Clinical trials: Experimental
Severe or Greater Tricuspid Regurgitation
A Prospective, Multicenter, Randomized Controlled Clinical Trial of Transcatheter Tricuspid Valve Clipping Systems.
The transcatheter tricuspid valve clipping system is specially designed for the treatment of tricuspid regurgitation. Under the guidance of ultrasound and DSA imaging, the investigational device is advanced into the right…
- Trial name
- NCT07433504
- Testing
- Experimental: Transcatheter tricuspid valve repair using the transcatheter tricuspid valve clipping system +GDMT, Guideline Directed Medical Therapy
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Shanghai Huihe Medical Technology Co., Ltd
Neck, Shoulder and Arm Syndrome
How Does Implementing a GetUp Assist Device in Addition to a Daily Low-intensity Functional or Traditional Training Program Affect Norwegian Female Office Workers' Physical Health After 12 Weeks?
This study aims to quantify the effect of daily transition routines between sitting and standing behaviour with an additional daily low-intensity traditional or functional training program on the physical health of sedentary…
- Trial name
- NCT06463041
- Testing
- Experimental, comparator and control
- Where
- Norway
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Aalborg University
COPD
Rehabilitation Training With Music-support & Exercise Tolerance in COPD and CRF Patients.
Therapeutic-rehabilitative interventions supported by music can be considered important resources in many clinical contexts. Some studies report the improvement of psychological (i.e.
- Trial name
- NCT05720780
- Testing
- MS group, C group
- Where
- 6 sites in Italy
- Volunteers
- 156 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Ischemic Stroke
Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe
A phase III, randomized, multi-center, investigational, open label clinical trial that will examine whether treatment with endovascular thrombectomy is superior to standard medical therapy alone in patients who suffer a Distal…
- Trial name
- DUSK (NCT05983757)
- Testing
- Experimental: endovascular thrombectomy in patients who suffer a distal medium vessel occlusion, Standard medical management
- Where
- 4 sites in United States
- Volunteers
- 584 people
- Sponsor
- Raul Nogueira
Irritable Bowel Syndrome
Efficacy of Glutamine Supplementation in Patients Suffering From Irritable Bowel Syndrome With Impaired Intestinal Permeability
Irritable bowel syndrome (IBS) affects approximately 5% of the general population and remains a daily problem in the practice of clinicians with inconsistent effectiveness of treatments while patients' expectations are high.
- Trial name
- MISSISIIPI (NCT06291038)
- Testing
- • Experimental group: treatment with glutamine at a dose of 5g 3 times a day for 8 weeks, • Control group: treatment with a protein powder (Protifar) (Placébo) 5g 3 times a day for 8 weeks.
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Rouen
Tolerability of NT-301 Nasal Spray, Pharmacokinetics of NT-301 Nasal Spray
Clinical Trial of Intranasal Delivery of NT-301
The purpose of this research project is to investigate the safety and tolerability of an approved drug (Apomorphine) when administered as a nasal powder spray formulation (NT-301) as well as collect information on how NT-301…
- Conditions
- Tolerability of NT-301 Nasal Spray, Pharmacokinetics of NT-301 Nasal Spray, Safety of NT-301 Nasal Spray, Performance of NT-301 Nasal Spray Device
- Trial name
- APPROVE (NCT06954428)
- Testing
- NT-301 1 mg, NT-301 2 mg
- Where
- 2 sites in Australia
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Nano PharmaSolutions Australia
Prediabetes
Effect of a Nutritional Product Containing Carob Extract on Carbohydrate Metabolism in Glucose-intolerant Subjects
Randomized, controlled, double-blind clinical trial with two parallel arms based on the product consumed (experimental product and placebo product) and conducted at a single center, to measure the efficacy of the liquid NUTIFOOD…
- Trial name
- NUTIFOOD (NCT07420998)
- Testing
- Experimental Product, Control product
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Idiopathic Generalized Epilepsy
Blinking and Yawning in Epilepsy: The Role of Dopamine
The objective of the present study is to assess dopaminergic reactivity with behavioural markers (i.e. yawning and blinking) in patients with idiopathic generalized epilepsy compared to matched healthy controls, after injection…
- Trial name
- BYE BYE DOPA (NCT01432821)
- Testing
- Apomorphine (Experimental product)
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stress, Stress Disorders
Manage Your Workingnegative Thoughts Through Hypnosis
Medical doctor generally are exposed to several risks and pressures, it is not a case that several meta-analyses have shown high stress and anxiety level in these workers. Stress management represents a very important topic.
- Trial name
- Hypnosis (NCT06778109)
- Testing
- Experimental: Hypnosis and negative memory
- Where
- 2 sites in Italy
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Padova
Low Back Pain, Chronic Low-back Pain
AuriculoTherapy NeuroImaging
This is a clinical study of patients who have low back pain (for at least 6 months). The goal is to understand, with brain imaging, how auriculotherapy (an acupuncture-like stimulation of the ear) may work to relieve pain.
- Conditions
- Low Back Pain, Chronic Low-back Pain, Back Pain, Low, Lumbar Disc Disease
- Trial name
- ATNI (NCT06825390)
- Testing
- Cryo-auriculotherapy, Experimental auricular stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Keith M Vogt
Bone Sarcoma, Osteosarcoma
Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients
This is a multicenter phase II study concerning patients with high-grade bone sarcoma (HGBS) without complete remission after standard treatment at diagnosis or at relapse.
- Trial name
- REGOMAIN (NCT04698785)
- Testing
- Treatment by regorafenib and best supportive care
- Where
- 16 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre Leon Berard
Laxity; Skin, Volume Deficiency in the Mid-Face
Prospective Clinical Evaluation of the Safety and Performance of the Aesthetic Medical Device MEC REGENERATE® (Injectable Recombinant Collagen-based Product)
Prospective, spontaneous, open-label pre-market clinical trial with a single injection session; monitoring visits at baseline and 60 days post-treatment.
- Conditions
- Laxity; Skin, Volume Deficiency in the Mid-Face, Wrinkles
- Trial name
- NCT07413445
- Testing
- Treatment with experimental device
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- 303 Pharma s.r.l.
Cognitive Deficits, Mild
Microbiome-Targeted Enhancement of Neurocognition With Probiotics-Riboflavin Combination
This randomized, double-blind, placebo-controlled trial will evaluate whether 12 weeks of supplementation with the probiotic Lactobacillus rhamnosus GG combined with colon-delivered riboflavin will improve cognitive performance…
- Trial name
- MENTOR (NCT07410052)
- Testing
- Experimental 1, Experimental 2
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Center for Health Sciences, Serbia
Education
Video-supported Training in Line With the Health Belief Model
Summary The only treatment method for those with incurable, irreversible, progressive, acute or chronic liver disease is liver transplantation.
- Trial name
- NCT06138379
- Testing
- Experimental: 1st Experimental Group, Experimental: 2nd Experimental Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Inonu University
Ventilator Acquired Pneumonia, Central Line Associated Blood Stream Infections (CLABSI)
Evidence-Based Nursing to Reduce Adverse Events Regarding Ventilator Associated Pneumonia, Pressure Injuries and Central Line Bloodstream Infection in Intensive Care Unit in Bangladesh
Quality of care is crucial for preventing adverse events such as infection in the intensive care units (ICUs). The most common ICU-acquired infections include pneumonia such as Ventilator Associated Pneumonia (VAP), Pressure…
- Conditions
- Ventilator Acquired Pneumonia, Central Line Associated Blood Stream Infections (CLABSI), Pressure Ulcer (PU), Medical Device Related Pressure Ulcer (MDRPU)
- Trial name
- EBP in Nursing (NCT07299799)
- Testing
- Education with EBP, This is a pre- and post- quasi-experimental study.
- Where
- 2 sites in Bangladesh, Japan
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Gestatiaonl Diabetes Mellitus
to Investigate Impact of Diet and Physical Activity Based Nurse Led Interventions on Maternal Outcomes and Neonatal Outcomes in Women With Gestational Diabetes Mellitus (GDM)
Gestational Diabetes Mellitus (GDM) is a growing maternal health concern associated with adverse neonatal outcomes such as macrosomia and shoulder dystocia, often aggravated by poor dietary habits and physical inactivity during…
- Trial name
- NCT07382869
- Testing
- Arm chair exercise, Walk, Diet plan will be given to experimental group.
- Where
- Pakistan
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Patient Engagement, Intensive Care (ICU)
The Effect of Family Member Voices on Dopamine, Serotonin Levels, and Pain in Patients in Intensive Care Units
In intensive care units, the frequent use of analgesics leads to polypharmacy and increased costs for patients. By embracing a patient-centered care principle, nursing believes that patients may be happier and experience reduced…
- Conditions
- Patient Engagement, Intensive Care (ICU), Family Members' Voices
- Trial name
- NCT07404813
- Testing
- Experimental Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Zeliha CENGİZ
Neoplasms, High Grade Glioma
HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma
This study is a clinical trial to assess the efficacy and confirm the safety of intratumoral inoculation of G207 (an experimental virus therapy) combined with a single 5 Gy dose of radiation in recurrent/progressive pediatric…
- Conditions
- Neoplasms, High Grade Glioma, Glioblastoma Multiforme, Malignant Glioma of Brain
- Trial name
- NCT04482933
- Testing
- Biological G207
- Where
- 5 sites in United States
- Sponsor
- Pediatric Brain Tumor Consortium
Pain and Anxiety
The Effect of Virtual Reality on Pain and Anxiety During Colposcopic Biopsy: A Randomized Controlled Trial
The study was planned as a prospective, two-arm (1:1) randomized controlled experimental study to determine the effect of virtual reality applied during colposcopic biopsy on pain and anxiety.
- Trial name
- NCT06811259
- Testing
- Virtual reality (in experimental group), Standart care
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Mersin University
Herpes Zoster, mRNA Vaccine
Study to Evaluate the Safety and Immunogenicity of a Lyophilized Herpes Zoster Virus mRNA Vaccine
This clinical trial included two parts, Part A and Part B. The goal of Part A is to evaluate the safety and preliminary immunogenicity of the lyophilized herpes zoster virus mRNA vaccine (HZ mRNA vaccine) in healthy populations…
- Trial name
- NCT07400003
- Testing
- Low-dose experimental vaccine, High-dose experimental vaccine, Active-controlled vaccine A
- Where
- China
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd