Clinical trials: Dexmedetomidine
Nephrolithiasis, Postoperative Pain
Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure used to remove large or complex kidney stones. Although effective, dilation of the surgical tract and the placement of a nephrostomy tube cause…
- Conditions
- Nephrolithiasis, Postoperative Pain, Quality of Recovery
- Trial name
- NCT07855068
- Testing
- Ketamine and Dexmedetomidine, Fentanyl
- Volunteers
- 100 people
- Sponsor
- Assiut University
Postoperative Analgesia
Erector Spinae Block Using a Dexmedetomidine Versus Magnesium Sulfate as an Adjuvant to Bupivacaine
This prospective parallel group randomized study will be conducted over 52 adult participants between 20 and 60 years ASA (American Association of Anesthesiologists) I and II undergoing lumbar spine surgery.
- Trial name
- NCT05694897
- Testing
- Erector spinae block using bupivacaine 0.25% and magnesium sulfate, Erector spinae block using bupivacaine and dememdetomidine
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Postoperative Pain
Dexmedetomidine Wound Infiltration in Cesarean Section
The effects of four different wound infiltration protocols in cesarean section will be investigated on parturient' pain intensity, PCA morphine consumption given, side effects and parturient' overall satisfaction.
- Trial name
- NCT03382938
- Testing
- Dexmedetomidine, Ropivacaine, Dexmedetomidine - Ropivacaine
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Breast Cancer Patients
Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block in Breast Cancer Patients
To Evaluate the effect of addition of Dexmedetomedine to ultrasound guided modified Pecs block on post operative analgesia \& stress response in patient undergoing modified radical mastectomy.
- Trial name
- NCT03046238
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
Inadequate; Pulmonary Function, Newborn
Use of ICON™ to Detect Hemodynamic Variables During Dexmedetomidine Sedation in Children Undergoing Pulmonary Function Test
To collect and analyze the physiologic data of the ICON™ during dexmedetomidine (DEX) sedation for neonatal pulmonary function testing.
- Trial name
- NCT03205943
- Sponsor
- Boston Children's Hospital
Post-operative Pain, Respiratory Depression
Dexmedetomidine for the Control of Post-Operative Pain in Thoracotomy Patients
The purpose of this study is to evaluate the safety, efficacy, hemodynamic and respiratory stability of a low-dose of dexmedetomidine infusion in post-operative surgical in-patients undergoing thoracic surgery after discharge…
- Trial name
- NCT00345384
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Baylor Research Institute
Pain Relief in Post Operative Patient
Comparison of Pain ReliefofBupivacaineWith Dexmedetomidine and Bupivacaine Alone in TransversusAbdominisPlane Block For Postoperative Anelgesia in Patients Undergoing Abdominal Surgeries
Postoperative pain related to abdominal surgeries poses significant burden on the healthcare system, in terms of increased use of different analgesics, delayed ambulation, pulmonary complications, DVT, and prolonged hospital…
- Trial name
- NCT05244252
- Testing
- dexmeditomidine and bupivacaine, Bupivacaine
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Medical College
Postoperative Delirium, PD
Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve
Elderly patients who undergo anesthesia and non-cardiac surgery are subject to deterioration of brain function including the development of postoperative delirium (PD) and postoperative cognitive dysfunction (POCD).
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00561678
- Testing
- Precedex (Dexmedetomidine)
- Where
- 10 sites in United States
- Volunteers
- 404 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gastrointestinal Disease
Sedation Using Intranasal Dexmedetomidine in Upper Gastrointestinal Endoscopy
Upper gastrointestinal endoscopy, like many other diagnostic and therapeutic procedures, may be associated with discomfort. Although upper endoscopy is usually of shorter duration and better tolerated by patients, most trials…
- Trial name
- NCT01887184
- Testing
- Dexmedetomidine
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Coronary Artery Disease, Low Cardiac Output Syndrome
Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting
Background: Despite improvements in surgical and anesthesia procedures over the past 15 years complications during cardiac surgery still remain high. Bridgewater B et al.
- Conditions
- Coronary Artery Disease, Low Cardiac Output Syndrome, Atrial Fibrillation, Postoperative Complications
- Trial name
- NCT05514652
- Testing
- Low opioid anesthesia
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Heart Institute, Ministry of Health of Ukraine
Undergoing ERCP for Diagnostic or Therapeutic Purposes
Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP
Endoscopic retrograde cholangiopancreatography (ERCP) takes a longer time and is more complex to perform than the other parallel procedures, causing discomfort to patients. It is commonly performed under sedation endoscopy.
- Trial name
- DEMMER (NCT01404689)
- Testing
- Dexmedetomidine, normal saline
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Seoul National University Hospital
Opioid Free Anesthesia, Thoracic Surgery
Opioid-free Anesthesia and Thoracoscopy Surgery
Evaluation of a service OFA (Opioid-free Anesthesia) protocol on post-operative pain of patients operated on by video-thoracoscopic carcinologic surgery by counting them to a group of patients receiving standard general…
- Trial name
- OFAT (NCT05308355)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Nantes University Hospital
Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Primarily Acting on the Respiratory System
Dexmedetomidine Versus Propofol for Sedation in Stereotactic Brain Biopsy
Pre-operative anxiety leads to higher sympathetic stimulation. Propofol in the main drug used during interventional or imaging techniques that need sedation.
- Trial name
- NCT03375385
- Testing
- dexmedetomidine/ propofol
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Vitreoretinal Surgeries, Local Anesthesia
Comparative Study Between Dexmedetomidine & Neostigmine as an Adjuvant to Local Anesthetic Mixture in Peribulbar Block in Vitreoretinal Surgeries
The majority of patients undergoing ophthalmic surgeries are elderly, with multiple chronic diseases, with increased risk of morbidity and mortality under general anesthesia.
- Trial name
- NCT06501352
- Testing
- Dexmedetomidine, Neostigmine, Saline
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Ain Shams University
Cesarean Section
Comparative Study of Fentanyl vs Dexmedetomidine as Adjuvants to Intrathecal Bupivacaine in Cesarean Section
The quality of the spinal anesthesia has beenreported to be improved by the addition of opioids (such as morphine, fentanyl and sufentanil) and other drugs (such as dexmedetomidine, clonidine, magnesium sulfate (Mg), neostigmine…
- Trial name
- NCT06785285
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Gynecologic Disease
the Effect of Dexmedetomidine and Licodaine on Acute Postoperative Pain in Gynecological Laparoscopy
The aim of this study is to investigate the effect of opioid-free anesthesia using dexmedetomidine and lidocaine instead of remifentanil infusion, on the acute postoperative pain after the gynecological laparoscopy
- Trial name
- NCT04906889
- Testing
- Dexmedetomidine Hydrochloride, Remifentanil Hydrochloride, Lidocaine Hydrochloride
- Where
- 2 sites in South Korea
- Sponsor
- The Catholic University of Korea
Delirium, Postoperative Cognitive Deficit (POCD)
Neuroprotection With Dexmedetomidine in Patients Undergoing Elective Cardiac or Abdominal Surgery (Neuprodex)
The drug Dexmedetomidine will be investigated in 72 patients (men and women) undergoing elective cardiac or abdominal surgery. The study medication will be administered perioperatively by intravenous infusion continuously (at the…
- Trial name
- NCT02096068
- Testing
- Dexmedetomidine (Dexdor®), 0.9% Sodium Chloride
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Claudia Spies
Perioperative Period
Treatment of Supraventricular Tachycardia in Patients With Non-cardiac Surgery by Dexmedetomidine
Supraventricular tachycardia (SVT) is a common arrhythmia in the perioperative period, which is associated with adverse stimulus such as cardiovascular risk factors, emotional tension, hypoxia, CO2 accumulation, hypokalemia…
- Trial name
- NCT04284150
- Testing
- Dexmedetomidine; Midazolam;
- Volunteers
- 60 people
- Sponsor
- Lianyungang Hospital Affiliated Bengbu Medical College
Anesthesia, Intravenous
Target Effect-site Concentration of Remifentanil in Transperineal Prostate Puncture
The research about the target effect-site concentration of remifentanil, inhibiting stress reaction of the perineal prostate puncture when Dexmedetomidine being continuous pumping
- Trial name
- NCT03428191
- Testing
- Remifentanyl+Dexmedetomidine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese Medical Association
Magnetic Resonance Imaging, Anesthesia
Two Anesthetic Techniques in Magnetic Resonance Imaging (MRI)
The goal of this study is to determine if there is a significant difference in the quality of care between the investigators' two standard anesthesia techniques for children undergoing a MRI of the body and/or extremity MRI.
- Trial name
- NCT00894751
- Testing
- dexmedetomidine, propofol
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati