Clinical trials: Experimental
Osteoarthritis, Hip, Arthroplasty Complications
A Randomized RSA Study Comparing HXLPE to Conventional Polyethylene in Cemented Total Hip Arthroplasty
A prospective randomized study comparing two types of cemented acetabular components, a highly-crosslinked polyethylene or conventional polyethylene in total hip arthroplasty.
- Trial name
- NCT04322799
- Testing
- Device: Randomization between prosthetic components
- Where
- Sweden
- Volunteers
- 57 people
- Sponsor
- Umeå University
Hip Fractures, Gait, Unsteady
Comparison of Sliding Hip Screw to Intra Medullary Nailing in the Treatment of Intertrochanteric Hip Fracture
Shortening of the abductor lever arm is a particular concern with the SHS, and the resultant biomechanical alterations may impair gait, including decreased cadence, gait speed and increased double support time on the injured…
- Conditions
- Hip Fractures, Gait, Unsteady, Function
- Trial name
- NCT03906032
- Testing
- TFNA IM Nail, Sliding hip screw
- Where
- Ireland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Waterford
Diabetes (DM), Dry Mouth
Effects of Chewing Gum for Dry Mouth in Diabetes
Dry mouth can seriously affect the quality of life of individuals because it affects chewing and swallowing functions. One of the diseases in which dry mouth occurs as a side effect of many diseases and/or treatments is diabetes…
- Trial name
- NCT07084532
- Testing
- Chewing gum, Standart therapy group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Çankırı Karatekin University
Recurrent Breast Carcinoma, Stage IV Breast Cancer
Erlotinib Hydrochloride and Bevacizumab in Treating Patients With Stage IV Breast Cancer
This phase II trial studies how well erlotinib hydrochloride and bevacizumab work in treating patients with stage IV breast cancer.
- Trial name
- NCT00054132
- Testing
- Bevacizumab, Erlotinib Hydrochloride, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- National Cancer Institute (NCI)
Central Venous Catheter
The Use of Point of Care Ultra Sound for Correct Placement of Central Venous Catheter
Central venous catheter (CVC) is an essential tool in the management of both medical and surgical patients. Establishing venous access is critically important and is sometimes technically challenging.
- Trial name
- NCT02472132
- Testing
- POC US
- Where
- Israel
- Volunteers
- 186 people
- Sponsor
- Soroka University Medical Center
Atopic Dermatitis
Exploratory Study of the Cutaneous Penetration of Biodegradable Polymeric Microparticles in Atopic Dermatitis
This proof of concept study aims to assess in patients suffering from atopic dermatitis if polymeric microparticles reach the pilosebaceous follicles of inflamed skin.
- Trial name
- MicroIskin (NCT02369432)
- Testing
- Biodegradable and biocompatible polymeric microparticles containing a fluorochrome applied to the skin followed by a skin biopsy
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Healthy
Young Age Soccer Player's Lower Limb Muscle Imbalance and Functional Status
A randomized controlled trial is designed to examine the effects of low-load and high-velocity eccentric exercises on lower limb muscular properties, imbalances and functional status of 13-15 years old female football players.
- Trial name
- NCT06053632
- Testing
- Low-load and high-velocity - lying prone - eccentric hamstring exercise
- Where
- Lithuania
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Advanced Solid Tumor
A Phase I Study of SCC244 in Patients with Advanced MET Alterations Solid Tumors
This is a Phase 1a/1b multi-center and open label study to evaluate the safety, tolorability, pharmacokinetics and priliminary efficacy of SCC244 in advanced solid tumors patients with c-MET alteration
- Trial name
- NCT03457532
- Testing
- Gumarontinib Tablets
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Haihe Biopharma Co., Ltd.
Asthma
Effectiveness of Fluticasone Furoate/ Umeclidinium/ Vilanterol (FF/UMEC/VI) Using the Connected Inhaler System (CIS) as Compared With Fluticasone Proprionate/ Salmeterol (FP/SAL) Plus Tiotropium (TIO) in Inadequately Controlled Asthma
Asthma is a common, chronic respiratory disease affecting 1-18 percent of the population. It is accepted that much of the uncontrolled asthma is due to poor adherence and asthma outcomes in such cases may improve simply by…
- Trial name
- NCT03376932
- Testing
- FF/UMEC/VI, FP/SAL, Tiotropium
- Sponsor
- GlaxoSmithKline
Vestibular Schwannoma, Inner Ear Disease
Vestibular Precision: Physiology & Pathophysiology
This project will investigate the role of noise in the vestibular system, and in particular its effects on the variability (precision) of vestibular-mediated behaviors.
- Conditions
- Vestibular Schwannoma, Inner Ear Disease, Dizziness, Neurofibromatosis 2
- Trial name
- NCT04890132
- Testing
- VOR precision training
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Chemotherapy Training
Virtual Reality Application in Chemotherapy Administration in Nurse Staff
The present study wants to design a training program for chemotherapy with using VR among nurse staff. Then the investigators design a protocol to compare the training effects in the VR program and ISO document.
- Trial name
- NCT04840732
- Testing
- VR training program, usual care
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Psoriasis of Scalp
Immune Spatial Features of Guselkumab Cutaneous Response
This study examines the effect of IL-23 blockade with Guselkumab on the immune cells of scalp psoriasis lesions.
- Trial name
- NCT05858632
- Testing
- Guselkumab
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Influenza
Safety and Immunogenicity of BPL-1357, A BPL-Inactivated, Whole-Virus, Universal Influenza Vaccine
Background: Influenza (flu) is a virus that infects people of all ages. Some people may have mild flu symptoms. Others may get very sick and even die from the flu.
- Trial name
- NCT05027932
- Testing
- BPL-1357
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breast Cancer, Triple Negative Breast Cancer
Study of Antivascular Therapy Combined With Chemotherapy Versus Chemotherapy in Adjuvant Therapy of TNBC-BLIS Patients (BCTOP-T-A03)
This is a randomized, open-label phase III clinical trial comparing antivascular therapy combined with standard chemotherapy and standard chemotherapy in adjuvant therapy for patients with triple-negative breast cancer…
- Trial name
- NCT05909332
- Testing
- Antivascular therapy, Chemotherapy
- Where
- 15 sites in China
- Volunteers
- 764 people
- Sponsor
- Fudan University
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Diarrhea
Recombinant Human Lactoferrin Administered Orally for the Prevention of Antibiotic Associated Diarrhea in Adult Patients
The purpose of the study is to Evaluate the Efficacy and Safety of Recombinant Human Lactoferrin Administered Orally for the Prevention of Antibiotic Associated Diarrhea in Adult Patients.
- Trial name
- NCT01382199
- Testing
- Lactoferrin
- Volunteers
- 340 people
- Sponsor
- Ventria Bioscience
Malaria, HIV
Dolutegravir Interactions With Artemisinin-based Combination Therapies
Malaria and HIV are found in the same regions of the world and developing countries are most affected by both diseases. For malaria, new drugs have been introduced called ACTs.
- Trial name
- DolACT (NCT02242799)
- Testing
- Dolutegravir 50mg od, Artemether-lumefantrine combination, Artesunate-amodiaquine
- Where
- Uganda
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Vasoplegic Syndrome, Liver Transplant; Complications
Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients
This study will evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.
- Trial name
- NCT04054999
- Testing
- Hydroxocobalamin, Methylene Blue
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Non Small Cell Lung Cancer, Esophageal Cancer
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
The objective of this study is to evaluate the safety, tolerability, and efficacy of BL-B01D1 in patients with Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors.
- Conditions
- Non Small Cell Lung Cancer, Esophageal Cancer, Small Cell Lung Cancer, Nasopharyngeal Cancer
- Trial name
- NCT05983432
- Testing
- BL-B01D1
- Where
- 37 sites in United States, France and 3 more
- Volunteers
- 540 people
- Sponsor
- SystImmune Inc.
Stroke Sequelae, Brain Ischemia
EEG Based BCI for Upper Limb Rehabilitation in Stroke
Biomedical and Engineering approaches form a key element to neurological rehabilitation of upper limbs. Brain Computer Interface (BCI) using Motor execution and Motor Imagery are known to aid motor recovery in stroke.
- Trial name
- NCT04188132
- Testing
- EEG -BCI based Feedback for rehabilitation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Houston
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