Clinical trials: Clarithromycin
Helicobacter Pylori Infection
Helicobacter Pylori Eradication According to DPO-PCR Methods (K-CREATE) Study)
Clarithromycin-containing triple therapy is still the primary therapy approved by the Korean government. However, studies of antibiotic resistance have shown that regional resistance patterns to antibiotics such as clarithromycin…
- Trial name
- NCT04147065
- Testing
- Duration of eradication regimen
- Where
- South Korea
- Volunteers
- 1,230 people, healthy volunteers welcome
- Sponsor
- Incheon St.Mary's Hospital
Helicobacter Pylori Infection
Study of Levofloxacin-based Concomitant Therapy for H. Pylori Eradication in Diabetic Patients
The study aims to evaluate H. pylori eradication rate in diabetic patients by using novel 10-day levofloxacin-based concomitant therapy compared with conventional 10-day sequential therapy.
- Trial name
- NCT02466919
- Testing
- Pantoprazole, Amoxicillin, Metronidazole
- Volunteers
- 114 people
- Sponsor
- Chung-Tai Wu
Gastric Ulcer
Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Gastric Ulcer Participants With or Without Helicobacter Pylori Infection
The purpose of this study is to demonstrate the non-inferior efficacy of TAK-438 versus lansoprazole in the treatment of participants with gastric ulcer.
- Trial name
- NCT03050307
- Testing
- TAK-438, Lansoprazole, Bismuth-Containing Quadruple Therapy
- Where
- 81 sites in China, Philippines and 2 more
- Volunteers
- 234 people
- Sponsor
- Takeda
Helicobacter Pylori Infection
Exploratory Study to Standard Triple Therapy With Tegoprazan(by Dose) in H. Pylori Positive Patients
This exploratory study is designed to compare safety and efficacy between a Tegoprazan dose-specific standard triple therapy and Lansoprazole standard triple therapy in H. pylori positive patients.
- Trial name
- NCT05933031
- Testing
- Tegoprazan 50 mg Triple Therapy, Tegoprazan 100 mg Triple Therapy, Lansoprazole Triple Therapy
- Where
- South Korea
- Volunteers
- 381 people
- Sponsor
- HK inno.N Corporation
Gastric Cancer
Chlorambucil Compared With No Further Therapy Following Anti-Helicobacter Therapy in Treating Patients With Low-Grade Lymphoma of the Stomach
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known whether chlorambucil is more effective than observation in treating low-grade lymphoma…
- Trial name
- NCT00003617
- Testing
- chlorambucil, clarithromycin, omeprazole
- Where
- 30 sites in Hong Kong, Poland and 3 more
- Volunteers
- 200 people
- Sponsor
- Lymphoma Trials Office
Helicobacter Pylori Infection
Efficacies of Antimicrobial Susceptibility-Guided Versus Empirical Therapy for Rescue Treatment of Helicobacter Pylori Infection
The purpose of this study is to assess efficacy of 14-day antimicrobial susceptibility test guided quadruple therapy for the rescue treatment of Helicobacter pylori infection, then comparing it with 14-day empirical therapy…
- Trial name
- NCT03658746
- Testing
- two sensitive antibiotics(amoxicillin, clarithromycin, metronidazole, tinidazole, levofloxacin, furazolidone and tetracycline), one proton pump inhibitor, colloidal bismuth pectin, two antibiotics based on personal medication history(amoxicillin,levofloxacin, furazolidone)
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Shandong University
Aggressive Periodontitis, Generalized
Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy
To assess the local effect of the antimicrobial therapy using clarithromycin association with photodynamic therapy (PDT) in the treatment of generalized aggressive periodontitis (GAgP).
- Trial name
- NCT03142776
- Testing
- periodontal debridement, photodynamic therapy, systemic clarithromycin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia
The Influence of Helicobacter Pylori Eradication on Gastric Pathology: a Long-term, Prospective Cohort Study
Helicobacter pylori (H. pylori) infection, affecting an estimated 50% of the global population, is a main cause of chronic gastritis, peptic ulcers and gastric cancer.
- Conditions
- Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia, Operative Link on Gastric Intestinal Assessment
- Trial name
- NCT02933229
- Testing
- biopsy, H. pylori eradication
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Preterm Premature Rupture of Membranes (PPROM), Prophylaxis
Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes
To investigate the effects of different antibiotic regimens used in preterm premature rupture of membranes (PPROM) on maternal and fetal outcomes after 34 weeks of gestation.
- Conditions
- Preterm Premature Rupture of Membranes (PPROM), Prophylaxis, Perinatal Outcomes
- Trial name
- NCT07148622
- Testing
- Antibiotic regimen 1: sulbactam + ampicillin + azithromycin, Antibiotic regimen 2: ceftriaxone + clarithromycin + amoxicillin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yuzuncu Yil University
Helicobacter Pylori
The Influence of FP-10 on the Eradication Rates of H. Pylori by a Triple Therapy
FP-10 is a food ingredient derived from milk casein. FP-10 can inhibit H. pylori to attach to the gastric epithelium. FP-10 has been made clear to decrease the intragastric urease activity (which is assumed to be produced by H.
- Trial name
- NCT00281047
- Testing
- FP-10
- Where
- 7 sites in Japan
- Volunteers
- 138 people
- Sponsor
- Hamamatsu University
Nonhematologic Malignancies, Lymphoma
Pharmacokinetics Study of Oral IXAZOMIB in Participants With Advanced Nonhematologic Malignancies or Lymphoma
This is an open-label, multicenter, sequential, 5-arm, phase 1 study of oral IXAZOMIB designed to assess drug-drug interaction with ketoconazole (Arm 1), the relative bioavailability of 2 capsule formulations of IXAZOMIB (Arm 2)…
- Trial name
- NCT01454076
- Testing
- Ixazomib 2.5 mg, Ixazomib 4 mg Capsule A, Ixazomib 4 mg Capsule B
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Gastric Cancer, H Pylori Infection
H. Pylori Screen-and-treat Study in a Population of Young Adults
Gastric cancer remains a major challenge to public health on a global scale. H. pylori related cancer burden contributes to the largest proportion of cancer cases attributable to infections in Europe.
- Conditions
- Gastric Cancer, H Pylori Infection, H Pylori Eradication, H-pylori
- Trial name
- NCT06275204
- Testing
- Bismuth-based quadruple therapy, Levofloxacin-based quadruple therapy, Standard triple therapy
- Where
- 7 sites in Croatia, Ireland and 4 more
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Bronchiolitis Obliterans, Acute Obliterating Bronchiolitis
Use of Clarithromycin in Mustard-Induced Bronchiolitis
We looked for the effectiveness of low-dose long-term prescription of clarithromycin in mustard-induced chronic pulmonary lesions, especially bronchiolitis obliterans
- Trial name
- NCT00381147
- Testing
- Clarithromycin
- Where
- Iran
- Sponsor
- Baqiyatallah Medical Sciences University
Helicobacter Pylori
Vonoprazan Hp Dual or Triple Eradication Regimes
To evaluate the efficacy and safety of dual or triple regimes for Helicobacter Pylori eradication using Vonoprazan as the antiacid agent.
- Trial name
- NCT05345210
- Testing
- Vonoprazan Fumarate+Amoxycillin+Clarithromycin 14days (VAC14), Vonoprazan Fumarate+Amoxycillin 14days (VA14), Vonoprazan Fumarate+Amoxycillin 7days (VA7)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Intracerebral Hemorrhage, Atrial Fibrillation
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF).
- Trial name
- ASPIRE (NCT03907046)
- Testing
- Apixaban, Aspirin
- Where
- 187 sites in United States
- Volunteers
- 700 people
- Sponsor
- Yale University
Helicobacter Pylori
Efficacy and Safety of Keverprazan-amoxicillin Dual Therapy for Helicobacter Pylori First-line Treatment
This is an open-label, randomized controlled study. The study plans to enroll 414 subjects with Helicobacter pylori infection, who will be randomly assigned to the experimental group (Keverprazan dual therapy for 10 days or…
- Trial name
- NCT07122024
- Testing
- Keverprazan 10 days, Keverprazan 14 days, Rabeprazole
- Where
- China
- Volunteers
- 414 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chemotherapy Effect
Perioperative Oxaliplatin With S-1 Combined H. Pylori Eradication in the Management of Locally Advanced Gastric Cancer
This study focuses on patients with H. pylori-positive resectable locally advanced adenocarcinoma of the gastric and oesophagogastric junction. It evaluates the perioperative oxaliplatin with S-1 (SOX) combined H.
- Trial name
- NCT06510010
- Testing
- Oxaliplatin With S-1 (SOX) Combined H. Pylori Eradication (Amoxicillin + clarithromycin + omeprazole + colloidal bismuth subcitrate), Oxaliplatin With S-1 （SOX）
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
COVID19
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 Mahmoud ELkazzaz(1),Tamer Haydara(2), Mohamed Abdelaal(3), Abedelaziz Elsayed(4) ,Yousry Abo-amer(5), Hesham Attia(6), Quan…
- Trial name
- Isotretinoin (NCT04353180)
- Testing
- Drug Isotretinoin (13 cis retinoic acid ) capsules+standard treatment, Isotretinoin(Aerosolized 13 cis retinoic acid) +standard treatment, Isotretinoin (13 cis retinoic acid ) capsules
- Where
- 2 sites in Egypt
- Volunteers
- 100,000 people
- Sponsor
- Kafrelsheikh University
Aggressive Periodontitis
Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
The aim of this study is to assess the clinical outcomes of full-mouth ultrasonic debridement combined with clarithromycin or amoxicillin + metronidazole association for the treatment of generalized aggressive periodontitis…
- Trial name
- NCT02969928
- Testing
- Full-mouth ultrasonic debridement, Clarithromycin, Amoxicillin
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Helicobacter Pylori Eradication Rate
Modified Non-clarithromycin Triple Therapy in Eradicating Helicobacter Pylori
Helicobacter pylori (H. pylori) infects more than 50% of the population in the world(1), especially 47-66% in China.
- Trial name
- NCT02776371
- Testing
- Modified non-clarithromycin triple therapy, Sequential therapy
- Where
- China
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Shandong University