Clinical trials: Dexmedetomidine
Cognitive Dysfunction
Dexmedetomidine and Esmolol Early Post Operative Cognitive Dysfunction
Dexmedetomidine is a highly selective α2adrenoceptor agonist recently introduced to anesthesia that produces dose dependent sedation, anxiolysis, and analgesia (involving spinal and supraspinal sites) without respiratory…
- Trial name
- NCT03892512
- Testing
- Esmolol Hydrochloride, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Beni-Suef University
Postoperative Pain Management
Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine
The investigators are evaluating postoperative outcomes in patients undergoing hip replacement surgery performed with either spinal or general anesthesia, who also receive a suprainguinal fascia iliaca block using either…
- Trial name
- NCT07316166
- Testing
- Dexmedetomidine, Ropivacaine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rhode Island Hospital
Orthopedic Disorder
Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation
The purpose of this study is to compare the sedation efficacy of dexmedetomidine and remimazolam for intraoperative sedation during regional block.
- Trial name
- NCT05447507
- Testing
- Remimazolam, Dexmedetomidine
- Where
- South Korea
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Brain Tumor, Cerebrovascular Disorders
The Neuroprotective Effects of Dexmedetomidine During Brain Surgery
Dexmedetomidine (DEX) is a Alpha-2 specific agonist, is a common ICU sedation medication. In brain tumor resection craniotomy, it is proven to be effective in improving postoperative hypertension and tachycardia, mitigates…
- Trial name
- NCT02878707
- Testing
- Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
Posterior Fossa Tumor
Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery.
The goal of this clinical trial is to evaluate the effects of ultrasound-guided versus blind greater occipital nerve block (GONB), with or without Dexmedetomidine as an adjuvant, in pediatric patients undergoing posterior fossa…
- Trial name
- NCT07878156
- Testing
- Bupivacaine 0.25%, Dexmedetomidine 1mcg/kg, Blind greater occipital nerve block
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Opioid Free Anesthesia, Opioid Based Anesthesia
Intraoperative Infusion of Dexmedetomidine Versus Lidocaine or Magnesium Sulphate for Enhanced Quality of Recovery After Spine Surgery Fixation
Thoracolumbar fixation is a major spine surgery; it is performed to stabilize the spine after trauma, deformity or advanced degenerative disease.
- Conditions
- Opioid Free Anesthesia, Opioid Based Anesthesia, Spine Fixation Surgeries, Opiod-Related Disorders
- Trial name
- NCT07843953
- Testing
- Group ( L): LICOCAINE, GROUP Dexmedetomidine, Group M: Magnesium sulphate
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Analgesia
Extension of Analgesia by Combined Injection of Dexamethasone and Dexmedetomidine After Arthroscopic Shoulder Surgery
The main objective of the study is to demonstrate the efficacy of Dexmedetomidine on the prolongation of analgesia obtained by interscalenic bloc of the brachial plexus and intravenous injection of Dexamethasone (efficacy…
- Trial name
- INDEX (NCT04394481)
- Testing
- Dexmedetomidine, Ropivacaine, Dexamethasone
- Where
- France
- Volunteers
- 122 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Anesthesia, Drug Interaction
The Application and Validation of Triple Drug Response Surface Models on Density Spectral Array in Clinical Anesthesia
Precision anesthesia is the current trend. The benefits including faster recovery, earlier return to normal activity, increased patient satisfaction and shorter length of stay.
- Conditions
- Anesthesia, Drug Interaction, Anesthesia; Functional
- Trial name
- NCT05525351
- Testing
- Bispectral index (BIS) or Patient State Index (PSI), Propofol, Alfentanil
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Inhalation Anesthesia
Comparison of Midazolam or Dexmedetomidine on Epileptiform EEG During Sevoflurane Mask Induction
Induction with high sevoflurane concentrations may trigger epileptiform electroencephalographic activity without motor or cardiovascular manifestations in healthy patients.
- Trial name
- NCT03394430
- Testing
- Midazolam, Dexmedetomidine
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Pediatric Patients Receiving Venoarterial Extracorporeal Membrane Oxygenation
Population Pharmacokinetics of Vancomycin, Meropenem, Milrinone, Dexmedetomidine and Fentanyl in Pediatric Patients During Extracorporeal Membrane Oxygenation
Extracorporeal membrane oxygenation (ECMO) has been used primarily in newborns since it was first successfully implemented in the 1970s, and has recently increased use in infants and young children.
- Trial name
- NCT04701099
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Abnormal Menstrual Cycle
Effect of Dexmedetomidine on Bispectral Index and Propofol Requirements During Different Menstrual Cycle
The study was done to evaluate the effects of the follicular and luteal phases of the menstrual cycle on sedation level at loss of consciousness and bispectral index reach to 50 during propofol anesthesia, in patients with and…
- Trial name
- NCT02035930
- Testing
- dexmedetomidine
- Volunteers
- 110 people
- Sponsor
- Fudan University
Adverse Effect of Drugs and Medicaments in Therapeutic Use, Adverse Effects in the Therapeutic Use of Anaesthetics
The Effect of Opioid Free Anesthesia in Bariatric Surgeries
This is a prospective randomized controlled study that will be carried out on morbid obese patients admitted to Tanta University hospitals for laparoscopic bariatric surgeries.
- Trial name
- Opioidfree (NCT04048200)
- Testing
- Fentanyl, Dexmedetomidine Ketamine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Adenoid Hypertrophy
A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients
This proposed study will assess analgesic efficacy of a multi-modal, non-opioid analgesic regimen for providing surgical analgesia in pediatric patients undergoing adenoidectomy and to assess recovery characteristics in the…
- Trial name
- NCT03714919
- Testing
- Dextromethorphan, Acetaminophen, Dexmedetomidine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Arlyne Thung
Acute Ischemic Stroke
Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke
This study aims to conduct a multicenter, prospective, randomized clinical trial to scientifically evaluate the safety and efficacy of different perioperative sedation methods during endovascular thrombectomy in acute ischemic…
- Trial name
- PEACE (NCT06139692)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 4 sites in China
- Volunteers
- 810 people
- Sponsor
- Jinling Hospital, China
Pain and Cognitive Dysfunction Management in Hip Surgery
Prospective Comparative Study Between Ultrasound-guided Quadratus Lumborum Block Versus Fascia Iliaca Compartment Block for Postoperative Pain and Cognitive Dysfunction Management in Patient Undergoing Hip Surgery
Hip fractures are more common in older people due to osteoporosis. It is estimated that around six million patients worldwide will suffer hip fractures annually by 2050 as the population ages [1].
- Trial name
- NCT06407544
- Testing
- peripheral nerve block, PCA device as rescue medication with IV morphine 1mg if VAS more than 4
- Volunteers
- 60 people
- Sponsor
- Sohag University
Dexmedetomidine, Gastric Emptying
Effect of Dexmedetomidine on Gastric Emptying, Assessed by Ultrasound in Laparoscopic Cholecystectomy
The aim of this study is to evaluate the effect of dexmedetomidine on gastric emptying assessed by gastric ultrasound in patients undergoing laparoscopic cholecystectomy.
- Conditions
- Dexmedetomidine, Gastric Emptying, Ultrasound, Laparoscopic Cholecystectomy
- Trial name
- NCT06634524
- Testing
- Dexmeditomidine, Normal saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Obstructive Sleep Apnea, Surgery
Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA
Patients with obstructive sleep apnea (OSA) are at increased risk of developing sleep disturbances after surgery. Dexmedetomidine is a highly selective α2-adrenergic agonist with sedative, analgesic, and anxiolytic effects.
- Conditions
- Obstructive Sleep Apnea, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06566482
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Cancer of Liver, Cancer of Pancreas
Effects of Dexmedetomidine During IRE Procedures for Solid Tumours
The purpose of the study is to evaluate effects of dexmedetomidine on anaesthesia during IRE procedures for solid tumours
- Trial name
- NCT02044224
- Testing
- Dexmedetomidine
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University Hospital
Fracture of Proximal Femur
Effect of Dexmedetomidine and Bupivacaine for Paravertebral Block
Fracture femur is a common that results in severe pain. Many methods of regional and peripheral analgesia have been described to treat such pain.
- Trial name
- NCT02801188
- Testing
- Bupivacaine, Mixture of bupivacaine and dexmedetomidine
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Mansoura University
Pain Management, Noncardiac Surgery
Preemptive Analgesia Of Dexmedetomidine Reduces Per-operation Pain
Background:Preemptive analgesia is the initiation of analgesic regimen before the onset of nociceptive stimulation, preventing the amplification of pain due to peripheral and central sensitization and thereby reducing subsequent…
- Trial name
- NCT06671327
- Testing
- Preemptive Dexmedetomidine injection, Sodium Chloride 0.9% Inj
- Where
- China
- Volunteers
- 208 people
- Sponsor
- China International Neuroscience Institution