Clinical trials: Conventional therapy
Premature Lungs, Respiratory Distress Syndrome
Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants
This study is being conducted to determine whether prophylactic administration of surfactant by the Less Invasive Surfactant Administration (LISA) method reduces the need for mechanical ventilation in the first 72 hours of life…
- Conditions
- Premature Lungs, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- CaLI (NCT04209946)
- Testing
- Less Invasive Surfactant Administration LISA, Continuous Positive Airway Pressure CPAP
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Sharp HealthCare
Neuroblastoma
NANT 2015-02: A Phase 1 Study of Lorlatinib (PF-06463922)
Lorlatinib is a novel inhibitor across ALK variants, including those resistant to crizotinib. In this first pediatric phase 1 trial of lorlatinib, the drug will be utilized as a single agent and in combination with chemotherapy…
- Trial name
- NCT03107988
- Testing
- Lorlatinib, Cyclophosphamide, Topotecan
- Where
- 13 sites in United States, Canada and 2 more
- Volunteers
- 65 people
- Sponsor
- New Approaches to Neuroblastoma Therapy Consortium
Low Back Pain, Mechanical, Biofeedback, Pain, Chronic, Low Back Pain
The Effects of Dynamic Neuromuscular Stabilization Exercises in Addition to Conventional Treatment on Functional Capacity, Core Stabilization Muscle Strength, and Balance in Female Patients With Chronic Low Back Pain
Low back pain, which is currently considered a public health problem, is commonly encountered. A significant proportion of low back pain cases is of mechanical origin.
- Trial name
- NCT07199842
- Testing
- Dynamic Neuromuscular Stabilization Exercises in Addition to Conventional Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Safiye Esin
Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8
Conventional or Hypofractionated Radiation Therapy in Treating Patients With Prostate Cancer
This phase III trial studies how well hypofractionated radiation therapy works compared to the conventional one in treating patients with prostate cancer.
- Conditions
- Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
- Trial name
- NCT03987386
- Testing
- Hypofractionated Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 186 people
- Sponsor
- M.D. Anderson Cancer Center
Orthodontic Patient Experience
Orthodontic Patient Experience of Intraoral Scans Versus Alginate Impressions
CONTEXT: Digital scanning systems are becoming more and more popular with the advent of the COVID-19 pandemic. The risks surrounding aerosol-generating procedures (AGP) has resulted in practitioners changing their normal practice…
- Trial name
- OPESI (NCT05194956)
- Testing
- Intraoral scan, Alginate impressions
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Endometrial Cancer
Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Endometrial Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00005583
- Testing
- cisplatin, doxorubicin hydrochloride, epirubicin hydrochloride
- Where
- 23 sites in Belgium, France and 9 more
- Volunteers
- 400 people
- Sponsor
- Nordic Society of Gynaecological Oncology - Clinical Trials Unit
Ulcer Foot, Chronic Skin Ulcer
Platelet Rich Plasma (PRP) Bio Stimulant Gel Dressing in Treating Chronic Non Healing Leg and Foot Ulcers: Cost and Effectiveness
Background Chronic non-healing ulcer is a common problem met in clinical practice and represents a burden to the patients. Chronic ulcer lacks growth factors (GFs) to promote the healing process and is frequently followed by…
- Conditions
- Ulcer Foot, Chronic Skin Ulcer, Non-Healing Ulcer of Skin
- Trial name
- NCT04065594
- Testing
- PRP dressing, conventional ordinary dressing
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Antiplatelet, Antithrombotic
In Vivo Evaluation of Anti-inflammatory and Antithrombotic Health Promoting Properties of Extra Virgin Olive Oil Versus Classic Table Olive Oil in Healthy Subjects
This study aims to evaluate the in vivo antithrombotic and anti-inflammatory effects of extra virgin olive oil daily consumption at recommended doses for 1 month compared to similar consumption of classic table olive oil, in the…
- Conditions
- Antiplatelet, Antithrombotic, Anti-Inflammatory Agents, Non-Steroidal
- Trial name
- HealthAgriloil (NCT07784166)
- Testing
- Olive Oil 1, Olive Oil 2
- Where
- Greece
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Prostate Cancer
RADAR Trial - Randomised Androgen Deprivation and Radiotherapy
The principal objectives of the RADAR trial is to address the hypotheses; 1) that 18 months androgen deprivation in conjunction with radiotherapy is superior to 6 months androgen deprivation prior to and during radiotherapy; 2)…
- Trial name
- NCT00193856
- Testing
- Leuprorelin Acetate, Zoledronic Acid, Conventional external beam therapy
- Where
- 24 sites in Australia, New Zealand
- Volunteers
- 1,071 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Brain Tumor
Feasibility of Mask-Free Radiotherapy for Brain Tumor Patients
The aim of this study is to investigate the technical feasibility of brain radiotherapy without immobilization masks using surface imaging to ensure accurate patient positioning and continuous motion monitoring.
- Trial name
- MASKLESS (NCT07323966)
- Testing
- Surface Guided Radiation Therapy without mask
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Idiopathic Nephrotic Syndrome
Short-term gluCOCOrticoid in Adult STEROID-sensitive Nephrotic Syndrome: The COCO-ASTEROID Study
This study will compare a short-term course (12 week) glucocorticoid regimen with the Conventional 24-week regimen as originally proposed by KDIGO.
- Trial name
- NCT07151456
- Testing
- Conventional 24-week glucocorticoid regimen, short-term course (12 week) glucocorticoid regimen
- Where
- China
- Volunteers
- 224 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Elderly
Effects of Training in a Virtual Environment in Healthy Elderly
The objective of this work was to compare the effects of two balance training programs, one Nintendo Wii Fit-based and the other traditionally-based without the use of a gaming system, on the (1) balance, (2) gait, (3)…
- Trial name
- NCT01741402
- Testing
- Virtual Reality Training, Physical Therapy
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Tumors Metastatic to Brain
Radiation Therapy With or Without Thalidomide in Treating Patients With Brain Metastases
Randomized phase III trial to compare the effectiveness of radiation therapy with or without thalidomide in treating patients who have brain metastases. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00033254
- Testing
- radiation therapy, thalidomide, quality-of-life assessment
- Where
- United States
- Volunteers
- 332 people
- Sponsor
- National Cancer Institute (NCI)
Autoimmune Encephalitis, Early-stage Panencephalitis
Monitoring of Outcomes of Cellular and Exosome-based Therapies in Autoinflammatory and Post-infectious Neuroinflammatory Syndromes
This is a prospective, non-randomized, observational registry study evaluating the clinical outcomes of patients with autoimmune or post-infectious neuroinflammatory syndromes receiving stem cell-derived biologics (including…
- Conditions
- Autoimmune Encephalitis, Early-stage Panencephalitis, Neuroinflammatory Demyelination
- Trial name
- NCT07145502
- Testing
- Allogeneic MSC infusions (IV)
- Where
- Poland
- Volunteers
- 76 people
- Sponsor
- Biocells Medical
Systemic Lupus Erythematosus
Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Systemic Lupus Erythematosus
This study is to evaluate the safety and efficacy of human umbilical cord derived mesenchymal stem cells transplantation in systemic lupus erythematosus.
- Trial name
- NCT03219801
- Testing
- mesenchymal stem cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Hebei Medical University
End Stage Renal Disease on Dialysis
Effects of pHA Hemoperfusion Plus Hemodialysis on Protein-Bound Uremic Toxins
This single-center, prospective cohort Study evaluates whether adding the pHA130 hemoperfusion cartridge to conventional hemodialysis (HD) or hemodiafiltration (HDF) more effectively reduces protein-bound uremic…
- Trial name
- NCT07016841
- Testing
- pHA130 hemoperfusion device, HD/HDF, HA130 hemoperfusion device
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Migraine, Nutraceuticals
Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine
Migraine is a common disabling neurological condition that significantly affects quality of life. While traditional prophylactic treatments (e.g., beta-blockers, antiepileptics) are effective, they may be associated with side…
- Trial name
- NCT07147972
- Testing
- Propranolol 80 mg, Magnesium 400Mg
- Volunteers
- 100 people
- Sponsor
- Fayoum University
Type 2 Diabetes Mellitus, Coronary Artery Disease
DARE: Diabetes in cArdiac REhabilitation
The aim of the DARE study is to see whether strict glycemic control during cardiac rehabilitation may ameliorate the improvement of exercise capacities (VO2 peak, peak workload, ventilatory threshold)in patients with type 2…
- Trial name
- NCT00354237
- Testing
- Conventional antidiabetic treatment, Intensive insulin treatment
- Where
- 12 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Intracranial Atherosclerosis, Optical Coherence Tomography
Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis
To evaluate the clinical significance of optical coherence tomography (OCT) in interventional treatment of intracranial atherosclerotic stenosis (ICAS).
- Conditions
- Intracranial Atherosclerosis, Optical Coherence Tomography, Plaque, Atherosclerotic, Artery Stenosis
- Trial name
- OCT-ICAS (NCT05550077)
- Testing
- Optical Coherence Tomography, Percutaneous transluminal angioplasty and stenting
- Where
- China
- Volunteers
- 400 people
- Sponsor
- jiaoliqun
Growth Modification
Three-Dimensional Assessment of Dentoskeletal Changes Associated With a Modified Twin Block Appliance
The aim of the current study is to evaluate the skeletal, dental, soft tissue, TMJ, and upper airway size changes associated with a new design of twin block compared to the conventional twin block appliance.
- Trial name
- NCT06589206
- Testing
- modified design of twin block
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
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