Clinical trials: Celecoxib
Healthy Volunteer
Bioequivalence Study of Generic Celecoxib 200 mg Capsules
To determine and compare the rate and extent of absorption of a test formulation with that of a reference innovator formulation when given as equal labeled dose in healthy subjects under fasting conditions
- Trial name
- NCT06337422
- Testing
- Celecoxib 200 mg capsule
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- International Bio service
Osteoarthritis
The Phosphodiesterase 3 Inhibitor Cilostazol as an Adjunct to Conventional Therapy in Patients With Osteoarthritis
Cilostazol is able to suppress the degradation of type II collagen in human chondrocytes induced by IL-1b. Cilostazol add-on for celecoxib therapy has synergistic anti-arthritic potential by inhibiting proinflammatory cytokine…
- Trial name
- NCT04789837
- Testing
- Cilostazol 50 MG
- Where
- Egypt
- Sponsor
- Sadat City University
Healthy Volunteers
A Pilot Open-Label Crossover Bioavailability Study of Celecoxib in Healthy Volunteers
A pharmacokinetic study in healthy volunteers to determine the relative bioavailability of three formulations of celecoxib to the approved formulation.
- Trial name
- NCT00813241
- Testing
- celecoxib reference formulation, celecoxib test formulation A1, celecoxib test formulation B2
- Where
- Singapore
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Healthy
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B
Cardiovascular complications of NSAIDs, selective for inhibition of COX-2, stimulated interest in microsomal prostaglandin E synthase-1 (mPGES-1) as an alternative drug target.
- Trial name
- NCT02413203
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alzheimer Disease, Dementia
Delaying Alzheimer Disease Symptoms With Anti-Inflammatory Drugs
The purpose of this study is to determine whether the anti-inflammatory drug celecoxib can delay the onset of Alzheimer Disease (AD) in people with Age Associated Memory Impairment (AAMI).
- Trial name
- NCT00065169
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pain Management, C Section
Pain After Scheduled Cesarean Delivery: Spinal Morphine With or Without Levobupivacaine Wound Infiltration
The goal of this observational study is to learn whether injecting a numbing medicine (levobupivacaine, a local anesthetic) into the surgical wound at the end of a cesarean delivery improves pain control in women who also receive…
- Conditions
- Pain Management, C Section, Obstetric Pain, Levobupivacaine
- Trial name
- LEVO-CS (NCT07859956)
- Testing
- Levobupivacaine, Intrathecal Morphine
- Where
- Colombia
- Volunteers
- 336 people
- Sponsor
- Fundación Santa Fe de Bogota
Pain, Postoperative
Dextromethorphan Use in Multimodal Analgesia Regimens for Total Knee Arthroplasty
Total knee arthroplasty (TKA) is one of the most painful orthopedic procedures. After TKA surgery, postoperative pain relief may be achieved using a variety of techniques.
- Trial name
- NCT02987920
- Testing
- Dextromethorphan, Acetaminophen, Oxycodone
- Volunteers
- 23 people
- Sponsor
- University of Southern California
Sarcoma, Melanoma
Tumor Cell Vaccines and ISCOMATRIX With Chemotherapy After Tumor Removal
Background: A tumor cell vaccine is an experimental cancer treatment. Cancer cells are collected from a patient and then used to develop a vaccine.
- Conditions
- Sarcoma, Melanoma, Epithelial Malignancies, Pleural Malignancy
- Trial name
- NCT01341496
- Testing
- Epigenetically Modified Autologous Tumor, Cyclophosphamide, Celecoxib
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Cancer Institute (NCI)
Nerve Block, Dexmedetomidine
Dexmedetomidine as Adjuvant for FNB in TKA
The aim of the study was to find out whether addition of dexmedetomidine to lower concentration of ropivacaine preoperatively in femoral nerve block (FNB) would intensify analgesia and preserve quadriceps muscle strength after…
- Trial name
- NCT03658421
- Testing
- Dexmedetomidine, ultrasound-guided femoral nerve block, intravenous patient-controlled analgesia pump with morphine
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Breast Cancer
Celecoxib in Preventing Breast Cancer in At-Risk Premenopausal Women
RATIONALE: Chemoprevention therapy uses certain drugs to try to prevent the development or recurrence of cancer. Celecoxib may be effective in preventing breast cancer in at-risk women.
- Trial name
- NCT00056082
- Testing
- celecoxib
- Where
- 3 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cancer of Ovary, Cancer of the Ovary
Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines
This study will evaluate the immunologic and potential clinical effectiveness of intensive locoregional sequential intraperitoneal (IP) cisplatin (IPC) with intravenous (iv) paclitaxel followed by peritoneal infusion of a…
- Conditions
- Cancer of Ovary, Cancer of the Ovary, Neoplasms, Ovarian, Ovarian Cancer
- Trial name
- NCT02432378
- Testing
- Cisplatin + celecoxib + DC vaccine, Cisplatin + CKM + Celecoxib + DC Vaccine
- Where
- 2 sites in United States
- Sponsor
- Roswell Park Cancer Institute
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Chemokine Modulation Therapy and Standard Chemotherapy Before Surgery for the Treatment of Early Stage Triple Negative Breast Cancer
This phase I trial studies how well chemokine modulation therapy and standard chemotherapy given before surgery work in treating patients with early stage triple negative breast cancer.
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT04081389
- Testing
- Celecoxib, Cyclophosphamide, Doxorubicin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Roswell Park Cancer Institute
Pain
Study To Evaluate Efficacy And Safety Of An Additional Dose Of Celecoxib (YM177) In Patients With Post-Tooth Extraction Pain
To evaluate efficacy and safety of additional dose of celecoxib, as compared to placebo, in patients with post lateral mandibular impacted third molar tooth extraction pain.
- Trial name
- NCT01062113
- Testing
- Celecoxib
- Where
- 22 sites in Japan
- Volunteers
- 255 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.