Clinical trials: Conventional therapy
CABG-patients, Saphenectomy
Clinical Impact of Surgical Wound Morbidity According to the Type of Saphenous Vein Harvesting Technique (Endoscopic vs. Open) in Patients Undergoing Myocardial Revascularization Surgery
The goal of this clinical trial is to compare two different techniques: endoscopic saphenous vein harvesting versus conventional open harvesting in patients undergoing coronary artery bypass grafting, either alone or in…
- Conditions
- CABG-patients, Saphenectomy, Endoscopic Surgery, Wound Complications
- Trial name
- EndOSiC (NCT07002658)
- Testing
- Harvesting of the saphenous vein graft
- Where
- Spain
- Volunteers
- 356 people
- Sponsor
- Hospital San Carlos, Madrid
Dry Eye Syndromes
Umbilical Cord Serum Versus Conventional Eyedrops
Dry eye disease (DED) is a chronic ocular surface disease and the prevalence of DED has been reported as high as 50%. Recently, The international Dry Eyes Workshop II (DEWS II) defines dry eye as a "multifactorial disease of the…
- Trial name
- NCT04217785
- Testing
- Optive, Ophthalmic Solution, Umbilical Cord Serum eye drops, Genteal lubricant gel
- Where
- 3 sites in Malaysia
- Volunteers
- 102 people
- Sponsor
- National University of Malaysia
Anterior Cruciate Ligament Injuries
Efficacy of the NXSignal Device for the Treatment of Anterior Cruciate Ligament Injuries
Injury to the anterior cruciate ligament (ACL) is very common among sports professionals and the general population [. Unlike other joint injuries, it is reversible, but it can damage adjacent tissues, particularly the meniscus…
- Trial name
- NCT05207943
- Testing
- Non-invasive Neuromodulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Las Palmas de Gran Canaria
Spinal Cord Injury
Effects of Wheelchair Treadmill and Conventional Exercises on Trunk Balance in Spinal Cord Injury Patients
This study aims to determine whether wheelchair treadmill exercises improve trunk balance and stability compared to conventional wheelchair exercises.
- Trial name
- NCT06876285
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara City Hospital Bilkent
Neck Pain, Virtual Reality
Additional Benefits of Virtual Reality Therapy for Individuals With Neck Pain
This study aimed to investigate the effect of adding virtual reality therapy to conventional treatment in patients with chronic neck pain on pain, neck disability index, kinesiophobia, insomnia severity questionnaire, hospital…
- Conditions
- Neck Pain, Virtual Reality, Rehabilitation
- Trial name
- NCT06235515
- Testing
- rehabilitation program, virtual reality
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Sarcoma
Radiation Therapy With or Without SU5416 in Treating Patients With Soft Tissue Sarcoma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as SU5416 may stop the growth of cancer by stopping blood flow to the tumor.
- Trial name
- NCT00023725
- Testing
- semaxanib, conventional surgery, radiation therapy
- Where
- 226 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
Prostate Cancer, Sexual Dysfunction
Intensity-Modulated Radiation Therapy With or Without Decreased Radiation Dose to Erectile Tissue in Treating Patients With Stage II Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Intensity-modulated radiation therapy (radiation directed at the tumor more precisely than in standard radiation therapy) may reduce damage to healthy…
- Conditions
- Prostate Cancer, Sexual Dysfunction, Sexuality and Reproductive Issues
- Trial name
- NCT00084552
- Testing
- radiation therapy
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Fox Chase Cancer Center
Cerebral Palsy, Bilateral Cerebral Palsy
Effects of HABIT-ILE in Adults with Bilateral Cerebral Palsy
This randomized controlled trial (RCT) aims to evaluate the effects of intensive Hand and Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) in improving body structure, function, daily activities, and…
- Trial name
- NCT06767930
- Testing
- Hand and Arm Bimanual Intensive Therapy Including Lower Extremities, Conventional intervention
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Coronary Artery Disease
OPTImal Management of Antithrombotic Agents: OPTIMA-2 Trial
High on-treatment platelet reactivity (HOPR) is associated with increased risk of cardiovascular events in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- OPTIMA-2 (NCT01955200)
- Testing
- Clopidogrel, Cilostazol, Ticagrelor
- Where
- China
- Volunteers
- 1,724 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Mitral Regurgitation
Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation
The timing of surgical intervention in asymptomatic patients with severe degenerative mitral regurgitation (MR) remains controversial.
- Trial name
- NCT01703806
- Testing
- Early Surgery, Watchful Observation
- Where
- 2 sites in South Korea
- Volunteers
- 1,063 people
- Sponsor
- Asan Medical Center
Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia
Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients.
To evaluate the safety, efficacy and pharmacokinetics of nilotinib over time in the Ph+ chronic myelogenous leukemia (CML) in pediatric patients (from 1 to <18 years).
- Trial name
- DIALOG (NCT01844765)
- Testing
- nilotinib
- Where
- 36 sites in United States, France and 11 more
- Volunteers
- 59 people
- Sponsor
- Novartis Pharmaceuticals
Stage I Kidney Wilms Tumor, Stage II Kidney Wilms Tumor
Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor
This phase III trial is studying vincristine, dactinomycin, and doxorubicin with or without radiation therapy or observation only to see how well they work in treating patients undergoing surgery for newly diagnosed stage I…
- Conditions
- Stage I Kidney Wilms Tumor, Stage II Kidney Wilms Tumor, Stage III Kidney Wilms Tumor
- Trial name
- NCT00352534
- Testing
- 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection, Chest Radiography
- Where
- 240 sites in United States, Australia and 5 more
- Volunteers
- 808 people
- Sponsor
- Children's Oncology Group
Rectal Cancer
Multi-Technology Integrated Total Mesorectal Excision Versus Conventional Total Mesorectal Excision for the Treatment of Middle and Distal Rectal Cancer.
A multicenter, prospective, randomized, controlled clinical trial of multi-technology integration total mesorectal excision (MTI-TME) versus conventional total mesorectal excision (C-TME) for the treatment of middle and distal…
- Trial name
- NCT06613399
- Testing
- MTI-TME, C-TME
- Volunteers
- 324 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Primary Dysmenorrhea
Primary Dysmenorrhea and Mobilization.
72 women diagnosed with primary dysmenorrhea were included in the study and divided into four groups. the first group received treatment with a mobilization approach, the second group received motor imagery-focused exercises and…
- Trial name
- NCT07314021
- Testing
- FEMOB, MOPEXE, Conventional Treatment group
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medipol University
Diabetes, Lower Limb Ischemia
Autologous Bone Marrow Mononuclear Cells Therapy in Diabetic Lower Limb Ischemia
This study is to evaluate the safety and efficacy of autologous bone marrow mononuclear cells transplantation in diabetic patients with lower limb ischemia.
- Trial name
- NCT01937416
- Testing
- autologous bone marrow mononuclear cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Hebei Medical University
Percutaneous Nephrolithotomy, Renal Stones
Effectiveness of US-Guided PCNL Different Positions in Renal Stones Treatment
The aim of this study is to compare the effectiveness of Ultrasound-Guided Percutaneous nephrolithotomyin different positions supine, prone positions and flank suspend supine position in renal stones treatment.
- Conditions
- Percutaneous Nephrolithotomy, Renal Stones, Ultrasound Therapy; Complications
- Trial name
- NCT05855057
- Testing
- Flank suspended supine position percutaneous nephrolithotomy, Supine percutaneous nephrolithotomy group, Prone percutaneous nephrolithotomy group
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Benha University
Food Allergy in Children, Milk Allergy
Comparison Between a Rush and a Conventional Oral Immunotherapy Protocol to Treat Cow's Milk and Hen´s Egg Allergy. CompITO Study
This study investigates the efficacy and safety of two different OIT schemes to treat milk and egg allergic children
- Conditions
- Food Allergy in Children, Milk Allergy, Egg Allergy
- Trial name
- compITO (NCT06976775)
- Testing
- "Rush" regimen, "Conventional" regimen
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Pablo Rodríguez del Rio
Sarcoma
Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00379457
- Testing
- dactinomycin, carboplatin, cyclophosphamide
- Where
- 27 sites in Austria, Belgium and 6 more
- Volunteers
- 600 people
- Sponsor
- European Paediatric Soft Tissue Sarcoma Study Group
Pleomorphic Rhabdomyosarcoma, Stage IIB Adult Soft Tissue Sarcoma AJCC v7
Sorafenib Tosylate, Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With High-Risk Stage IIB-IV Soft Tissue Sarcoma
This phase II trial studies how well sorafenib tosylate, combination chemotherapy, radiation therapy, and surgery work in treating patients with high-risk stage IIB-IV soft tissue sarcoma.
- Conditions
- Pleomorphic Rhabdomyosarcoma, Stage IIB Adult Soft Tissue Sarcoma AJCC v7, Stage III Adult Soft Tissue Sarcoma AJCC v7, Stage IV Adult Soft Tissue Sarcoma AJCC v7
- Trial name
- NCT02050919
- Testing
- Epirubicin Hydrochloride, External Beam Radiation Therapy, Ifosfamide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- OHSU Knight Cancer Institute
Castration-resistant Prostate Cancer
Metastasis-directed Therapy in Castration-refractory Prostate Cancer
The aim is to define the postponement of next line systemic treatment (NEST), by the use of metastasis-directed therapy in patients with oligoprogressive castration-refractory prostate cancer.
- Trial name
- MEDCARE (NCT04222634)
- Testing
- Radiotherapy (SBRT) and/or surgery (metastasectomy)
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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