Clinical trials: Clarithromycin
Helicobacter Pylori Infection
Efficacy of Therapy Based on Fecal Molecular Antimicrobial Susceptibility Tests for Helicobacter Pylori Infection
This study aims to evaluate the efficacy and safety of 14-day quadruple therapy based on fecal molecular antimicrobial susceptibility tests for the first-line eradication of H.
- Trial name
- NCT05718609
- Testing
- Rabeprazole, Colloidal Bismuth Pectin Granules, Amoxicillin
- Where
- China
- Volunteers
- 855 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Multiple Myeloma and Plasma Cell Neoplasm
Chemoprevention Therapy in Treating Patients at High Risk of Developing Multiple Myeloma
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Dehydroepiandrosterone and clarithromycin may be effective in preventing multiple myeloma.
- Trial name
- NCT00006219
- Testing
- clarithromycin, prasterone
- Where
- 3 sites in United States
- Sponsor
- Mayo Clinic
Healthy Volunteers
Dabigatran in an Interaction Probe Drug Cocktail
Four periods of oral dosing following overnight fasting (1. known metabolic probe drug cocktail consisting of caffeine, diclofenac, esomeprazole, metoprolol, midazolam; 2. dabigatran + cocktail; 3. dabigatran alone; 4.
- Trial name
- D-cocktail (NCT02361619)
- Testing
- Caffeine, Diclofenac, Esomeprazole
- Where
- Finland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Chronic Rhinosinusitis Without Nasal Polyps
Corticosteroid Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
The purpose of this study is to determine the most effective route to administer steroids to patients with chronic sinusitis, specifically a type of chronic sinusitis not associated with nasal polyps (CRSsNP).
- Trial name
- NCT01676415
- Testing
- Prednisone, Topical mometasone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northwestern University
Gastric Tumor, Helicobacter Pylori
Helicobacter Pylori Eradication After Endoscopic Resection of Gastric Tumors
The purpose of this study is to determine whether Helicobacter pylori eradication could reduce the new tumor development after endoscopic resection of gastric tumor.
- Conditions
- Gastric Tumor, Helicobacter Pylori, Endoscopic Resection, Metachronous Neoplasms
- Trial name
- NCT01510730
- Testing
- eradication treatment of Helicobacter pylori infection
- Where
- South Korea
- Volunteers
- 855 people
- Sponsor
- Seoul National University Hospital
Helicobacter Pylori Infections, Atrophic Gastritis
Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality
Currently no ideal preventive modalities are available for reducing gastric-cancer caused mortality in organized population-based application.
- Conditions
- Helicobacter Pylori Infections, Atrophic Gastritis, Gastric Cancer
- Trial name
- GISTAR (NCT02047994)
- Testing
- Triple therapy
- Where
- Latvia
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Opportunistic Infections, HIV Related, Disseminated Mycobacterium Avium Complex Infection
Enhanced Treatment Strategy for Disseminated MAC Infection in HIV Patients: A Randomized Controlled Trial
Background: Disseminated Mycobacterium avium complex (MAC) infection remains a serious opportunistic infection in patients with advanced HIV infection, particularly among those with severe immunosuppression.
- Trial name
- NCT07585461
- Testing
- Standard Triple Therapy, Experimental: Standard Triple Therapy Plus Fluoroquinolone
- Volunteers
- 124 people
- Sponsor
- Shanghai Public Health Clinical Center
Helicobacter Pylori Infection, Eradication Treatments
Prospective Randomised Trial of First and Second Line Treatments of RCT of First and Second Line H Pylori Treatments in Slovenia
Study is prospective randomised multicentric. The primary objective of the study is to compare the efficacy of two first-line therapy regimens and two second-line therapy regimens (ie, after failure of first-line treatment) in…
- Trial name
- NCT04359966
- Testing
- Esomeprazole 40mg, Clarithromycin 500 mg, Metronidazole 400 mg,, Esomeprazole 40mg, Bismuth subcitrate 120 mg, Amoxicillin 500 mg, Metronidazole 400 mg, Esomeprazole 40mg, Amoxicillin 500 mg, Levofloxacin 500 mg
- Where
- 3 sites in Slovenia
- Volunteers
- 560 people
- Sponsor
- Slovenian Society for Gastroenterology and Hepatology
Mycobacterium Avium Complex Lung Disease
Use of Clarithromycin and Rifabutin for the Treatment of M. Avium Complex (MAC) Lung Disease
To determine the safety and tolerance of clarithromycin given three times per week in combination with multiple drugs including rifabutin three times per week
- Trial name
- NCT00598897
- Testing
- clarithromycin, rifabutin
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- The University of Texas Health Science Center at Tyler
Helicobacter Pylori Infection
Comparison of 12-day Reverse Hybrid Therapy and 12-day Standard Triple Therapy for Helicobacter Pylori Infection
Reverse hybrid therapy is a one-step two-phase treatment for Helicobacter pylori infection with less cost than standard triple therapy.
- Trial name
- REHYTRI (NCT02359435)
- Testing
- Reverse hybrid therapy, Standard triple therapy
- Where
- Taiwan
- Volunteers
- 440 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Self Efficacy
Genotypic Resistance Guided Therapy in Helicobacter Pylori Eradication
We aimed to compare the efficacy of genotypic resistance guided sequential therapy vs. empiric therapy in the third line therapy.
- Trial name
- NCT01725906
- Testing
- empirical therapy, Genotypic resistance guided therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori
Nitazoxanide and Lansoprazole Based Regimens for H. Pylori Management
The study will evaluate the eradication rate and tolerability of modified LOAD regimens (three antibiotics and a proton pump inhibitor (lansoprazole)) for management of HP infection in treatment-naive patients as well as patients…
- Trial name
- NILE (NCT05184491)
- Testing
- Naïve patients - ACO therapy, Naïve patients - LNDL therapy, Naïve patients - MNDL therapy
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- National Liver Institute, Egypt
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori in Children
This study is designed to compare the eradication rates，safety and compliance of tailored therapy to those of standard triple therapy in children with H. pylori infection.
- Trial name
- NCT02635191
- Testing
- Tailored Group, Standard group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Helicobacter Pylori Infection, Antimicrobial Susceptibility Testing
Antimicrobial Susceptibility Testing Guided Antibiotic Selection Strategies in Salvage Helicobacter Pylori Treatment
Helicobacter pylori (H. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer.
- Trial name
- NCT02988089
- Testing
- Clarithromycin susceptibility dependant strategy, 2 susceptible antibiotics (amoxicillin, clarithromycin, metronidazole, tinidazole,levofloxacin, furazolidone and tetracycline ), proton pump inhibitor (PPI) and Colloidal Bismuth Pectin
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Gastritis
7 Days vs. 14 Days of Vonoprazan-based Triple Therapy for H. Pylori Eradication
The study aims to test the efficacy of 7 days vs. 14 days of Vonoprazan-triple therapy in the eradication of Helicobacter Pylori infection in adolescents and young children.
- Conditions
- Helicobacter Pylori Infection, Gastritis, Vonoprazan, Adolescents
- Trial name
- VOTE-HP (NCT06576882)
- Testing
- Vonoprazan, Amoxicillin, Clarithromycin
- Where
- Egypt
- Volunteers
- 326 people
- Sponsor
- Alexandria University
Healthy Volunteers, Patients
Drug Interaction Study on Linaprazan Glurate Capsules
This study is a drug-drug interaction (DDI) investigation involving Linaprazan Glurate capsules and a combination of clarithromycin tablets, amoxicillin capsules, and bismuth potassium citrate capsules.
- Trial name
- NCT07294846
- Testing
- Linaprazan Glurate Capsules, Bismuth Potassium Citrate Capsules, Amoxicillin Capsules
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Infection
Bioequivalency Study of Clarithromycin Tablets Under Fasting Conditions
The objective of this study was the bioequivalence of a potential generic 250 mg clarithromycin tablet formulation compared with Abbott Laboratories 250 mg clarithromycin tablet, Biaxin® following a single 250 mg dose…
- Trial name
- NCT00601315
- Testing
- Clarithromycin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Helicobacter Pylori Infection, Helicobacter Pylori gyrA Levofloxacin Resistance Mutation
Helicobacter Pylori 23S rRNA/gyrA Gene Mutation Detection Kit (Fluorescence PCR Fusion Curve Method)
The purpose of this study was to evaluate the detection ability of Helicobacter pylori 23S rRNA/gyrA gene mutation detection kit (fluorescent PCR fusion curve method) for Helicobacter pylori gene mutation.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori gyrA Levofloxacin Resistance Mutation, Fecal Drug Resistance Gene Detection, Helicobacter Pylori Infection, Susceptibility to
- Trial name
- NCT05410652
- Testing
- Detection of fecal samples with diagnostic kit, Sanger Sequencing group, Bacterial culture and drug sensitivity test of gastric mucosa samples
- Where
- 4 sites in China
- Volunteers
- 1,176 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Pneumonia
A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Clarithromycin Extended Release for the Treatment of Pneumonia in Adult Patients
The study was performed to confirm that a single, 2.0 g oral dose of azithromycin sustained release (SR) at least as effective as 7 days of clarithromycin extended release (ER), 1.0 g by mouth once daily, when used to treat…
- Trial name
- NCT00643227
- Testing
- clarithromycin extended release (ER), azithromycin SR
- Where
- 72 sites in United States, Argentina and 5 more
- Volunteers
- 504 people
- Sponsor
- Pfizer
Persistence of Infection With Helicobacter Pylori
The Role of Cathepsin X in Infection With the Helicobacter Pylori
The immune response to Helicobacter pylori (Hp) importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria.
- Trial name
- NCT01137942
- Testing
- clarithromycin, metronidazole, proton pump inhibitor
- Where
- Slovenia
- Volunteers
- 14 people
- Sponsor
- University Medical Centre Ljubljana