Clinical trials: Experimental, completed
Depression
OxSYPan: Oxford Study With Young People on Antidepressants
Fluoxetine is commonly used to treat adolescent depression, but the neural mechanisms underlying antidepressant drugs in the young brain are still poorly understood.
- Trial name
- OxSYPan (NCT03436173)
- Testing
- Fluoxetine, Peppermint syrup
- Volunteers
- 32 people
- Sponsor
- University of Oxford
Atrial Fibrillation
Non-invasive Quantification of Atrial Fibrosis by MRI in Atrial Fibrillation
Three groups of patients will be considered: a control group (n = 10); a group of patients with paroxysmal or persistent AF with AF cryoablation procedure - within this group, MRI will replace CT-scan usually performed in routine…
- Trial name
- QUAFI (NCT02885883)
- Testing
- MRI 3T
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Stroke
Stroke Upper Limb Rehabilitation With Robot Operators: a Synergistic Approach for Human-Robot Interaction and Rehabilitative Trials.
In clinical scenario, clinical scales and kinematic analysis are usually used for the evaluation of patients. However, these methods are limited, since they may suffer from the lack of objectivity and sensitivity.
- Trial name
- SULLRO (NCT07768683)
- Testing
- Upper Limb robotic training
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Villa Beretta Rehabilitation Center
Atrial Fibrillation, Atrial Flutter
Suture Closure AFtEr VEIN Access for Cardiac Procedures (SAFE-VEIN) Trial
Primary objective: To compare the safety and efficacy of closure strategies post venous access procedures. Hypothesis: We anticipate that the use of a venous closure device will decrease the time to hemostasis (TTH), time to…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Heart Block, Pulmonary Embolism and Thrombosis
- Trial name
- SAFE-VEIN (NCT04632641)
- Testing
- Perclose ProGlide Suture-Mediated Closure System (SMC) - LARGE-BORE PROCEDURES, Figure 8 Suture - LARGE-BORE PROCEDURES
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Wake Forest University Health Sciences
Acute Mountain Sickness
Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide
The primary objective of the study will be to determine whether rapid remote limb ischemic preconditioning (RIPC) combined with acetazolamide can further reduce the incidence of acute mountain sickness (AMS) during the 6-hour…
- Trial name
- NCT05023941
- Testing
- Acetazolamide, Doctormate® (twice daily for 6 days), Doctormate® (forth daily for 3 days)
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Ji Xunming,MD,PhD
Tuberculosis
The Impact of Involving Informal Health Providers for Tuberculosis Control in Sudan
Training and engaging of unpaid informal providers (such as tea-sellers, women's groups, youth clubs, small traders and religious groups) from poorer localities in TB disease recognition, referral and community awareness raising…
- Trial name
- Triage-Plus (NCT01841541)
- Testing
- Referral of presumptive of TB cases by informal providers
- Where
- Sudan
- Volunteers
- 380 people
- Sponsor
- Liverpool School of Tropical Medicine
Increase Intake of Vegetables or Tomatoes, Health
Feasibility Study to Increase Vegetable Consumption
The objective of this study is to determine if differences exist in the total vegetable intake of groups that eat either tomato products versus raw vegetable product.
- Trial name
- VEG1 (NCT02287441)
- Testing
- Tomato, Raw
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Tobacco Use Cessation
Tobacco Quitlines:Adjunct to Dental Office Tobacco Intervention
The purpose of the study is to compare two methods for providing brief dental office-based interventions designed to help patients quit either cigarette smoking or smokeless tobacco use, and to compare these two dental…
- Trial name
- NCT00384254
- Testing
- 5 A, 3 A
- Where
- United States
- Volunteers
- 2,177 people
- Sponsor
- Oregon Research Institute
HER2-positive Breast Cancer, Stage III Ovarian Epithelial Cancer
Vaccine Therapy With Sargramostim (GM-CSF) in Treating Patients With Her-2 Positive Stage III-IV Breast Cancer or Ovarian Cancer
RATIONALE: Vaccines may help the body build an effective immune response to kill tumor cells. Colony-stimulating factors, such as GM-CSF, may increase the number of immune cells found in bone marrow or peripheral blood.
- Conditions
- HER2-positive Breast Cancer, Stage III Ovarian Epithelial Cancer, Stage III Ovarian Germ Cell Tumor, Stage IIIA Breast Cancer
- Trial name
- NCT00436254
- Testing
- pNGVL3-hICD vaccine, sargramostim, flow cytometry
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Washington
Alcohol Drinking, Alcohol Use Disorder
Effect of Theta Burst Stimulation on Alcohol Cue Reactivity
Alcohol Use Disorder (AUD) is prevalent, devastating, and difficult to treat. The intransigence of AUD is readily apparent in the Trauma Unit of Wake Forest University Baptist Hospital, wherein 23% of trauma related admissions…
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Trauma Injury, Alcohol Dependence
- Trial name
- NCT04223154
- Testing
- Real iTBS to the dlPFC
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
HIV, Sexual Behavior
Development of a Methamphetamine Early Intervention
Methamphetamine abuse has a strong and consistent epidemiologic association with high-risk sexual behavior and both prevalent and incident HIV in men who have sex with men (MSM), and some authorities have advocated…
- Conditions
- HIV, Sexual Behavior, Methamphetamine, Behavioral Research
- Trial name
- NCT01174654
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- University of Washington
Congenital Adrenal Hyperplasia
Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal Hyperplasia
This study is a randomized, double-blind, active-controlled, phase III study of Chronocort® compared with immediate-release hydrocortisone replacement therapy in participants aged 16 years and over with Congenital Adrenal…
- Trial name
- CONnECT (NCT05063994)
- Testing
- Chronocort, Cortef
- Where
- 21 sites in United States, France and 1 more
- Volunteers
- 55 people
- Sponsor
- Neurocrine UK Limited
Heart Failure With Reduced Ejection Fraction, Thoracic Epidural Anesthesia
Thoracic Epidural Anesthesia Reduces Mortality and Rehospitalization for Patients With Heart Failure With Reduced Ejection Fraction
Despite significant scientific breakthrough in management, patients with heart failure with reduced ejection fraction (HFrEF) remain high morbidity and mortality, with a 5-year survival rate of 25% after hospitalization for…
- Trial name
- NCT06068166
- Testing
- TEA plus GDMT, GDMT
- Volunteers
- 1,840 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Melatonin Bioavailability
Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects
This study is conducted to clinically document the melatonin and zinc bioavailability of a dietary supplement containing delayed release melatonin, zinc and lemon balm
- Trial name
- NCT05419466
- Testing
- dietary supplement, 1 tablet containing delayed release melatonin, zinc and lemon balm
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Larena SAS
Adult Solid Neoplasm
Tivantinib and Temsirolimus in Treating Patients With Solid Tumors That is Metastatic or Cannot be Removed by Surgery
This phase I trial studies the side effects and best dose of tivantinib when given in combination with temsirolimus in treating patients with solid tumors that have spread to other parts of the body or cannot be removed by…
- Trial name
- NCT01625156
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Temsirolimus
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
HIV Infections
CCR5 Inhibitor Treatment Intensification on CD4+ T-cell Recovery
CCTG 590 is a open-label study to evaluate the impact of therapy intensification with Maraviroc (MVC) (a CCR5 inhibitor) to a stable suppressive HIV antiretroviral regimen on the rate of CD4+ T-cell recovery and gene expression…
- Trial name
- NCT00925756
- Testing
- Maraviroc
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Diego
Malignant Neoplasm
Medical Physics Direct Patient Care for the Improvement of Patient Understanding of Care
This phase II trial studies how well medical physics direct patient care works in improving patients' understanding of their cancer treatment.
- Trial name
- NCT04266522
- Testing
- Informational Intervention, Counseling, Questionnaire Administration
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Asthma
Bronchodilator Properties and Safety in Asthma
Recent large clinical studies have demonstrated the interest of LAMA therapy in the management of asthma, when compared to LABA.
- Trial name
- NCT01951222
- Testing
- V0162
- Where
- Germany
- Volunteers
- 59 people
- Sponsor
- Pierre Fabre Medicament
Homeless Services, Human Services Training
Implementation, Fidelity, and Outcomes Following Novel and Usual Critical Time Intervention Training
Clinical social workers and other staff providing direct care to individuals experiencing homelessness face multiple challenges in obtaining training and implementing evidence-based practices in diverse community settings.
- Trial name
- NCT02427022
- Testing
- CTI
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Center for Social Innovation, Massachusetts
Self Harm
Multicenter Study to Evaluate the Clinical and Cost-effectiveness of a Culturally Adapted Therapy (C-MAP)
To evaluate the clinical and cost-effectiveness of a culturally adapted therapy (C-MAP) in patients with a history of self-harm
- Trial name
- C-MAP (NCT02742922)
- Testing
- Culturally adapted therapy (C-MAP)
- Where
- 7 sites in Pakistan
- Volunteers
- 901 people
- Sponsor
- Pakistan Institute of Living and Learning
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