Clinical trials: Experimental, completed
Advanced Solid Tumors
Safety Study of Bevacizumab, Everolimus and LBH589 (BEL) for Advanced Solid Tumors
The main purpose of this study is to test the safety of three study drugs, bevacizumab (Avastin™), Everolimus (Afinitor™) and LBH589 (Panobinostat) when they are given together.
- Trial name
- BEL (NCT01055795)
- Testing
- Bevacizumab, Everolimus and LBH589
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Herbert Hurwitz
Instability, Joint, Shoulder Dislocation
Improvement of Fatigue in Unstable Shoulder Through a Therapeutic Exercise Program in Physiotherapy
Background: Glenohumeral instability is a highly prevalent pathology; however, there is great controversy in its definition. Traditionally, structural problems such as labral injury or bone loss in the glenoid cavity were…
- Conditions
- Instability, Joint, Shoulder Dislocation, Fatigue, Therapeutic Alliance
- Trial name
- NCT05443295
- Testing
- MoveUS Program, Control intervention
- Where
- 2 sites in Spain
- Volunteers
- 108 people
- Sponsor
- University of Malaga
G6PD Deficiency
Validation of Diagnostics to Identify Glucose-6-phosphate Dehydrogenase Activity in the US
The primary objective of this study is to assess the accuracy of the SD Biosensor STANDARD G6PD Analyzer in measuring G6PD activity when used by trained health care workers.
- Trial name
- NCT04010695
- Testing
- SD Biosensor G6PD Analyzer, Pointe Scientific Test Kit, HemoCue System
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- PATH
Acne Vulgaris
Clinical Study Comparing the Efficacy and Safety of IDP-126 Gel in the Treatment of Acne Vulgaris
This is a multicenter, randomized, double-blind, vehicle-controlled, 12-week study designed to assess the safety, tolerability, and efficacy of IDP-126 Gel in comparison IDP-126 Vehicle Gel at Weeks 2, 4, 8, and 12.
- Trial name
- NCT04214639
- Testing
- IDP-126 Gel, IDP-126 Vehicle Gel
- Where
- 13 sites in United States, Canada
- Volunteers
- 183 people
- Sponsor
- Bausch Health Americas, Inc.
Hamstring Contractures
Neuromodulation in Patients With Hamstring Shortening
The flexibility of the hamstrings is a very important component both for general health and when exercising. The lack of hamstring flexibility has been related to the increase in the likelihood of suffering a large number of…
- Trial name
- NCT03637439
- Testing
- Ultrasound-guided Percutaneous Neuromodulation, Ultrasound-guided Percutaneous Needle
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Jose Antonio Garcia Vidal
Tuberculosis
Predictive Values of Next Generation Interferon Gamma Release Assays for Latent Tuberculosis Infection
This study will assess the next generation of blood tests for latent TB infection, which may be able to indicate how treatment is working as well as in diagnosis infection.
- Trial name
- NextGen (NCT02512939)
- Testing
- blood test, not yet marketed, no trade name
- Where
- 5 sites in United Kingdom
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- University College, London
Gingival Recession, Smoking
The Role of Smoking and Gingival Crevicular Fluid Markers on Coronally Advanced Flap Outcomes
Cigarette smoking is a patient-related factor that can affect healing of periodontal tissues and the success rate of root-coverage procedures.
- Trial name
- NCT03539939
- Testing
- Coronally Advanced Flap
- Volunteers
- 15 people
- Sponsor
- Ege University
Healthy
Study of an Extended Release (ER) Tablet, Single and Repeated Dosing
The purpose is to study the safety and tolerability of increasing doses of AZD1305 and how the medication is metabolised by the body (how it is taken up, distributed, and how it disappears from the body).
- Trial name
- NCT00689039
- Testing
- AZD1305
- Where
- Sweden
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Tobacco-Related Carcinoma
Examining the Impact of Nicotine Pouches in Rural Ohio and Ohio Appalachia
This clinical trial examines the impact of nicotine patches on preventing cancer in rural and Appalachia Ohio residents. Nicotine pouches are new smokeless tobacco products that are marketed as substitutes for smokeless tobacco…
- Trial name
- NCT05730439
- Testing
- Biospecimen Collection, Nicotine Oral Pouch, Questionnaire Administration
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Diabetes Mellitus, Type 2
Plant-Based Dietary Intervention in Type 2 Diabetes
The purpose of the study is to assess whether, in individuals with type 2 diabetes, a low-fat, vegan diet improves blood glucose control more effectively than a control diet based on current American Diabetes Association (ADA)…
- Trial name
- NCT00276939
- Testing
- Low-fat, low-Glycemic Index, vegan diet
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Physicians Committee for Responsible Medicine
Coronary Heart Disease
A Long Term Extension of Study NC19453 Evaluating Safety and Efficacy of RO4607381
This 2 arm study will assess the long term safety and efficacy of RO4607381 in patients with coronary heart disease or a coronary heart disease (CHD) risk equivalent who have completed study NC19453.
- Trial name
- NCT00400439
- Testing
- dalcetrapib (RO4607381)
- Where
- 9 sites in United States
- Volunteers
- 77 people
- Sponsor
- Hoffmann-La Roche
Obesity, NAFLD
Study of NGM395 in Adult Participants
Study of NGM395 in adult participants.
- Trial name
- NCT04187339
- Testing
- NGM395
- Where
- Australia
- Volunteers
- 38 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Moderate to Severe Plaque Psoriasis
Study of NDI-034858 in Participants With Moderate to Severe Plaque Psoriasis
This is a Phase 2b, randomized, multicenter, double-blind, placebo-controlled, multiple-dose study designed to evaluate the efficacy, safety, and tolerability of NDI-034858 in participants with moderate to severe plaque…
- Trial name
- NCT04999839
- Testing
- NDI-034858 study drug
- Where
- 69 sites in United States, Canada
- Volunteers
- 259 people
- Sponsor
- Takeda
Obsessive-Compulsive Disorder
Metacognitive Therapy for Patients With Obsessive-Compulsive Disorder
Cognitive behavior therapy is the most effective treatment of obsessive-compulsive disorder. However, the majority of treated patients remain symptomatic.
- Trial name
- NCT01483339
- Testing
- Metacognitive Therapy, Exposure and Response Prevention
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- Philipps University Marburg
Stomach Neoplasms
Docetaxel in Locally Advanced Gastric Adenocarcinoma
Study objectives: To determine Ro resection rate of Docetaxel, cisplatin and fluorouracil combination for the treatment of neoadjuvant gastric carcinoma.
- Trial name
- NEOTAX (NCT00343239)
- Testing
- Docetaxel, Cisplatin, Fluorouracil
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Sanofi
Healthy, Head and Neck Cancer
Rehabilitation Assessment and Progress Tracking System Based on Video Images for Dysphagic Patients
The current cervical range of motion (CROM) and tongue movement measurement methods are not reliable between observers, which is not practical in real-world usage.
- Trial name
- NCT05141539
- Testing
- Rehabilitation assessment software, VFSS and FOIS
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Gaucher Disease
Plant Cell Expressed Recombinant Human Glucocerebrosidase Extension Trial
Gaucher disease, the most prevalent lysosomal storage disorder, is caused by mutations in the human glucocerebrosidase gene (GCD) leading to reduced activity of the lysosomal enzyme glucocerebrosidase and thereby to the…
- Trial name
- NCT00705939
- Testing
- Taliglucerase alfa
- Where
- 11 sites in United States, Australia and 6 more
- Volunteers
- 45 people
- Sponsor
- Pfizer
Motivational Interview, Addiction
The Effect of Motivational Interviews on the Digital Game Addiction Levels of Nursing Students
The aim of this study is to reveal the effect of motivational interviewing based on change stages on digital game addiction. This study will be conducted with a total of 72 individuals assigned by a randomization site from all…
- Trial name
- NCT05457777
- Testing
- Motivational interview in digital game addiction
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fidan Balkaya
Previously Untreated and Histologically Confirmed Stage III (Unresectable) or Stage IV Melanoma
Study of Ipilimumab in the Immune System
Participants will be taking 3 mg/kg ipilimumab intravenously over a 90-minute period every 3 weeks for a total of four doses. Tumor-infiltrating lymphocytes (TILs)will be analyzed for functional characteristics.
- Trial name
- NCT01715077
- Testing
- Ipilimumab at 3 mg/kg dose
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University Health Network, Toronto
Carcinoma, Non-Small-Cell Lung
A Study of Dabrafenib in Combination With Trametinib in Chinese Patients With BRAF V600E Mutant Metastatic NSCLC
This was a single-arm, open label, multicenter phase II, study of dabrafenib in combination with trametinib in Chinese participants with BRAF V600E mutation positive, stage IV NSCLC (American joint committee on cancer staging 8th…
- Trial name
- NCT04452877
- Testing
- Dabrafenib, Trametinib
- Where
- 8 sites in China
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
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