Clinical trials: Experimental, completed
Healthy Volunteers
Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 3 of 4)
The purpose of this study is to evaluate the ability of PRT064445 to reverse the effects of several blood thinner drugs on laboratory tests. The study also is evaluating the blood levels of PRT064445 given at different doses.
- Trial name
- NCT03551730
- Testing
- PRT064445/Enoxaparin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Portola Pharmaceuticals
Obesity, Overweight
The Effect of Mashed Potato Composition on Food Intake, Satiety and Blood Glucose
Potato is one of the world's most popular foods and is widely accepted as a staple food. The objective of this study is to determine the effect of consuming instant mashed potatoes with and without fat on glycemic response…
- Conditions
- Obesity, Overweight, Diabetes, Metabolic Syndrome
- Trial name
- NCT02009254
- Testing
- Dietary treatment
- Sponsor
- University of Toronto
Schizophrenia
Safety and Tolerability Study of Drug to Treat Schizophrenia
The purpose of this study is to evaluate the long-term safety of SM-13496 in patients with schizophrenia.
- Trial name
- NCT00044005
- Testing
- Lurasidone 20 mg, Lurasidone 40 mg, Lurasidone 80mg
- Where
- 26 sites in United States
- Volunteers
- 98 people
- Sponsor
- Sumitomo Pharma America, Inc.
Malocclusion, Angle Class II
Low-level Laser Therapy With a 635nm Diode Laser on Orthodontic Mini-implants Stability.
The study aimed to clinically estimate an influence of a 635nm diode laser on the primary and secondary stability of orthodontic mini-implants placed in a maxilla, to assess mini-implants failure rate (mini-implant loss) and to…
- Trial name
- NCT04175405
- Testing
- Irradiation of implants with 635nm laser
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Tobacco Use
Be A Quitter: Illinois Small Business EX Program Dissemination
Disseminate the EX tobacco cessation program to Illinois small businesses
- Trial name
- NCT07097194
- Testing
- EX program
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Healthy
Effect of Multiple BI 1356 Doses of on the Multiple-dose Pharmacokinetics of a Combination of Ethinylestradiol and Levonorgestrel in Healthy Female Premenopausal Subjects
The objective was to investigate the effect of multiple oral doses of 5 mg BI 1356 on the steady-state pharmacokinetics of ethinylestradiol (EE) and levonorgestrel (LNG), the components of Microgynon®
- Trial name
- NCT02175394
- Testing
- Microgynon®, BI 1356
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Autism
Treatment for Children With Autism and Anxiety
Children with high-functioning autism spectrum disorders (ASD) are at high risk for developing significant anxiety symptoms. Cognitive behavior therapies (CBT) are frequently used for children with anxiety symptoms with good…
- Trial name
- NCT01727466
- Testing
- Facing Your Fears
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Asthma, Sleep
Sleep Quality in High School Students With Asthma - II
The overall goal of this project is to develop and to preliminarily validate a novel intervention to be delivered in the high school setting that integrates two evidence-based, school-based interventions for urban adolescents…
- Conditions
- Asthma, Sleep, Asthma in Children
- Trial name
- NCT03329066
- Testing
- MAST - Managing Asthma & Sleep in Teens, ASMA - Asthma Self-Management for Adol, Information & Referral Control Group
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Columbia University
Port Wine Stain
A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.
The researchers want to collect data on safety and efficacy of combined pulsed dye laser and rapamycin to improve fading/blanching of port wine stain birthmarks as compared to pulsed dye laser alone, which is the current standard…
- Trial name
- NCT00830466
- Testing
- Laser and rapamycin versus laser alone
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, Irvine
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Cyclosporine Drug Interaction on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers. Drug-Drug Interaction 2 (DDI2) Study
The main goal of this pharmacokinetic study in healthy volunteers is to evaluate the potential effect of cyclosporine (probe inhibitor of P glycoprotein [P-gp] and breast cancer resistance protein [BCRP] transporters) on CHF6001…
- Trial name
- DDI2 (NCT06892756)
- Testing
- CHF6001 dry powder inhaler (DPI), Cyclosporine, CHF6001 DPI
- Where
- Bulgaria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Epithelial Ovarian Cancer, Fallopian Tube Cancer
Intraperitoneal Therapy For Ovarian Cancer With Carboplatin Trial
The purpose of this study is: Phase A: To confirm the feasibility of paclitaxel administered by intravenous (IV) infusion weekly plus concurrent carboplatin administered by intraperitoneal (IP) injection once every 3 weeks…
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- iPocc (NCT01506856)
- Testing
- Paclitaxel(intravenous) + Carboplatin(intravenous), Paclitaxel(intravenous) + Carboplatin(intraperitoneal)
- Where
- 62 sites in United States, Hong Kong and 4 more
- Volunteers
- 655 people
- Sponsor
- Gynecologic Oncology Trial & Investigation Consortium
Arthroplasty, Replacement, Knee, Robotics
Comparison of Ambulatory and Functional Improvement by Morning Walk
The aim of this study is to determine the clinical efficacy and feasability of gait rehabilitation robot through approving functional improvement by an end-effector typed gait robot in patients underwent total knee arthroplasty.
- Trial name
- NCT03183856
- Testing
- Morning walk, no Morning walk
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Ulsan University Hospital
Overweight and Obesity
Familial Overweight: Comparing Use of Strategies
The purpose of this study is to compare the efficacy of two different approaches (prescribed \& self-directed) to the treatment of childhood obesity and their relative impact on child weight status, physical activity, and diet.
- Trial name
- FOCUS (NCT00746629)
- Testing
- FOCUS
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Recurrent Ovarian Carcinoma
Atezolizumab With Bevacizumab and Chemotherapy vs Bevacizumab and Chemotherapy in Early Relapse Ovarian Cancer
This is a phase III, randomized, partially blinded, multicenter trial to evaluate the efficacy and safety of atezolizumab plus bevacizumab and chemotherapy compared to placebo plus bevacizumab and chemotherapy in patients with…
- Trial name
- NCT03353831
- Testing
- Bevacizumab, Atezolizumab, Chemotherapy
- Where
- 111 sites in Austria, Belgium and 10 more
- Volunteers
- 574 people
- Sponsor
- AGO Research GmbH
Diabetes Mellitus Type 2
Effectiveness of Two Interventions in Patients With Low Educational Level With Diabetes to Reduce Inequalities in Self-care Behavior
The purpose of this cluster randomized trial is to determine whether an intervention implemented in a General Surgery, based in improving patient-provider communication, results in a better diabetes self-management in patients…
- Trial name
- NCT01849731
- Testing
- Face-to-face, Face-to-face intervention plus telephone reinforcement
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- Andalusian School of Public Health
Type 1 Diabetes, Hypoglycemia
Pilot Feasibility Study for HypoPals, a Mobile Health Program for Improving Hypoglycemia Management.
A mobile health program "HypoPals", which incorporates data from continuous glucose monitoring systems (CGMs) and sends personalized text messages to help people sharpen their low blood sugar symptom detection skills, and help…
- Trial name
- NCT05916131
- Testing
- Basic Education, Hypoglycemia Symptom Detection Training, Education Plus
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
COPD
Effect of an Individual Counseling Session on Physical Activity Level of Individuals With COPD
The goal of this randomized clinical trial is to study the effect of an individual counseling session on the level of physical activity and motivation to practice physical exercise in individuals with COPD.
- Trial name
- NCT05961553
- Testing
- Physical Activity Counseling session, Pulmonary Reabilitation
- Where
- Portugal
- Volunteers
- 22 people
- Sponsor
- Polytechnic Institute of Porto
Tooth Decay
Surgical Extrusion for the Clinical Crown Lengthening: a 12-months Clinical Study
This is a prospective study in which surgical extrusion of single-rooted teeth is carried out by the same operator in 15 consecutive patients.
- Trial name
- NCT04350853
- Testing
- Surgical extrusion
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Universitat Internacional de Catalunya
Invasive Aspergillosis
F901318 Single Ascending Dose Study in Healthy Male Volunteers
F901318 is a potent new antifungal agent for the treatment of systemic fungal infections. This study will test it for the first time in man with the objective of assessing its safety, tolerability and pharmacokinetic profile.
- Trial name
- NCT02142153
- Testing
- F901318
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- F2G Ltd
Allergic Rhinitis, Rhinitis, Allergic
AI-Guided Ultrasound Needling of Xinwu Point for Allergic Rhinitis
This study evaluated a new way to perform acupuncture at a deep point called the Xinwu point (sphenopalatine ganglion) for allergic rhinitis (hay fever-like nasal allergy).
- Trial name
- NCT07778537
- Testing
- AI-guided Xinwu-point acupuncture, Blind Xinwu-point acupuncture
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Daxing Teaching Hospital, Capital Medical University
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