Clinical trials: Clopidogrel
Osteoarthritis of the Knee, Coagulopathy
Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anticoagulants
The purpose of this study is to see if using a topical nonsteroidal antiinflammatory drug (Pennsaid) to treat osteoarthritis knee pain will affect coagulation values in patients who are also taking anticoagulant or antithrombotic…
- Trial name
- ATCCTCP-1 (NCT01511939)
- Testing
- Pennsaid
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Nathan Wei, MD, FACP, FACR:
Intracranial Arteriosclerosis, Ischemic Stroke
Intracranial Stenting in Non-acute Symptomatic Ischemic Stroke
In non-acute symptomatic ischemic stroke, the decision-making of medical treatment plus intracranial stenting has been more and more popular, especially in patients with intracranial large severe stenosis or occlusive artery.
- Conditions
- Intracranial Arteriosclerosis, Ischemic Stroke, Intracranial Arterial Diseases, Arterial Occlusive Diseases
- Trial name
- INSIS (NCT05063630)
- Testing
- Medical treatment plus intracranial stenting, Medical treatment alone
- Where
- Vietnam
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Cerebral Infarction, Atherosclerosis
Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis II
This study will recruit 480 acute stroke patients with symptomatic intracranial stenosis (M1 segment of Middle cerebral artery (MCA) or basilar artery). They will be randomly assigned into cilostazol group or clopidogrel group.
- Trial name
- TOSS-2 (NCT00130039)
- Testing
- clopidogrel, Cilostazol
- Where
- 19 sites in Hong Kong, Philippines and 2 more
- Volunteers
- 457 people
- Sponsor
- Asan Medical Center
Myocardial Ischemia, CLOPIDOGREL, POOR METABOLISM of (Disorder)
Genotyping Influences Outcome of Coronary Artery Stenting
This study evaluated epidemiology and clinical outcome of clopidogrel related various genotyping in Korean patients who had undergone percutaneous coronary intervention as a all comer registry form.
- Trial name
- GENIUS (NCT02707445)
- Testing
- Clopidogrel
- Volunteers
- 5,000 people
- Sponsor
- Korea University Anam Hospital
Coronary Artery Disease
Healthy Volunteer Study of Clopidogrel and Rifampicin
The principal research question is: Can platelet P2Y12 receptor blockade by the antithrombotic drug clopidogrel be significantly enhanced by coadministration of the antibiotic rifampicin? Clopidogrel is an antithrombotic drug in…
- Trial name
- NCT00696566
- Testing
- Clopidogrel and Rifampicin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Chronic Thrombocytopenia, Immune Thrombocytopenia
Efficacy and Safety of Oral E5501 Plus Standard of Care for the Treatment of Thrombocytopenia in Adults With Chronic Immune Thrombocytopenia (Amendment 02)
Core Study: To demonstrate that the efficacy of avatrombopag (in addition to standard of care) is superior to placebo (in addition to standard of care) for the treatment of adult participants with chronic immune thrombocytopenia…
- Trial name
- NCT01438840
- Testing
- Avatrombopag, Standard of care
- Where
- 25 sites in Australia, Belgium and 9 more
- Volunteers
- 49 people
- Sponsor
- Eisai Inc.
Myocardial Infarction
APRICOT-3: Antithrombotics in the Prevention of Reocclusion In COronary Thrombolysis -3
Reocclusion of the infarct artery is observed in about 30% of patients within three months after successful thrombolysis for acute myocardial infarction (MI).
- Trial name
- NCT00138034
- Testing
- Percutaneous coronary intervention (PCI)
- Where
- Netherlands
- Volunteers
- 49 people
- Sponsor
- Heartcenter, University Medical Center St. Radboud
COVID-19
Preventing Cardiac Complication of COVID-19 Disease With Early Acute Coronary Syndrome Therapy: A Randomised Controlled Trial.
The outbreak of a novel coronavirus (SARS-CoV-2) and associated COVID-19 disease in late December 2019 has led to a global pandemic. At the time of writing, there have been 150 000 confirmed cases and 3500 deaths.
- Trial name
- C-19-ACS (NCT04333407)
- Testing
- Aspirin 75mg, Clopidogrel 75mg, Rivaroxaban 2.5 MG
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- Imperial College London
Acute ST SEgment Elevation Myocardial Infarction
Thromboelastography As An Assessment Tool for Possible Clopidogrel and Aspirin Resistance
TEG is an established technique to assess the quality of clot formation' used mainly in surgery and obstetrics to determine possible bleeding diathesis.
- Trial name
- TEG (NCT00697021)
- Testing
- Aspirin (200mg) and/or Plavix (150mg) dosage according to TEG, Aspirin 100mg and Plavix 75mg
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Stable Coronary Artery Disease, Percutaneous Coronary Intervention
Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease
The purpose of this study is to conduct a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, evaluating the effects and change of endothelial function and gut microbiota after berberine…
- Trial name
- NCT04434365
- Testing
- Berberine, Aspirin, Clopidogrel
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Aortic Valve Disorder
Combined Transcatheter Aortic Valve Implantation and Percutaneous Closure of the Left Atrial Appendage
Atrial fibrillation (AF) is a common comorbidity of patients candidates to transcatheter aortic valve implantation (TAVI). The management of chronic oral anticoagulation (OAC) for the prevention of ischemic stroke is very…
- Trial name
- TAVI-LAAC (NCT02678871)
- Testing
- Lotus or ACURATE neo Heart valve system (or subsequent CE marked iterations), WATCHMAN
- Where
- 6 sites in Germany, Italy and 2 more
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atrial Fibrillation
Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study
In patients with atrial fibrillation (AF) complicated with coronary artery disease (CAD), antiplatelet drugs are commonly used for the prevention of recurrence of stent thrombosis and cardiovascular events in combination with…
- Trial name
- AFIRE (NCT02642419)
- Testing
- Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel), Rivaroxaban
- Where
- Japan
- Volunteers
- 2,200 people
- Sponsor
- Japan Cardiovascular Research Foundation
Cardiovascular Diseases, Heart Diseases
A Trial of CS-747 (Prasugrel) Compared With Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention (PCI)
The purpose of this study is to evaluate the effects of a drug known as CS-747 (also known as prasugrel) on subjects having a procedure called a percutaneous coronary intervention (also referred to as PCI) in which a doctor will…
- Trial name
- NCT00059215
- Testing
- Prasugrel (CS-747), Clopidogrel
- Where
- 2 sites in United States, Canada
- Volunteers
- 905 people
- Sponsor
- Eli Lilly and Company
Clopidogrel Resistance, Secondary Stroke Prevention
Effect of Primidone on Platelet Responsiveness in Patients Determined to be Clopidogrel Resistant
The purpose of this study is to determine whether adding primidone will improve the metabolism of clopidogrel thereby increasing metabolite levels within the blood stream and platelet response to clopidogrel in patients who were…
- Trial name
- NCT02008123
- Testing
- Primidone
- Where
- United States
- Sponsor
- Dent Neuroscience Research Center
Patients on Clopidogrel, Platelets Transfusion
Frequency of Platelets Transfusion & Post-Operative Bleeding Risk in Patients on Clopidogrel Undergoing CABG
The goal of this retrospective cohort study Is to Primarily be platelet transfusion frequency and postoperative bleeding risk, analysis using descriptive and inferential statistics in all eligible patients admitted to the cardiac…
- Trial name
- NCT07600060
- Where
- Pakistan
- Volunteers
- 227 people
- Sponsor
- Aga Khan University
Idiopathic Thrombocytopenic Purpura
A Phase 3, Multicenter, Randomized, Double-blind,Active-controlled, Parallel-group Trial With an Open-labelExtension Phase to Evaluate the Efficacy and Safety of OralE5501 Versus Eltrombopag, in Adults With Chronic ImmuneThrombocytopenia (Idiopathic Thrombocytopenic Purpura)
Core study: To compare the efficacy of avatrombopag (in addition to standard) of care to eltrombopag (in addition to standard of care) for the treatment of adult participants with chronic immune thrombocytopenia (idiopathic…
- Trial name
- NCT01433978
- Testing
- Eltrombopag, Avatrombopag, Standard of care
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Eisai Inc.
Coronary Heart Disease, Stable Angina Pectoris
Studies of Traditional Chinese Medicine Clinical Efficacy Evaluation Index
The purpose of the trial is to take stable angina pectoris of coronary heart disease (CHD) as examples to build a standard evaluation system for efficacy of traditional Chinese medicine (TCM). 1.
- Trial name
- NCT01502943
- Testing
- Louxiangdan Tongxin granules, Chixiangshen Tongxin granules, Western basis treatment
- Where
- 10 sites in China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Liaoning University of Traditional Chinese Medicine
Ischemic Stroke
Citicoline in Ischemic Stroke, a Randomized Trial
Along with the current clinical trial, the efficacy and safety of a 2000 mg daily citicoline administered within 24 hours of the first-ever ischemic stroke and lasted 12 months compared to 1000 mg were assessed through MoCA…
- Trial name
- NCT06210646
- Testing
- Citicoline 2000, citocoline 1000
- Where
- Egypt
- Volunteers
- 800 people
- Sponsor
- Kafrelsheikh University
Acute Coronary Syndrome
Clopidogrel Pharmacogenetic Score System
The aim of the present study is to evaluate candidate variables,including Cytochrome P450 2C19(CYP2C19) genotypes, clinical and demographic variables,to establish a simple risk score that can be easily adopted by clinicians to…
- Trial name
- CPASS (NCT01990989)
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Head and Neck Cancer, Thromboembolism
Flavopiridol in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of flavopiridol in treating patients who have…
- Trial name
- NCT00020189
- Testing
- acetylsalicylic acid, alvocidib, clopidogrel bisulfate
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)