Clinical trials: Experimental
Primary Open Angle Glaucoma (POAG), Primary Open Angle Glaucoma of Both Eyes
Qlaris Phase 2 Study of QLS-111 in POAG And/or OHT Patients
Qlaris' Phase 2 clinical trial investigating the safety, tolerability, and ocular hypotensive efficacy of QLS-111 in primary open-angle glaucoma (POAG) or ocular hypertension patients.
- Conditions
- Primary Open Angle Glaucoma (POAG), Primary Open Angle Glaucoma of Both Eyes, Primary Open-Angle Glaucoma, Unspecified Eye, Ocular Hypertension (OHT)
- Trial name
- NCT06016972
- Testing
- Experimental: QLS-111 ophthalmic solution, (0.015%), Experimental: QLS-111 ophthalmic solution, (0.03%), Experimental: QLS-111 ophthalmic solution, (0.075%)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Qlaris Bio, Inc.
Schizophrenia, Psychotic Disorders
Investigation of Objective Cognitive Effort in Neuropsychological Evaluation of Psychotic Disorders
Psychotic disorders are characterised by a heterogeneity of symptoms, including cognitive disorders, which predict functional outcome. To date, the evaluation of cognitive functions essentially measures performance.
- Conditions
- Schizophrenia, Psychotic Disorders, Cognitive Impairment, Motivation
- Trial name
- INVESTIGECCO (NCT06782672)
- Testing
- Cardiovascular measurements, Experimental memory task, Questionnaire and semi-structured psychological interview
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Maxillary Hypoplasia
Skeletal and Dental Changes with Hyrax-type Rapid Maxillary Expander Anchored to Permanent Versus Deciduous Molars
The aim of the study is to compare the skeletal and dental maxillary expansion obtained with an Hyrax tooth-borne expander anchored either on the 2nd deciduous molars (V) or on the 1st permanent molars (6)
- Trial name
- DENTHYRAX (NCT05773573)
- Testing
- Experimental group, Control group
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Montpellier
Hospitalization in Children
Effect of Superhero Clothing and Figure on Hospital Adjustment in Children During Hospitalization
Healthcare professionals and administrators who serve children are aware of the role of play in children's lives and with this awareness, they design playrooms and areas for children in hospitals.
- Trial name
- NCT06763263
- Testing
- Experimental, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Nisa Meriç Turan
Punctate Palmoplantar Keratoderma Type 1, Pachyonychia Congenita
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC
This Phase 1b, open-label, single-center, prospective trial will be assessing the safety, tolerability, and efficacy of topical KM-001 1% in patients with PPPK1 or PC diseases. In this study 2 cohorts will be recruited: 1.
- Trial name
- NCT05956314
- Testing
- KM-001 cream 1% 12 weeks treatment., Physical Examination, Vital Signs
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Orvida Pharma (formerly Kamari Pharma)
Cervical Cancer
Home-based Cervical Cancer Screening Project
Cervical cancer is a public health problem in Cameroon.In 2020, the country had a crude incidence of 20.2 per 100 000 women for an incidence to mortality ratio of 0.65.
- Trial name
- CASAHO (NCT06166420)
- Testing
- Experimental, Active comparator
- Where
- Cameroon
- Volunteers
- 2,079 people, healthy volunteers welcome
- Sponsor
- Prof. Patrick Petignat
Aggression Childhood, Teen Dating Violence
Trauma-Informed Peer Aggression and Dating Violence Prevention for Preteens Receiving Intensive Mental Health Services
The goal of this clinical trial is to learn if this intervention (Social Skills, Problem Solving, emotion Regulation, and psycho-Education on Trauma: A Trauma-Informed Peer Aggression and Teen Dating Violence Prevention Program…
- Trial name
- SPARE (NCT06769282)
- Testing
- Experimental: Intervention (SPARE) plus Treatment as Usual, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Rhode Island Hospital
Nursing Students
The Effect of Micro Teaching Method on Nursing Students' Psychomotor Skills, Attitudes, Self-Efficacy and Clinical Stress Level
Objective: This study was conducted to evaluate the effect of the micro-teaching method on nursing students' psychomotor drug administration skills, attitudes towards clinical practice, self-efficacy and clinical stress levels.
- Trial name
- Microteach (NCT06769542)
- Testing
- Experimental (micro teaching)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Inonu University
Children, Nebulizer Therapy
The Effect of Using Nebula Bear on Anxiety and Fear During Nebulizer Application in Children
Many respiratory system diseases are treated with inhalers. Providing inhaler treatment is provided by nebulizer devices. Taking the exact and effective dose of inhaler treatment affects the patient's recovery process.
- Trial name
- NCT06769802
- Testing
- Experimental, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Havva Nur Özlenir
Gastric Cancer
Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia
The beneficial of perioperative usage of thoracic epidural anesthesia and analgesia in various thoracic and upper abdominal surgery are well studied.
- Trial name
- NCT05124704
- Testing
- 5-8ml 0.375% ropivacaine, 5-8ml normal saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wang Jiangling
HIV, Drug Addiction
Treating South African Pregnant Women for Methamphetamine
The purpose of this study was to develop and initially evaluate an efficacious, comprehensive, culturally sensitive, women-centered model of care for pregnant South African women by adapting and refining PI Jones'…
- Trial name
- NCT01386138
- Testing
- Psycho-education, Experimental
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- RTI International
Prosthetic-joint Infection
A Second Trial of the Abbreviated Protocol Two-Stage Exchange
Apex-2 is a multi-site, parallel group, randomized trial. Patients will be randomly assigned in a 1:1 ratio to the Experimental Arm or the Control Arm.
- Trial name
- Apex-2 (NCT05607030)
- Testing
- VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics
- Where
- 19 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Multiple Myeloma, Primary Plasma Cell Leukemia
Study of CT071 Injection in RRMM or PPCL
A Clinical Trial to Explore the Safety and Efficacy of CT071 injection in Patients with Relapsed/Refractory Multiple Myeloma or Primary Plasma Cell Leukemia
- Trial name
- NCT05838131
- Testing
- Experimental: CAR-T cells Infusion
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Changzheng Hospital
Gestational Diabetes Mellitus in Pregnancy
Can Albumin/C-reactive Protein Ratio be Utilized for Predicting Gestational Diabetes Diagnosis or the Adverse Outcomes
This study provides a comprehensive evaluation of the potential utility of the albumin/high-sensitivity C-reactive protein (hsCRP) ratio in diagnosing gestational diabetes mellitus (GDM) and predicting adverse pregnancy outcomes.
- Trial name
- Alb/hsCRP (NCT06761053)
- Testing
- Intervention/Exposure for the GDM Group (Experimental Arm), Intervention/Exposure for the Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- ALI BAHADIRLI
Cancer
A Supportive Care Intervention for Older Caregivers of Older Adults with Advanced Cancer
This project assesses the feasibility of utilizing the geriatric assessment as a tool to identify distressed older caregivers of older adults with cancer.
- Trial name
- NCT05244915
- Testing
- Experimental (Delphi Surveys), Experimental (Focus Groups), Qualitative interviews
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Rochester
Relapse, Orthodontic Retention
The Effectiveness of 3 Orthodontic Fixed Retention Schemes on Post-treatment Stability and Gingival Recession
There is high possibility of relapse of the lower anterior teeth after orthodontic treatment. Relapse is related with the initial orthodontic anomaly, pathology of surrounding tissues, patient's age and sex and compliance and the…
- Trial name
- OrthRe10tion (NCT05926934)
- Testing
- Experimental: Single strand β-Ti fixed retainer, Experimental: SS fixed retainer, Experimental: Twisted fixed retainer
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Athens
Position Differences, Nutrition
Effect of Cradle Position During Orogastric Tube Feeding on Comfort, Physiological Parameters and Vomiting
The study was planned to determine the effect of the cradle position applied during orogastric tube feeding in premature newborns on comfort, physiological parameters and vomiting frequency.
- Conditions
- Position Differences, Nutrition, Nursing Care
- Trial name
- CRADLE (NCT06759285)
- Testing
- Experimental (cradle position)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Selcuk University
Exercise Fatigue
Development and Evaluation of Functional Probiotic Powder in Human Trials
Purpose: To optimize the preparation process of probiotic powder and assess its impact on healthy athletes, providing a scientific basis for functional foods.
- Trial name
- FPPHT (NCT06760468)
- Testing
- Control, Experimental Group
- Volunteers
- 60 people
- Sponsor
- Chengdu Sport University
Hand Massage, Pain
The Effect of Hand Massage on Pain, Anxiety, Fear and Nausea After Surgery in Children
This study was conducted to determine the effect of hand massage on postoperative anxiety, pain, fear, and nausea and vomiting after pediatric surgery. This is a randomized, controlled experimental study.
- Conditions
- Hand Massage, Pain, Anxiety, Fear
- Trial name
- NCT06756529
- Testing
- hand massage
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Fatma Akıl
Spinal Metastases, Local Control
Evaluate the Efficacy of Radiofrequency Ablation/Vertebroplasty with or Without SBRT for Treating Painful Spinal Vertebral Metastases
This study is a prospective, multicenter, open, practical, randomized controlled, non inferiority effect clinical study initiated by researchers, which aims to evaluate the clinical efficacy and safety of radiofrequency…
- Conditions
- Spinal Metastases, Local Control, Pain Cancer
- Trial name
- NCT06756087
- Testing
- Radiofrequency Ablation (RFA)/Vertebroplasty+Stereotactic Radiotherapy, Experimental
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine