Clinical trials: Experimental, completed
Recessive Dystrophic Epidermolysis Bullosa
A Phase 1/2 Trial of PTR-01 in Adult Patients With Recessive Dystrophic Epidermolysis Bullosa (RDEB)
Protocol PTR-01-001 is a Phase 1/2 study of PTR-01. The study is divided into an up to 4-week Screening Period, a 10-week Treatment Period and an 8-week Follow-up Period.
- Trial name
- PTR-01-001 (NCT03752905)
- Testing
- PTR-01, Normal saline
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Phoenix Tissue Repair, Inc.
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Basophilic Leukemia
Vorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or Myelodysplastic Syndromes or Myeloproliferative Disorders
This phase I trial is studying the side effects and best dose of vorinostat when given together with cytarabine and etoposide in treating patients with relapsed or refractory acute leukemia or myelodysplastic syndromes or…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7)
- Trial name
- NCT00357305
- Testing
- vorinostat, cytarabine, etoposide
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Eating Disorders, Female Athlete Triad
Efficacy of the Female Athlete Body Project (FAB)
Given the cost of treating eating disorders and the substantial morbidity and mortality associated with these disorders, prevention of eating disorders has considerable public health significance.
- Trial name
- FAB (NCT01735994)
- Testing
- Healthy Weight, Brochure
- Where
- United States
- Volunteers
- 481 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Child Rearing, Risk Reduction Behavior
Age 9 Follow-up of Preventive Intervention (Denver)
To examine the impact of prenatal and infancy home visiting by paraprofessionals and by nurses from child age 2 through 9.
- Conditions
- Child Rearing, Risk Reduction Behavior, Reproductive Behavior
- Trial name
- DenverY09 (NCT00438594)
- Testing
- home visitation
- Volunteers
- 584 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Polycythemia Vera
Effects of Imatinib Mesylate in Polycythemia Vera
The purpose of this study is to determine the activity of Glivec 400 mg po daily, as single agent, in inducing a haematological response in Polycythemia Vera.
- Trial name
- NCT00430066
- Testing
- Imatinib Mesylate
- Volunteers
- 9 people
- Sponsor
- Niguarda Hospital
Healthy Males 65-75 Yrs Old
Determination of Protein Requirement in Elderly Male Subjects 65-75 Yrs Old.
Minimal data are available on protein requirements throughout the lifespan. Currently available recommendations are based on nitrogen balance data. The limitations of the nitrogen balance method have been well described.
- Trial name
- NCT01943266
- Testing
- protein intake
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Anxiety, Depression
CO-PARENT: COVID-19 - Parent Action in Response to Emotions and Needs for Treatment
The purpose of this research study is to collect information to better understand caregiver responses to COVID-19 stress and to help caregivers cope with these stressors.
- Conditions
- Anxiety, Depression, Traumatic Stress Disorder
- Trial name
- Co-PARENT (NCT04431856)
- Testing
- Unified Protocol for COVID-19 Parenting Stress (UP-COVID), SHG
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Miami
Leukemia, Myeloid, Acute
Phase I/IIa Trial to Investigate BI 6727 (Volasertib) as Monotherapy or in Combination With Cytarabine in Acute Myeloid Leukaemia
The trial will be performed in two parts, a phase I part and a phase IIa part. In the phase I part of the trial, BI 6727 will be investigated as monotherapy and in combination with low dose cytarabine (LD-Ara-C) in patients with…
- Trial name
- NCT00804856
- Testing
- Volasertib, Cytarabine
- Where
- 27 sites in Austria, Belgium and 5 more
- Volunteers
- 180 people
- Sponsor
- Boehringer Ingelheim
Tooth Loss
Ridge Preservation With Putty Allografts
The study will consist of randomized controlled clinical study trial comparing the results of a demineralized putty allorgraft versus a combined mineralized/demineralized putty allograft in approximately 30 patients, 15 per…
- Trial name
- NCT03956251
- Testing
- Combined Mineralized/Demineralized Putty Allograft, Demineralized Putty Allograft
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Obstetric, Violence Against Women
ROLE-PLAYİNG BASED TRAİNİNG ON OBSTETRİC VİOLENCE AWARENESS
This study was conducted to determine the effects of obstetric violence awareness training given to midwifery students through the role-playing technique on the students' perception levels of obstetric violence and midwifery care…
- Conditions
- Obstetric, Violence Against Women, Midwifery
- Trial name
- NCT07360951
- Testing
- Obstetric Violence Awareness Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Inonu University
Arterial Blood Gas Analysis Education
Concept Mapping and Gamification in Arterial Blood Gas Analysis Education
Arterial blood gas (ABG) analysis is a complex clinical competency that requires the integrated interpretation of acid-base balance, oxygenation, and ventilation parameters in relation to the clinical presentation.
- Trial name
- NCT07611851
- Testing
- Concept Mapping, Traditional Education, Gamification-Based Education
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cemile Nida Kayış
Diabetes Mellitus, Type 2
A Study To Evaluate The Safety And Efficacy Of An Investigational Diabetes Drug In Poorly Controlled Type II Diabetics
The purpose of this research study is to determine if a new investigational diabetes drug is safe and effective in treating people who have Type II diabetes mellitus with very high HbA1c or FPG (fasting plasma glucose) levels.
- Trial name
- NCT00067951
- Testing
- rosiglitazone/metformin
- Where
- 94 sites in United States, Australia and 3 more
- Volunteers
- 190 people
- Sponsor
- GlaxoSmithKline
Health Knowledge, Attitudes, Practice
Easy Peasy: Health Effects of Supplementation With Vegetables
The proposed study aims to test the effects of supplementing healthy individuals (with low baseline vegetable consumption) with 5 servings of vegetables (80-120g per serving) per day for 4 weeks on blood lipids and other…
- Trial name
- NCT05869929
- Testing
- Vegetables
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Migraine in Children, Migraine
A Study in Children and Young People With Migraine to Learn What the Body Does to Eptinezumab
The purpose of the study is to investigate how the body absorbs, distributes, and get rid of eptinezumab when given directly into a vein.
- Trial name
- NCT04537429
- Testing
- Eptinezumab
- Where
- 9 sites in United States
- Volunteers
- 28 people
- Sponsor
- H. Lundbeck A/S
ADHD
Neurobiological Basis of Response to Vyvanse in Adults With ADHD: an fMRI Study of Brain Activation
The purpose of this study is to determine the effects of Vyvanse, an FDA approved medication used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD), on brain activity in adults with attention-deficit…
- Trial name
- NCT01924429
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jeffrey Newcorn
Radiculopathy Lumbar, Low Back Pain
Evaluation of Transforaminal Epidural Steroid Injection in Radicular Low Back Pain According to MSU Classification
Low back pain is a common disease in all ages and it effects seriously quality of life. Medical treatment,interventional methods and surgery are the treatment options.
- Conditions
- Radiculopathy Lumbar, Low Back Pain, Disc Herniation, Injections, Epidural
- Trial name
- NCT06275529
- Testing
- Transforaminal Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Chronic Plaque-type Psoriasis
AIN457 Regimen Finding Study in Patients With Moderate to Severe Psoriasis
The purpose of the study is to determine whether, in patients with moderate to severe plaque-type psoriasis, AIN457 administered subcutaneously reduces the severity of psoriasis symptoms and the extent to which the patient's body…
- Trial name
- NCT00941031
- Testing
- AIN457, AIN457A
- Where
- 62 sites in United States, France and 5 more
- Volunteers
- 404 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Postoperative Sore Throat, Cough, Hoarseness
Hyaluronic Acid for Prevention of Post-Intubation Sore Throat and Hoarseness
The goal of this clinical trial is to find out whether applying Endotra Gel, a hyaluronic acid-based gel, to the endotracheal tube can help reduce sore throat and hoarseness after surgery.
- Conditions
- Breast Cancer, Postoperative Sore Throat, Cough, Hoarseness, Endotracheal Intubation, General Anesthesia
- Trial name
- NCT07040631
- Testing
- Endotra Gel
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Pusan National University Yangsan Hospital
Limbus Corneae Insufficiency Syndrome
Safety Study of Stem Cell Transplant to Treat Limbus Insufficiency Syndrome
The purpose of the study is to determine whether allogenic bone marrow stem cell transplant is safe and effective in the treatment of limbus insufficiency syndrome versus allogenic limbus stem cell transplant.
- Trial name
- NCT01562002
- Testing
- Stem Cell with Amniotic Membrane Transplant
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Rheumatoid Arthritis
A Study Assessing the Safety and Efficacy of Sarilumab Added to Non-MTX DMARDs or as Monotherapy in Japanese Patients With Active Rheumatoid Arthritis (SARIL-RA-HARUKA)
Primary Objective: To document the long-term safety of sarilumab added to non-methotrexate (non-MTX) disease-modifying antirheumatic drugs (DMARDs) or as monotherapy.
- Trial name
- NCT02373202
- Testing
- Sarilumab, Sulfasalazine, Leflunomide
- Where
- 40 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Sanofi
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