Clinical trials: Experimental, completed
Hepatic Impairment
Pharmacokinetics of AGO178 in Participants With Liver Impairment
AGO178 was developed for the treatment of depression. A new formulation is being tested in the present study: a tablet to be placed and dissolved under the tongue (sublingual tablet).
- Trial name
- NCT01531309
- Testing
- AGO178
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
COVID-19
Ivermectin for Severe COVID-19 Management
In this multicenter study; it was aimed to investigate the effectiveness and safety of ivermectin use in the treatment of patients with severe COVID-19 pneumonia that have no mutations which alter ivermectin metabolism and cause…
- Trial name
- NCT04646109
- Testing
- Ivermectin
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Disruptive Behavior Disorder
Addressing Behaviour and Treatment Effectiveness Project (A.B.A.T.E. Project)
This study investigates the effectiveness of a clinic-adapted version of the Coping Power program compared to individualized child and family treatment for children with disruptive behaviour and their parents.
- Trial name
- ABATE (NCT02488499)
- Testing
- Coping Power, Individualized Treatment
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- Centre for Addiction and Mental Health
Osteoarthritis, Hip, Arthroplasty Complications
A Randomized RSA Study Comparing HXLPE to Conventional Polyethylene in Cemented Total Hip Arthroplasty
A prospective randomized study comparing two types of cemented acetabular components, a highly-crosslinked polyethylene or conventional polyethylene in total hip arthroplasty.
- Trial name
- NCT04322799
- Testing
- Device: Randomization between prosthetic components
- Where
- Sweden
- Volunteers
- 57 people
- Sponsor
- Umeå University
Hip Fractures, Gait, Unsteady
Comparison of Sliding Hip Screw to Intra Medullary Nailing in the Treatment of Intertrochanteric Hip Fracture
Shortening of the abductor lever arm is a particular concern with the SHS, and the resultant biomechanical alterations may impair gait, including decreased cadence, gait speed and increased double support time on the injured…
- Conditions
- Hip Fractures, Gait, Unsteady, Function
- Trial name
- NCT03906032
- Testing
- TFNA IM Nail, Sliding hip screw
- Where
- Ireland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Waterford
Diabetes (DM), Dry Mouth
Effects of Chewing Gum for Dry Mouth in Diabetes
Dry mouth can seriously affect the quality of life of individuals because it affects chewing and swallowing functions. One of the diseases in which dry mouth occurs as a side effect of many diseases and/or treatments is diabetes…
- Trial name
- NCT07084532
- Testing
- Chewing gum, Standart therapy group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Çankırı Karatekin University
Recurrent Breast Carcinoma, Stage IV Breast Cancer
Erlotinib Hydrochloride and Bevacizumab in Treating Patients With Stage IV Breast Cancer
This phase II trial studies how well erlotinib hydrochloride and bevacizumab work in treating patients with stage IV breast cancer.
- Trial name
- NCT00054132
- Testing
- Bevacizumab, Erlotinib Hydrochloride, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- National Cancer Institute (NCI)
Healthy
Young Age Soccer Player's Lower Limb Muscle Imbalance and Functional Status
A randomized controlled trial is designed to examine the effects of low-load and high-velocity eccentric exercises on lower limb muscular properties, imbalances and functional status of 13-15 years old female football players.
- Trial name
- NCT06053632
- Testing
- Low-load and high-velocity - lying prone - eccentric hamstring exercise
- Where
- Lithuania
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Advanced Solid Tumor
A Phase I Study of SCC244 in Patients with Advanced MET Alterations Solid Tumors
This is a Phase 1a/1b multi-center and open label study to evaluate the safety, tolorability, pharmacokinetics and priliminary efficacy of SCC244 in advanced solid tumors patients with c-MET alteration
- Trial name
- NCT03457532
- Testing
- Gumarontinib Tablets
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Haihe Biopharma Co., Ltd.
Chemotherapy Training
Virtual Reality Application in Chemotherapy Administration in Nurse Staff
The present study wants to design a training program for chemotherapy with using VR among nurse staff. Then the investigators design a protocol to compare the training effects in the VR program and ISO document.
- Trial name
- NCT04840732
- Testing
- VR training program, usual care
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Influenza
Safety and Immunogenicity of BPL-1357, A BPL-Inactivated, Whole-Virus, Universal Influenza Vaccine
Background: Influenza (flu) is a virus that infects people of all ages. Some people may have mild flu symptoms. Others may get very sick and even die from the flu.
- Trial name
- NCT05027932
- Testing
- BPL-1357
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Malaria, HIV
Dolutegravir Interactions With Artemisinin-based Combination Therapies
Malaria and HIV are found in the same regions of the world and developing countries are most affected by both diseases. For malaria, new drugs have been introduced called ACTs.
- Trial name
- DolACT (NCT02242799)
- Testing
- Dolutegravir 50mg od, Artemether-lumefantrine combination, Artesunate-amodiaquine
- Where
- Uganda
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Vasoplegic Syndrome, Liver Transplant; Complications
Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients
This study will evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.
- Trial name
- NCT04054999
- Testing
- Hydroxocobalamin, Methylene Blue
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Shoulder Pain, Hemiplegia
Shoulder Passive Range of Motion and Positioning Exercise on Hemiplegic Stroke Patients
Several factors associated with the hemiplegic shoulder pain after stroke includes rotator cuff injury, bicipital tendonitis, impingement, spasticity, limited external rotation of shoulder joint, adhesive capsulitis, shoulder…
- Conditions
- Shoulder Pain, Hemiplegia, Stroke, Rotator Cuff Injury
- Trial name
- NCT03045432
- Testing
- video-teaching, oral-teaching, regular rehabilitation program
- Volunteers
- 104 people
- Sponsor
- Chang Gung Memorial Hospital
Epidural Anesthesia, Shivering
The Effect of Oral Pregabalin on Epidural-induced Shivering and Epidural Characteristics
Background: The previous reports tried to reduce shivering and improve neuroaxial anesthesia characteristics by the systemic use of different drugs.
- Trial name
- NCT03721432
- Testing
- Pregabalin 150mg
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- Beni-Suef University
Prostate Cancer, Colorectal Cancer
Impact of Exercise on Mitochondria in Cancer Patients.
The aim is to investigate the impact of prostate and colorectal cancer on mitochondrial quantity and quality along with muscle mass and function and whether this can be modified through the use of a home-based short-term exercise…
- Trial name
- ICCE-Mito (NCT04558398)
- Testing
- Resistance exercise training, High-intensity interval training
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Locally Advanced Lung Cancer; Metastatic Lung Cancer
Anti-PD-1 in Combination With Chemotherapy as First-Line Treatment to Lung Cancer
This is a Phase II, open-label, 4-cohort study of the monoclonal antibody BGB-A317 in combination with standard platinum-based chemotherapy in participants with advanced NSCLC or SCLC.
- Trial name
- NCT03432598
- Testing
- Tislelizumab, Paclitaxel, Gemcitabine
- Where
- 7 sites in China
- Volunteers
- 54 people
- Sponsor
- BeiGene
mHealth
VR-3D Movie-based Education
Atrial fibrillation (AF), which is the most common cardiac arrhythmia in adults, is associated with a high risk of stroke and other thromboembolic complications.
- Trial name
- NCT03104231
- Testing
- three-dimensional (3D) movie
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Hemodialysis
Effect of Whole Body Vibration on Walking Performance in Elderly Hemodialysis Patients
The purpose of this study is to evaluate the efficacy of whole body vibration for 12 weeks on walking performance in elderly hemodialysis patients.
- Trial name
- NCT04774731
- Testing
- Whole Body Vibration
- Where
- Japan
- Volunteers
- 98 people
- Sponsor
- Osaka University
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