Clinical trials: Duloxetine
Lumbosacral Radiculopathy
Procedural Framing and Epidural Steroid Injection Outcomes
Back pain is the leading cause of disability and military medical boards across the globe. Epidural steroid injections (ESI) are the most commonly performed pain procedure in the world.
- Trial name
- PEACE (NCT07498140)
- Testing
- Behavioral manipulation of ESI expectations, No behavioral manipulation of ESI expectations, No behavioral manipulation of pharmacotherapy expectations
- Where
- 4 sites in United States, Thailand and 1 more
- Volunteers
- 210 people
- Sponsor
- Northwestern University
Vaginal Hysterectomy, Postoperative Pain
Evaluating the Efficacy and Safety of Preoperative Administration of Duloxetine for Pain Management in Women Undergoing Hysterectomy Via Vaginal Route
Hysterectomy performed through the vaginal route (HVR) is the preferred method for women seeking hysterectomy to address uterine concerns such as premalignant conditions and fibroids.
- Conditions
- Vaginal Hysterectomy, Postoperative Pain, vNOTES
- Trial name
- NCT06429605
- Testing
- duloxetine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Depression Disorders, Herpetic Neuralgia
Ketamine for Postherpetic Neuralgia With Depression
This clinical trial examines the antidepressant efficacy and safety of a single low-dose intravenous esketamine combined with oral duloxetine in patients with postherpetic neuralgia and depression (duration more than 1 month).
- Trial name
- NCT06968624
- Testing
- Intravenous Ketamine Infusions, Intravenous normal saline, Oral Duloxetine 60mg
- Volunteers
- 50 people
- Sponsor
- Huazhong University of Science and Technology
Osteoarthritis Knee Pain
A Study Comparing Duloxetine Versus Placebo in Patients Taking a Nonsteroidal Anti-inflammatory Drug (NSAID) for Knee Pain Due to Osteoarthritis
The study will test the hypothesis that, in patients with knee pain due to osteoarthritis (OA) who are taking nonsteroidal anti-inflammatory drugs (NSAIDs) but still have significant knee pain, duloxetine 60 to 120 milligrams…
- Trial name
- NCT01018680
- Testing
- Duloxetine
- Where
- 35 sites in United States, Puerto Rico
- Volunteers
- 524 people
- Sponsor
- Eli Lilly and Company
Oncology
Comparative Clinical Study Evaluating the Possible Efficacy of Duloxetine, Gabapentin and Lacosamide on Oxaliplatin-Induced Peripheral Neuropathy in Cancer Patients
This study aims to investigate the possible efficacy of duloxetine, gabapentin and lacosamide on oxaliplatin-induced peripheral neuropathy in patients with gastrointestinal cancer.
- Trial name
- NCT05510856
- Testing
- Duloxetine, Gabapentin, Lacosamide
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Tanta University
Chronic Visceral Pain, Major Depressive Disorder
Esketamine Adjuvant Therapy for Patients With Chronic Visceral Pain Comorbid Major Depressive Disorder
Ketamine is a dissociative anesthetic and powerful analgesic. At low doses, ketamine can desensitize the central pain pathway and modulate opioid receptors.
- Trial name
- NCT04847245
- Testing
- Pregabalin 75mg tid + Duloxetine, Intravenous administration of esketamine 0.125 mg/kg+Duloxetine, Intravenous administration of esketamine 0.25 mg/kg +Duloxetine
- Volunteers
- 80 people
- Sponsor
- Peking University
Diabetic Neuropathy, Painful
A Study in Participants With Diabetic Peripheral Neuropathic Pain in China
The purpose of this trial is to assess the efficacy of duloxetine 60 milligrams (mg) once daily (QD) compared with placebo, on the change in pain severity from baseline to 12 weeks as measured by the weekly mean of the daily pain…
- Trial name
- NCT01179672
- Testing
- Duloxetine
- Where
- 15 sites in China
- Volunteers
- 405 people
- Sponsor
- Eli Lilly and Company
Depression
Efficacy and Safety of Fixed Doses of BMS 820836 in the Treatment of Patients With Treatment Resistant Major Depression
The purpose of the study is to evaluate the efficacy of study drug (BMS-820836) as compared with continued Duloxetine/Escitalopram in the treatment of patients with treatment resistant depression (TRD).
- Trial name
- NCT01369095
- Testing
- Duloxetine, Escitalopram, BMS-820836
- Where
- 93 sites in United States, Argentina and 10 more
- Volunteers
- 976 people
- Sponsor
- Bristol-Myers Squibb
Infertility, Male, Depression
Impact of Duloxetine on Male Fertility
The investigators are conducting a placebo-controlled, randomized control trial with duloxetine in healthy, fertile men not previously on any antidepressants.
- Trial name
- NCT03038867
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Laparoscopic Hysterectomy, Postoperative Recovery
Perioperative Duloxetine for Pain Management After Laparoscopic Hysterectomy
The aim of the investigators of the study is to evaluate the effect of peri-operative duloxetine on post-operative recovery in patients undergoing laparoscopic hysterectomy.
- Conditions
- Laparoscopic Hysterectomy, Postoperative Recovery, Postoperative Pain
- Trial name
- NCT03350334
- Testing
- Duloxetine
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Acibadem University
Urinary Incontinence, Stress
Efficacy and Safety Stress Urinary Incontinence Study
Study F1J-MC-SBBT will examine the effect of duloxetine treatment in women with SUI. The inclusion and exclusion criteria of this Phase 3 study will ensure that all subjects have a clinical diagnosis of SUI.
- Trial name
- NCT00475358
- Testing
- Duloxetine
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks.
- Trial name
- PREDICT (NCT06245109)
- Testing
- Duloxetine, Celecoxib
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Northwestern University
Urinary Stress Incontinence
Efficacy and Safety of Duloxetine
The purpose of this study is to monitor the long term safety and efficacy of duloxetine in the treatment of severe pure genuine stress incontinence.
- Trial name
- NCT00190619
- Testing
- Duloxetine
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Eli Lilly and Company
THA
Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT
The primary objective of this study is to compare total narcotic intake standardized via milligram morphine equivalents between duloxetine and placebo cohorts after a total hip arthroplasty.
- Trial name
- NCT06807866
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Miami
Fibromyalgia
Vagus Nerve Stimulation in Fibromyalgia
Vagus nerve stimulation is thought to reduce sympathetic nerve outflow and so can improve sympathetic hyperactivity in fibromyalgia patients.
- Trial name
- NCT06237595
- Testing
- Vagus nerve stimulation, Medical treatment, Combined vagus nerve stimulation and medical treatment
- Where
- Egypt
- Volunteers
- 87 people
- Sponsor
- Kasr El Aini Hospital
Urinary Incontinence, Stress
Effectiveness of Duloxetine in the Treatment of Stress Urinary Incontinence(Uncontrolled Leakage of Urine)
The study evaluates the effectiveness of duloxetine in reducing urinary incontinence occurrences in women due to physical stress(e.g. stomach pressure on bladder).
- Trial name
- NCT00190827
- Testing
- duloxetine
- Where
- 8 sites in Brazil, Canada and 6 more
- Volunteers
- 500 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder
Major depressive disorder (MDD) is a serious medical illness associated with significant suicidal risk and marked disability. Despite the availability of numerous treatments, achievement of consistent and favorable long-term…
- Trial name
- NCT03538691
- Testing
- Brexpiprazole, Antidepressant therapy
- Where
- United States
- Volunteers
- 1,149 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Fibromyalgia
An Extension Study of Duloxetine in Fibromyalgia (Extension of F1J-JE-HMGZ, NCT01552057)
The purpose of the study is to assess the safety and efficacy of duloxetine in participants with fibromyalgia at long-term use.
- Trial name
- NCT01621191
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 149 people
- Sponsor
- Eli Lilly and Company
Healthy
Impact of Genetic Polymorphism on Drug-Drug Interactions Involving CYP2D6
CYP2D6 is characterized by a huge variability in the general population, mainly because of genetic polymorphism and drug-drug interactions (DDIs). CYP2D6 genotype is known to have an impact on the extent of DDIs.
- Trial name
- NCT03054220
- Testing
- Dextromethorphan 5 MG, Tramadol 10 mg, Duloxetine 60mg
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules