Clinical trials: Caffeine
Critical Illness
Real-time NOMA Evaluation
Alerts related to outlier clinician behavior are generated in real-time by an intelligent system continuously scraping EHR (electronic health record) data.
- Trial name
- NCT06996626
- Testing
- Revealed Alerts, Unrevealed Alerts
- Where
- 2 sites in United States
- Volunteers
- 7,445 people
- Sponsor
- David T Huang
Low Back Pain
A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol
Non inferiority, multicentric, double blind study whose the primary objective is to compare the effectiveness of two products in pain reduction.
- Trial name
- NCT01421433
- Testing
- Tandrilax, Dolamin Flex
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Farmoquimica S.A.
Sepsis, Deterioration, Clinical
Outcomes of Digital Alerting Systems in Secondary Care
Why? The investigators are trying to find out if participants that suddenly deteriorate on the ward can be identified sooner by wearing a wearable sensor.
- Trial name
- NCT04638738
- Testing
- SensiumVitals wearable patch sensor
- Where
- United Kingdom
- Volunteers
- 650 people
- Sponsor
- Imperial College London
Shift-work Disorder
Role of Sleep Reactivity in Shift Work Disorder
The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD). The primary hypothesis is that those with high sleep reactivity will show persistent SWD symptoms after experimental…
- Trial name
- REACT (NCT05424406)
- Testing
- Active phototherapy, Control phototherapy, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
Hypoxic-Ischemic Encephalopathy
Caffeine for Hypoxic-Ischemic Encephalopathy
Hypoxic-ischemic encephalopathy (HIE) due to perinatal asphyxia is common and often fatal. Therapeutic hypothermia reduces mortality and morbidity in infants with HIE.
- Trial name
- NCT03913221
- Testing
- Caffeine Citrate 5 mg/kg, Caffeine Citrate 10 mg/kg
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
Healthy
Salivary Proteome and Sensitivity to Bitterness
This study aims to establish whether the protein composition of healthy males contribute to their sensitivity to the bitterness of caffeine.
- Trial name
- PROTAMER (NCT01079338)
- Testing
- caffeine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Healthy Volunteers, Caffeine
Caffeine Dose: Performance and Recovery
The goal of this clinical trial is to learn how different doses of caffeine taken in the evening affect rowing performance, sleep quality, and daytime alertness in trained male university rowers.
- Conditions
- Healthy Volunteers, Caffeine, Sleep Quality
- Trial name
- NCT07090421
- Testing
- Cellulose Powder, Caffeine 3 mg/kg Oral Powder, Caffeine 6 mg/kg Oral Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ulaç Can YILDIRIM
Caffeine, Exercise
7-Day Caffeine and Upper-Body Power in Active Women
This study investigated the effects of a 7-day caffeine supplementation on heart rate variability, cognitive performance, and upper-body anaerobic power in active women.
- Conditions
- Caffeine, Exercise, Physical Fitness
- Trial name
- NCT07771556
- Testing
- Caffeine
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Birjand University of Medical Sciences
Pulmonary Embolism, Deep Vein Thrombosis
Discharge ALERT: Quality Improvement Initiative
Brigham and Women's Hospital will coordinate a Quality Improvement Initiative at other hospitals that focuses on whether physician notification prior to discharge of high risk VTE patients will reduce the incidence of VTE after…
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Prophylaxis, Venous Thromboembolism
- Trial name
- Discharge (NCT00853463)
- Testing
- Alert
- Where
- 22 sites in United States
- Volunteers
- 2,515 people
- Sponsor
- Brigham and Women's Hospital
Drug Drug Interaction (DDI)
Drug-Drug Interaction (DDI) Study for TD-9855
This study is designed to assess the effect of fluvoxamine, itraconazole and smoking on the PK disposition of multiple doses TD-9855 in healthy male subjects.
- Trial name
- NCT03432793
- Testing
- TD-9855, Fluvoxamine, Itraconazole
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Multiple Sclerosis, Insomnia
Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis
The incidence of insomnia is estimated to be as high as 90% in individuals with MS due to insomnia being underdiagnosed. Sleep disturbances in people with MS have been associated with reduced cognitive performance, physical…
- Trial name
- CALM (NCT06428006)
- Testing
- Cognitive behavioral therapy for insomnia, Sleep and lifestyle education
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Kansas Medical Center
Infection, Coronavirus, Infections
Xofluza-Wearables Feasibility-Study
The goal of this prospective, interventional, single-center study is to assess whether the early detection of Influenza with smart wearable device algorithms and alerting, rapid testing, and subsequent Baloxavir treatment…
- Conditions
- Infection, Coronavirus, Infections, Influenza, Transplant
- Trial name
- NCT06161454
- Testing
- Baloxavir Marboxil
- Where
- United States
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Healthy Nutrition
Study of the Neurophysiological Response to Foodstuffs
The goal of this clinical trial is to investigate the effect of perception of sensory attributes of different foodstuffs on physiological and neurophysiological response in health adults.
- Trial name
- NCT06051175
- Testing
- Bitter taste perception, Salty taste perception, Sweet taste perception
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Infant,Premature, Caffeine
Baby-CINO: CaffeINe Treatment Optimisation in Premature Infants
This study investigates how brain activity and breathing changes in premature babies when their dose of caffeine treatment is changed or stopped.
- Trial name
- Baby-CINO (NCT06416956)
- Testing
- Caffeine
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Cognitive Function, Mood
The Effects of Caffeine and L-theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood
Although the beneficial effects of caffeine on cognition and mood have been reported in a number of studies, relatively few studies have looked at the effects of caffeine in combination with other phytonutrients despite the fact…
- Trial name
- NCT00981955
- Testing
- Caffeine and L-theanine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Acute Ischemic Stroke
Caffeinol Hypothermia Protocol
Caffeinol is a combination of caffeine and alcohol. The amount given is about the same as 1-2 glasses of wine and 3-4 cups of coffee. The patient receives a one time dose given over two hour while being cooled to 34.5 C.
- Trial name
- NCT00299416
- Testing
- Caffeinol, hypothermia
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Healthy
Influence of Coffee Consumption on BIA-derived Body Composition Parameters
Body composition analysis is frequently used in both clinical and research settings for evaluation of nutritional status and follow-up.
- Trial name
- NCT03745508
- Testing
- Instant Coffee
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Liver Disease
Inhibition of VAP-1 by Caffeine in Healthy Human Volunteers Study
Worldwide, liver related morbidity and mortality continue to rise. It is the 5th commonest cause of death in the UK. Liver damage consists of two main components - a) damage to the cells of the liver, called hepatocytes, meaning…
- Trial name
- NOCTUA (NCT02098785)
- Testing
- Caffeine citrate
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Birmingham
Drug Biotransformation, Membrane Transport
Repeated Dose Study for the Investigation of Heritability of and Genetic Influences on Drug Pharmacokinetics
This human pharmacokinetic study investigates, whether processes of drug metabolism and transport are determined by genetic or hereditary factors.
- Trial name
- NCT01845194
- Testing
- Codeine, Midazolam, Pravastatin
- Where
- Germany
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
Shoulder Arthroplasty and Fracture Repair
Tornier Shoulder Outcomes Study to Examine Safety and Functional Outcomes in Shoulder Arthroplasty and Fracture Patients
The Tornier Shoulder Outcomes Study is designed to collect safety and efficacy data on designated commercially available Tornier Shoulder repair products.
- Trial name
- NCT02047955
- Testing
- Shoulder Arthroplasty
- Where
- 15 sites in United States
- Volunteers
- 7,500 people
- Sponsor
- Stryker Trauma and Extremities
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