Clinical trials: Doxycycline
Acne Vulgaris, Pediatrics
Subantimicrobial Doxycycline in Acne
Antibiotic resistance is a public health problem that worsens the more physicians prescribe standard dose antibiotics for acne. Regardless of race, acne vulgaris is one of the most common dermatologic conditions among pediatric…
- Trial name
- NCT05399290
- Testing
- Doxycycline Hyclate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Colorectal Cancer, Skin Toxicities
Pre-emptive Low-dose Doxycycline During Anti-EGFR Treatment
Up to 60% of patients with metastatic colorectal cancer can be treated with one of monoclonal antibodies targeted against epidermal growth factor receptor (EGFR).
- Trial name
- STLDD-1 (NCT01380262)
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Rosacea
Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo
The purpose of this study is to assess relapse, efficacy and safety in subjects with rosacea during long-term treatment with either Oracea® or placebo, after an initial 12-week regimen of Oracea® and MetroGel® 1%.
- Trial name
- NCT01426269
- Testing
- Doxycycline, Metronidazole
- Where
- 11 sites in United States
- Volunteers
- 235 people
- Sponsor
- Galderma R&D
Healthy Volunteers, Fungal Infections
A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity
This study will examine the phototoxicity, a reaction to light that is like exaggerated sunburn, which occurs in people who take medications such as voriconazole, a medication used to fight fungus.
- Conditions
- Healthy Volunteers, Fungal Infections, Bacterial Infections
- Trial name
- NCT00353158
- Testing
- Doxycycline, Voriconazole
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Cetuximab-induced Papulopustular (Acneiform) Rash Who Have, Metastatic Colorectal Cancer or Head and Neck Squamous Cell Carcinoma
Study of Prophylactic Topical Dapsone 5% Gel Versus Moisturizer for Cetuximab-induced Papulopustular (Acneiform) Rash in Patients With mCRC or HNSCC Without Previous or Concurrent RT
The purpose of this study is to see if the investigators can prevent or reduce the severity of the Cetuximab-related acne rash. Two different topical agents will be applied to the skin.
- Trial name
- NCT01931150
- Testing
- Topical Dapsone 5% Gel, Moisturizer, oral antibiotics
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acne Vulgaris
Placebo Controlled Efficacy and Safety Study of CD2475/101 40 mg Tablets vs. Placebo and Doxycycline 100 mg Capsules Once Daily in the Treatment of Inflammatory Lesions of Acne Vulgaris
The primary objectives of the study is to show CD2475/101 40mg tablets taken once a day for 16 weeks is superior to the placebo in Change from baseline to Week 16(Last Observation Carry Forward, Intent To Treat) in inflammatory…
- Trial name
- NCT01320033
- Testing
- CD2475/101 40 mg, Doxycycline 100 mg
- Where
- 31 sites in United States
- Volunteers
- 662 people
- Sponsor
- Galderma R&D
Cutaneous T-cell Lymphoma, Mycosis Fungoides
Doxycycline for the Treatment of Cutaneous T-Cell Lymphoma
This study looks at the efficacy of Doxycycline for the treatment of Cutaneous T-cell Lymphomas.
- Conditions
- Cutaneous T-cell Lymphoma, Mycosis Fungoides, Sezary Syndrome
- Trial name
- CTCL (NCT02341209)
- Testing
- Doxycycline monohydrate
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rochester General Hospital
Acne
Comparative Efficacy and Safety of Benzoyl Peroxide Used in Combination With Clindamycin vs. Benzoyl Peroxide Used in Combination With Clindamycin and Doxycycline in the Treatment of Moderate Acne
To compare the efficacy and safety of Benzoyl peroxide used in combination with clindamycin vs. Benzoyl peroxide used in combination with clindamycin and doxycycline in the treatment of moderate acne
- Trial name
- NCT00837213
- Testing
- Benzoyl peroxide with clindamycin, Benzoyl peroxide with clindamycin and doxycycline
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Stiefel, a GSK Company
Type 2 Diabetes, Obesity
Examination of the Anti-inflammatory and Insulin Sensitizing Properties of Doxycycline in Humans
Obesity is a heightened state of inflammation in which production of cytokines and matrix metalloproteinases (MMPs) result in loss of function of insulin receptors and insulin resistance.
- Trial name
- DOXY (NCT01375491)
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Acne Vulgaris
Comparative Study of Metformin Versus Doxycycline in Moderate to Severe Adult Acne Vulgaris Patients.
The goal of this clinical trial is to compare the effect of doxycycline and metformin in treatment of acne vulgaris patients. The main question is aimed to answer is whether metformin is more effective than doxycycline in…
- Trial name
- NCT06252194
- Testing
- Metformin and doxycycline
- Where
- Bangladesh
- Volunteers
- 120 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Syphilis Infection, Gonorrhea
The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.
The objective of this research is to evaluate the efficacy and safety of doxycycline in MSM for preventing sexually transmitted infections (gonorrhea, chlamydia, and syphilis) in Thailand Participation in this study will last…
- Conditions
- Syphilis Infection, Gonorrhea, Chlamydia
- Trial name
- ThaiDoxyPEP (NCT07397403)
- Testing
- Doxycycline (200mg/day)
- Where
- Thailand
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bangrak STIs Center
HIV, Gonorrhea
Improving Clinic Delivery of HIV-related Anal Health Services
This project will test ways to reduce stigma in healthcare settings so that more providers offer, and more patients receive, important anal sex-related HIV services, including anorectal sexually transmitted infection (STI)…
- Conditions
- HIV, Gonorrhea, Chlamydia, Anal Cancer Squamous Cell
- Trial name
- PEACHES 2 (NCT07464236)
- Testing
- PEACHES 2.0 Implementation Strategies
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Intrauterine Adhesion
Intrauterine Stent Placement Following Hysteroscopic Septum Resection
The study hopes to learn the best way to prevent internal scar tissue after septum removal. The use of an intrauterine foley catheter balloon may prevent the formation of adhesions following surgery.
- Trial name
- NCT07032506
- Testing
- Intraoperative placement of an inflated intrauterine pediatric foley catheter, No Catheter placement, Hormonal Therapy Agent
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Weill Medical College of Cornell University
Unsafe Sex, Risk-Taking
Combined Prevention of Sexually Transmitted Infections (STIs) in Men Who Have Sex With Men and Using Oral Tenofovir Disoproxil Fumarate/ Emtricitabine (TDF/FTC) for HIV Pre-Exposure Prophylaxis (PrEP)
The study ANRS 174 Doxyvac is a clinical trial that will use Combined Prevention of Sexually Transmitted Infections (STIs) in Men Who Have Sex with Men and using oral TDF/FTC for HIV Pre-Exposure Prophylaxis (PrEP) and…
- Trial name
- DOXYVAC (NCT04597424)
- Testing
- Experimental: doxycycline, Bexsero® vaccine
- Where
- 9 sites in France
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Diabetes Mellitus With Periodontal Disease
The Effect of Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus(DM) ®
Aim: The purpose of this study is to investigate the effect of nonsurgical periodontal therapy plus subgingivally doxycycline gel 3% on glycemic control in type 2 diabetes mellitus (type 2 DM) patients who have periodontitis.
- Trial name
- NCT02735837
- Testing
- Doxycycline Group
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Amirhossein Farahmand
Acne
Photodynamic Therapy Compared to Adapalene 0.1% Gel Plus Doxycycline in the Treatment of Acne Vulgaris
Acne vulgaris is a common inflammatory skin disease that affects more than 85% of teens and some people may continue throughout adulthood.
- Trial name
- NCT01245946
- Testing
- Photodynamic therapy, Conventional therapy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology)
Adjunctive Doxycycline for Central Nervous System Tuberculosis
Although tuberculosis is now considered a treatable disease, central nervous system tuberculosis (CNS-TB) when managed with the current standard-of-care (SOC), still has mortality rates ranging from 30-50% even in tertiary…
- Conditions
- Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology), Tuberculosis, Central Nervous System, Tuberculosis; Meningoencephalitis (Etiology)
- Trial name
- DIRECT (NCT06446245)
- Testing
- Doxycycline, Anti Tuberculosis Drug, Adjunctive corticosteroid
- Where
- 6 sites in Indonesia, Malaysia and 1 more
- Volunteers
- 200 people
- Sponsor
- National University Hospital, Singapore
Chronic Endometritis
Randomized Controlled Trial of Berberine in Combination With Doxycycline in the Treatment of Chronic Endometritis
Study Subjects: Eligible patients were initially diagnosed with chronic endometritis (CE) by CD138 testing through outpatient hysteroscopy.
- Trial name
- NCT07180563
- Testing
- Participants were treated with doxycycline + berberin for chronic endometritis (intervention group)., At present, the commonly used clinical treatment for chronic endometritis is oral doxycycline
- Where
- China
- Volunteers
- 206 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Erythema Migrans, Post-Lyme Disease Symptoms
Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome
Background: While doxycycline is a standard antibiotic for treatment of erythema migrans in Europe as well as in the USA, the effectiveness of cefuroxime axetil in the treatment of adult patients with erythema migrans has been…
- Trial name
- NCT01518192
- Testing
- doxycycline, cefuroxime axetil
- Where
- 2 sites in Slovenia
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Rotator Cuff Injury
Trial of the Use of Doxycycline After Rotator Cuff Repair
The purpose of this study is to examine healing after rotator cuff repair in subjects either treated with Doxycycline or placebo post-operatively.
- Trial name
- NCT02388477
- Testing
- Doxycycline, sugar pill
- Where
- United States
- Sponsor
- Milton S. Hershey Medical Center