalist or Specialist Palliative Care for Seriously Ill Inpatients
This stepped-wedge, cluster-randomized pragmatic trial among six hospitals at University of Pennsylvania Health System will test a behavioral intervention embedded within the electronic health record that nudges hospital…
- Trial name
- NCT05502861
- Testing
- Generalist + Specialist palliative care, Pre-Intervention phase
- Where
- United States
- Volunteers
- 18,884 people
- Sponsor
- University of Pennsylvania