Clinical trials: Experimental
Transversalis Fascia Plane Block, Intrathecal Dexmedetomidine
Transversalis Fascia Plane Block Versus Intrathecal Dexmedetomidine in Patients Undergoing Cesarean Section
This study aims to compare the analgesic efficacy of the transversalis fascia plane (TFP) block and intrathecal dexmedetomidine in patients undergoing cesarean section (CS).
- Conditions
- Transversalis Fascia Plane Block, Intrathecal Dexmedetomidine, Cesarean Section
- Trial name
- NCT07170267
- Testing
- Transversalis fascia plane block, Intrathecal dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Newborn; Vitality, Iron Deficiency Anemia
The Importance of Delayed Cord Clamping
After birth, the umbilical cord is usually clamped and separated from the placenta within the first 30 seconds. Although the exact time to clamp the umbilical cord is unknown, allowing placental transfusion after birth has many…
- Trial name
- NCT06405867
- Testing
- delayed cord clamping (> 60 sec)
- Where
- Turkey (Türkiye)
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Chronic Obstructive Pulmonary Disease
Comparative Effects of ACBT and Slow Expiration in Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is characterized by nonreversible airway obstruction. A diagnosis of COPD is determined by clinical assessment of airflow limitation and symptoms such as cough and wheeze; however, the…
- Trial name
- NCT05922267
- Testing
- ACTIVE CYCLE OF BREATHING TECHNIQUES, SLOW EXPIRATION WITH OPEN GLOTTIS IN LATERAL POSITION
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Insomnia, Cognitive Impairment
The Effect of Aromatherapy on Sleep and Cognitive Level in the Elderly
This research aims to investigate the effect of aromatherapy on sleep duration, sleep quality, falling asleep time and cognitive functions of elderly individuals in the short term and to improve the general health status and…
- Conditions
- Insomnia, Cognitive Impairment, Elderly
- Trial name
- NCT06208800
- Testing
- Blend Aromatherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medipol University
Resistance Training, Muscle Hypertrophy
High- and Low-Load Resistance Training
The goal of this clinical trial is to learn whether low-load resistance training performed to muscle failure can produce similar increases in muscle size and strength as high-load resistance training in healthy untrained young…
- Trial name
- NCT07412600
- Testing
- Low-load resistance training (30% 1RM), High-load resistance training (75% 1RM)
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Anorexia Nervosa, Anorexia
Positive Affect Treatment (PAT) to Target Reward Mechanisms in Anorexia Nervosa
The goal of the proposed research is to determine the extent to which Positive Affect Treatment (PAT), a novel treatment targeting reward mechanisms, can effectively target the psychological reward deficits that maintain anorexia…
- Trial name
- NCT04007900
- Testing
- Positive Affect Treatment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Minnesota
Teeth, Impacted
Bupivacaine in the Treatment of Postoperative Pain of Impacted Third Molar Extraction
The third molars are the teeth that are most frequently included and impacted, extraction is one of the most performed treatments by maxillofacial surgeons in their clinical practice.
- Trial name
- NCT03950700
- Testing
- Bupivacaine-epinephrine, Saline Solution
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CES University
Degree of Adherence of Symptomatic OLP Patients to Their Medications
Adherence to Topical and Systemic Medications Among Symptomatic Oral Lichen Planus Patients: A Pilot Randomized Clinical Trial
This trial will assess the effect of adjunctive use of explanatory leaflet or daily text message reminder compared to standard instructions alone in degree of adherence of symptomatic OLP patients to their medications.
- Trial name
- NCT07879300
- Testing
- standard verbal instructions, Explanatory leaflets, text msgs
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Angle Class II, Division 1 Malocclusion
"Effects of Piezocision vs Micro-osteoperforations on the Rate of Maxillary Canine Retraction
Acceleration of orthodontic tooth movement persuades tremendous rise in the interest of adolescents and aduts, as it not only shortens the treatment duration but also lessens the incidence of white spot lesions, root resorption…
- Trial name
- NCT04743700
- Testing
- Piezocision, Micro-osteoperforations
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Hemodialysis Complication
Exercise on Mitochondrial Functions of Lymphocyte in Hemodialysis
To improve aerobic capacity, muscular function and health-related quality of life in patients with end-stage renal disease (ESRD), regular exercise is recommended.
- Trial name
- NCT06417307
- Testing
- Supervised exercise training, Control group
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy
Relative Bioavailability of Dabigatran and Diclofenac After Dabigatran Etexilate and Diclofenac Single Dose Alone or Following Concomitant Multiple Oral Administrations in Healthy Male and Female Volunteers
To investigate the relative bioavailability of dabigatran with and without concomitant administration of diclofenac and the relative bioavailability of diclofenac with and without concomitant administration of dabigatran etexilate
- Trial name
- NCT02171507
- Testing
- Dabigatran etexilate, Diclofenac
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Melanoma
Complete Lymph Node Dissection vs Watchful Waiting in Patients With Malignant Melanoma (Thickness of 1,0mm+ and Evidence of Metastases in the Sentinel Node)
Sentinel lymph node biopsy (SLNB) is considered as standard diagnostic procedure in melanoma patients carrying a reasonable risk for metastases.
- Trial name
- DeCOG-SLT (NCT02434107)
- Testing
- Completion Lymphadenectomy, Clinical Monitoring (Palpation and node ultrasound)
- Where
- 41 sites in Germany
- Volunteers
- 483 people
- Sponsor
- University Hospital Tuebingen
Traumatic Brain Injury
IRB-HSR# 14299: The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Cerebral Perfusion Pressure in Patients With Altered Intracranial Elastance
Patients who have a functioning intracranial pressure-monitoring device (either a subarachnoid bolt, or an intraventricular catheter) in place, and are either sedated, intubated, and mechanically ventilated (i.e.
- Trial name
- NCT01205607
- Testing
- ITPR -5 mm Hg then -9 mm Hg, ITPR -9 & then -5mm Hg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Graft Vs Host Disease
Safety Study of Preimplantation Factor (PIF-1) to Treat Acute Steroid-Resistant Graft-Versus-Host Disease (GVHD)
The primary goal of this study is to determine the safety and tolerability of a novel peptide - preimplantation factor (PIF-1) - in patients who develop acute steroid-resistant graft-versus-host disease (GVHD) after matched bone…
- Trial name
- PIF1GVHD (NCT00517907)
- Testing
- Preimplantation factor (PIF-1)
- Where
- Israel
- Volunteers
- 6 people
- Sponsor
- Hadassah Medical Organization
Quality of Life, Cognitive Impairment
Effect of the Mindfulness-Based Health Promotion Program (MBHP) in the Elderly: a RCT
According to the World Health Organization (WHO), it is estimated that by 2025 the number of older people in Brazil will be approximately 33.4 million and it will be the sixth population in absolute numbers of the elderly in the…
- Conditions
- Quality of Life, Cognitive Impairment, Psychological
- Trial name
- NCT03706807
- Testing
- Mindfulness-Based Intervention, Cognitive Stimulation
- Where
- Brazil
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Centro Mente Aberta de Mindfulness
Type 2 Diabetes, Severe Mental Disorder
Psychosis and Type 2 Diabetes Study (PODS)
People with severe mental illness (SMI), defined as psychotic and bipolar disorders, die 17-20 years earlier than the general population, the most common cause of death being cardiovascular diseases (CVD).
- Trial name
- NCT05496907
- Testing
- Diabetes specialist nurse-led collaborative care intervention
- Where
- 9 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- King's College London
Oral Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria
Evaluation of Fosmidomycin and Piperaquine in the Treatment of Acute Falciparum Malaria
The objective of this study is to explore the role of fosmidomycin and piperaquine as non-artemisinin-based combination therapy for acute uncomplicated Plasmodium falciparum when administered over three days.
- Trial name
- FOSPIP (NCT02198807)
- Testing
- Fosmidomycin-Piperaquine
- Volunteers
- 100 people
- Sponsor
- Jomaa Pharma GmbH
Atopic Dermatitis
Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4
The purpose of this trial is to investigate if tralokinumab changes the metabolism of selected CYP substrates in adults with moderate-to-severe AD after: 14 weeks of treatment with tralokinumab a single dose of tralokinumab
- Trial name
- NCT03556592
- Testing
- Tralokinumab, Caffeine, Warfarin
- Where
- 12 sites in United States, France and 1 more
- Volunteers
- 40 people
- Sponsor
- LEO Pharma
Hepatitis C, Chronic
A Study Evaluating Slow Response/Non-Rapid Response in Patients With Chronic Hepatitis C, Genotype 1, 2, 3 & 4 Treated With Pegasys (Peginterferon Alfa-2a) and Copegus (Ribavirin)
This multi-center study will evaluate the viral response in patients with chronic hepatitis C, genotype 1, 2, 3 \& 4 on standard anti-viral treatment with Pegasys (peginterferon alfa-2a) and Copegus (ribavirin).
- Trial name
- NCT01429792
- Testing
- peginterferon alfa-2a [Pegasys], ribavirin [Copegus]
- Where
- 26 sites in Israel
- Volunteers
- 1,013 people
- Sponsor
- Hoffmann-La Roche
Coronary Artery Disease, Heart Valve Diseases
Centrifugation vs. Multiple-pass Hemofiltration of the Residual Cardiopulmonary Bypass Volume
Traditional cardiac surgery requires patient connection to the Cardiopulmonary Bypass (CPB) apparatus which takes over the function of the heart and lungs while the surgeon performs the necessary surgery.
- Trial name
- NCT01416792
- Testing
- Centrifugation, Multiple-pass hemofiltration
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Saskatchewan
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