Clinical trials: Doxycycline
Persian Gulf Syndrome, Mycoplasma Infections
Antibiotic Treatment of Gulf War Veterans' Illnesses
In 1990 and 1991, the U.S. deployed approximately 700,000 troops to the Persian Gulf to liberate Kuwait from Iraqi occupation. While there were few casualties associated with the Gulf War, many individuals returned from this…
- Trial name
- NCT00007735
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Acne
Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne
Non-inferiority, randomized, controlled, multi-center, investigator-blind, parallel-group comparison study in subjects with severe acne vulgaris on the face.
- Trial name
- POWER (NCT01474590)
- Testing
- Epiduo/Tactuo, vehicle gel, doxycycline 200mg
- Where
- 25 sites in Canada
- Volunteers
- 266 people
- Sponsor
- Galderma R&D
Periodontal Disease, Diabetes Mellitus, Type 2
Treating Periodontal Infection: Effects on Glycemic
The purpose of this project is to obtain important preliminary data necessary to support design of a full scale, multicenter randomized clinical trial (RCT) to evaluate the effect of treating periodontal infection on glycemic…
- Trial name
- NCT00016835
- Testing
- Subgingival scaling and metronidazole, Subgingival scaling and doxycycline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Periodontal Diseases, Type 2 Diabetes
Azithromycin Versus Doxycycline on Restistin Level in Periodontitis Patients With Type 2 Diabetes
The aim of this study is to evaluate the adjunctive effects of systemic antibiotics used in nonsurgical periodontal treatment (NSPT), compared with NSPT alone, on the periodontal clinical parameters and resistin level in diabetic…
- Trial name
- NCT06199440
- Testing
- Group I, Group II, Group III
- Where
- Saudi Arabia
- Volunteers
- 15 people
- Sponsor
- King Abdulaziz University
Crohn's Disease
Antibiotics and Hydroxychloroquine in Crohn's
There is growing evidence that Crohn's disease may be caused by replication of bacteria, perhaps particularly E. coli, within macrophages (a specialized sort of white blood cell).
- Trial name
- APRiCCOT (NCT01783106)
- Testing
- Ciprofloxacin, Doxycycline, Hydroxychloroquine
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- Royal Liverpool University Hospital
Larynx, LIP
Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma
This randomized phase II trial studies how well metformin hydrochloride and doxycycline work in treating patients with head and neck squamous cell carcinoma that can be removed by surgery.
- Conditions
- Larynx, LIP, Oral Cavity, Pharynx
- Trial name
- NCT03076281
- Testing
- Metformin Hydrochloride, Doxycycline, Metformin +Doxycycline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Rosacea
Pharmacokinetics of Doxycycline in Skin of Healthy Volunteers
This study explored the impact of food on skin and plasma pharmacokinetics of doxycycline
- Trial name
- NCT03478436
- Testing
- Doxycycline
- Where
- Austria
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
STI
Weekly Doxycycline DOT for STI Prevention Among Cisgender Women Taking HIV PrEP in Kisumu, Kenya
The first study of doxycycline postexposure prophylaxis for cisgender women did not reduce incident STIs likely due to low use of doxycycline.
- Trial name
- NCT06582966
- Testing
- Doxycycline
- Where
- Kenya
- Volunteers
- 60 people
- Sponsor
- University of Washington
Non-ischemic Cardiomyopathy, Systolic Heart Failure (NYHA II-III)
Safety and Efficacy of Doxycycline in Patients With Non-Ischemic Cardiomyopathy
Non-ischemic cardiomyopathy and heart failure are highly influenced by the presence of systemic inflammation. Doxycycline is a FDA-approved drug to treat bacterial infections which also shows powerful anti-inflammatory effects.
- Trial name
- DOXY-HF (NCT01935622)
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Hidradenitis Suppurativa
Metformin for the Treatment of Hidradenitis Suppurativa (HS)
A randomized controlled trial investigating the metformin is the treatment for hidradenitis suppurativa. Metformin combined with doxycycline will be compared to the standard treatment of doxycycline monotherapy for HS severity…
- Trial name
- NCT04649502
- Testing
- Metformin
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- K.R. van Straalen
Lyme Borreliosis, Nervous System
Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.
The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults.
- Trial name
- DoBo (NCT07230028)
- Testing
- Hydroxychloroquin, Doxycycline
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Acne Vulgaris
Anti-microbial Role of Non-antibiotic Agents Against Cutibacterium Acnes in Patients With Acne Vulgaris
To evaluate and compare the anti-biofilm activity of Salicylic acid, Isotretinoin, and N-acetylcysteine against C. acne . To assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the…
- Trial name
- NCT06179056
- Testing
- assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline.
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis Infection
Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection
The frequency of Chlamydia trachomatis and Neisseria gonorrhoeae coinfection can vary depending on their individual incidence and prevalence rates.Single-agent therapy with ceftriaxone is the preferred regimen for treatment of…
- Trial name
- NCT05216744
- Testing
- Ceftriaxone 1000mg + doxycycline 100 mg, Cefixime 800mg + doxycycline 100 mg
- Where
- Vietnam
- Volunteers
- 125 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
Atypical Pneumonia
Treatment and Vaccine Development of Mycoplasma Pneumoniae
A randomized clinical trial comparing treatment effectiveness of azithromycin and doxycycline for pediatric Mycoplasma pneumonia.
- Trial name
- NCT03911440
- Testing
- Doxycycline, Azithromycin
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Methicillin-resistant Staphylococcus Aureus, Skin Infection
Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Skin and Soft Tissue Infections Treatment
The purpose of this study is to compare how well two different antibiotics, doxycycline (DOXY) and trimethoprim/sulfamethoxazole (TMP/SMX), work at curing uncomplicated skin and soft tissue infection (uSSTI) such as 1.Boils (pus…
- Trial name
- TODOS (NCT03637400)
- Testing
- TMP-SMX, DOXY
- Where
- 3 sites in United States
- Volunteers
- 269 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
ST Elevation Myocardial Infarction, Anterior Wall Myocardial Infarction
Effect of Doxycycline on Cardiac Remodelling in STEMI Patients
Subsequent to the loss of myocardium post-myocardial infarction (MI), the affected ventricle undergoes some dynamic structural and functional changes known as remodeling. Cardiac remodeling progresses into heart failure (HF).
- Conditions
- ST Elevation Myocardial Infarction, Anterior Wall Myocardial Infarction, Heart Failure, Remodeling, Ventricular
- Trial name
- NCT03960411
- Testing
- Doxycycline 100Mg Capsule
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Felix Chikita Fredy, MD
Myeloma, Non-Hodgkin's Lymphoma
Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT)
This is an adaptive platform study to find out how safe and effective different strategies are in comparison to each other, for preventing infection in patients with blood cancers.
- Conditions
- Myeloma, Non-Hodgkin's Lymphoma, Leukemia
- Trial name
- NCT07202052
- Testing
- Intravenous immunoglobulin, Trimethoprim / Sulfamethoxazole, Amoxicillin clavulanic acid
- Where
- 3 sites in Australia
- Volunteers
- 900 people
- Sponsor
- Monash University
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?
The principal objective of this study is to compare the incidence of ventriculostomy related infections (VRIs) in patients who receive twenty-four hours of antibiotics, beginning no more than sixty minutes prior to EVD placement…
- Conditions
- Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Ventriculitis, Cerebral, Hydrocephalus
- Trial name
- NCT05001750
- Testing
- Long term (continuous) prophylactic antibiotics, 24 hours antibiotics
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Montefiore Medical Center
Papulopustular Rosacea
A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea.
This is a 16-week, multicenter, randomized, parallel-group, double-blind, controlled study. After assessing eligibility during a screening period of up to 30 days, approximately 320 subjects at least 18 years old who are…
- Trial name
- MVOR-1 (NCT05296629)
- Testing
- DFD-29, Doxycycline
- Where
- 27 sites in United States
- Volunteers
- 323 people
- Sponsor
- Journey Medical Corporation
Periodontal Disease
Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy.
The aim of this clinical study is to asses the effect of ultrasonic periodontal debridement associated to locally delivered doxycycline (20%) by PLGA microspheres on chronic generalized periodontitis treatment.
- Trial name
- NCT02487186
- Testing
- Doxicicline, Full-mouth debridment
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Campinas, Brazil