Clinical trials: Conventional therapy
Reccurent/Metastatic Solid Tumor Disease
A Randomized Phase II Trial Comparing Therapy Based on Tumor Molecular Profiling Versus Conventional Therapy in Patients With Refractory Cancer
SHIVA is a proof of concept randomized phase II trial which compares two treatment strategies for patients with refractory cancer.
- Trial name
- SHIVA (NCT01771458)
- Testing
- Targeted therapy based on molecular profiling : Imatinib, Tumor biopsy, Standard Chemotherapy
- Where
- 8 sites in France
- Volunteers
- 742 people
- Sponsor
- Institut Curie
Bariatric Surgery Candidate, Atelectasis, Postoperative Pulmonary
Ventilation Distribution After Bariatric Surgery
Obese patients have an increased risk of developing post-operative respiratory complications due to their comorbidities. They have a restrictive ventilatory defect with reduction of lung volumes and expiratory flow limitation…
- Trial name
- NCT03975348
- Testing
- High flow nasal cannula, Continuous positive airway pressure, Facemask
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Trieste
Low Back Pain, Recurrent, Neuropathic Pain
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting
The investigators will select two study groups from a population of patients with severe chronic low back pain (CLBP) of facet joint (FJ) origin already treated with conventional radiofrequency ablation (CRFA) of the medial…
- Conditions
- Low Back Pain, Recurrent, Neuropathic Pain, Facet Joint Pain, Central Sensitisation
- Trial name
- NCT04542798
- Testing
- Radiofrequency COSMAN
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital General Universitario de Valencia
Ventilator Weaning, Sarcopenia
Comparison of Sarcopenia Index, Diaphragm Ultrasonography, and Traditional Weaning Parameters in Predicting Successful Weaning From Mechanical Ventilation
This study investigates whether the Sarcopenia Index (SI = serum creatinine/cystatin C × 100), a simple biomarker derived from routine blood tests, can predict weaning success in critically ill patients undergoing invasive…
- Conditions
- Ventilator Weaning, Sarcopenia, Diaphragm Ultrasonography
- Trial name
- NCT07844421
- Testing
- sarcopenia index, diaphragma ultrasound, parameters of mechanical ventilation (MV)
- Volunteers
- 80 people
- Sponsor
- Kocaeli City Hospital
COVID-19
Effectiveness of Remedesvir in COVID-19 Patients Presenting at Mayo Hospital Lahore
Currently, several drugs including Remdesivir, hydroxychloroquine, chloroquine, ritonavir+lopinavir, Tocilizumab, Arbidol and interferon are under randomised controlled trials (RCTs) for efficacy and/or safety evaluations in…
- Trial name
- NCT04871633
- Testing
- Remdesivir, Conventional
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- King Edward Medical University
Osteopenia, Total Knee Arthroplasty
Vibration Applications After Total Knee Arthroplasty in Osteopenic Women
Osteoarthritis (OA) is a chronic degenerative disease characterized by the destruction of articular cartilage, leading to functional impairment of surrounding bone and soft tissues.
- Trial name
- NCT06988033
- Testing
- Whole Body Vibration Therapy, Whole Body Vibration with Exercise, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istinye University
Stroke
Is the Rehabilitation Robotic a Safe and Effective Choice for Stroke Patients?
The effectiveness of robotic over conventional therapy is arguable and the best therapy strategy is still not clear. Basing on the existing evidence on motor learning and practice-induced neuroplasticity, the investigators plan…
- Trial name
- NCT03290833
- Testing
- Robotic, Conventional therapy
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Ten-Chen General Hospital
Pneumonia, Interstitial, Cancer Patients
Study of of Oxygen Nebulized Inhalation EGCG in Cancer Patients With New Coronary Pneumonia
Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions, such as anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects via modulation of a…
- Trial name
- NCT06924749
- Testing
- EGCG
- Where
- 2 sites in China
- Volunteers
- 111 people
- Sponsor
- Shandong Cancer Hospital and Institute
Chronic Low-back Pain
Effects of Basic Body Awareness Therapy on Pain, Sleep, Disability and Quality of Life in Chronic Low Back Pain
Chronic low back pain is a common problem worldwide. In treatment, conservative methods usually are used. Basic Body Awareness Therapy is related to mindfulness-based therapies and meditation techniques.
- Trial name
- NCT05080101
- Testing
- Conventional Therapy Program, Basic Body Awareness Therapy Group Program
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Hacettepe University
Bladder Cancer, TURBT
Sequential Chemotherapy Followed by Ultrahypofractionated Radiotherapy for Muscle-Invasive Bladder Cancer
Muscle-invasive bladder cancer (MIBC) is a potentially lethal disease for which radical cystectomy with appropriate systemic therapy remains a standard curative approach in medically fit patients. .
- Conditions
- Bladder Cancer, TURBT, Radiotherapy
- Trial name
- NCT07914101
- Testing
- Transurethral Resection of Bladder Tumor, Sequential Systemic Chemotherapy, radiotherapy
- Volunteers
- 71 people
- Sponsor
- Assiut University
Arthritis, Rheumatoid
Subcutaneous Golimumab (GLM) Plus DMARDs for Rheumatoid Arthritis, Followed by Intravenous/Subcutaneous GLM Strategy (P06129 AM2)
Part 1 of this trial will assess the safety and effectiveness of subcutaneous (SC) golimumab administered by autoinjector once monthly, when combined with different disease-modifying antirheumatic drug (DMARD) regimens used in…
- Trial name
- GO-MORE (NCT00975130)
- Testing
- SC golimumab, IV golimumab
- Volunteers
- 3,366 people
- Sponsor
- Merck Sharp & Dohme LLC
Dysphagia
Oral Enteral Nutrition in Delayed Onset Radiotherapy-related Swallowing Disorder in Nasopharyngeal Carcinoma
This is a prospective multicenter study with patients with delayed dysphagia after radiotherapy for NPC. Patients enrolled are randomly divided equally into the observation group and the control group.
- Trial name
- NCT06301763
- Testing
- Intermittent Oral-esophageal Tube Feeding, nasogastric tube feeding
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Muhammad
Cerebral Palsy
The Effect of Soft Orthoses on Balance and Gait Performance in Children With Cerebral Palsy
Most of the available studies that are relevant to motor rehabilitation for children with dyskinetic type of cerebral palsy are few and are comprised of small numbers of children.
- Trial name
- NCT04990193
- Testing
- Conventional Physical Therapy Protocol, TheraTog orthotic undergarment with its strapping system
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Umm Al-Qura University
Neck Pain
Acupoint Focused Ultrasound Versus Laserpuncture In Mechanical Neck Pain
this study will be conducted to compare the effect of Acupoint focused ultrasound and Laser puncture on pain intensity level, neck range of motion, and neck function in patient with chronic mechanical neck pain
- Trial name
- MNP (NCT05782621)
- Testing
- Acupoint focused ultrasound, Laserpuncture, conventional treatment
- Volunteers
- 45 people
- Sponsor
- Cairo University
Palatally Impacted Canines
Effect of Alveolar-decortication on Velocity of Tooth Movement
The purpose of this pilot clinical trial is to evaluate whether alveolar-decortication has the potential to reduce orthodontic treatment time following surgical exposure of palatally impacted canines.
- Trial name
- NCT01093352
- Testing
- Alveolar-decortication.
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Birmingham
To Investigate the Clinical Effect of Acupuncturing Ba Liao for Neurogenic Bladder Under the Guidance of Ultrasound
Clinical Study on Treatment of Neurogenic Bladder by Electroacupuncture on Ba Liao Point Under Ultrasound Guidance
To explore acupuncture under the premise of real-time, dynamic and accurate positioning of Ba liao point with ultrasound, observe the clinical efficacy of treating neurogenic bladder, clarify the essence of acupoints, and provide…
- Trial name
- NCT05447247
- Testing
- Acupuncturing Ba Liao point under ultrasound guidance
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Qilu Hospital of Shandong University
Dental Anxiety, Covid19
Music for Decreasing Dental Anxiety During Oral Surgery in Coronavirus Disease 2019 (COVID-19)
Approximately 100 patients undergoing oral surgery will be divided in 3 groups of musical audition to control anxiety: baroque (N=35), classicism (N=35) and control group (N=30).
- Trial name
- NCT05052034
- Testing
- Music
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- European University of Madrid
Pre-Eclampsia
Autogenic Training Effects on Pre-eclampsia
The purpose of study is to find the effects of autogenic training on blood pressure and anxiety in preeclampsia females. There is little of evidence to allow conclusions about effectiveness of autogenic training on preeclampsia…
- Trial name
- NCT05709834
- Testing
- Autogenic training, Conventional treatment
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Symptomatic Femoro-popliteal Chronic Total Occlusion
The Lumen Study: Comparing Devices for Patients With Symptomatic Femoro-popliteal Chronic Total Occlusion (CTO)
This is a prospective, multicenter, randomized, single-blind study enrolling up to 75 subjects at up to 5 sites in the US. Eligible subjects with symptomatic femoro-popliteal CTO will be randomized 2:1 to treatment with the…
- Trial name
- NCT02145299
- Testing
- TruePath CTO Device, CROSSER CTO Device
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Metastatic Osteosarcoma
Sorafenib in Treating Patients With Soft Tissue Sarcomas (Extremity Sarcoma Closed to Entry as of 5/30/07)
This phase II trial is studying how well sorafenib works in treating patients with soft tissue sarcoma. Sorafenib may stop the growth of soft tissue sarcoma by blocking blood flow to the tumor and blocking some of the enzymes…
- Conditions
- Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Metastatic Osteosarcoma, Recurrent Adult Soft Tissue Sarcoma, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
- Trial name
- NCT00330421
- Testing
- sorafenib tosylate, therapeutic conventional surgery, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
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