Clinical trials: Experimental, completed
Fungal Infection
Safety, Pharmacokinetics, Bioavailability, Food Effect, Drug-Drug Interaction Study of APX001 Administered Orally
This is a Phase l double-blind, placebo-controlled, randomized study to investigate the safety, tolerability, pharmacokinetics, bioavailability and food effect of single doses of APX001 administered intravenously and orally…
- Trial name
- NCT02957929
- Testing
- APX001 single IV dose, APX001 single oral dose 1, APX001 single oral dose 2
- Where
- 2 sites in Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Narrative Medicine
Meaning Making While Your Child is in Intensive Care
A quarter of a million children and teenagers are hospitalized annually in Pediatric Intensive Care Units (PICUs) in North America.
- Trial name
- NCT05627531
- Testing
- Narrative Medicine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Akron Children's Hospital
Fibromyalgia, Obesity
Nutrition and Coping Education for Symptom and Weight Management for Fibromyalgia
Research has shown that weight problems are very common in fibromyalgia. Research also suggests that overweight and obesity may contribute to worsening of fibromyalgia symptoms and biochemical vulnerability associated with…
- Trial name
- NCT00925431
- Testing
- Lifestyle Modification, Supportive education
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Utah
Healthy
A Healthy Female and Male Volunteers Aspirin Study
This is a study to compare the bioavailability of Acetyl Salicylic Acid (ASA) between Esomeprazole and Aspirin after multiple dose administration.
- Trial name
- NCT01448031
- Testing
- Capsule ASA 81mg/esomeprazole 20mg, Acetylsalicylzuur Apotex Cardio
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hyperlipidemias, Dyslipidemias
Study to Investigate Safety, Tolerability, PK and PD Response of SLN360 in Subjects With Elevated Lipoprotein(a)
This study will investigate the safety and tolerability of SLN360 in patients with elevated Lp(a).
- Conditions
- Hyperlipidemias, Dyslipidemias, Elevated Lp(a)
- Trial name
- NCT04606602
- Testing
- SLN360
- Where
- 8 sites in United States, Australia and 2 more
- Volunteers
- 70 people
- Sponsor
- Silence Therapeutics plc
Stroke, Hemiparesis
Constraint-Induced Movement Therapy (CIMT) with Motor Relearning Program (MRP) and Bobath Approach to Augment Functional Motor Recovery of Chronic Hemiparetic Arm
Hemiparesis is a condition characterized by weakness or the inability to move on one side of the body, making it difficult to perform everyday activities like eating or dressing (Iswatun et al., 2022).
- Conditions
- Stroke, Hemiparesis, Hemiparesis After Stroke, Motor Function
- Trial name
- CIMT-MRP (NCT06806553)
- Testing
- Constraint-Induced Movement Therapy (CIMT) With Motor Relearning Program (MRP), Bobath Therapy
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- University of Lahore
Osteo Arthritis Knee, Osteoarthritis
Mako Functionally Aligned Total Knee Arthroplasty vs Mako Mechanically Aligned Total Knee Arthroplasty
This study evaluates outcomes of robotic-arm assisted mechanically aligned total knee arthroplasty [MA TKA] versus robotic-arm assisted functionally aligned total knee arthroplasty [FA TKA].
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Surgery
- Trial name
- NCT04092153
- Testing
- Total knee arthroplasy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Cigarette Smoking
Testing the ETM: Examination and Comparison of Different Methods
This study will experimentally assess the comparability of in-lab and remote procedures with hypothetical and real ETM purchase outcomes.
- Trial name
- NCT05946031
- Testing
- Reat ETM, Hypothetical ETM
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Virginia Polytechnic Institute and State University
Sleep Quality
Effects of Binaural Beat Music on Elderly Sleep
Background: Older people in long-term care institutions often have poor sleep quality and depression, which may negatively affect their health and welfare. Binaural beat music (BBM) has been proposed as a possible intervention.
- Trial name
- NCT05975853
- Testing
- Binaural beat music group (BBM group), Control group
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Cheng Kung University
Alzheimer's Disease
A Phase 2a Study to Evaluate the Effect of Rilapladib (SB-659032) in Alzheimer's Disease
The study is designed to investigate the effects of rilapladib on biomarkers related to the Alzheimer's disease, and cognitive function.
- Trial name
- NCT01428453
- Testing
- 250mg rilapladib
- Where
- 30 sites in Bulgaria, Canada and 5 more
- Volunteers
- 124 people
- Sponsor
- GlaxoSmithKline
Oppositional Defiant Disorder, Oppositional Defiant Disorder in Children
Evaluation of Regulation Focused Psychotherapy for Children
The main objective of this project is to conduct a study of RFP-C for children with disruptive behaviors. Regulation Focused Psychotherapy for Children (RFP-C) is a twice a week, play therapy intervention.
- Trial name
- RFP-C (NCT03594253)
- Testing
- Regulation Focused Psychotherapy for Children
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yeshiva University
Healthy Adults
Phase 1 Seattle Dietary Biomarkers Development Center
The Seattle Dietary Biomarker Development Center (S-DBDC) aims to advance the science of measuring dietary intake by identification and validation of dietary biomarkers that improve upon self-reported diet.
- Trial name
- P1-SDBDC (NCT05580653)
- Testing
- Controlled feeding study of beef and/or pinto beans, Controlled feeding study of eggs and/or black beans
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marian Neuhouser
Alzheimer's Disease
A Study to Evaluate Albumin and Immunoglobulin in Alzheimer's Disease
The purpose of this study is to evaluate the changes in the cognitive, functional, behavioral and global domains based on the different applicable psychometric batteries and scales.
- Trial name
- AMBAR (NCT01561053)
- Testing
- Albumin 5%, Albumin 20%, Immunoglobulin
- Where
- 40 sites in United States, Spain
- Volunteers
- 347 people
- Sponsor
- Instituto Grifols, S.A.
Adenocarcinoma of Prostate
Short Course Radiotherapy for Localized Prostate Cancer
Hypofractionated external beam radiotherapy has been clinically used for localized prostate cancer in view of the low estimated alpha/beta ratio of prostate cancer cells.
- Trial name
- SHORT (NCT03518853)
- Testing
- Short-course Hypofractionated Once-weekly Radiation Therapy
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Tata Medical Center
Infertility, Female, Obesity
Effect of Lifestyle and/or Metformin Intervention on Pregnancy Outcome, A Pilot Randomized Controlled Trial
The purpose of pilot trial is to compare the efficacy of lifestyle intervention, metformin intervention, lifestyle combined with metformin intervention in improving assisted reproductive technology in non-polycystic ovary…
- Conditions
- Infertility, Female, Obesity, Insulin Resistance
- Trial name
- NCT03898037
- Testing
- weight loss intervention, metformin intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Ovarian Cancer
Cabazitaxel in Patients With Recurrent Ovarian Cancer After Failure of Standard Therapy.
Many ovarian cancer patients have been offered different standard cytostatics and gradually develop chemo-resistance. However, a considerable fraction of these patients are still in good general health and have a strong wish for…
- Trial name
- CaTo-ROC (NCT02560337)
- Testing
- Cabazitaxel
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Vejle Hospital
Malignant Glioma
Study of NPC-08 is to Treat for Newly-Diagnosed Malignant Glioma and Recurrent Glioblastoma Multiforme
The purpose of this study is to evaluate whether NPC-08 is safety and efficacy in the treatment of newly-diagnosed malignant glioma and recurrent glioblastoma multiforme.
- Trial name
- NCT00919737
- Testing
- NPC-08
- Where
- Japan
- Volunteers
- 24 people
- Sponsor
- Nobelpharma
Infection
Allergy Antibiotics And Microbial Resistance
ALBAMA study is designed to find out if the effects of Penicillin allergy assessment pathway (PAAP) intervention is on penicillin prescribing
- Trial name
- ALABAMA (NCT04108637)
- Testing
- penicillin allergy assessment pathway
- Where
- United Kingdom
- Volunteers
- 823 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Extracorporeal Circulation; Complications
Comparison of Two Dosages of Heparin Before Extracorporeal Circulation
In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery.
- Trial name
- NCT03752437
- Testing
- ACT (Activated Clotting Time), Heparin
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Astes
Congenital Diaphragmatic Hernia, Fetal Surgery
Fetal Surgery for Moderate Left Sided Congenital Diaphragmatic Hernia.
Isolated Congenital Diaphragmatic Hernia (CDH) can be diagnosed in the prenatal period, and remains associated with a 30 % chance of perinatal death and morbidity mainly because of pulmonary hypoplasia and pulmonary hypertension.
- Conditions
- Congenital Diaphragmatic Hernia, Fetal Surgery, Pulmonary Hypoplasia
- Trial name
- TOTAL moderate (NCT00763737)
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion
- Where
- 13 sites in United States, Australia and 8 more
- Volunteers
- 196 people
- Sponsor
- University Hospital, Gasthuisberg
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