Clinical trials: Doxycycline
Rosacea
A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea
The objective of this study is to evaluate the safety and efficacy of 40 mg doxycycline controlled-release capsules administered once daily for the treatment of rosacea compared with a placebo.
- Trial name
- NCT00126399
- Testing
- doxycycline
- Volunteers
- 528 people
- Sponsor
- CollaGenex Pharmaceuticals
Inflammatory Bowel Diseases
Minocyclin in Ulcerative Colitis as Added on Therapy
Ulcerative colitis (UC) is considered a subcategory of inflammatory bowel disease and the exact cause of ulcerative colitis remains undetermined.
- Trial name
- NCT06201793
- Testing
- Mesalazine, Minocycline
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Mostafa Bahaa
Osteomyelitis
Patients Response to Early Switch To Oral:Osteomyelitis Study
Based on the current literature, investigators hypothesize that patients with osteomyelitis who are treated with the standard approach of intravenous antibiotics for the full duration of therapy will have the same clinical…
- Trial name
- PRESTO:Osteo (NCT02099240)
- Testing
- oral antibiotics, intravenous antibiotics
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Julio Ramirez
Scrub Typhus
Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus
New antibiotics are required that have antibacterial activity against doxycyline resistant O. tsutsugamushi, that can be safely used in pregnant women and children, that have a low possibility of inducing resistance and that do…
- Trial name
- NCT00351182
- Testing
- Telithromycin, Doxycycline
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Dong-Min Kim
Mycoplasma Pneumoniae
Randomized Controlled Trial of Doxycycline to Prevent Acquisition of Mycoplasma Pneumoniae in an Outbreak Setting
This study was designed to determine whether taking daily doxycycline during an outbreak of Mycoplasma pneumoniae could prevent a person from getting infected and interrupt ongoing disease transmission during an outbreak.
- Trial name
- NCT00207584
- Testing
- Doxycycline treatment
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Acneiform Eruptions, Cancer, Treatment-Related
Doxycycline vs Isotretinoin for Acneiform Eruptions of TKI
Tyrosine Kinase inhibitors (TKIs) have become standard of care in patients with EGFR mutations in non-small cell lung cancer and other EGFR-mutated cancers.
- Trial name
- NCT04864717
- Testing
- Doxycycline 100mg po once daily x 6 months, Isotretinoin 40 mg po once daily x 6 months
- Where
- Canada
- Volunteers
- 98 people
- Sponsor
- Lady Davis Institute
Adult Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma Recurrent
A Phase II Study of Doxycycline in Relapsed NHL
The purpose of this study is to determine whether doxycycline is effective in the treatment of relapsed Non Hodgkin Lymphomas (NHL).
- Conditions
- Adult Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma Recurrent, Lymphoma, Follicular, Marginal Zone B-Cell Lymphoma
- Trial name
- NCT02086591
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Rochester
Helicobacter Pylori Infection
Tetracycline Versus Doxycycline for HP Rescue Therapy
This randomized controlled clinical trial will evaluate the efficacy and safety of proton pump inhibitor, bismuth, metronidazole, and either tetracycline or doxycycline for Helicobacter pylori rescue treatment.
- Trial name
- NCT05018923
- Testing
- Rabeprazole, Bismuth potassium citrate, Metronidazole
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetic Retinopathy
Evaluation of Doxycycline Verses Placebo for the Treatment of Severe Nonproliferative or Mild or Moderate Proliferative Diabetic Retinopathy
This 24 month randomized research study will evaluate whether doxycycline can 1) slow the deterioration or improve retinal function and/or 2) induce regression, or slow progression, of diabetic retinopathy in participants over 18…
- Trial name
- POC1 (NCT00511875)
- Testing
- doxycycline monohydrate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Thomas Gardner
Syphilis, Sexually Transmitted Infections
Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex with Men (DaDHS)
Syphilis is a sexually transmitted infection (STI) disproportionately affecting gay, bisexual and other men who have sex with men (gbMSM), with the potential for significant sequelae - particularly in those who are Human…
- Trial name
- NCT02864550
- Testing
- Doxycycline
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- British Columbia Centre for Disease Control
Blepharitis, Meibomianitis
Treatment of Patients With Blepharitis and Facial Rosacea
To determine the safety and efficacy of sub-antimicrobial dose COL-101 in the treatment of patients who have both blepharitis and facial rosacea
- Conditions
- Blepharitis, Meibomianitis, Dry Eye
- Trial name
- NCT00560703
- Testing
- COL-101 (doxycycline, USP) capsules
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- Galderma R&D
Periodontitis, Periodontal Diseases
The Influence of Local Antibiotic Therapy on the Outcomes Following Periodontal Regeneration Procedures.
Assessmnet of the influence of local antibiotic therapy on the clinical, radiological, microbiological parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) following periodontal regeneration…
- Trial name
- ANBperio (NCT07027137)
- Testing
- SRP+ANB+SURG, SRP+SURG
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Bialystok
Pelvic Inflammatory Disease
Efficacy and Safety of Fuke Qianjin Capsule in Patients With Pelvic Inflammatory Diseases
Randomized, double blind and positive-controlled clinical trial to assess the efficacy and safety of Fuke Qianjin Capsule compared to Doxycycline Hyclate Tablet in patients with mild to medium PID and its sequalae.
- Trial name
- NCT04723069
- Testing
- Control Group, Test Group
- Where
- Pakistan
- Volunteers
- 198 people
- Sponsor
- University of Karachi
Crohn's Disease
Study About the Effect of Doxycycline and Acetylcystein in the Treatment of CD-associated Fistulae
The investigators will study whether local instillation of Doxycycline and Acetylcystein results in fistula closure in CD patients.
- Trial name
- NCT01012726
- Testing
- Colonoscopy
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Gerhard Rogler
Lyme Disease
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease
Lyme disease is the most common tick-borne disease in the United States. It is caused by the spirochete Borrelia burgdorferi. It may exist in a chronic form and be the result of: 1) persistent infection by B.
- Trial name
- NCT00000938
- Testing
- ceftriaxone, doxycycline
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting
The purpose of this study is to determine whether doxycycline (Periostat) at a sub-antimicrobial dose will decrease reperfusion injury after coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB).
- Conditions
- Coronary Artery Bypass Grafting, Cardiopulmonary Bypass, Reperfusion Injury
- Trial name
- NCT00246740
- Testing
- Periostat
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of Alberta
Tick Borne Encephalitis
Tick-borne Encephalitis and Borrelial Antibodies in Serum
In Slovenia, tick-borne encephalitis and Lyme borreliosis are both endemic diseases with high incidence rates and they are both transmitted by a bite of infected Ixodes ricinus tick.
- Trial name
- NCT03956446
- Testing
- Doxycycline, Symptomatic therapy, Questionnaire
- Where
- Slovenia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Amyloidosis
Safety and Effect of Doxycycline in Patients With Amyloidosis
The tetracycline antibiotic doxycycline disrupts A beta amyloid fibrils (AB) in Alzheimer's disease, transthyretin (ATTR) amyloid fibrils in familial amyloidotic polyneuropathy, and immunoglobulin light chain (AL) amyloid fibrils…
- Trial name
- NCT01677286
- Testing
- Doxycycline 100 mg po bid x 12 months
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Boston University
Osteoarthritis
Doxycycline and OA Progression
This study will determine whether doxycycline decreases the severity or rate of progression of osteoarthritis (OA) in the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most popular agents used to treat OA, but…
- Trial name
- NCT00000403
- Testing
- Doxycycline
- Where
- 6 sites in United States
- Volunteers
- 432 people
- Sponsor
- Indiana University
Colitis, Ulcerative
Antibiotics for the Treatment of Ulcerative Colitis
Ulcerative colitis (UC) is an acute and chronic inflammatory bowel disease, whose cause is unknown. However, it is widely accepted that bacteria living in the large bowel are essential for the development of the disease.
- Trial name
- NCT00355602
- Testing
- Cefuroxime, Ciprofloxacin, Clarithromycin
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Dundee