Clinical trials: Dietary Intervention
Phenylketonuria (PKU) and Hyperphenylalaninemia, Brain Diseases, Metabolic, Inborn
Market Research of a Slow Release Protein Substitute for the Dietary Management of PKU
XPhePiccosMR is a prospective, single-arm, open label, observational study that aims to evaluate the acceptability and tolerability of XPhe Piccos, a slow-release, phenylalanine-free protein substitute in the form of tiny…
- Conditions
- Phenylketonuria (PKU) and Hyperphenylalaninemia, Brain Diseases, Metabolic, Inborn, Brain Disorder, Metabolic, Brain Diseases
- Trial name
- XPhePiccosMR (NCT07802366)
- Testing
- Slow release, phenylalanine-free protein substitute tablets
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- metaX Institut fuer Diatetik GmbH
Smoking Cessation, Harm Reduction
Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT
This study will determine whether a range of products along the reduced-risk continuum can reduce smoke exposure for individuals who fail to quit smoking using current medically approved nicotine replacement therapy (NRT)…
- Trial name
- NCT06088862
- Testing
- Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Obesity Prevention, Pediatric Obesity
Relationship Between Eating Patterns, Body Composition and the Detection of Fatty Liver in Children and Adolescents With Trisomy 21: LiverTy Project
Childhood obesity is a growing public health issue affecting millions of children worldwide, increasing the risk of metabolic and cardiovascular diseases in adulthood.
- Conditions
- Obesity Prevention, Pediatric Obesity, Trisomy 21, Down Syndrome (Trisomy 21)
- Trial name
- LiverTy (NCT06888570)
- Testing
- To evaluate fat liver content in the cases/controls population.
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Spinal Cord Injuries, Aging
Exercise and Nutrition Education for Older Adults With Spinal Cord Injury: A Pilot Randomized Controlled Trial
Older adults living with a spinal cord injury (SCI) experience an increased burden of secondary health conditions than, coupled with age-related complications, may negatively affect physical and mental health, as well as…
- Trial name
- NCT07845851
- Testing
- Individualized Exercise Training, Nutrition Education, Behavioral Support
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Coronary Artery Disease
Clinical and Biochemical Effects of a Defined Plant-Based Diet on Heart Disease
A plant-based diet will be utilized in the treatment of coronary artery disease.
- Trial name
- NCT06994624
- Testing
- Nutritional intervention
- Where
- United States
- Sponsor
- Georgia State University
Malignant Neoplasms of Female Genital Organs
Feasibility of the NEXT Steps Weight Loss Intervention +/- Resistance Training for Endometrial Cancer Survivors: Effect on Lean Mass & Biomarkers
The goal of this research study is to learn if a home-based physical activity program is feasible and can help endometrial cancer survivors lose weight.
- Trial name
- NCT02774759
- Testing
- Accelerometer, Questionnaires, Fitness Test
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Surgery, Time Restricted Feeding
Optimization of Diet Before Surgery (OptiSurg)
The overarching goal of this project is to assess whether a controlled short-term Time restricted feeding (TRF) intervention leads to metabolic benefits, improves recovery after vascular surgery and that TRF is safe.
- Trial name
- OptiSurg (NCT04627688)
- Testing
- Time restricted feeding, Standard dietary advices
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cancer
Evaluating the Impact of the McMaster Optimal Aging Portal on Cancer Prevention Behaviours in Underserved Populations
The goal of the McMaster Optimal Aging Portal is to be a trustworthy source for health information. The Portal team can see (through measuring analytics of website use) that thousands of people are using the Portal and the…
- Trial name
- NCT03186703
- Testing
- Tailored knowledge translation
- Where
- Canada
- Volunteers
- 549 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type 2 Diabetes
The DR-EAM Type 2 Diabetes Study
The goal of this 12-month interventional study is to analyse the clinical outcome benefits, scalability and cost-effectiveness of a digital Low-Calorie digital Type 2 diabetes mellitus (T2DM) remission program compared to usual…
- Trial name
- NCT05626842
- Testing
- Total Diet Replacement (800kcal/day)
- Where
- United Kingdom
- Volunteers
- 197 people
- Sponsor
- Oviva UK Ltd
Overweight and Obesity
Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment
Obesity has become an important public health issue that leads to insulin resistance, diabetes, hypertension, dyslipidemia, and cardiovascular diseases.
- Trial name
- NCT06069622
- Testing
- 24-hour ambulatory blood pressure, Liberal salt diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Obesity, Overweight
Targeting DNA-methylation Fingerprints Linked to Ultra-Processed Foods Consumption to Prevent Non-communicable Diseases: the METHYL-UP Study
Non-communicable diseases (NCD) are the main health challenge in industrialized countries. However, these diseases are preventable if an intervention based on lifestyle is implemented at the population level.
- Trial name
- METHYL-UP (NCT05319327)
- Testing
- Nutritional intervention, Control
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- IMDEA Food
Insulin Resistance, Obesity
Novel Dietary Interventions for Treating Insulin Resistance
Clinical and rodent studies have demonstrated the impact of specific dietary factors in modulating inflammation-related diseases including insulin resistance, type 2 diabetes, and cardiovascular disease.
- Conditions
- Insulin Resistance, Obesity, Metabolic Syndrome
- Trial name
- NCT02006394
- Testing
- Fish Oil, Polyphenol Capsules, Corn Oil Capsules
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of California, San Diego
Iodine Bioavailability
Impact of the Food Matrix on Iodine Bioavailability
This study is a randomized crossover trial, lasting 12 days in total, which will assess the difference in iodine bioavailability (as a percentage of iodine consumed that is excreted in urine) from three iodine-rich foods…
- Trial name
- NCT04867031
- Testing
- Milk, Fish, Seaweed
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Obesity
Catgut Implantation at Acupoints for the Treatment of Simple Obesity
The primary objective of this multicenter randomized controlled trial is to evaluate treatment effectiveness of intervening simple obesity people with catgut implantation at preferred acupoints, which excludes placebo effect; the…
- Trial name
- NCT02936973
- Testing
- Real catgut implantation at acupoints
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Hubei Hospital of Traditional Chinese Medicine
Nutritional Support, Aerobic Exercise
Study on Pulmonary Rehabilitation for Stable Chronic Obstructive Pulmonary Disease(COPD) Patients
To compare the difference of effectiveness for stable COPD patients with poor nutritional status among three groups named health education, upper and lower limb exercises, and oral nutritional supplements.
- Conditions
- Nutritional Support, Aerobic Exercise, Respiratory Function Tests, Body Composition
- Trial name
- NCT04741373
- Testing
- oral nutritional supplements, rehabilitation exercise, health education
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fudan University
Sleep, Gut Microbiome
Impact of Different Types of Higher Dietary Protein Intake on Sleep Quality in Singapore Older Adults
Today, insufficient sleep has become a growing global problem. Sleep is essential to health and changes in sleep patterns are a part of the aging process.
- Conditions
- Sleep, Gut Microbiome, Cardiometabolic Risk
- Trial name
- NCT05400005
- Testing
- Dietary protein
- Where
- Singapore
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Sodium Excess, Hypertension
Effects of a Six-Day Whole-Diet Intervention on Taste Perception and Dietary Behaviour in Young Adults
This study aims to investigate the effects of a specific diet modification on the pleasantness, desire, and saltiness intensities of selected foods and an ad libitum breakfast buffet through a randomized controlled trial with…
- Conditions
- Sodium Excess, Hypertension, Salty Taste
- Trial name
- NCT07726394
- Testing
- Experimental: Increased Salty Food Intake, Experimental: Decrease Salty Food Intake, Active Comparator: Maintain Usual Diet
- Where
- Malaysia
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Sunway University
Pediatric Obesity
PrOtein and WEight Loss in teenageRs
The aim of the proposed study is to provide important data on weight loss efficacy in overweight and obese adolescents on an isocaloric higher protein diet vs a lower protein diet utilizing the U.S.
- Trial name
- POWER (NCT02079831)
- Testing
- Energy Restriction, Higher protein, Lower Protein
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Inattention, Impulsivity
Developmental Origins of Attention Deficit Hyperactivity Disorder
This is a study evaluating the relationship between prenatal nutrition and neural development in infants born to mothers with Attention Deficit Hyperactivity Disorder (ADHD).
- Conditions
- Inattention, Impulsivity, Anxiety
- Trial name
- NCT01982422
- Testing
- Whole Food, Nutrient-Dense Dietary Intervention, Standard of Care
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Diet, Healthy
Mediterranean Diet and Mushrooms
The investigators propose to assess the effects of including mushrooms as part of a healthy eating pattern on indices of perceived mental health/anxiety/depression, along with risk factors for cardiovascular disease and type 2…
- Trial name
- NCT04259229
- Testing
- Mediterranean Diet -- Mushrooms, Mediterranean Diet -- Control
- Where
- 2 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Purdue University
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