Clinical trials: Caffeine
Hepatocellular Carcinoma (HCC)
Lenvatinib or Regorafenib for Advanced Hepatocellular Carcinoma After Immunotherapy (REVIVE)
The goal of this clinical trial is to learn if lenvatinib or regorafenib can help treat people with advanced liver cancer (hepatocellular carcinoma, HCC) that cannot be removed with surgery after first treatment with…
- Trial name
- REVIVE (NCT07495579)
- Testing
- Lenvatinib, regorafenib
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Asan Medical Center
Smoking
Effects of Smoking Environment on Craving and Smoking
The goal of this study is to evaluate the effects of exposure to standard smoking environments on ability to resist smoking as measured with a Delay to Smoking Task.
- Trial name
- CC2pilot (NCT02416986)
- Testing
- 6 hour smoking abstinence, Delay to Smoking Task (smoking cues), Delay to Smoking Task (nonsmoking cues)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Duke University
Post-Dural Puncture Headache
Bilateral Sphenopalatine Ganglion Block With or Without Bilateral Greater Occipital Nerve Block for Treatment of Obstetric Post-Dural Puncture Headache
Post-dural puncture headache is a common complication, following neuraxial techniques. The obstetric population is particularly prone to PDPH. Therefore, treatment of PDPH is a key issue in obstetric anesthesia.
- Trial name
- NCT04844229
- Testing
- Bilateral transnasal sphenopalatine ganglion block., Bilateral ultrasound guided greater occipital nerve block.
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Overactive Bladder
Behavioural Therapy With Checklist for Overactive Bladder
The aim of this study is to investigate the efficiency of this newly-established checklist for overactive bladder (OAB) and whether determinate to adherence and persistence rate of combination of behavioural therapy and…
- Trial name
- NCT03662893
- Testing
- behavioural therapy with written checklist form to complete, Antimuscarinic drugs used in overactive bladder, behavioural therapy with written guideline
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara Training and Research Hospital
Ventilation, ARDS
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
Ventilator associated events (VAE) is a quality metric defined by 48 hours of stability followed by 48 hours of escalation of ventilator settings within the ICU.
- Conditions
- Ventilation, ARDS, Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT06737432
- Testing
- RKP Monitoring Software
- Where
- United States
- Volunteers
- 875 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Alcohol Use Disorder
Preliminary Effectiveness of Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality
State the scientific aim(s) of the study, or the hypotheses to be tested. The purpose of the current study is to evaluate the usage and acceptability of the Soberlink's blood alcohol concentration (BAC) unit in collaboration with…
- Trial name
- Soberlink (NCT04380116)
- Testing
- Soberlink
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity
Long-term Effects of Green Tea on Gut Flora, Fat Absorption, Body Composition and Resting Energy Expenditure
Green tea may have positive effects for weight control and on body composition via several approaches such as a positive effect on the gut flora, a decrease in fat absorption from the intestines and an increase in resting energy…
- Trial name
- NCT01556321
- Testing
- green tea (757 mg/capsule [84.5 mg EGCG + 2.1 mg caffeine ]
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation
There is current research interest in the use of fruit and plant-based food products containing high levels of natural antioxidants and their impact on exercise, which may be particularly beneficial for recreationally or…
- Trial name
- NCT07210099
- Testing
- Concentrated olive fruit water, Anhydrous caffeine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Acute Kidney Injury, Chronic Kidney Diseases
Impact on Mortality of Screening for Kidney Disease Associated With a Specialized Intervention During Hospitalization in a Territorial Hospital Trust
Kidney disease in its chronic or acute form shares many risk factors for initiation, progression and prognosis with an increase in morbidity and mortality, the length of hospitalization and the cost associated with stages of…
- Trial name
- WARNING KD (NCT05033652)
- Testing
- WARNING KD
- Where
- 3 sites in France
- Volunteers
- 1,179 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Healthy
Developmental Regulation of Proteins Responsible for Transforming Drugs in the Body
This is a drug metabolism study in one-year old children involving caffeine and dextromethorphan.
- Trial name
- NCT00117715
- Testing
- Genotyping and Phenotyping using dextromethorphan and caffeine as probes
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Irritable Bowel Syndrome (IBS), Irritable Bowel Syndrome With Diarrhea (IBS-D)
Curcumin, Vitamin D and Green Tea in IBS-D
Irritable Bowel Syndrome (IBS) is a highly prevalent condition of the gastrointestinal tract that has significant impact on sufferer's quality of life. The diarrhoea variant (IBS-D) makes up around one third of all IBS sufferers.
- Trial name
- NCT07052890
- Testing
- Curcumin, vitamin d and green tea extract
- Where
- 3 sites in United Kingdom
- Volunteers
- 78 people
- Sponsor
- Dr Anthony Hobson
Sleep Terror, Sleepwalking
Development and Online Evaluation of an Online Course for Parasomnias
Parasomnias are unwanted events during sleep. These refer to sleep terrors, sleepwalking, sleep eating, nightmares, and movement during REM sleep.
- Conditions
- Sleep Terror, Sleepwalking, Nightmare Disorder, REM Sleep Behavior Disorder (iRBD)
- Trial name
- NCT07361315
- Testing
- Parasomnia Education, Sleep Hygiene Control
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Sleep Inertia, Caffeine
Delayed-release Bedtime Caffeine and Sleep Inertia Symptoms Immediately Upon Awakening
Sleep inertia (sometimes also referred to as sleep drunkenness) is a disabling state of increased sleepiness, impaired mood and reduced vigilance immediately upon awakening.
- Conditions
- Sleep Inertia, Caffeine, Placebo
- Trial name
- NCT04975360
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Apnea of Prematurity
Caffeine Use in the Management of Preterm Infants
This study aims to assess whether extending the duration of caffeine therapy will help preterm infants achieve full oral feeding faster.
- Trial name
- NCT06327152
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Irvine
Weight Loss, Thinness
Low Indexes of Metabolism - Information to Teams (LIMIT)
The purpose of this study is to determine whether alerting primary care providers by email about low values of BMI, HbA1c% or cholesterol will affect treatment and improve overall survival and other health indexes of people older…
- Conditions
- Weight Loss, Thinness, Malnutrition
- Trial name
- LIMIT (NCT02476578)
- Testing
- Volunteers
- 8,584 people
- Sponsor
- Clalit Health Services
Snoring
The Effect of Caffeine Reduction on Snoring and Quality of Life
Snoring is a problem for many people, often disturbing energy level, quality of sleep, and the relationship with a bed partner. Two observational studies that have indicated a relationship between the consumption of caffeine and…
- Trial name
- NCT00641810
- Testing
- Caffeine reduction
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Dietary Supplement, Exercise
Coffee Increases Physical and Cognitive Performance Both in Men and Women
The impact of caffeine habituation on acute responses to different doses of caffeinated coffee has received minimal attention. This study aimed to investigate the effects of different doses of coffee on physical and cognitive…
- Trial name
- NCT07474753
- Testing
- Low Dose Caffeine (LCOF), Moderate Dose Caffeine (MCOF), High Dose Caffeine (HCOF)
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Coronary Artery Disease
Effects of Espresso on Platelet Aggregability in Patients with Coronary Artery Disease
Discovered thousands of years ago, coffee is among the most consumed beverages in the world. The relationship between coffee and cardiovascular risk, more specifically coronary artery disease, is controversial.
- Trial name
- NCT04827251
- Testing
- Coffee
- Where
- Brazil
- Volunteers
- 29 people
- Sponsor
- University of Sao Paulo
HIV Infections
Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults
This is an open-label, single sequence study that is being conducted to investigate the potential drug-drug interaction (DDI) when GSK3640254 is co-administered with a cocktail of cytochrome P450 (CYP) enzymes and transporter…
- Trial name
- NCT04425902
- Testing
- GSK3640254 200 mg, Caffeine 200 mg, Metoprolol 100 mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Solid Tumor Malignancies
A Study to Evaluate the Effects of ASA404 Alone or in Combination With Taxane-based Chemotherapies on the Pharmacokinetics of Drugs in Patients With Advanced Solid Tumor Malignancies
The purpose of this study is to evaluate the potential inhibitory effects of ASA404 on CYP1A2, CYP2C9, CYP3A4 and CYP2C19 mediated metabolism on the respective probe drugs caffeine, diclofenac, simvastatin, and omeprazole…
- Trial name
- NCT01290380
- Testing
- ASA404, DMXAA, DXAA
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Novartis Pharmaceuticals
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