Clinical trials: Experimental, completed
Recessive Dystrophic Epidermolysis Bullosa
A Study of PTR-01 in Recessive Dystrophic Epidermolysis Bullosa
Protocol PTR-01-002 is a 3-part Phase 2, open-label study of PTR-01. While new patients will be enrolled, priority will be given to patients that satisfactorily completed study PTR-01-001.
- Trial name
- NCT04599881
- Testing
- PTR-01
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Phoenix Tissue Repair, Inc.
Moderate to Severe Systemic Sclerosis
A Phase 3 Study of KHK4827 in Patients With Systemic Sclerosis
To evaluate the efficacy and safety of KHK4827 in patients with systemic sclerosis who have moderate to severe skin thickening
- Trial name
- NCT03957681
- Testing
- KHK4827
- Where
- 6 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Herpes Labialis
Efficacy and Safety Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis
The purpose of this study is to determine whether ME-609 is more efficient than acyclovir and placebo for the treatment of recurrent herpes labialis.
- Trial name
- NCT00361881
- Testing
- ME-609, acyclovir in ME-609 vehicle, Vehicle
- Where
- United States
- Volunteers
- 1,443 people
- Sponsor
- Medivir
Fasting, Fed
Use of Breath Acetone aa a Marker of Energy Balance
This study aims at assessing whether breath acetone concentration is a good bio-marker of instantaneous energy balance in healthy subjects.
- Trial name
- ACEX (NCT03390881)
- Testing
- Fasting condition, Sugar condition, Fat condition
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Schizophrenia
A Study of Olanzapine in Patients With Schizophrenia
The primary objectives of the study is to confirm if the efficacy of intramuscular injection (IM) olanzapine 10 milligrams (mg) in patients with an exacerbation of schizophrenia with acute psychotic agitation is greater than…
- Trial name
- NCT00970281
- Testing
- Rapid-Acting Intramuscular Olanzapine
- Where
- 11 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Eli Lilly and Company
Malaria
A Study of AdCh63 ME-TRAP Alone and With MVA ME-TRAP
This is an open label phase I study, to assess the safety of a novel malaria vaccine, AdCh63 ME-TRAP, simian adenovirus encoding Plasmodium falciparum antigens.
- Trial name
- NCT00890019
- Testing
- AdCh63 ME-TRAP, AdCh63 ME-TRAP; MVA ME-TRAP
- Where
- 2 sites in United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Intracranial Hemorrhages
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage
The overall goal is to establish the safety and efficacy of colchicine in ICH patients for the prevention of major cardiovascular events and brain injury.
- Trial name
- CoVasc-ICH (NCT05159219)
- Testing
- Colchicine Pill
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Critical Illness, Physical Disability
Neuromuscular Electrical Stimulation (NMES) Preserves Muscle Mass in Intensive Care Unit (ICU)
Background: Low-frequency neuromuscular electrical stimulation (NMES) attenuates the loss of muscle mass of Intensive Care Unit (ICU) patients.
- Conditions
- Critical Illness, Physical Disability, Muscle Atrophy
- Trial name
- NCT05287919
- Testing
- Patients received the standard physical therapy (SPT) programme (passive mobilization) twice a day., Patients received the low-frequency neuromuscular electrical stimulation (NMES), Patients received the medium-frequency neuromuscular electrical stimulation (NMES)
- Where
- Chile
- Volunteers
- 54 people
- Sponsor
- Gabriel Nasri Marzuca-Nassr
Muscle Damage, Oxidative Stress
Iron Supplementation and Eccentric Exercise
Iron supplementation is very common in athletes, probably due to its catalytic role on the oxygen transport and optimal function of oxidative enzymes and proteins during exercise.
- Trial name
- NCT02374619
- Testing
- Iron supplement Resoferon Ferrous Sulfate
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Stomatitis
Laser for Oral Mucositis in Pediatric Onco-hematology
Children with cancer undergoing intensive chemotherapy (CT) regimens experience many side effects among which oral mucositis (OM) is one of the most debilitating.
- Trial name
- LAMPO (NCT02762019)
- Testing
- Laser therapy
- Where
- 8 sites in Italy
- Volunteers
- 101 people
- Sponsor
- IRCCS Burlo Garofolo
Healthy
Single Dose Administration of Ketamine 10, 20, 40 and 80 mg and 5 mg Solution for Infusion in 15 Healthy Subjects
This study is designed for descriptive pharmacokinetic characterization of ketamine and norketamine in serum, urine and feces after oral single dose administration of a new developed prolonged release tablet formulation…
- Trial name
- NCT02494830
- Testing
- Ketamine
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Coronary Artery Disease, Adherence
Using Feedback Reports to Improve Medication Adherence
The purpose of this research study is to improve statin medication adherence among Veterans with coronary artery disease with poor adherence to medications.
- Trial name
- NCT02480530
- Testing
- Individual Feedback, Feedback Friend
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Alzheimer Disease 10, Dementia
Cognitive Stimulation Therapy
The concept of cognitive stimulation in AD is one of the most popular approaches. Cognitive Stimulation Therapy (CST) is stated to be evidence-based best practice with robust clinical trials, administered according to specific…
- Conditions
- Alzheimer Disease 10, Dementia, Apathy, Anxiety
- Trial name
- NCT05808530
- Testing
- Cognitive Stimulation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Hasan Kalyoncu University
Healthy
Study to Assess the Safety, Tolerability, and Pharmacokinetics of HFB30132A Against COVID-19 in Healthy Adults
The purpose of this study is to test the safety and tolerability of HFB30132A when it is given by intravenously to healthy participants.
- Trial name
- NCT04590430
- Testing
- HFB30132A
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- HiFiBiO Therapeutics
Healthy
Tolerability and Pharmacokinetics of BIIB 722 CL Drinking Solution and of BIIB 722 CL Filmcoated Tablet in Healthy Subjects
Safety and pharmacokinetics after oral single rising doses of BIIB 722 CL
- Trial name
- NCT02227030
- Testing
- BIIB 722 CL solution, BIIB 722 CL tablet
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Interventions Pain
The Effects on Pain of Acupressure and Foot Reflexology Before Heel Lancing in Newborns
This study aimed to determine the effects of foot reflexology and acupressure on the KI3 and St36 points on pain during interventions when these procedures were administered before heel lancing in term newborns.
- Trial name
- NCT04643730
- Testing
- Acupressure methods, Foot Reflexology Methods, Control Grup
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Cataract, Spherical Aberrations
Optical Quality After Implantation of a Spherical or Aspherical Intraocular Lens in Hypermetropic Patients
The purpose of this study is to evaluate differences in the depth of focus after implantation of a spherical or aspheric IOL in hypermetropic and emmetropic patients.
- Conditions
- Cataract, Spherical Aberrations, Intraocular Lenses, Depth of Focus
- Trial name
- NCT01995630
- Testing
- AMO Tecnis ZA9003, AMO Sensar AR40e
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Medical University of Graz
Melanoma
Randomised Study to Compare the Efficacy of AZD6244 vs TMZ
The primary purpose of this study is to compare the efficacy of AZD6244 (ARRY-142886) with temozolomide in patients with advanced melanoma
- Trial name
- NCT00338130
- Testing
- AZD6244, Temozolomide
- Where
- 33 sites in United States, Argentina and 8 more
- Volunteers
- 239 people
- Sponsor
- AstraZeneca
Healthy
A Multiple-ascending-dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Pomalidomide (CC-4047) in Healthy Male Subjects
To evaluate the safety, tolerability, and pharmacokinetics of pomalidomide administered orally once a day for 5 days, at daily doses of 0.5 mg, 1 mg, or 2 mg.
- Trial name
- NCT01474330
- Testing
- Pomalidomide
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Celgene
Pain, Postoperative
Pain After Tonsillectomy Study
Pain is a common experience in childhood. Healthy children can undergo up to 20 painful procedures by the age of 5. Moreover, millions of children undergo surgery (e.g., tonsillectomies) each year, which is commonly linked to…
- Trial name
- PAT (NCT03538730)
- Testing
- Memory Reframing
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Calgary
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