Clinical trials: Conventional therapy
Cerebrovascular Accident (CVA), Chronic Disease
Upper Limb Task-Oriented Rehabilitation With Robotic Exoskeleton for Hemiparetic Stroke Patients
The aim of this study is to evaluate the effects of an assisted rehabilitation treatment through a robotic exoskeleton device on the functional recovery in a group of patients with hemiparesis from lesion of the first motor…
- Conditions
- Cerebrovascular Accident (CVA), Chronic Disease, Stroke Rehabilitation
- Trial name
- RH-LEXOS (NCT03319992)
- Testing
- Upper Arm Rehabilitation Light Exoskeleton (RH-LEXOS)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna
Primary Peritoneal Carcinoma, Stage III Ovarian Cancer
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer or Primary Peritoneal Cancer
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which combination chemotherapy regimen is most effective in treating ovarian epithelial cancer and…
- Conditions
- Primary Peritoneal Carcinoma, Stage III Ovarian Cancer, Stage IV Ovarian Cancer
- Trial name
- NCT00011986
- Testing
- Paclitaxel, Carboplatin, Gemcitabine Hydrochloride
- Where
- United States
- Volunteers
- 4,312 people
- Sponsor
- Gynecologic Oncology Group
Locally Advanced Non-Small Cell Lung Cancer
Hypofractionated Versus Conventional Chemoradiotherapy Followed by Consolidative Immunotherapy in Locally Advanced NSCLC
Consolidative immunotherapy following concurrent chemoradiotherapy, based on the PACIFIC trial, has become the standard treatment for locally advanced non-small cell lung cancer (LANSCLC).
- Trial name
- NCT07052669
- Testing
- Hypofractionated Radiation Therapy, Conventionally Fractionated Radiation Therapy, Concurrent Chemotherapy
- Where
- 3 sites in China
- Volunteers
- 311 people
- Sponsor
- Sun Yat-sen University
Ulcer Foot, Chronic Skin Ulcer
Platelet Rich Plasma (PRP) Bio Stimulant Gel Dressing in Treating Chronic Non Healing Leg and Foot Ulcers: Cost and Effectiveness
Background Chronic non-healing ulcer is a common problem met in clinical practice and represents a burden to the patients. Chronic ulcer lacks growth factors (GFs) to promote the healing process and is frequently followed by…
- Conditions
- Ulcer Foot, Chronic Skin Ulcer, Non-Healing Ulcer of Skin
- Trial name
- NCT04065594
- Testing
- PRP dressing, conventional ordinary dressing
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Zagazig University
High-flow Nasal Cannula Oxygen
Evaluating High-flow Nasal Cannula Oxygen Therapy Through LUS During Weaning
Respiratory distress after extubation is associated with increased morbidity and mortality. Its multifactorial pathophysiology causes a loss of pulmonary aeration during the weaning process, the clinical translation being…
- Trial name
- NCT03384394
- Testing
- high-flow nasal cannula oxygen, Conventional oxygen therapy
- Volunteers
- 250 people
- Sponsor
- lu xiao
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication
Platform of Randomized Adaptive Clinical Trials in Critical Illness
PRACTICAL is a randomized multifactorial adaptive platform trial for acute hypoxemic respiratory failure (AHRF). This platform trial will evaluate novel interventions for patients with AHRF across a range of severity states…
- Conditions
- Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
- Trial name
- PRACTICAL (NCT05440851)
- Testing
- Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL)
- Where
- 103 sites in United States, Australia and 8 more
- Volunteers
- 6,250 people
- Sponsor
- University Health Network, Toronto
Stroke, Proprioceptive Disorders
Combined Effects of PNF and Electrical Muscle Stimulation on Spasticity and Hand Function in Stroke Patients.
To determine the combined effects of proprioceptive neuromuscular facilitation and electrical muscle stimulation on spasticity and hand function in stroke patients.
- Conditions
- Stroke, Proprioceptive Disorders, Balance; Distorted
- Trial name
- NCT05916872
- Testing
- experimental group, control group
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
SCI - Spinal Cord Injury
The Efficacy of Upper Extremity Wearable Robotic Orthosis on Improving Upper Extremity Motor Function and Activities of Daily Living in Persons With Spinal Cord Injury
To evaluate the usefulness of an upper extremity (UE) assistive device, called (MyoPro) in improving upper extremity activities in people with incomplete spinal cord injury (iSCI)
- Trial name
- MyoMo in SCI (NCT04855812)
- Testing
- MyoMo, Myo-SB, Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Kessler Foundation
Melanoma (Skin Cancer)
Comparing Intravenous or Intradermal Administration of Anti-CTLA-4 in Combination With Anti-PD1 Treatment in Patients With Melanoma
This study investigates whether a single intradermal (i.d.) injection of low-dose anti-CTLA-4 (ipilimumab), given at the tumour site, can enhance immune activation when combined with standard intravenous (i.v.) anti-PD-1 therapy…
- Trial name
- IpiD (NCT07615881)
- Testing
- Group 1 - Intradermal ipilimumab, Group 2 - Conventional treatment
- Volunteers
- 18 people
- Sponsor
- Amsterdam UMC, location VUmc
Atrial Fibrillation
Short Term Warfarin Therapy for Radiofrequency Catheter Ablation of Atrial Fibrillation
We hypothesized that in patients with low CHADS-VASc score (2 or < 2), there is no difference in thromboembolic or bleeding events between patients with short term warfarin therapy (2 weeks after catheter ablation) and…
- Trial name
- NCT01991951
- Testing
- warfarin
- Where
- South Korea
- Volunteers
- 520 people
- Sponsor
- Korea University Anam Hospital
Gastrointestinal Stromal Tumor
Imatinib Mesylate With or Without Surgery in Treating Patients With Metastatic Gastrointestinal Stromal Tumor That is Responding to Imatinib Mesylate
RATIONALE: Surgery may remove residual disease in patients with gastrointestinal stromal tumor that is responding to imatinib mesylate.
- Trial name
- NCT00956072
- Testing
- imatinib mesylate, therapeutic conventional surgery
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Chronic Neck Pain, Neck Pain
Cost-Effectiveness Analysis of a Virtual Reality-Assisted Hypnotherapy Program on Quality of Life in Patients with Chronic Neck Pain: a Multicenter, Randomized, Prospective, Comparative, Open-Label, Parallel-Group Study
This randomized, prospective study aims to evaluate the effectiveness and cost-efficiency of a Virtual Reality (VR)-assisted hypnotherapy program on quality of life in patients with chronic neck pain.
- Trial name
- NCT06697795
- Testing
- Virtual Reality-Assisted Hypnotherapy, Standard Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- University of Beykent
Stroke
Kinesio Taping Along With Functional Activation Pattern in Stroke Patients
In stroke; gait deviation occurs usually due to weakness in the tibialis anterior and over activation/spasticity of planter flexors.
- Trial name
- NCT05425212
- Testing
- Functional activation with kinesio tapping, Conventional physical therapy
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Muscle Weakness, Cervical Disability
Effectiveness of a Training Protocol With the Cervical Device in Subjects With Deep Cervical Muscle Strength Deficit.
The purpose of this study is to evaluate the clinical results produced by a training protocol with the new device for cervical treatment (CDAT) and the conventional training protocol (CT) versus a control group (C) in subjects…
- Trial name
- NCT05288712
- Testing
- Training protocol with the device cervical for treatment (CDAT), Conventional training protocol
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Universitat Internacional de Catalunya
Caries
Antimicrobial Photodynamic Therapy as an Adjunct for Management of Deep Caries Lesions
Alternatively to conventional treatments, chemo-mechanical caries removal agents can be used. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT).
- Trial name
- NCT05236205
- Testing
- Caries removal with a lowspeed drill, Partial removal of carious tissue with the administration of Papacarie™, Partial removal of carious tissue with the administration of Papacarie™ and application of Bixa Orellana extract (20%)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Dental Implantation
Plasma Rich in Growth Factors in the Preservation of the Alveolar Ridge After Simple Molar Tooth Extractions.
This Randomized Clinical Trial aims to study the efficacy and safety of PRGF-Endoret in alveolar ridge preservation after single molar extractions.
- Trial name
- NCT04945629
- Testing
- Alveolar ridge preservation with a PRP (PRGF-Endoret), Blood clot and simple suture
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Fundación Eduardo Anitua
Lung, Diseases
Non-invasive Ventilation Assisted Fiber-optic Bronchoscopy
The purpose of this study is the evaluation of using bi-level positive airway pressure ventilation in candidates for fiber-optic bronchoscopy regarding benefits and drawbacks.
- Trial name
- NCT06115395
- Testing
- non- invasive ventilator, fiber-optic bronchoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Recurrent Hodgkin Lymphoma, Refractory Hodgkin Lymphoma
Gemcitabine, Bendamustine, and Nivolumab in Patients With Relapsed or Refractory Classical Hodgkin Lymphoma
This phase I/II trial studies the side effects and best dose of gemcitabine, bendamustine, and nivolumab when given together and to see how well they work in treating patients with classic Hodgkin lymphoma that has come back or…
- Conditions
- Recurrent Hodgkin Lymphoma, Refractory Hodgkin Lymphoma, Classical Hodgkin Lymphoma, Hodgkin Lymphoma
- Trial name
- NCT03739619
- Testing
- Bendamustine, Gemcitabine, Nivolumab
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Post-traumatic Stress Disorder, Depression
SimCoach Evaluation: A Virtual Human Intervention to Encourage Servicemember Help-seeking for PTSD and Depression
SimCoach, a computer program featuring a virtual human that speaks and gestures in a videogame-like interface, is designed to encourage servicemembers, especially those with signs or symptoms of post-traumatic stress disorder…
- Trial name
- NCT02335528
- Testing
- SimCoach
- Volunteers
- 333 people
- Sponsor
- RAND
Neuroblastoma, Medulloblastoma
Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer
The purpose of this study is to test the feasibility (ability to be done) of experimental technologies to determine a tumor's molecular makeup (gene expression profile) and mutations.
- Conditions
- Neuroblastoma, Medulloblastoma, Brain Tumors, Rare Tumors
- Trial name
- NCT01802567
- Testing
- Guided Therapy- Pediatric Gene Analysis Platform
- Where
- 13 sites in United States
- Volunteers
- 52 people
- Sponsor
- Giselle Sholler
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