Clinical trials: Doxycycline, completed
Induced Abortion, Postaboral Pelvic Inflammatory Disease
To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy
Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when…
- Conditions
- Induced Abortion, Postaboral Pelvic Inflammatory Disease, Sexually Transmitted Infections
- Trial name
- NCT01842100
- Testing
- Universal antibiotic prophylaxis, Screen-and-treat
- Where
- China
- Volunteers
- 2,193 people
- Sponsor
- The University of Hong Kong
Blepharitis, Meibomianitis
Treatment of Patients With Blepharitis and Facial Rosacea
To determine the safety and efficacy of sub-antimicrobial dose COL-101 in the treatment of patients who have both blepharitis and facial rosacea
- Conditions
- Blepharitis, Meibomianitis, Dry Eye
- Trial name
- NCT00560703
- Testing
- COL-101 (doxycycline, USP) capsules
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- Galderma R&D
Healthy
Food Study of Doxycycline Monohydrate Tablets 100 mg and Adoxa Tablets 100 mg
The objective of this study was to investigate the bioequivalence of Mylan's doxycycline monohydrate 100 mg tablets to Par's Adoxa® 100 mg tablets following a single, oral 100 mg (1 x 100 mg) dose administered under fed…
- Trial name
- NCT00648180
- Testing
- Doxycycline Monohydrate Tablets 100 mg, Adoxa Tablets 100 mg
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
COVID, Covid-19
Trial of Combination Therapy to Treat COVID-19 Infection
In this trial patients will be treated with either a combination of therapies to treat COVID-19 or a placebo. Treatment will last 10 days, and patients will be followed for 6 months.
- Conditions
- COVID, Covid-19, Corona Virus Infection, Coronavirus Infection
- Trial name
- NCT04482686
- Testing
- Ivermectin, Doxycycline Hcl, Zinc
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- ProgenaBiome
Mansonella Perstans Infection, Mp Microfilaremia
Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis
This study will examine: 1) the safety and effectiveness of the drug doxycycline in reducing the number of Mansonella perstans (Mp) worms in the blood of infected patients, and 2) the effects of doxycycline followed by…
- Trial name
- NCT00340691
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
H. Pylori Infection
A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection
All patients who presented with epigastric pain and dyspeptic symptoms will undergo endoscopic gastric biopsies. The patients will be subjected to: Full history taking, clinical examination, liver function tests, renal function…
- Trial name
- NCT06050824
- Testing
- Comparing Load and Concomitant therapy
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Helwan University
Refractory Mycoplasma Pneumoniae Pneumonia
Combined Diagnostic Approach for Refractory Mycoplasma Pneumonia in Children
This study evaluates whether a combined approach using bronchoscopy, chest CT scoring, and monocyte subpopulation analysis can improve clinical outcomes for children with refractory Mycoplasma pneumoniae pneumonia (RMPP) when…
- Trial name
- NCT07064278
- Testing
- Bronchoscopy with Bronchoalveolar Lavage, Chest CT with Scoring, Monocyte Subpopulation Analysis
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Children's Hospital of Hebei Province
Aneurysm
Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial
The primary aim of this study is to determine if doxycycline (100 mg bid) will inhibit (by at least 40%) the increase in greatest transverse diameter of small abdominal aortic aneurysms (3.5-5.0 cm in men, 3.5-4.5 cm in women)…
- Trial name
- N-TA^3CT (NCT01756833)
- Testing
- Doxycycline
- Where
- 22 sites in United States
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Osteoarthritis
Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
The purpose of this study is to investigate antibiotic treatment to target bacteria about the shoulder. This bacteria, Propionibacterium acnes, is detected in many revision shoulder surgeries and is thought to contribute to…
- Trial name
- NCT03115177
- Testing
- Doxycycline, Cefazolin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Rush University Medical Center
ESI-related Bleeding
Management of Etonogestrel Subdermal Implant-related Bleeding
This is a double-blinded, randomized, prospective placebo-controlled clinical trial to be conducted within the Mayo Clinic and the Mayo Clinic Health System.
- Trial name
- NCT01658995
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Petra M. Casey
Rosacea
Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo
The purpose of this study is to assess relapse, efficacy and safety in subjects with rosacea during long-term treatment with either Oracea® or placebo, after an initial 12-week regimen of Oracea® and MetroGel® 1%.
- Trial name
- NCT01426269
- Testing
- Doxycycline, Metronidazole
- Where
- 11 sites in United States
- Volunteers
- 235 people
- Sponsor
- Galderma R&D
Acne Vulgaris
Comedone Extraction and Oral Doxycycline In The First Line Treatment of Moderate Acne Vulgaris
The objective of the study was to evaluate the effectiveness of comedone extraction compared to oral antibiotics as the main therapy of moderate acne vulgaris (MAV); and to determine the expression of HIF-1 alpha by examining the…
- Trial name
- NCT04206631
- Testing
- Doxycycline Capsule, Comedone extraction
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Rheumatoid Arthritis, Psoriatic Arthritis
Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an inflammatory form of arthritis that causes joint pain and damage. RA attacks the lining of the joints (synovium), causing swelling that can result in aching and throbbing, and eventually deformity.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Periodontal Disease
- Trial name
- NCT01198509
- Testing
- doxycycline, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Polycystic Ovarian Syndrome (PCOS), Irregular Menstrual Cycles
Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome
The purpose of this study is to study the effect of a commonly used antibiotic, doxycycline, on the production of ovarian hormones and menstrual cycles in women with Polycystic Ovarian Syndrome (PCOS).
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Irregular Menstrual Cycles, Androgen Excess
- Trial name
- MI-PCOS (NCT01788215)
- Testing
- doxycycline, Sugar Pill
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Drug-Induced Liver Injury
Risk of Acute Liver Injury in Users of Antimicrobials
Moxifloxacin is a broad-spectrum antibacterial agent used to treat common community-acquired respiratory tract infections, complicated intra-abdominal infections, and pelvic inflammatory disease.
- Trial name
- NCT01434173
- Testing
- Moxifloxacin (Avelox, BAY12-8039), Amoxicillin, Amoxicillin plus clavulanic acid, Cefuroxime, Clarithromycin, Doxycycline, Levofloxacin, Telithromycin
- Where
- United States
- Volunteers
- 1,299,056 people
- Sponsor
- Bayer
Bullous Pemphigoid
Observational Study Assessing Outcomes, Treatment Patterns and Related Costs in Patients in Bullous Pemphigoid
The study is an observational, multi-center, prospective, non-interventional and open-label data collection study assessing outcomes, treatment patterns, adverse events and costs in patients diagnosed with bullous pemphigoid.
- Trial name
- EDP-PB (NCT02837965)
- Testing
- treatment with topical superpotent corticosteroid therapy, treatment with systemic therapy (methotrexate), treatment systemic therapy (prednisone)
- Where
- France
- Volunteers
- 149 people
- Sponsor
- CHU de Reims
Fever
Comparative Efficacy of Single-dose Doxycycline Versus Standard 5- Day Amoxicillin Treatment
Abstract: Background The current practice in Senegal is to use broad-spectrum antibiotics including amoxicillin and/or cotrimoxazole in case of non-malarial fevers. First-line treatment with doxycycline has cured such patients.
- Trial name
- NCT03765931
- Testing
- Doxycycline, Amoxicillin
- Where
- Senegal
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Rosacea, Papulopustular Rosacea
Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea
To evaluate the efficacy of once-daily application of 1% and 3% HY01 Topical Gel, as assessed by the change in inflammatory lesion count from baseline over the 12-week treatment period in patients with moderate-to-severe…
- Trial name
- NCT03263273
- Testing
- 1% Topical Minocycline Gel, 3% Topical Minocycline Gel, Topical Vehicle Gel
- Where
- 23 sites in United States
- Volunteers
- 270 people
- Sponsor
- Hovione Scientia Limited
Erythema Migrans
Inflammatory Mediators in Erythema Migrans
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with erythema migrans to gain better insight into pathogenesis of early Lyme borreliosis…
- Trial name
- NCT03956212
- Testing
- Doxycycline 7 days, Doxycycline 14 days
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Hailey-Hailey Disease
Skin Microbiome Profile in Hailey-Hailey Disease
"Hailey-Hailey disease is an autosomal dominant disorder caused by a genetic defect in a calcium ATPase (ATP2C1) leading to a defect in keratinocyte adhesion.
- Trial name
- NCT05007223
- Testing
- Doxycycline
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital