Clinical trials: Experimental, completed
Healthy Adult Subjects, Healthy Elderly Subjects
Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers
This is the first clinical trial to evaluate ascending multiple oral doses in healthy adult and healthy elderly subjects to characterize the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BIIB118
- Trial name
- NCT02691702
- Testing
- BIIB118, Melatonin
- Where
- 2 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Biogen
Feeding and Eating Disorders of Childhood
Impact of the "Ten Steps for Healthy Feeding of Children Younger Than Two Years" in Health Centers
A cluster randomized field trial to evaluate the impact that training healthcare workers in healthy feeding practices has on the nutrition and health of children.
- Trial name
- NCT00635453
- Testing
- Dietary Advice
- Where
- Brazil
- Volunteers
- 715 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Neonatal Respiratory Failure, Tracheal Intubation Morbidity
Providing Oxygen During Intubation in the NICU Trial
Tracheal intubation in the NICU is frequently complicated by severe oxygen desaturation. Apneic oxygenation, a method of applying free flowing oxygen via nasal cannula to apneic patients undergoing intubation, prevents or delays…
- Trial name
- POINT (NCT05451953)
- Testing
- Apneic Oxygenation, Standard of Care
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Healthy Subjects, Bioavailability
Bioavailability of Oleanolic Acid Formulated as Functional Olive Oil
The oral bioavailability of Oleanolic acid (OA) when formulated as functional olive oil, and its mechanisms of systemic transport, will be approached by mean of randomized and controlled trial with 20 healthy volunteers.
- Trial name
- BIO-OLTRAD (NCT05529953)
- Testing
- Oleanolic acid (CAS no. 598-02-1; PubChem CID 10494), Control commercial olive oil
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council
Fallopian Tube Cancer, Ovarian Cancer
Study Comparing Tumor Debulking Surgery Versus Chemotherapy Alone in Recurrent Platinum-Sensitive Ovarian Cancer
It is still not clear whether a positive AGO-score just selects patients with less aggressive biologic tumor behavior who as well would have had a positive outcome by chemotherapy only, or , if it is a score selecting patients…
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
- Trial name
- DESKTOPIII (NCT01166737)
- Testing
- Tumor Debulking Surgery (surgery in recurrent ovarian disease)
- Where
- 86 sites in Austria, Belgium and 10 more
- Volunteers
- 408 people
- Sponsor
- AGO Study Group
Tardive Dyskinesia
NBI-98854 for the Treatment of Tardive Dyskinesia in Subjects With Schizophrenia or Schizoaffective Disorder (KINECT Study)
The purpose of this study is to evaluate the efficacy, safety, and tolerability of two doses (50 and 100 mg) of NBI-98854 administered once daily for the treatment of Tardive Dyskinesia (TD) symptoms.
- Trial name
- NCT01688037
- Testing
- NBI-98854
- Where
- 51 sites in United States, Puerto Rico
- Volunteers
- 109 people
- Sponsor
- Neurocrine Biosciences
Postural Orthostatic Tachycardia Syndrome
A Shared Medical Appointment Intervention for Quality of Life Improvement in POTS
Postural orthostatic tachycardia syndrome (POTS) is a clinical syndrome encompassing a myriad of debilitating symptoms that does not have any FDA approved drug therapies.
- Trial name
- NCT05454137
- Testing
- Shared medical appointment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arizona
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Stem Cell Mobilization in Diabetic Neuropathy Subjects Receiving SB-509
The primary and secondary objectives of this study are: Primary: To evaluate stem-cell-mobilization in subjects with diabetic neuropathy receiving SB-509.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Polyneuropathy
- Trial name
- NCT00665145
- Testing
- SB-509
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Sangamo Therapeutics
Myocarditis
AbataCept for the Treatment of Immune-cHeckpoint Inhibitors Induced mYocarditiS
Immune-checkpoint-inhibitors (ICI) have revolutionized treatment for about 20 cancer types. They unleash anti-tumor immune responses.
- Trial name
- ACHLYS (NCT05195645)
- Testing
- Abatacept 250 MG
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dry Eye Syndrome
SYSTANE® Family - Meibomian Deficiency
The purpose of this study was to assess the efficacy of the SYSTANE® family of products (SYSTANE® Lid Wipes, SYSTANE® BALANCE Lubricant Eye Drops, and SYSTANE® Vitamins) on meibomian gland functionality in subjects with lipid…
- Trial name
- M-12-077 (NCT01733745)
- Testing
- SYSTANE® Lid Wipes, SYSTANE® BALANCE, SYSTANE® Vitamins
- Volunteers
- 26 people
- Sponsor
- Alcon Research
Dermatology/Skin - Other
Photograph Quality Rating Scale Study ("PQRS Study")
Advances in smart phone-based photography (both quality and image transmission) offer the potential to greatly improve access to pediatric dermatologists.
- Trial name
- PQRS (NCT03246945)
- Testing
- Instructions on taking photographs provided, see methods
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Healthy
Comparison of Mechanical Penetration Enhancers on Metvixia Skin Penetration
Exploratory, mono-center, randomized, intra-individual, controlled trial involving healthy volunteers to compare the effect on MAL penetration into the skin following various mechanical penetration enhancement techniques.
- Trial name
- NCT02511145
- Testing
- occlusive bandage, ablative fractional CO2 laser pretreatment, Microneedles pretreatment
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Breast Carcinoma, Breast Ductal Carcinoma In Situ
Effect of PACK Health Support Program on Patient Reported Outcomes in Patients With Breast Cancer
This trial studies the effect of an electronic health (eHealth) support program called PACK Health on patient reported health outcomes in patients with breast cancer.
- Conditions
- Breast Carcinoma, Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma, Recurrent Breast Carcinoma
- Trial name
- NCT04022772
- Testing
- Best Practice, Medical Chart Review, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- M.D. Anderson Cancer Center
Sleep Apnea
Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea
Currently, there is no pharmacological intervention for OSA that targets multiple pathophysiological deficits in combination. Here the investigators study the effect on sleep apnea severity of combinations of pharmacological…
- Trial name
- ComboPlus (NCT03892772)
- Testing
- SAS0421a, SAS0421b, SAS0421c
- Where
- 2 sites in United States, Australia
- Volunteers
- 23 people
- Sponsor
- Brigham and Women's Hospital
Vascular Reaction to Medications
Variability in Adrenergic Response
The goal of this project is to determine the genetic factors contributing to interindividual differences in response to physiological and pharmacological vasoconstrictors and vasodilators.
- Trial name
- NCT00838695
- Testing
- Phenylephrine
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Healthy
A Study of the Absorption, Metabolism, and Excretion of Tucatinib in Healthy Participants
This study will look at how a drug (tucatinib) leaves the body and what happens to tucatinib while it is still in the body. Healthy participants will get one dose of tucatinib by mouth.
- Trial name
- NCT03758339
- Testing
- tucatinib
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cascadian Therapeutics Inc.
Effectiveness of SMS to Fix PC Interval
Effectiveness of Fixed PC Interval Using SMS for Afternoon Colonoscopy
The purpose of this study is to evaluate the effectiveness of SMS (short message service of mobile phone) reminder to fix PC interval for bowel preparation in afternoon colonoscopy.
- Trial name
- NCT01675739
- Testing
- Short message service of mobile phone (SMS), polyethylene glycol (PEG)
- Where
- South Korea
- Volunteers
- 280 people
- Sponsor
- Inje University
Breast Cancer, Metastatic Cancer
Irinotecan and Temozolomide in Treating Patients With Breast Cancer Who Have Received Previous Treatment for Brain Metastases
RATIONALE: Drugs used in chemotherapy, such as irinotecan and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00617539
- Testing
- irinotecan hydrochloride, temozolomide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Gut Microbiome, Glucose Control
Exploring Glycemic Responses Through Continuous Monitoring in a Healthy Population
PREDICT REFINE is a sub-study of PREDICT 3 with the primary aim of exploring glycemic responses through continuous glucose monitoring in a healthy population.
- Trial name
- NCT06900439
- Testing
- Dietary Intervention
- Where
- United Kingdom
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Zoe Global Limited
Tuberculosis
Food Effect Study on the Bioavailability and PK of PA-824 Tablets in Healthy Adult Subjects (CL-009)
This will be a Phase 1, single-center, randomized, balanced, single-dose, two-period, two-sequence, crossover, open-label study to evaluate the effect of food on the pharmacokinetics of PA-824.
- Trial name
- CL-009 (NCT01830439)
- Testing
- PA-824 200mg, PA-824 50mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Global Alliance for TB Drug Development
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