Clinical trials: Caffeine
HBOC Syndrome, DNA Damage
Nutritional Intervention and DNA Damage of Patients With HBOC
Breast and Ovarian Cancer Syndrome (HBOC) is characterized by mutations in tumor suppressor genes such as BRCA1 and BRCA2, which increase the carrier's risk of developing breast and ovarian cancer, especially before 40.
- Conditions
- HBOC Syndrome, DNA Damage, Nutrition Therapy
- Trial name
- NCT05306002
- Testing
- Antioxidant therapy
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Shift-Work Sleep Disorder, Insomnia
Fire Fighter Fatigue Management Program: Operation Fight Fatigue
Firefighters frequently work extended duration shifts and long work weeks which have adverse effects on alertness, health, safety and performance.
- Conditions
- Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT01672502
- Testing
- Sleep health education provided via a web-based program, Sleep disorder detection and treatment, Optimization of Sleep in Fire Station
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Drug Interaction
KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism
Carvedilol is a non-selective beta-blocker in common clinical use, used to treat hypertension, heart failure, and angina pectoris symptoms associated with coronary artery disease.
- Trial name
- KF2022#4 (NCT06566794)
- Testing
- Caffeine Tablet, Bupropion Hydrochloride Capsels, Repaglinide Capsels
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Depressed GCS
CaffeinICU Study - A Study on Oral Caffeine in ICU Patients With Coma
Background: Depressed Glasgow Coma Scale (GCS) is common among critically ill patient s in the intensive care unit (ICU). It is one of the main reasons that hampers liberation from mechanical ventilation among ICU patients.
- Trial name
- CaffeinICU (NCT05232734)
- Testing
- Caffeine Citrate 20 MG/ML Oral Solution
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- Singapore General Hospital
Fetal Distress
Effect of Maternal Chocolate Consumption on Fetal Non-Stress Test (NST) Reactivity.
This is a single-blind, randomized, parallel-group, superiority clinical trial. The study aims to determine whether a single intake of 30g of dark chocolate (≥80% cocoa) by pregnant women with a non-reactive fetal non-stress test…
- Trial name
- CHOCO-NST (NCT07418151)
- Testing
- Dark Chocolate, Sugar-free White Chocolate
- Where
- Honduras
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Honduras
Patient Reported Outcomes
Ambulatory Cancer Care Electronic Symptom Self-Reporting for Surgical Patients
The aim of this study is to understand and improve the experience of patients after surgery by comparing two methods of following symptoms while the patient recovers at home.
- Trial name
- NCT03178045
- Testing
- Team Monitoring, Enhanced Feedback
- Where
- United States
- Volunteers
- 2,793 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Preterm Birth
Effect of Early Use of Caffeine Citrate in Preterm Neonates
This work is designed to study the effect of the early use of caffeine citrate in preterm neonates who need respiratory support on morbidity and short term neonatal outcome.
- Trial name
- NCT04001712
- Testing
- Caffeine Citrate
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Ain Shams University
Diabetes
Improved Glycemic Control in Adult Subjects With Type 1 Diabetes on MDI Using Insulin Guidance Software
140 subjects will be enrolled into the clinical study and randomized into the Control Group or the Experimental Group by block randomization. The subjects must meet all inclusion and none of the exclusion criteria.
- Trial name
- NCT00552734
- Testing
- Insulin Guidance Software
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Colorado, Denver
Health Behavior
An Evaluation of the Effects of a Non-Caffeinated Energy Dietary Supplement
This study tested the effects of a botanical blend to a caffeine and a placebo condition on 1) self-reported alertness, anxiety, and headaches 2) multiple measures of attention 3) physical performance and 4) stress biomarkers.
- Trial name
- NCT04895800
- Testing
- Phytovive, Caffeine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Quality of Life, Family Caregivers
JOYof ART - an Intervention Study
Music, dance and visual arts are suggested to support health and well-being of older people. Intervention studies, however, are scarce.
- Trial name
- JOYofART (NCT03080870)
- Testing
- Art
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- University of Eastern Finland
Carrier State, Heat Stroke
Genetic Risk Factor for Heat Stroke
The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults.
- Conditions
- Carrier State, Heat Stroke, Dehydration
- Trial name
- NCT06847256
- Testing
- Heat Challenge
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Iowa
Fatigue
"WakeUp" for Vigilance Following Lunch
This is a single center, double-blind, placebo and active controlled clinical trial comprised of a single drink of WakeUp beverage (in 3 doses) compared to Caffeine (100mg) and placebo given to health volunteers.
- Trial name
- NCT04685005
- Testing
- "Wake Up", Caffeine
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Malignant Melanoma
A Pharmacokinetic Study of RO5185426 in Combination With a Drug Cocktail in Patients With Metastatic Melanoma
This open-label single-arm study will evaluate the effect of RO5185426 [RG7204; PLEXXIKON: PLX4032] on the pharmacokinetics of five CYP450 substrates (caffeine, warfarin + vitamin K, omeprazole, dextromethorphan, midazolam)…
- Trial name
- NCT01001299
- Testing
- Drug cocktail, RO5185426
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Hoffmann-La Roche
Healthy
How Does Altering the Timing of Pre-exercise Low-dose Caffeine Ingestion Affect Endurance Exercise Performance
Investigate how manipulating the time between caffeine ingestion and exercise may alter exercise performance and cognition
- Trial name
- NCT02985606
- Testing
- Caffeine powder -60, Caffeine powder -30, Caffeine powder 0
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Cardiovascular Disease
The Effect of High and Low Roasted Coffee on Vascular Response
Evidence suggests that a diet rich in plant phenolic compounds may induce beneficial vascular effects. Coffee is a good source of phenolic compounds called chlorogenic acids (CGA), however the level of CGA is reduced during the…
- Trial name
- NCT01813981
- Testing
- Low roast coffee, High roast coffee, Control (Caffeine dissolved in water)
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Reading
Migraine Disorders
Caffeine/Propranolol Intervention for Acute Migraine
This is a research study to assess the safety of caffeine/propranolol at different dose levels. We want to find out what effects, good and/or bad, it has on patients and their migraines.
- Trial name
- NCT01080677
- Testing
- caffeine/propranolol combination tablet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Drug-Interactions
Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates
This is a single center, open-label, fixed sequence Phase 1, drug-drug interaction (DDI) study in healthy subjects.
- Trial name
- NCT04764851
- Testing
- ecopipam HCl ~2mg/kg/day, Cohort 1 Probe Cocktail, Cohort 2 Probe Cocktail
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emalex Biosciences Inc.
Apnea of Prematurity, Intraventricular Hemorrhage
MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine
Over the last 30 years the survival rates for babies born prematurely have improved greatly with research. As these babies grow up, we have found that many of the premature babies have learning and movement problems.
- Conditions
- Apnea of Prematurity, Intraventricular Hemorrhage, Brain Injury
- Trial name
- NCT00809055
- Testing
- Caffeine citrate
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Washington University School of Medicine
Wrong Patient Computerized Physician Order Entry Errors
Investigating Wrong-Patient Computerized Physician Order Entry (CPOE) Errors
With the increased adoption of CPOE systems, it is important to recognize that design flaws have resulted in the creation of new types of iatrogenic medical errors.
- Trial name
- NCT01262053
- Testing
- Passive Intervention, Active Intervention, Control
- Where
- United States
- Volunteers
- 4,028 people
- Sponsor
- Montefiore Medical Center
Performance Enhancement
CAF & Firefighters Performance
The aim of the study being to investigate chewing caffeine-containing gum could effectively improve firefighters' balance under conditions of brain fatigue.
- Trial name
- CAF & FFT (NCT07570030)
- Testing
- Caffeine (300 mg)
- Where
- Taiwan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Chih-Hui Chiu
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