Clinical trials: Conventional therapy
Arthritis, Rheumatoid
Efficacy and Safety of GSK3196165 (Otilimab) Versus Placebo and Sarilumab in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological Disease-modifying Antirheumatic Drug (DMARDs) and/or Janus Kinase (JAK) Inhibitors
This study (contRAst 3 [202018: NCT04134728]) is a Phase 3, randomized, multicenter, double-blind study to assess the safety and efficacy of GSK3196165 in combination with conventional (cs) DMARD[s]) or the treatment of adult…
- Trial name
- contRAst 3 (NCT04134728)
- Testing
- GSK3196165 (Otilimab), Sarilumab, csDMARDs
- Where
- 131 sites in United States, Argentina and 13 more
- Volunteers
- 550 people
- Sponsor
- GlaxoSmithKline
Pancreatic Cancer
Individualized Drug Treatment for Treating Patients With Pancreatic Cancer
RATIONALE: Treating tumor tissue in the laboratory with different drugs may help doctors find the best drug for treating individual patients with pancreatic cancer.
- Trial name
- NCT00276744
- Testing
- cetuximab, capecitabine, docetaxel
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Diabetes Mellitus, Type 2, Coronary Artery Disease
SMBG Protocols Predicting Glucose Levels in Senior Diabetes Mellitus With CAD
Self-monitoring of blood glucose (SMBG) is a common way to assess glycemic control in diabetes management. Multiple times of blood glucose measurements by fingerstick in the same day are of tough challenge to it.
- Trial name
- NCT01954771
- Testing
- SMBG, CGMS
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Beijing Anzhen Hospital
Psychogenic Non-epileptic Seizures, Motivational Interviewing
Motivational Interviewing to Enhance Adherence of Patients With Psychogenic Non-epileptic Seizures
All subjects will attend an initial clinic visit with the neuropsychiatrist and epileptologist. At the end of this visit, those subjects randomized to motivational interviewing will be questioned using standardized motivational…
- Trial name
- NCT02598076
- Testing
- motivational interviewing, standard psychotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Prostate Cancer
Observation or Radical Treatment in Patients With Prostate Cancer
RATIONALE: Sometimes prostate tumours may not need treatment until they progress. In this case, observation may be sufficient. Radical treatments, such as radical prostatectomy or radiation therapy, may be effective in treating…
- Trial name
- NCT00499174
- Testing
- conventional surgery, brachytherapy, external beam radiation therapy
- Where
- 13 sites in Canada
- Volunteers
- 180 people
- Sponsor
- NCIC Clinical Trials Group
Estrogen Receptor-negative Breast Cancer, HER2-negative Breast Cancer
Pegylated Liposomal Doxorubicin Hydrochloride and Carboplatin Followed by Surgery and Paclitaxel in Treating Patients With Triple Negative Stage II-III Breast Cancer
This phase II trial studies how well pegylated liposomal doxorubicin hydrochloride and carboplatin followed by surgery and paclitaxel work in treating patients with stage II-III breast cancer that does not have estrogen…
- Conditions
- Estrogen Receptor-negative Breast Cancer, HER2-negative Breast Cancer, Progesterone Receptor-negative Breast Cancer, Stage IIA Breast Cancer
- Trial name
- NCT02315196
- Testing
- pegylated liposomal doxorubicin hydrochloride, epirubicin hydrochloride, carboplatin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Rutgers, The State University of New Jersey
Dental Caries, Secondary Dental Caries
A Comparative Study of Papacarie® and the Conventional Method for Dental Caries Treatment
The purpose study are to evaluate the efficacy of Papacarie® for caries removal in comparison to the conventional drilling method.
- Conditions
- Dental Caries, Secondary Dental Caries, Personal Satisfaction
- Trial name
- NCT01641861
- Testing
- Papacarie®, Conventional method
- Where
- Thailand
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Knee Osteoarthritis, Kidney Yin Deficiency
Needling Techniques for Knee Osteoarthritis
The thirty-nine-week open-label clinical study investigates the efficacy of acupuncture for Knee Osteoarthritis (KOA) as adjunctive therapy to analgesics compared to analgesics only and assesses the effects after 9 and 24 weeks…
- Conditions
- Knee Osteoarthritis, Kidney Yin Deficiency, Kidney Yang Deficiency
- Trial name
- NCT05014542
- Testing
- Acupuncture, Conventional Medical Treatment
- Where
- Croatia
- Volunteers
- 64 people
- Sponsor
- Svijetlana Perculija Durdevic
Congenital Adrenal Hyperplasia
Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1
Children with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency tend to have elevated circulating levels of androgens, which can accelerate skeletal maturation and adversely impact adult height.
- Trial name
- NCT02574910
- Testing
- Abiraterone acetate
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Texas Southwestern Medical Center
Esophageal Cancer
Combination Chemotherapy in Treating Patients With Previously Untreated Stage II or Stage III Esophageal Cancer That Can Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, floxuridine, docetaxel, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00448760
- Testing
- Docetaxel, Floxuridine, Leucovorin
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Miami
Venous Thrombosis
Evaluation of the Duration of Therapy for Thrombosis in Children
The Kids-DOTT trial is a randomized controlled clinical trial whose primary objective is to evaluate non-inferiority of shortened-duration (6 weeks) versus conventional-duration (3 months) anticoagulation in children with…
- Trial name
- Kids-DOTT (NCT00687882)
- Testing
- Shortened duration (6 weeks) of anticoagulant therapy, Conventional duration (3 months) of anticoagulant therapy, No Intervention
- Where
- 63 sites in United States, Australia and 4 more
- Volunteers
- 532 people
- Sponsor
- Johns Hopkins All Children's Hospital
Stress
The Effects of a Music Intervention on Stress, Anxiety and Academic Performance on Nursing Students
This study is examining the effect of listening to music on personal variables such as stress, anxiety, and academic performance.
- Trial name
- NCT05590910
- Testing
- Music
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pleomorphic Rhabdomyosarcoma, Stage IIB Adult Soft Tissue Sarcoma AJCC v7
Sorafenib Tosylate, Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With High-Risk Stage IIB-IV Soft Tissue Sarcoma
This phase II trial studies how well sorafenib tosylate, combination chemotherapy, radiation therapy, and surgery work in treating patients with high-risk stage IIB-IV soft tissue sarcoma.
- Conditions
- Pleomorphic Rhabdomyosarcoma, Stage IIB Adult Soft Tissue Sarcoma AJCC v7, Stage III Adult Soft Tissue Sarcoma AJCC v7, Stage IV Adult Soft Tissue Sarcoma AJCC v7
- Trial name
- NCT02050919
- Testing
- Epirubicin Hydrochloride, External Beam Radiation Therapy, Ifosfamide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- OHSU Knight Cancer Institute
Neuroblastoma, Medulloblastoma
Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer
The purpose of this study is to test the feasibility (ability to be done) of experimental technologies to determine a tumor's molecular makeup (gene expression profile) and mutations.
- Conditions
- Neuroblastoma, Medulloblastoma, Brain Tumors, Rare Tumors
- Trial name
- NCT01802567
- Testing
- Guided Therapy- Pediatric Gene Analysis Platform
- Where
- 13 sites in United States
- Volunteers
- 52 people
- Sponsor
- Giselle Sholler
Ann Arbor Stage IIB Hodgkin Lymphoma, Ann Arbor Stage IIIB Hodgkin Lymphoma
Brentuximab Vedotin and Combination Chemotherapy in Treating Children and Young Adults With Stage IIB, Stage IIIB, IVA, or IVB Hodgkin Lymphoma
This phase III trial studies brentuximab vedotin and combination chemotherapy to see how well they work compared to combination chemotherapy alone in treating children and young adults with stage IIB with bulk, stage IIIB, IVA…
- Conditions
- Ann Arbor Stage IIB Hodgkin Lymphoma, Ann Arbor Stage IIIB Hodgkin Lymphoma, Ann Arbor Stage IVA Hodgkin Lymphoma, Ann Arbor Stage IVB Hodgkin Lymphoma
- Trial name
- NCT02166463
- Testing
- Bleomycin Sulfate, Brentuximab Vedotin, Cyclophosphamide
- Where
- 199 sites in United States, Canada and 1 more
- Volunteers
- 600 people
- Sponsor
- National Cancer Institute (NCI)
Cardiovascular Diseases, Heart Diseases
Occluded Artery Trial (OAT)
The purpose of this study is to determine whether opening an occluded infarcted artery 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients reduces the composite endpoint of mortality, recurrent…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Heart Failure, Congestive
- Trial name
- OAT (NCT00004562)
- Testing
- Beta adrenergic blockers, Platelet inhibitors, PTCA and stents
- Where
- United States
- Volunteers
- 2,201 people
- Sponsor
- NYU Langone Health
Breast Cancer
Paclitaxel, Cyclophosphamide & Doxorubicin, Autologous Dendritic Cells & Surgery in Stage II/III Breast Cancer (Women)
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, cyclophosphamide, and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00499083
- Testing
- therapeutic autologous dendritic cells, aromatase inhibition therapy, cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Nebraska
Pain
Unmodulated 5 Kilohertz Currents Versus TENS: Effect on Pain Thresholds, Tactile Threshold, and Nerve Conduction
The purpose of this study is to determine whether the transcutaneous application of unmodulated 5 Kilohertz (KHz) alternating currents are effective in decreasing the thermal and mechanical experimental pain and cause changes in…
- Trial name
- NCT02320838
- Testing
- 5 KHz, TENS
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Chronic Knee Pain
Patients With Chronic Knee Pain Treated With Conventional Radiofrequency of the Genicular Nerves
Management of chronic knee pain remains a challenge to the treating physician. A radiofrequency treatment of the genicular nerves is a not yet established but promising technique.
- Trial name
- RECORGEN (NCT04234984)
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- Ziekenhuis Oost-Limburg
Hypersensitivity Reactions
Conventional Prophylactic Oral Dexamethasone vs Short-course IV Dexamethasone in Paclitaxel Hypersensitivity
This study is a single center, prospective, randomized, open-label study aimed at determining the most effective means of preventing hypersensitivity reactions in gynecologic oncology patients receiving paclitaxel infusions.
- Trial name
- NCT03598426
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Loma Linda University