Clinical trials: Caffeine
Heart Failure
Innovative Care of Older Adults With Chronic Heart Failure: A Comparative Effectiveness Clinical Trial (I-COACH)
An estimated 6.5 million adults in the U.S. have Heart Failure (HF) and the prevalence is increasing. HF is characterized by poor quality of life but this is amenable to self-management.
- Trial name
- I-COACH (NCT04304833)
- Testing
- Provider-Based Care Model Arm, mHealth Model Arm
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Arkansas
Rheumatologic Disease
Systemic Sclerosis (SSc) Vasculopathy: Improved Clinical Monitoring and Treatment
Systemic sclerosis (SSc; scleroderma) is a multi-organ systemic disease characterized by activation of immune cells, which results in vascular dysfunction (vasculopathy) and subsequent scarring (fibrosis).
- Trial name
- Scleroderma (NCT02530996)
- Testing
- BH4, Vasculopathy assessment
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Migraine Disorders, Migraine, Acute
TREXIMET® Versus Butalbital-containing Combination Medications for the Acute Treatment of Migraine in Adults
Study TRX109011/TRX109013, A Randomized, Double-blind, Double-dummy, Placebo-controlled, Crossover Study to Evaluate the Efficacy of TREXIMET® (Sumatriptan + Naproxen Sodium) versus Butalbital-containing Combination Medications…
- Trial name
- NCT00573170
- Testing
- TREXIMET®, Butalbital-containing Combination Medications (BCM)
- Where
- 107 sites in United States
- Volunteers
- 375 people
- Sponsor
- GlaxoSmithKline
Menopause, Sleep Disturbance
Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
A randomized, double-blind, placebo-controlled, direct-to-consumer trial assessing the impact of health and wellness products on hormonal health and associated health outcomes in women with menopausal health issues
- Conditions
- Menopause, Sleep Disturbance, Anxiety, Depression
- Trial name
- NCT06749288
- Testing
- Radicle Revive Active Study Product 4.1 Usage
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Dyspepsia, Functional Gastrointestinal Disorders
Traditional Dietary Advice Versus Reassurance-alone in Postprandial Functional Dyspepsia
Functional dyspepsia is common, affecting 7.2% of the global population, and associated with substantial health impairment. Almost 80% of patients with functional dyspepsia report meal-related symptoms and are classified as…
- Trial name
- NCT05718960
- Testing
- Reassurance-alone, Traditional dietary advice
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Self-Management, Quality of Life
Efficacy of a Self-advocacy Serious Game Intervention
Individuals with cancer must overcome multiple, ongoing challenges ("self-advocate") related to their cancer experience to receive patient-centered care.
- Trial name
- NCT04813276
- Testing
- Strong Together serious game, Enhanced Care as Usual
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- University of Pittsburgh
Exercise Physiology, Nutritional Supplementation
Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill Run
This study will examine how three commonly used pre-run nutritional supplements-caffeine, L-citrulline, and an exogenous ketone supplement-affect physiological and perceptual responses during a fixed-pace 5 km treadmill run in…
- Trial name
- NCT07854223
- Testing
- Caffeine, L-Citrulline, Exogenous Ketone (Beta-Hydroxybutyrate)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Food Consumption and Appetite, Food Habits
Associations Between Genetic Markers of Caffeine Metabolism, Appetite Hormones and Body Weight
The effect of caffeine on appetite and body weight is controversial. Mostly epidemiological studies exist that show either a negative effect (reduction of appetite and body weight) or no effect.
- Conditions
- Food Consumption and Appetite, Food Habits, Caffeine
- Trial name
- NCT04514588
- Testing
- caffeine consumption
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gkouskou Kalliopi
Caffeine
Effects of Caffeinated Gum on a Basketball-specific Tests in Basketball Players
This study investigated the effects of chewing 3 mg/kg of caffeinated gum on basketball free throw accuracy and basketball -specific performance.
- Trial name
- NCT06016985
- Testing
- caffeine gum
- Where
- Taiwan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Chih-Hui Chiu
Fatigue, Mental Alertness
A Study to Evaluate the Effect of EnXtra® and EnXtra® + Caffeine on Mental Alertness and Fatigue in Healthy Individuals
Acute Stage: The present study is a randomized, double-blind, placebo-controlled, single-dose, 4-way, cross-over, study. Approximately not more than 170 individuals will be screened and considering a screening failure rate of…
- Trial name
- NCT06560008
- Testing
- EnXtra® (300 mg) + Caffeine (200 mg)
- Where
- 3 sites in India
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Heart Failure
Health Information Technology in Heart Failure Care
The objective of this proposal is to develop, implement, and test the effectiveness of a computerized clinical decision support system for hospitalized patients with heart failure.
- Trial name
- NCT02858674
- Testing
- Pop Up Interruption Alert, Side Bar Non Interruptive Provider Checklist
- Where
- United States
- Volunteers
- 958 people
- Sponsor
- NYU Langone Health
Low; Birthweight, Extremely (999 Grams or Less)
Low Birth Weight Fetuses With Caffeine Use
Globally, it has been estimated that 15.5% of all infantsare born low birth weight, defined as birthweight less than 2,500 g .
- Trial name
- NCT03757780
- Testing
- Questionaire
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Diabetes Mellitus, Type 2
Quitting Caffeine for Better Glucose Metabolism
This project is a pilot study of caffeine abstinence in coffee-drinkers who have type 2 diabetes. Evidence suggests that caffeine may impair the control of glucose levels, especially in those people who have type 2 diabetes.
- Trial name
- NCT01030796
- Testing
- Caffeine abstinence
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Complication,Postoperative
Continuous Wireless Monitoring of Vital Signs and Automated Alerts of Postsurgical Patient Deterioration.
The primary aim of the current study is to assess the effect of continuous wireless vital sign monitoring with generation of real-time alerts, compared to blinded monitoring without alerts on the cumulative duration of any…
- Trial name
- WARD-RCT-SX (NCT04640415)
- Testing
- Active Alarms
- Where
- 2 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cerebrovascular Accident, Perceptual Disorders
Effectiveness of Rehabilitation on the Recovery of Patients Post Right Stroke With Unilateral Spatial Neglect
Unilateral spatial neglect (USN) is believed to be a disorder of attention, characterized by impairment in the ability to perceive or respond to stimuli presented to the contralesional space, and which is not attributable to…
- Trial name
- NCT00305513
- Testing
- The phasic alerting treatment
- Where
- Israel
- Volunteers
- 6 people
- Sponsor
- Hadassah Medical Organization
Healthy Volunteers
Phase 1 Study to Determine the Effects of PBT2 on the Pharmacokinetic Profile of Caffeine
This study is designed to determine the pharmacokinetic (PK) profile of a single oral dose of caffeine and the effects that PBT2 has on the metabolism of caffeine in healthy volunteers.
- Trial name
- NCT02109497
- Testing
- PBT2
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Prana Biotechnology Limited
CYP1A2 Polymorphism, Caffeine and Resistance Training
Caffeine, CYPA12 and Resistance Training
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance.
- Trial name
- NCT06610123
- Testing
- Caffeine and Resistance training
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Traumatic Brain Injury
Optimized Sleep After Brain Injury: Sleep Hygiene Intervention After Traumatic Brain Injury
OSABI is a pilot study of a sleep hygiene protocol for sleep disruptions associated with TBI during inpatient rehabilitation. Twenty participants will be allocated (by minimization) either into a standard of care protocol or a…
- Trial name
- OSABI (NCT02838082)
- Testing
- Sleep Hygiene Protocol, Standard of Care
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Craig Hospital
Fatigue; Muscle, Heart, Fatigue, Mental
Effects of Oral Nicotine and Caffeine Pouches on Anaerobic Performance, Autonomic Function, Cognition, and Behavior
The goal of this randomized placebo controlled crossover trial is to determine effects of oral nicotine and caffeine pouches on anaerobic performance, autonomic function, cognition, and behavior in adult non-obese adult male…
- Trial name
- NCT06529055
- Testing
- Oral Pouch - Nicotine, Oral Pouch - Caffeine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern Mississippi
Amyotrophic Lateral Sclerosis, Cytochrome P-450 Enzyme System
A Study of LY3873862 in Participants With Sporadic or Familial Amyotrophic Lateral Sclerosis (ALS).
The main purpose of this study in participants with Sporadic or Familial Amyotrophic Lateral Sclerosis (ALS) is to test the safety of different doses and to determine the amount of LY3873862 that gets into the bloodstream and how…
- Trial name
- NCT07883590
- Testing
- LY3873862, CYP450 Drug Cocktail
- Where
- 4 sites in United States, Canada
- Volunteers
- 32 people
- Sponsor
- Eli Lilly and Company
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