Clinical trials: Clopidogrel, completed
Acute Myocardial Infarction
The Effects of Facilitated Percutaeous Coronary Intervention in Acute Myocardial Infarction
The purpose of this study to investigate whether the administration of high-dose tirofiban before primary PCI could reduce myocardial infarct size, using analysis of contrast-enhanced magnetic resonance imaging.
- Trial name
- NCT00611169
- Testing
- tirofiban
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Prasugrel/Clopidogrel Maintenance Dose Washout Study
The primary objective of the study is to describe the cumulative proportion of participants who return to baseline platelet P2Y12 receptor function over time (up to 12 days post last maintenance dose) following discontinuation of…
- Trial name
- NCT01014624
- Testing
- Prasugrel, Clopidogrel
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- Daiichi Sankyo
Intracranial Artery Occlusion With Infarction
Endovascular Recanalization and Standard Medical Management for Symptomatic Nonacute Intracranial Artery Occlusion Trial
Background The management of patients with symptomatic nonacute intracranial artery occlusion (sNA-ICAO), which is a special subset with high morbidity and a high probability of recurrent serious ischemic events despite standard…
- Trial name
- NCT04864691
- Testing
- endovascular recanalization
- Where
- 15 sites in China
- Volunteers
- 453 people
- Sponsor
- Feng Gao
Healthy Volunteers
Reproducibility and Comparison of Platelet Function Assays With Aspirin and Clopidogrel (MK-0000-167)
This study will evaluate whether the antiplatelet effects of Aspirin 300 mg daily and Clopidogrel 75 mg daily can be reproducibly measured using several point of care platelet function assays
- Trial name
- NCT01108588
- Testing
- Aspirin, Clopidogrel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Coronary Artery Disease
Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery.
Running title: Effect of Clopidogrel on Postoperative Bleeding in Patients undergoing Coronary Artery Bypass Surgery Title: Clopidogrel and bleeding in patients undergoing coronary artery bypass grafting.
- Trial name
- NCT00724880
- Testing
- Clopidogrel
- Volunteers
- 135 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Coronary Artery Disease, Acute Coronary Syndrome
Genotyping Infarct Patients to Adjust and Normalize Thienopyridine Treatment
The objective of GIANT Study is to evaluate the clinical impact of genetic resistance to thienopyridine profile determination (CYP2C19 gene) and the clinical impact of compliance to an adjusted thienopyridine treatment on STEMI…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Genetic Resistance to Clopidogrel, Compliance to Thienopyridine Treatment
- Trial name
- GIANT (NCT01134380)
- Where
- 12 sites in France
- Volunteers
- 1,500 people
- Sponsor
- Biotronik France
Influence of PRU Values on Primary Outcome
High on Treatment Platelet Reactivity Following Peripheral Endovascular Procedures
Antiplatelet therapy with clopidogrel is recommended following peripheral endovascular procedures. The clinical significance of an inadequate response to clopidogrel following percutaneous coronary interventions has been recently…
- Trial name
- PRECLOP (NCT01744613)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Patras
Systolic Heart Failure
Platelet Inhibition in Patients With Systolic Heart Failure
The investigators aim to determine if patients with systolic heart failure treated with prasugrel achieve greater platelet inhibition compared to those treated with clopidogrel.
- Trial name
- NCT01765400
- Testing
- Prasugrel 10 mg daily x 2 weeks, Clopidogrel 75 mg daily x 2 weeks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Pharmacokinetics
Fasted Bioequivalence Study of Clopidogrel Film-coated Tablets, 75 mg in 48 Healthy, Adult Male and Female Subjects.
This study was designed to compare bioequivalence of the Test Product Clopidogrel bisulfate, film-coated tablets, 75 mg (JSC Farmak, Ukraine) and Reference Product Plavix® 75 mg film-coated tablets (Sanofi Winthrop Industrie…
- Trial name
- NCT05125549
- Testing
- Сlopidogrel bisulfate film-coated tablets, 75 mg (JSC Farmak, Ukraine), Plavix® 75 mg film-coated tablets (Sanofi Winthrop Industrie, France)
- Where
- Ukraine
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Joint Stock Company "Farmak"
Post Polypectomy Bleeding
Safety of Cold Snare Polypectomy in Patients With Uninterrupted Antiplatelet Agent
Polypectomy is regarded as high risk for bleeding. Several guidelines recommend continuous use of aspirin during polypectomy. However for clopidogrel, widely used antiplatelet agent, cessation of 5-7 is recommended.
- Trial name
- NCT04328987
- Testing
- cold snare polypectomy
- Where
- South Korea
- Volunteers
- 314 people
- Sponsor
- Incheon St.Mary's Hospital
HIV-1 Infection
Targeting Platelets in Chronic HIV Infection
Advances in antiretroviral therapy (ART) have resulted in increased survival of the HIV-infected population; however, this gain in longevity is associated with an increased risk of cardiovascular disease (CVD).
- Trial name
- NCT02578706
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Stroke, Transient Ischemic Attack
Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis
The purpose of this study is to evaluate the efficacy and safety of stent implantation in patients with symptomatic extra- and intracranial artery stenosis and to determine its role in secondary prevention of ischemic stroke.
- Conditions
- Stroke, Transient Ischemic Attack, Atherosclerosis, Stenosis
- Trial name
- ESSCAS (NCT00691314)
- Testing
- Stent implantation (Wingspan, Coroflex, and TiTAN2), Standard medical treatment
- Where
- 10 sites in China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Tooth Extraction, Postoperative Hemorrhage
Post-extraction Bleeding in Older Adults on Uninterrupted Antiplatelet Therapy
This prospective, assessor-blinded, controlled observational study compares bleeding after simple tooth extraction between adults aged 40 years or older who continue their antiplatelet therapy (aspirin, clopidogrel or dual…
- Conditions
- Tooth Extraction, Postoperative Hemorrhage, Platelet Aggregation Inhibitors
- Trial name
- NCT07913035
- Testing
- Antiplatelet therapy (uninterrupted), Simple tooth extraction with stepwise local haemostatic protocol
- Where
- Vietnam
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Disease Susceptibility
Clopidogrel Pharmacogenomics Project
Loss-of-function mutation of the gene encoding the CYP450 2C19 enzyme has emerged as a likely determinant of resistance to clopidogrel therapy.
- Trial name
- NCT01097343
- Testing
- clopidogrel 75 mg, Clopidogrel 150 mg
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Aortic Valve Disease, Myocardial Infarction
Aspirin Versus Aspirin + ClopidogRel Following Transcatheter Aortic Valve Implantation: the ARTE Trial
The purpose of this study is to compare aspirin + clopidogrel with aspirin alone as antithrombotic treatment following transcatheter aortic valve implantation (TAVI) for the prevention of major ischemic events [myocardial…
- Conditions
- Aortic Valve Disease, Myocardial Infarction, Stroke
- Trial name
- ARTE (NCT01559298)
- Testing
- Aspirin (80 mg/d) + clopidogrel (75 mg/d), Aspirin
- Where
- 2 sites in Canada
- Volunteers
- 178 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Atrial Fibrillation
ASA Plavix Feasibility Study With WATCHMAN Left Atrial Appendage Closure Technology
The purpose of the study is to characterize the performance of the WATCHMAN LAA Closure Device in atrial fibrillation patients for which long term warfarin therapy is contraindicated.
- Trial name
- ASAP (NCT00851578)
- Testing
- WATCHMAN
- Where
- 4 sites in Czechia, Germany
- Volunteers
- 150 people
- Sponsor
- Boston Scientific Corporation
Ischemic Stroke
Intensive Drug Therapy for Ischemic Stroke Caused by Severe Intracranial Arterial Stenosis
To observe the safety and efficacy of intensive drug therapy for ischemic stroke caused by severe intracranial arterial stenosis.Patients with acute stroke caused by intracranial arterial stenosis (stenosis rate ≥70%) were…
- Trial name
- NCT05996978
- Testing
- Intensive Drug Therapy
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Stable Angina, Unstable Angina
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - Coronary Intervention With Next Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy (HOST-IDEA) Trial
We had little experience in coronary intervention with recently introduced newer drug-eluting stent (DES) platforms, despite great anticipation, and optimal duration of dual antiplatelet therapy (DAPT) for these stent systems…
- Conditions
- Stable Angina, Unstable Angina, Non-ST Segment Elevation Myocardial Infarction
- Trial name
- HOST-IDEA (NCT02601157)
- Testing
- 3-months DAPT, 1-year DAPT
- Where
- 12 sites in South Korea
- Volunteers
- 2,173 people
- Sponsor
- Seoul National University Hospital
Healthy
A Bioequivalence Study Comparing Clopidogrel/Aspirin Combination Tablet With Coadministration of Clopidogrel and Aspirin
The purpose of this study is to evaluate pharmacokinetics and safety after oral administration of clopidogrel and aspirin in free combination as HCP0911.
- Trial name
- NCT01448330
- Testing
- HCP0911 / clopidogrel, aspirin
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Coronary Heart Disease
Pharmacodynamic and Short-term Effects of Half-dose Ticagrelor With or Without Aspirin vs DAPT From Day of PCI in CCS
Six months of aspirin plus clopidogrel remains the recommended antiplatelet regimen after percutaneous coronary intervention (PCI) for chronic coronary syndrome (CCS), with the more potent P2Y₁₂ inhibitors reserved for the acute…
- Trial name
- NCT07622056
- Testing
- Aspirin 100 mg + clopidogrel (300 mg load → 75 mg daily) ×6 months, then aspirin monotherapy, Aspirin 100 mg + ticagrelor (90 mg load → 45 mg twice daily) ×6 months, then aspirin monotherapy, Ticagrelor (90 mg load → 45 mg twice daily) monotherapy; aspirin stopped at day 2 after randomisation; continued indefinitely
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- Kaohsiung Veterans General Hospital.