Clinical trials: Experimental
Non-Small-Cell Lung Cancer
Vebreltinib Plus PLB1004 Versus Platinum-based Doublet Chemotherapy in Patients With EGFRm, MET+, Locally Advanced or Metastatic NSCLC Following EGFR-TKI Failure
Efficacy and Safety of Vebreltinib in Combination With PLB1004 Versus Platinum-based Doublet Chemotherapy in Patients With EGFR Mutations, MET Amplification and/or Overexpression, Locally Advanced or Metastatic Non-Small Cell…
- Trial name
- KYLIN-3 (NCT06970782)
- Testing
- Vebreltinib, PLB1004, Pemetrexed plus Carboplatin or Cisplatin
- Volunteers
- 278 people
- Sponsor
- Avistone Biotechnology Co., Ltd.
Delirium
The Effect of Applying Multidisciplinary Bundle Intervention on the Delirium Incidence in Critically Ill Patients
The patients will exposed to different intervention through three nights (ear plug, eye mask). 50 patients in the age range 18- 60 years admitted to ICU of Assiut university hospitals will be randomly allocated into into two…
- Trial name
- Ghada (NCT02637882)
- Testing
- Ear plug, Eye mask, Mixed intervention (ear plug and eye mask)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Phase II, Ivonescimab
A Phase II Study of Ivonescimab Combined With Intraperitoneal Paclitaxel in Patients With High-Grade Metastatic Appendiceal Adenocarcinoma (AA)
To evaluate the safety and effectiveness of Ivonescimab combined with intraperitoneal paclitaxel (IP PTX) in patients with unresectable metastatic high-grade Appendiceal Adenocarcinoma (AA).
- Conditions
- Phase II, Ivonescimab, Intraperitoneal, Paclitaxel
- Trial name
- NCT07753824
- Testing
- Ivonescimab, IP PTX
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Anxiety
Transforming Health and Reducing Perinatal Anxiety Through Virtual Engagement
The goal of this clinical trial is to evaluate whether digital cognitive behavioral therapy (dCBT) can be used to address clinical anxiety in marginalized and low-income pregnant people in California.
- Trial name
- THRIVE (NCT06404450)
- Testing
- Digital CBT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Acupressure, Post-Op Complication
Effect of Acupressure on Recovery of Bowel Function in Patients Post Cesarean Section
Research objectives To compare the efficacy of acupressure with no acupressure to examine time to first flatus in patient post cesarean section ; Acupressure at ST-36 Zusanli (lateral to anterior crest of tibia, in the tibialis…
- Conditions
- Acupressure, Post-Op Complication, Cesarean Section, Bowel Ileus
- Trial name
- NCT04620850
- Testing
- Acupressure
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Nausea
Inhaled Isopropyl Alcohol Versus Placebo to Manage Nausea at Electronic Dance Music Festivals
BACKGROUND Studies have shown that isopropyl alcohol inhalation is effective for the relief of nausea in the emergency department.
- Trial name
- NCT04307550
- Testing
- Isopropyl alcohol
- Where
- 9 sites in Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Anthony Seto
Dry Eye Syndrome, Keratoconjunctivitis Sicca
Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye Syndrome
A Multi-Center, Phase 2/3, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Clinical Trial to Assess the Safety and Efficacy of Voclosporin Ophthalmic Solution (0.05%, 0.10%, 0.20%) Compared to Vehicle in Subjects…
- Trial name
- AUDREY (NCT04147650)
- Testing
- 0.05% Voclosporin Ophthalmic Solution (VOS), 0.10% VOS, 0.20% VOS
- Where
- 9 sites in United States
- Volunteers
- 508 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Cancer
Visual Communication: Digital Tool to Improve the Understanding of Treatment Options for Patients With Cancer and Increase Satisfaction of the Overall Experience for Patients, Caregivers, and Providers
This is a study in patients with newly diagnosed cancer to prospectively evaluate the feasibility of integration of a visual communication tool for patients/caregivers/providers by determining whether such a tool can increase…
- Trial name
- NCT06927050
- Testing
- Visual Communication Tool
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- NYU Langone Health
Cannabis
Delta-8-THC vs. Delta-9-THC on Simulated Driving Performance
Delta-8-THC is an isomer of delta-9-THC that has become widely available due to the legalization of hemp and its derivatives. Very little controlled research has been conducted with delta-8-THC and some research suggests it…
- Trial name
- NCT06218550
- Testing
- Delta-9-THC, Delta-8-THC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postoperative Care
Rocking Chairs as Post-operative Treatment for Older Adults After Hip Surgery
Feasibility and acceptability randomized controlled trial exploring the use of a rocking chair after a total hip arthroplasty in adults who are aged 65 or older.
- Trial name
- FAIRChair (NCT07544550)
- Testing
- Active rocking in a rocking chair, Sitting upright in a stationary chair
- Volunteers
- 60 people
- Sponsor
- University of Missouri, Kansas City
Advanced Solid Tumors
A Phase I Study of NK042 Cell Injection in Advanced Solid Tumors
This is a single-arm, open-label, multi-center phase 1 clinical study designed to evaluate the safety and preliminary efficacy of NK042 cell injection in patients with advanced solid tumors.
- Trial name
- NKSOLID (NCT06773091)
- Testing
- NK042, Fludarabine (FLU), Cyclophosphamide (CTX)
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Shanghai NK Cell Technology Co., LTD
Myopia
Dispensing Study for a New Study Lens
This study investigated the performance criteria over one week of daily wear to determine if the comfilcon A asphere lens (test) performed equivalently to the comfilcon A sphere (control) in terms of measurement and subjective…
- Trial name
- NCT02642991
- Testing
- Phenacite, comfilcon A
- Where
- 3 sites in United States, Canada
- Volunteers
- 44 people
- Sponsor
- CooperVision, Inc.
PAIN, ANXIETY
Burn Patient Care, Virtual Reality, Music, Pain, Anxiety and Pain Anxiety
Different non-pharmacological methods such as virtual reality glasses and music can be applied by nurses within the scope of care interventions for the management of pain and anxiety in burn patients during dressing changes and…
- Conditions
- PAIN, ANXIETY, PAIN ANXIETY
- Trial name
- NCT05688891
- Testing
- Virtual reality, Music
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Ewing Sarcoma
RAPID: Phase 2 Platform Trial Of Promising Drugs For AYA Patients With R/R Ewing Sarcoma & DSRCT
The goal of this clinical research study is to learn if new anticancer drugs or drug combinations can help to control relapsed/refractory ES, DSRCT, or SRCS.
- Trial name
- NCT07781891
- Testing
- LX-101
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Atrial Fibrillation (AF)
Digitally Rendered Interventions And Knowledge To Limit Ethanol-Associated Atrial Fibrillation Severity
Per the 2021 National Survey on Drug Use and Health administered by the U.S. Department of Health and Human Services, 85% of all American adults consume alcohol.
- Trial name
- DRINK-LESS (NCT06995391)
- Testing
- Contemporary Guideline-Adherence, Alcohol Abstinence
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, San Francisco
Postoperative Pain
Effect of Noise Blocking During General Anesthesia on Postoperative Pain
To investigate the effect of noise blocking during general anesthesia on postoperative pain in patients undergoing laparoscopic abdominal surgery.
- Trial name
- NCT05540691
- Testing
- Wear noise-cancelling earphones
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Knee Osteoarthritis
Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
Evaluate the efficacy and safety of Allogenic Adipose Tissue-Derived Mesenchymal Stem Cells Therapy
- Trial name
- NCT06570291
- Testing
- Mesenchymal Stem Cells, Sodium Hyaluronate Injection
- Where
- 2 sites in China
- Volunteers
- 520 people
- Sponsor
- Wuxi Cellular Biopharmaceutical Group Ltd.
Alzheimer Disease
Study Evaluating Single Ascending Doses of AAB-001 Vaccine SAD Japanese Patients With Alzheimers Disease
Evaluate safety, tolerability, and pharmacokinetics of single doses of the investigational AAB-001 Vaccine in Japanese patients with Alzheimer's disease.
- Trial name
- NCT00397891
- Testing
- bapineuzumab
- Where
- 4 sites in Japan
- Volunteers
- 80 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Body Fat Disorder
CoolSculpting and EMS for the Abdomen
Evaluate the use of Electromagnetic Muscle Stimulation as an adjunctive treatment to CoolSculpting.
- Trial name
- ECA (NCT03738891)
- Testing
- Zeltiq CoolSculpting System alone, Electromagnetic Muscle Stimulation alone, EMS followed by CoolSculping
- Where
- 4 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Cesarean Section Complications, Spinal Anesthesia
Vasopressor Infusion in Cesarean Delivery
Comparison will be conducted between continuous variable infusions of both drugs (Phenylephrine and Norepinephrine) with starting doses of 0.75 mcg/Kg/min and 0.1 mcg/Kg/min respectively for prophylaxis against Post-spinal…
- Trial name
- NCT03248791
- Testing
- Phenylephrine, Norepinephrine, Bupivacaine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
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