Clinical trials: Doxycycline
Advanced Cancers, Malignant Pleural Effusions
Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis
The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.
- Trial name
- NCT02623959
- Testing
- Questionnaires, Fentanyl Patch, Fentanyl (IV)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Amyloidosis, Amyloid
Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis
This study measures circulating, misfolded ATTR oligomers in asymptomatic ATTRm amyloidosis genetic carriers longitudinally over five years.
- Conditions
- Amyloidosis, Amyloid, Amyloid Neuropathies, Familial, Amyloid Cardiomyopathy
- Trial name
- MED-hATTR (NCT03431896)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- The Cleveland Clinic
Pulmonary Disease, Chronic Obstructive
Antibiotics in Chronic Obstructive Pulmonary Disease (COPD)
It is not clear whether antibiotic therapy is needed in patients with mild to moderate exacerbation of chronic obstructive lung disease.
- Trial name
- TAExaCOP (NCT00952861)
- Testing
- Doxycycline
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
Lyme Borreliosis
Doxycycline in Therapy of Erythema Migrans
The investigators will compare the outcome of three groups of erythema migrans patients treated with doxycycline: a group without any accompanying symptoms, with mild symptoms and with severe symptoms that require lumbar puncture.
- Trial name
- NCT01475708
- Testing
- Doxycycline
- Where
- Slovenia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Helicobacter Pylori
Nitazoxanide and Lansoprazole Based Regimens for H. Pylori Management
The study will evaluate the eradication rate and tolerability of modified LOAD regimens (three antibiotics and a proton pump inhibitor (lansoprazole)) for management of HP infection in treatment-naive patients as well as patients…
- Trial name
- NILE (NCT05184491)
- Testing
- Naïve patients - ACO therapy, Naïve patients - LNDL therapy, Naïve patients - MNDL therapy
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- National Liver Institute, Egypt
Lymphoma, T-Cell, Cutaneous
CTCL Directed Therapy
Cutaneous lymphomas are rare cancers of lymphocytes (white blood cells) that involve the skin. Mycosis Fungoides (MF) is the most common type of Cutaneous T-cell lymphoma (CTCL) that typically presents with red, scaly patches…
- Trial name
- NCT03116659
- Testing
- Doxycycline, Imiquimod
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
COVID, Covid-19
Trial of Combination Therapy to Treat COVID-19 Infection
In this trial patients will be treated with either a combination of therapies to treat COVID-19 or a placebo. Treatment will last 10 days, and patients will be followed for 6 months.
- Conditions
- COVID, Covid-19, Corona Virus Infection, Coronavirus Infection
- Trial name
- NCT04482686
- Testing
- Ivermectin, Doxycycline Hcl, Zinc
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- ProgenaBiome
HELICOBACTER PYLORI INFECTIONS
Levofloxacin-Based Sequential Therapy Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication
This randomized controlled trial aims to compare the efficacy and safety of levofloxacin-based sequential therapy versus bismuth-based quadruple therapy for eradication of Helicobacter pylori infection in adult patients.
- Trial name
- NCT07574983
- Testing
- Levofloxacin-Based Sequential Therapy, Bismuth-Based Quadruple Therapy
- Volunteers
- 90 people
- Sponsor
- University of Health Sciences Lahore
Rosacea
A Controlled Study to Assess the Efficacy, Safety and Tolerability of Oral DFD-29 Extended Release Capsules
Clinical assessments of efficacy will be conducted based on Investigator's Global Assessment (IGA, modified scale without erythema), Clinician's Erythema Assessment (CEA), and on inflammatory lesion counts at Weeks 4, 8, 12 and…
- Trial name
- NCT03340961
- Testing
- DFD-29 Extended Release Capsules (40 mg), DFD-29 Extended Release Capsules (20 mg), Oraycea® (doxycycline) Capsules
- Where
- 14 sites in Germany
- Volunteers
- 205 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Alzheimer's Disease
Effects of Doxycycline and Rifampicin on Biomarkers of Alzheimer's Disease in the Cerebrospinal Fluid
This study will determine if biomarkers found in the cerebrospinal fluid of people with Alzheimer's disease, are affected by treatment with two common antibiotics, doxycycline and rifampicin, suggesting a disease-modifying effect…
- Trial name
- NCT00439166
- Testing
- doxycycline, rifampicin
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Duodenal Ulcer Due to Helicobacter Pylori
The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers
Helicobacter pylori (Hp) infection is one of the important causes of gastrointestinal diseases, including gastritis, peptic ulcer, and malignancies, nd the eradication of Hp can effectively cure or prevent these diseases.
- Trial name
- NCT03342456
- Testing
- Doxycycline Hyclate Enteric-Coated Capsules, Amoxicillin Capsules, Ilaprazole Enteric-Coated Tablets
- Where
- 7 sites in China
- Volunteers
- 184 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Helicobacter Pylori Infection
Comparing Efficacy of 14-day Therapy Doxycycline With Bismuth Subsalicylate Versus Levofloxacin With Tinadizole on Treatment Helicobacter Pylori
Comparison Efficacy of 10-days Therapy with Doxycycline with Bismuth Subsalicylate Versus Levofloxacine with Tinadizole on Eradication of Helicobacter Pylori in Syrian population.
- Trial name
- NCT04348786
- Testing
- Doxycycline, Levofloxacin 500mg
- Where
- Syria
- Volunteers
- 78 people
- Sponsor
- Damascus Hospital
Chronic Obstructive Pulmonary Disease, Inflammation
Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
COPD is a progressive pulmonary disease that is characterized by an inflammatory process in the airways and the lungs which leads to progressive airway obstruction. The inflammation is associated with tissue loss and remodelling.
- Conditions
- Chronic Obstructive Pulmonary Disease, Inflammation, Pulmonary Emphysema
- Trial name
- NCT00857038
- Testing
- Doxycycline
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Medical Center Alkmaar
Diabetes Mellitus, Type 2
Doxycycline in Type II Diabetes
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia, weight loss, and cardio-metabolic complications.
- Trial name
- NCT06329882
- Testing
- Sitagliptin 100mg, Doxycyclin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mostafa Bahaa
Diabetic Foot Ulcer
Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers
This study is a double-blind, one center, two-arm study with a two (2) week Run-In, evaluating the efficacy of a once-daily administration of NanoDOX™ Hydrogel topically applied to diabetic ulcers in concert with professionally…
- Trial name
- NCT00764361
- Testing
- doxycycline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NanoSHIFT LLC
Lyme Disease
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seropositive Chronic Lyme Disease
Lyme disease is the most common tick-borne disease in the United States. It is caused by the spirochete Borrelia burgdorferi. It may exist in a chronic form and be the result of: 1) active infection by B.
- Trial name
- NCT00001101
- Testing
- ceftriaxone, doxycycline
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Brucellosis, Osteoarthritis
Efficacy & Safety of Fluoroquinolone-Based Brucellosis Regimens (BRUCE)
Brucellosis is a globally distributed zoonosis with persistent clinical management challenges. The World Health Organization(WHO)-recommended doxycycline-rifampin (DOX-RIF) dual regimen may drive rifampin-associated antimicrobial…
- Trial name
- BRUCE (NCT07779629)
- Testing
- Doxycycline + Rifampicin, Doxycycline + Levofloxacin, Doxycycline + Moxifloxacin
- Where
- China
- Sponsor
- The First Affiliated Hospital of Shihezi University
Brucellosis, Osteoarticular Brucellosis
All-Oral Fluoroquinolone-Based Triple Therapies for Adults With Imaging-Confirmed Osteoarticular Brucellosis
Brucellosis is a globally distributed zoonosis with persistent clinical management challenges. The World Health Organization (WHO)-recommended doxycycline-rifampin (DOX-RIF) dual regimen may drive rifampin-associated…
- Trial name
- BRUCE-O (NCT07887152)
- Testing
- Doxycycline + Rifampicin + Ceftriaxone (intravenous therapy for 4 weeks), Triple oral regimen (Doxycycline + Rifampicin + Levofloxacin), Triple oral regimen (Doxycycline + Rifampicin + Moxifloxacin)
- Volunteers
- 150 people
- Sponsor
- The First Affiliated Hospital of Shihezi University
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients
This study investigates if long term use of the antibiotic doxycycline can reduce exacerbations in COPD patients. Half of the patients will receive doxycycline which the other half will receive a placebo.
- Trial name
- NCT02305940
- Testing
- Doxycycline
- Where
- 3 sites in United Kingdom
- Volunteers
- 222 people
- Sponsor
- Imperial College London
Pleural Neoplasm
Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions
This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE).
- Trial name
- NCT03465774
- Testing
- Doxycycline, Indwelling Catheter, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- M.D. Anderson Cancer Center