Clinical trials: Doxycycline
Migraine Disorders, Headache, Migraine
The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine
The purpose of this study is to determine the effects of triptans and doxycycline on neuroinflammatory markers in acute migraine.
- Conditions
- Migraine Disorders, Headache, Migraine, Migraine, Migraine Headache
- Trial name
- NCT01653522
- Testing
- Triptan, Doxycycline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Polyp of Nasal Sinus
Doxycycline in Treating Patients With Chronic Rhinosinusitis With Nasal Polyps
The Department of Otolaryngology at Mount Sinai is looking for adults with sinus disease with polyps, otherwise called chronic rhinosinusitis with nasal polyps (CRSwNP).
- Trial name
- NCT02569437
- Testing
- Doxycycline, methylprednisolone, nasal saline spray
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Periodontitis
Effects of Low-Dose Doxycycline on Oral Bone Loss
The primary purpose of this clinical trial is to determine whether low-dose doxycycline can reduce alveolar bone density loss in postmenopausal osteopenic women with periodontitis and not on hormone replacement therapy (i.e.…
- Trial name
- NCT00066027
- Testing
- 20 mg doxycycline hyclate
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- University of Nebraska
Cystic Fibrosis
Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients
The purpose of this study is to examine the role of a well-known and well-tolerated antibiotic, doxycycline, in the treatment of cystic fibrosis patients who are hospitalized.
- Trial name
- DOXY (NCT01112059)
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Poor Glycemic Control
Periodontal Care and Glycemic Control in Diabetes
Diabetes is a prevalent and costly disease among users of VA care. Goals of diabetes care include the prevention and/or delay of complications via adequate glycemic control.
- Conditions
- Diabetes Mellitus, Poor Glycemic Control, Peridontal Disease
- Trial name
- NCT00012688
- Testing
- Doxycycline HCI 10mg po for 2 weeks, Ultrasonic scaling with 0.12% chlorhexidine gluconate
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- US Department of Veterans Affairs
Chronic Obstructive Pulmonary Disease
Placebo Versus Antibiotics in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
The role of antibiotic therapy in patients with COPD remains controversial. While the outcome of several clinical trials is in favour of antibiotics, the quality of these studies in insufficient.
- Trial name
- NCT00170222
- Testing
- doxycycline
- Where
- Netherlands
- Volunteers
- 258 people
- Sponsor
- Medical Center Alkmaar
Immediate Implant Placement
Evaluation of Doxycycline Nanoparticle With Gelatin Sponge on Immediate Implant in Esthetic Region
The goal of this clinical trial is to Evaluate the effect of Doxycycline nanoparticles along with gelatin sponge in immediate implant cases in esthetic zone.
- Trial name
- NCT06809829
- Testing
- Immediate Implant Placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Kafrelsheikh University
Leishmaniasis, Cutaneous
Intralesional Voriconazole, or Intralesional Cryotherapy, or Oral Doxycycline in the Treatment of Cutaneous Leishmaniasis
Leishmaniasis is a vector-borne disease caused by obligate, intracellular protozoa of the genus Leishmania and transmitted by phlebotomine sandflies.
- Trial name
- NCT05708625
- Testing
- Intralesional Sodium stibogluconate, Intralesional Cryotherapy, Intralesional Voriconazole
- Where
- Libya
- Volunteers
- 136 people
- Sponsor
- Zagazig University
Diabetes Mellitus
Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis
The purpose of the study is to compare the efficacy and tolerance of 6- versus 12-week antibiotic therapy in patients with diabetic foot osteomyelitis treated medically.
- Trial name
- C H R O N O S (NCT02123628)
- Testing
- duration of the antibiotic therapy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Tourcoing Hospital
Doxycycline STI PEP
Doxycycline PEP and 4CMenB as a Comprehensive Prevention Strategy in MSM and TGW at High Risk for Bacterial STIs Within the Swiss HIV Cohort Study
The study aims at assessing effectiveness of offering event-driven Doxy PEP and 4CMenB immunization in MSM/TGW at high STI risk.
- Trial name
- DOXY-MEN (NCT06242730)
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Chronic Endometritis
Efficacy of Dead Sea Peloid Gel in Chronic Endometritis
This study evaluates the effect of Dead Sea Peloid Gel in the treatment of Chronic Endometritis in women with reproductive disorders.
- Trial name
- NCT02680275
- Testing
- Dead Sea Peloid Gel
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Scientific Center for Family Health and Human Reproduction Problems, Russia
To Determine Bioequivalence Under Fasting Conditions
Bioequivalence Study Doxycycline Tablets and Monodox Capsules Under Fasting Conditions
To compare the rate and extent of absorption of doxycycline tablet (Par) versus doxycycline capsule (Monodox)(Oclassen).
- Trial name
- NCT00652795
- Testing
- Doxycycline Monohydrate, Monodox
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Mild Leptospirosis
Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte)
Leptospirosis is a globally distributed neglected tropical disease affecting subtropical and tropical areas, such as the Caribbean and the Indian Ocean, with favorable climatic conditions for disease transmission.
- Trial name
- LEPTO3 (NCT04211649)
- Testing
- 3 days of antibiotherapy
- Where
- 5 sites in French Guiana, Guadeloupe and 3 more
- Volunteers
- 220 people
- Sponsor
- University Hospital Center of Martinique
Anal Chlamydia Infection
Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM
A clinical trial to compare the efficacy of azithromycin (Arm 1) vs. doxycycline (Arm 2) administered per CDC's STD Treatment Guidelines for rectal Chlamydia trachomatis (CT) in men who have sex with men (MSM).
- Trial name
- NCT03608774
- Testing
- Azithromycin, Doxycycline
- Where
- 2 sites in United States
- Volunteers
- 177 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Periodontitis
Efficacy of Local Doxycycline Gel Delivery Versus Doxycycline Nanoparticles Prepared Gel in The Treatment of Stage II Periodontitis
To evaluate the Efficacy of Local Doxycycline Gel Delivery Versus Doxycycline Nanoparticles Prepared Gel in The Treatment of stage II Periodontitis Materials and methods: forty five patients (n=45) were selected from the…
- Trial name
- NCT06994455
- Testing
- scaling and root planing along with antibiotic intervention, scaling and root planing
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
Head and Neck Cancer
Topical Antisepsis in Head and Neck Cancer Surgery
This is a single-arm prospective trial of an intra- and postoperative topical antiseptic bundle. The study will recruit patients undergoing an open surgical resection of the upper aerodigestive tract requiring a planed…
- Trial name
- NCT04721626
- Testing
- Chlorhexidine Gluconate, Povidone-iodine, Tetracycline Ointment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical College of Wisconsin
Lymphedema, Lymphatic Filariasis
A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-SL (NCT02929134)
- Testing
- Doxycycline
- Where
- Sri Lanka
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- The Task Force for Global Health
MRSA
MRSA Decolonization in Complicated Carriage
Multicenter open-label cluster randomized controlled trial determining the superiority of doxycycline-rifampicin compared to trimethoprim-rifampicin for the decolonization treatment of complicated MRSA carriership.
- Trial name
- CLEANEST (NCT05268120)
- Testing
- doxycycline 200 mg q.d. - rifampicin 600mg b.i.d., trimethoprim 200mg b.i.d. - rifampicin 600mg b.i.d.
- Where
- Netherlands
- Volunteers
- 211 people
- Sponsor
- Leiden University Medical Center
Diabetes Mellitus With Periodontal Disease
The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus
Aim: The purpose of this study is to investigate the effect of nonsurgical periodontal therapy plus doxycycline on glycemic control in type 2 diabetes mellitus (type 2 DM) patients who have periodontitis.
- Trial name
- NCT02845024
- Testing
- Doxycycline Group
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Epistaxis
NOrth American Study for the Treatment of Recurrent epIstaxis With DoxycycLine: The NOSTRIL Trial
The purpose of this research study is to determine whether Doxycycline can be used to control nosebleeds (epistaxis) for patients with Hereditary Hemorrhagic Telangiectasia (HHT).
- Trial name
- NOSTRIL (NCT04167085)
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, Los Angeles