Clinical trials: Experimental, completed
Diabetes Mellitus, Type 1
MyDiaText Text Messaging Intervention for Diabetes
To test a text messaging intervention using MyDiaText and financial incentives to determine whether such an intervention will improve self-reported self-care behaviors in children 12 to 18 years old.
- Trial name
- NCT02927639
- Testing
- MyDiaText
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Children's Hospital of Philadelphia
Colorectal Cancer
Dose Finding and Pharmacokinetics/Pharmacodynamics Study of Apatinib in the Treatment of Advanced Colorectal Cancer
RATIONALE: Apatinib is a tyrosin-inhibitor agent targeting at vascular endothelial growth factor receptor (VEGFR), and it's anti-angiogenesis effect has been viewed in preclinical tests.
- Trial name
- NCT01531777
- Testing
- Apatinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Hypertension
Internet-Based Strategic Transdisciplinary Approach To Risk Reduction And Treatment
I-START is a randomized controlled trial that will evaluate the efficacy of an internet-based program of behavioural counseling for adaptive lifestyle change to subjects diagnosed with hypertension.
- Trial name
- I-START (NCT00815477)
- Testing
- Web-based lifestyle counseling messages, Generic Information
- Where
- 3 sites in Canada
- Volunteers
- 387 people
- Sponsor
- University Health Network, Toronto
Healthy
Buprenorphine Disposition and CYP3A
To evaluate role of CYP3A in buprenorphine disposition and effect
- Trial name
- NCT01576575
- Testing
- Buprenorphine Control, Buprenorphine + Rifampin, Buprenorphine + Grapefruit juice
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obstructive Sleep Apnea, Central Sleep Apnea
Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing
The purpose of this study is to evaluate the accuracy of Somnarus diagnostic technology for diagnosis of sleep apnea in human subjects.
- Conditions
- Obstructive Sleep Apnea, Central Sleep Apnea, Mixed Sleep Apnea, Cheyne-Stokes Respiration
- Trial name
- NCT02034175
- Testing
- SomnaPatch, Polysomnography
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Somnarus Inc
Postoperative Ileus
Goal Directed Fluid Therapy and Postoperative Ileus
Despite Goal Directed Fluid Therapy (GDFT) has shown a reduction of hospitalization and overall complications in patients undergoing abdominal surgery, there is a need to address the effect of implementing GDFT on the incidence…
- Trial name
- NCT01818375
- Testing
- Goal Directed Fluid Therapy (GDFT)-Esophageal doppler guided, Standard fluid therapy
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- Gabriele Baldini, MD, MSc, Assistant Professor
Ventilator Associated Pneumonia ( VAP), Sepsis
High Dose of Vitamin C on Mechanically Ventilated Septic Patients in Intensive Care Unit
Prospective, Randomized clinical trial study will be carried out in intensive care unit in Ain Shams University Hospitals on 40 forty septic patients admitted to ICU and mechanically ventilated.
- Trial name
- NCT04029675
- Testing
- Vitamin C
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Simulation-based Learning, Communication Skills
Therapeutic Communication Training in Perinatal Loss: Simulation-Based Approaches
This study aims to evaluate the effect of simulation-based education on nursing students' therapeutic communication skills in managing perinatal loss.
- Conditions
- Simulation-based Learning, Communication Skills, Paper-Pencil Simulation, High-fidelity Simulation
- Trial name
- NCT06959875
- Testing
- High-Fidelity Simulation-Based Therapeutic Communication Training, Paper-Pencil Simulation-Based Therapeutic Communication Training
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Migraine
A Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Elismetrep (K-304) in the Treatment of Migraine
This is a double-blind, randomized, multicenter, outpatient evaluation of the safety and efficacy of elismetrep as compared to placebo in the acute treatment of migraine.
- Trial name
- NCT06848075
- Testing
- Elismetrep (K-304) 2 mg, Elismetrep (K-304) 5 mg, Elismetrep (K-304) 10 mg
- Where
- 66 sites in United States
- Volunteers
- 431 people
- Sponsor
- TriGemX Bio, Inc.
Myelodysplastic Syndrome
Clofarabine in High Risk Myelodysplastic Syndrome (MDS)
This study aims to determine the maximal tolerated dose (MTD) and dose limiting toxicities (DLTs) of low dose IV clofarabine for MDS patients after treatment failure of azacitidine.
- Trial name
- NCT01063257
- Testing
- Clofarabine
- Where
- 5 sites in France
- Volunteers
- 76 people
- Sponsor
- Groupe Francophone des Myelodysplasies
COPD
The Effect of Inhaled PUL-042 on Rhinovirus-induced Symptoms in Smokers With GOLD Stage 0 COPD
This is a study examining the effect of inhaled PUL-042 on peak lower respiratory symptoms as measured by subject diary in early stage COPD subjects who are experimentally infected with rhinovirus.
- Trial name
- NCT03794557
- Testing
- Sterile Water Injection, PUL-042 Inhalation Solution
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Pulmotect, Inc.
Weightlessness, Weightlessness; Adverse Effect
Thigh Cuffs to Prevent the Deconditioning Induced by 5 Days of Dry Immersion
The objective of the study is to investigate whether thigh cuffs help to prevent and/or reduce the deconditioning induced by 5 days of dry immersion and in particular the fluid shift and its related ophthalmological disorders.
- Trial name
- DI-Cuff (NCT03915457)
- Testing
- Dry immersion Control Group, Thigh cuffs intervention
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Healthy
A Multiple Ascending Dose Study to Investigate Safety of KBP-7072 in Healthy Subjects
This is a double-blind, placebo-controlled, multiple oral dose study to evaluate safety, tolerability, and pharmacokinetic of KBP-7072 in healthy subjects.
- Trial name
- NCT04532957
- Testing
- KBP-7072
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KBP Biosciences
Leukemia
Clofarabine, Idarubicin, and Cytarabine (CIA) Versus Fludarabine, Idarubicin, and Cytarabine (FLAI) in Acute Myelogenous Leukemia (AML) and High-Risk Myelodysplastic Syndrome
The goal of this clinical research study is to learn if the combination of clofarabine, idarubicin, and cytarabine, or the combination of fludarabine, idarubicin, and cytarabine can help control Acute myeloid leukemia (AML) and…
- Trial name
- NCT01289457
- Testing
- Clofarabine, Idarubicin, Cytarabine
- Where
- United States
- Volunteers
- 282 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
A Safety and Immunology Study of a Modified Vaccinia Vaccine for HER-2(+) Metastatic Breast Cancer
The current trial, BNIT-BR-002, will evaluate the safety and biological activity of a fixed dose of MVA-BN®-HER2, with and without Herceptin, following 1st- or 2nd-line chemotherapy in patients with Her-2-positive metastatic…
- Trial name
- NCT00485277
- Testing
- MVA-BN-HER2
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Bavarian Nordic
Health Behavior, Motor Activity
Healthy Habits Program for High Cardiovascular Risk Patients: Randomized Controlled Clinical Trial
The purpose of this study is to determine the effectiveness of a program to improve habits in a population with cardiovascular disease, comparing two different educational techniques (cognitive behavioral therapy group vs.
- Conditions
- Health Behavior, Motor Activity, Food Habits
- Trial name
- NCT01861977
- Testing
- Cognitive Behavioral Therapy, Informational Workshop
- Where
- Argentina
- Volunteers
- 101 people
- Sponsor
- Hospital Italiano de Buenos Aires
Atopic Asthma
Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites
The aim of this study is to draw blood from patients with well-defined atopic asthma that will be subsequently used in invitro experiments to investigate the activation potency of Prostaglandin D2 metabolites to the DP2 receptor…
- Trial name
- 18-03 EONOV (NCT03665701)
- Testing
- Blood Sampling
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Ultrasound Guided Central Venous Cannulation
Ultrasound Guided Axillary Venous Cannulation in Pediatrics
The purpose of this prospective randomized study was to compare landmark-subclavian venous access to ultrasound-guided axillary venous access when performed by pediatric anesthesiologists.
- Trial name
- NCT02806401
- Testing
- landmark, US_Ax
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Seoul National University Hospital
Genu Varum, Genu Valgus
IMU-based Assessment of Motor Control in a Population of Young Subjects With Paramorphisms and Dysmorphisms
While various complex pathologies of the developmental age, such as Infantile Cerebral Palsy or Neuromuscular Diseases, are notoriously considered causes of alteration of locomotor development, it is scarcely known whether…
- Conditions
- Genu Varum, Genu Valgus, Flat Feet, Cavus Foot
- Trial name
- MOTOR-CHILD (NCT05763901)
- Testing
- Clinical tests and motor control evaluation using Inertial Measurement Units
- Where
- Italy
- Volunteers
- 151 people
- Sponsor
- Istituto Ortopedico Rizzoli
Metabolic Health, Fruit and Vegetable Intake
Comparing Approaches to Increasing Fruit and Vegetable Intake and Their Influence on Metabolic Health
This experimental study aims to evaluate the effects of different strategies for increasing fruit and vegetable intake and to see how these interventions influence markers of health in people aged 18-65 who currently consume…
- Trial name
- NCT06628401
- Testing
- Educational information (Control), Educational information (Increasing F&V intake), Educational information (Increasing F&V intake + Juice)
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Courtney Neal
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